Pathway: PTN

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the PTN pathway:

Specificity Index HSPC as target: 0.968
HSPC as source: 0.585

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the PTN pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target PTN Source FGF FGF Secreted Signaling 0.0976 0.0291739717591973 Scatter Plot
Source PTN Source NT NT Secreted Signaling 0.1009 0.0240737920752235 Scatter Plot
Target PTN Source CD1D2 CD1D2 Cell-Cell Contact 0.1013 0.0234720135666463 Scatter Plot
Target PTN Target GDF GDF Secreted Signaling 0.1051 0.0187535968006973 Scatter Plot
Target PTN Source CD34 CD34 Cell-Cell Contact 0.1063 0.0173667586127504 Scatter Plot
Target PTN Target GAS GAS Secreted Signaling 0.1107 0.0132708890462543 Scatter Plot
Target PTN Source IL6 IL6 Secreted Signaling 0.1127 0.0116665139994271 Scatter Plot
Source PTN Source IL6 IL6 Secreted Signaling 0.1129 0.011563596894113 Scatter Plot
Source PTN Source VCAM VCAM Cell-Cell Contact 0.1140 0.0107234168855123 Scatter Plot
Source PTN Source CD86 CD86 Cell-Cell Contact 0.1150 0.0100774435848096 Scatter Plot
Source PTN Source EPHB EPHB Cell-Cell Contact 0.1159 0.0095201839735997 Scatter Plot
Source PTN Source PSAP PSAP Secreted Signaling 0.1159 0.0094773864519927 Scatter Plot
Source PTN Source NOTCH NOTCH Cell-Cell Contact 0.1160 0.0094380546587214 Scatter Plot
Target PTN Target COMPLEMENT COMPLEMENT Secreted Signaling 0.1173 0.0086579544092106 Scatter Plot
Target PTN Source LIGHT LIGHT Secreted Signaling 0.1177 0.0084137940529237 Scatter Plot
Source PTN Source RANKL RANKL Secreted Signaling 0.1210 0.006765104512192 Scatter Plot
Source PTN Source LAMININ LAMININ ECM-Receptor 0.1249 0.0051599208027583 Scatter Plot
Target PTN Source SEMA3 SEMA3 Secreted Signaling 0.1267 0.0045407451151937 Scatter Plot
Target PTN Target SEMA3 SEMA3 Secreted Signaling 0.1310 0.0033419131235948 Scatter Plot
Target PTN Source PSAP PSAP Secreted Signaling 0.1316 0.0031851267316673 Scatter Plot
Source PTN Source GALECTIN GALECTIN Secreted Signaling 0.1318 0.0031533990309284 Scatter Plot
Target PTN Source APELIN APELIN Secreted Signaling 0.1325 0.0030028784920177 Scatter Plot
Source PTN Source VEGF VEGF Secreted Signaling 0.1373 0.0020931234734711 Scatter Plot
Target PTN Target VEGF VEGF Secreted Signaling 0.1390 0.001831920477322 Scatter Plot
Source PTN Source THY1 THY1 Cell-Cell Contact 0.1393 0.0017999528542389 Scatter Plot
Source PTN Source WNT WNT Secreted Signaling 0.1404 0.0016442531781192 Scatter Plot
Target PTN Source RANKL RANKL Secreted Signaling 0.1420 0.0014606236901977 Scatter Plot
Target PTN Source MK MK Secreted Signaling 0.1429 0.0013597043560959 Scatter Plot
Source PTN Source GAS GAS Secreted Signaling 0.1432 0.0013275155360109 Scatter Plot
Target PTN Source SEMA4 SEMA4 Cell-Cell Contact 0.1457 0.0010830163798637 Scatter Plot
Source PTN Source IGF IGF Secreted Signaling 0.1459 0.0010648529297404 Scatter Plot
Source PTN Source PROS PROS Secreted Signaling 0.1467 0.0010042536033096 Scatter Plot
Target PTN Source THY1 THY1 Cell-Cell Contact 0.1479 0.000909496485401 Scatter Plot
Source PTN Source MK MK Secreted Signaling 0.1504 0.000738770550723 Scatter Plot
Target PTN Source CADM CADM Cell-Cell Contact 0.1505 0.0007362964695871 Scatter Plot
