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ACTIVIN ADIPONECTIN AGT ANGPT ANGPTL ANNEXIN APELIN BAFF BMP CCL COMPLEMENT CSF CX3C CXCL ENHO FGF FLT3 GALECTIN GAS GDF GH GRN IFN-II IGF IL1 IL16 IL17 IL2 IL6 IL7 KIT LIFR LIGHT LT MIF MK NODAL NPR2 NRG NT OSM PARs PDGF PERIOSTIN PROS PSAP PTN RANKL SEMA3 SLURP SPP1 TGFb TNF TWEAK VEGF VISFATIN WNT ncWNT
ALCAM APP BST2 CADM CD1D2 CD200 CD22 CD23 CD34 CD39 CD45 CD46 CD52 CD6 CD80 CD86 CDH CEACAM CLEC CSPG4 EPHA EPHB ESAM GP1BA ICAM ICOS ITGAL-ITGB2 JAM LAIR1 LCK MAG MHC-I MHC-II NCAM NGL NKG2D NOTCH PECAM1 SELE SELL SELPLG SEMA4 SEMA5 SEMA6 SEMA7 THY1 VCAM VISTA
AGRN BSP COLLAGEN DMP1 FN1 LAMININ TENASCIN THBS VTN VWF
ALCAM APP BST2 CADM CD1D2 CD200 CD22 CD23 CD34 CD39 CD45 CD46 CD52 CD6 CD80 CD86 CDH CEACAM CLEC CSPG4 EPHA EPHB ESAM GP1BA ICAM ICOS ITGAL-ITGB2 JAM LAIR1 LCK MAG MHC-I MHC-II NCAM NGL NKG2D NOTCH PECAM1 SELE SELL SELPLG SEMA4 SEMA5 SEMA6 SEMA7 THY1 VCAM VISTA AGRN BSP COLLAGEN DMP1 FN1 LAMININ TENASCIN THBS VTN VWF ACTIVIN ADIPONECTIN AGT ANGPT ANGPTL ANNEXIN APELIN BAFF BMP CCL COMPLEMENT CSF CX3C CXCL ENHO FGF FLT3 GALECTIN GAS GDF GH GRN IFN-II IGF IL1 IL16 IL17 IL2 IL6 IL7 KIT LIFR LIGHT LT MIF MK NODAL NPR2 NRG NT OSM PARs PDGF PERIOSTIN PROS PSAP PTN RANKL SEMA3 SLURP SPP1 TGFb TNF TWEAK VEGF VISFATIN WNT ncWNT



Signaling Pathway Summary Table

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Signaling Pathway Name Signaling Pathway Category Number of Active Cell Types Across all HSPCs Highest Interaction Intensity Across all HSPCs
ALCAM Cell-Cell Contact 3 0.001
APP Cell-Cell Contact 144 0.119
BST2 Cell-Cell Contact 102 0.026
CADM Cell-Cell Contact 16 0.020
CD1D2 Cell-Cell Contact 6 0.001
CD200 Cell-Cell Contact 54 0.013
CD22 Cell-Cell Contact 25 0.011
CD23 Cell-Cell Contact 8 0.006
CD34 Cell-Cell Contact 90 0.089
CD39 Cell-Cell Contact 18 0.003
CD45 Cell-Cell Contact 50 0.038
CD46 Cell-Cell Contact 12 0.002
CD52 Cell-Cell Contact 150 0.065
CD6 Cell-Cell Contact 3 0.001
CD80 Cell-Cell Contact 4 0.005
CD86 Cell-Cell Contact 17 0.007
CDH Cell-Cell Contact 8 0.002
CEACAM Cell-Cell Contact 12 0.008
CLEC Cell-Cell Contact 30 0.002
CSPG4 Cell-Cell Contact 4 0.006
EPHA Cell-Cell Contact 30 0.003
EPHB Cell-Cell Contact 30 0.009
ESAM Cell-Cell Contact 58 0.041
GP1BA Cell-Cell Contact 8 0.005
ICAM Cell-Cell Contact 258 0.082
ICOS Cell-Cell Contact 12 0.005
ITGAL-ITGB2 Cell-Cell Contact 150 0.025
JAM Cell-Cell Contact 131 0.036
LAIR1 Cell-Cell Contact 21 0.013
LCK Cell-Cell Contact 6 0.021
MAG Cell-Cell Contact 4 0.006
MHC-I Cell-Cell Contact 50 1.100
MHC-II Cell-Cell Contact 31 0.071
NCAM Cell-Cell Contact 62 0.023
NGL Cell-Cell Contact 3 0.001
NKG2D Cell-Cell Contact 6 0.007
NOTCH Cell-Cell Contact 84 0.011
PECAM1 Cell-Cell Contact 40 0.053
SELE Cell-Cell Contact 6 0.014
SELL Cell-Cell Contact 192 0.117
SELPLG Cell-Cell Contact 252 0.093
SEMA4 Cell-Cell Contact 126 0.021
SEMA5 Cell-Cell Contact 18 0.001
SEMA6 Cell-Cell Contact 39 0.003
SEMA7 Cell-Cell Contact 21 0.005
THY1 Cell-Cell Contact 30 0.019
VCAM Cell-Cell Contact 94 0.086
VISTA Cell-Cell Contact 6 0.007
AGRN ECM-Receptor 48 0.004
BSP ECM-Receptor 30 0.017
COLLAGEN ECM-Receptor 226 0.577
DMP1 ECM-Receptor 18 0.007
FN1 ECM-Receptor 120 0.165
LAMININ ECM-Receptor 228 0.039
TENASCIN ECM-Receptor 30 0.086
THBS ECM-Receptor 82 0.527
VTN ECM-Receptor 6 0.007
VWF ECM-Receptor 6 0.012
ACTIVIN Secreted Signaling 6 0.002
ADIPONECTIN Secreted Signaling 12 0.117
AGT Secreted Signaling 8 0.008
ANGPT Secreted Signaling 72 0.013
ANGPTL Secreted Signaling 120 0.056
ANNEXIN Secreted Signaling 37 0.052
APELIN Secreted Signaling 12 0.002
BAFF Secreted Signaling 70 0.024
BMP Secreted Signaling 27 0.003
CCL Secreted Signaling 194 0.054
COMPLEMENT Secreted Signaling 32 0.017
CSF Secreted Signaling 38 0.032
CX3C Secreted Signaling 1 0.001
CXCL Secreted Signaling 105 0.041
ENHO Secreted Signaling 6 0.001
FGF Secreted Signaling 70 0.037
FLT3 Secreted Signaling 36 0.005
GALECTIN Secreted Signaling 306 0.117
GAS Secreted Signaling 48 0.048
GDF Secreted Signaling 35 0.002
GH Secreted Signaling 4 0.012
GRN Secreted Signaling 150 0.030
IFN-II Secreted Signaling 6 0.009
IGF Secreted Signaling 40 0.006
IL1 Secreted Signaling 18 0.003
IL16 Secreted Signaling 21 0.008
IL17 Secreted Signaling 5 0.001
IL2 Secreted Signaling 34 0.010
IL6 Secreted Signaling 10 0.002
IL7 Secreted Signaling 32 0.013
KIT Secreted Signaling 30 0.052
LIFR Secreted Signaling 42 0.007
LIGHT Secreted Signaling 30 0.003
LT Secreted Signaling 23 0.005
MIF Secreted Signaling 264 0.238
MK Secreted Signaling 144 0.238
NODAL Secreted Signaling 8 0.001
NPR2 Secreted Signaling 3 0.001
NRG Secreted Signaling 12 0.001
NT Secreted Signaling 2 0.002
OSM Secreted Signaling 54 0.012
PARs Secreted Signaling 156 0.207
PDGF Secreted Signaling 90 0.013
PERIOSTIN Secreted Signaling 24 0.008
PROS Secreted Signaling 36 0.007
PSAP Secreted Signaling 6 0.105
PTN Secreted Signaling 76 0.222
RANKL Secreted Signaling 12 0.004
SEMA3 Secreted Signaling 35 0.011
SLURP Secreted Signaling 6 0.003
SPP1 Secreted Signaling 222 0.137
TGFb Secreted Signaling 222 0.013
TNF Secreted Signaling 138 0.007
TWEAK Secreted Signaling 36 0.014
VEGF Secreted Signaling 50 0.042
VISFATIN Secreted Signaling 90 0.008
WNT Secreted Signaling 30 0.002
ncWNT Secreted Signaling 16 0.001