Target PTN Source IGF IGF Secreted Signaling 0.1513 0.0006866216063392 Scatter Plot
Target PTN Source ncWNT ncWNT Secreted Signaling 0.1586 0.0003692443000285 Scatter Plot
Source PTN Source CD34 CD34 Cell-Cell Contact 0.1590 0.0003582162539795 Scatter Plot
Target PTN Source CSF CSF Secreted Signaling 0.1639 0.0002334322617373 Scatter Plot
Source PTN Source APELIN APELIN Secreted Signaling 0.1665 0.0001834551191291 Scatter Plot
Target PTN Source CX3C CX3C Secreted Signaling 0.1681 0.000158904806131 Scatter Plot
Target PTN Source CD86 CD86 Cell-Cell Contact 0.1717 0.000113725268054 Scatter Plot
Target PTN Source CCL CCL Secreted Signaling 0.1720 0.0001114576909841 Scatter Plot
Target PTN Source GDF GDF Secreted Signaling 0.1729 0.0001019436086002 Scatter Plot
Target PTN Target RANKL RANKL Secreted Signaling 0.1733 0.00009783842350392832 Scatter Plot
Target PTN Target BMP BMP Secreted Signaling 0.1773 0.00006685206980402836 Scatter Plot
Source PTN Source LIFR LIFR Secreted Signaling 0.1799 0.00005240331148949862 Scatter Plot
Source PTN Source GDF GDF Secreted Signaling 0.1816 0.00004434583121236365 Scatter Plot
Target PTN Source LAMININ LAMININ ECM-Receptor 0.1816 0.000044185165898247015 Scatter Plot
Target PTN Source PROS PROS Secreted Signaling 0.1874 0.00002467586221261688 Scatter Plot
Target PTN Source NOTCH NOTCH Cell-Cell Contact 0.1879 0.00002345075896133448 Scatter Plot
Source PTN Source ANGPTL ANGPTL Secreted Signaling 0.1905 0.000017907528068691178 Scatter Plot
Target PTN Source GP1BA GP1BA Cell-Cell Contact 0.1909 0.000017281563780443397 Scatter Plot
Target PTN Target SEMA7 SEMA7 Cell-Cell Contact 0.1933 0.0000134719701743515 Scatter Plot
Source PTN Source PDGF PDGF Secreted Signaling 0.1937 0.000012865293929586782 Scatter Plot
Target PTN Source NT NT Secreted Signaling 0.1967 0.000009381783753028491 Scatter Plot
Source PTN Source FGF FGF Secreted Signaling 0.1972 0.000008937898296964546 Scatter Plot
Source PTN Source LIGHT LIGHT Secreted Signaling 0.1989 0.000007444882124739472 Scatter Plot
Target PTN Source ANGPTL ANGPTL Secreted Signaling 0.2011 0.0000058236014214208005 Scatter Plot
Source PTN Source ANGPT ANGPT Secreted Signaling 0.2091 0.000002409094271796672 Scatter Plot
Target PTN Source IL2 IL2 Secreted Signaling 0.2110 0.000001938611370499935 Scatter Plot
Target PTN Source VEGF VEGF Secreted Signaling 0.2114 0.000001846885466827752 Scatter Plot
Target PTN Target CD39 CD39 Cell-Cell Contact 0.2118 0.0000017611072801314706 Scatter Plot
Target PTN Source AGRN AGRN ECM-Receptor 0.2119 0.000001745171921688032 Scatter Plot
Target PTN Target MIF MIF Secreted Signaling 0.2130 0.0000015411710806347469 Scatter Plot
Target PTN Target TWEAK TWEAK Secreted Signaling 0.2137 0.0000014250396028987303 Scatter Plot
Source PTN Source MHC-II MHC-II Cell-Cell Contact 0.2155 0.0000011567750819714422 Scatter Plot
Target PTN Target ACTIVIN ACTIVIN Secreted Signaling 0.2158 0.0000011066825088635706 Scatter Plot
Target PTN Source CXCL CXCL Secreted Signaling 0.2204 0.0000006476512108343086 Scatter Plot
Target PTN Source CD46 CD46 Cell-Cell Contact 0.2231 0.0000004648035452351568 Scatter Plot
Target PTN Source EPHB EPHB Cell-Cell Contact 0.2246 0.0000003903799430238015 Scatter Plot
Source PTN Source JAM JAM Cell-Cell Contact 0.2246 0.00000038852181866208586 Scatter Plot
Target PTN Source PDGF PDGF Secreted Signaling 0.2383 0.00000006950672470819925 Scatter Plot
Target PTN Source TWEAK TWEAK Secreted Signaling 0.2415 0.000000045615600734159866 Scatter Plot
Target PTN Source ICAM ICAM Cell-Cell Contact 0.2450 0.000000028525967603299223 Scatter Plot
Target PTN Target SEMA6 SEMA6 Cell-Cell Contact 0.2463 0.00000002395225794118272 Scatter Plot
Target PTN Source VCAM VCAM Cell-Cell Contact 0.2502 0.00000001421889788135388 Scatter Plot
Target PTN Target KIT KIT Secreted Signaling 0.2517 0.000000011492186466034921 Scatter Plot
Target PTN Source LCK LCK Cell-Cell Contact 0.2540 0.000000008377147471799473 Scatter Plot
Target PTN Source GAS GAS Secreted Signaling 0.2579 0.000000004866120565519037 Scatter Plot
Target PTN Source IL7 IL7 Secreted Signaling 0.2606 0.000000003291316497146477 Scatter Plot
Target PTN Target SLURP SLURP Secreted Signaling 0.2690 0.000000000976128727938569 Scatter Plot
Target PTN Target SEMA5 SEMA5 Cell-Cell Contact 0.2745 0.00000000042994514572129165 Scatter Plot
Target PTN Source BMP BMP Secreted Signaling 0.2760 0.00000000034038791351765384 Scatter Plot
Target PTN Target FGF FGF Secreted Signaling 0.2763 0.0000000003272856601911625 Scatter Plot
Target PTN Target CDH CDH Cell-Cell Contact 0.2774 0.00000000027443373836338616 Scatter Plot
Target PTN Source CDH CDH Cell-Cell Contact 0.2774 0.00000000027443373836338616 Scatter Plot
Target PTN Target EPHB EPHB Cell-Cell Contact 0.2801 0.0000000001821883055972175 Scatter Plot
Target PTN Source FLT3 FLT3 Secreted Signaling 0.2802 0.00000000017979894135155509 Scatter Plot
Target PTN Source SEMA7 SEMA7 Cell-Cell Contact 0.2838 0.00000000010251196881507387 Scatter Plot
Target PTN Source MIF MIF Secreted Signaling 0.2870 0.00000000006130481781773905 Scatter Plot
Target PTN Source LIFR LIFR Secreted Signaling 0.2870 0.00000000006129638594174104 Scatter Plot
Target PTN Source COLLAGEN COLLAGEN ECM-Receptor 0.2876 0.00000000005613254986718464 Scatter Plot
Target PTN Source ESAM ESAM Cell-Cell Contact 0.2920 0.00000000002735963970765964 Scatter Plot
Target PTN Source JAM JAM Cell-Cell Contact 0.3098 0.0000000000013809806629972036 Scatter Plot
Target PTN Source MHC-II MHC-II Cell-Cell Contact 0.3112 0.000000000001081839228663543 Scatter Plot
Target PTN Source GALECTIN GALECTIN Secreted Signaling 0.3126 0.0000000000008569268687938889 Scatter Plot
Target PTN Target PARs PARs Secreted Signaling 0.3131 0.000000000000776366897501763 Scatter Plot
Target PTN Source MHC-I MHC-I Cell-Cell Contact 0.3200 0.00000000000022599646768543542 Scatter Plot
Target PTN Source ANGPT ANGPT Secreted Signaling 0.3227 0.0000000000001403395852080852 Scatter Plot
Target PTN Target WNT WNT Secreted Signaling 0.4234 0.00000000000000000000003571203527833444 Scatter Plot
Target PTN Source BST2 BST2 Cell-Cell Contact 0.4485 0.00000000000000000000000003984545769759122 Scatter Plot
Target PTN Source ANNEXIN ANNEXIN Secreted Signaling -0.5048 0.0000000000000000000000000000000010669641240459 Scatter Plot
Target PTN Source CD52 CD52 Cell-Cell Contact -0.4679 0.00000000000000000000000000014254485139546916 Scatter Plot
Target PTN Source VISTA VISTA Cell-Cell Contact -0.4620 0.0000000000000000000000000008324433622052765 Scatter Plot
Target PTN Target ICAM ICAM Cell-Cell Contact -0.4166 0.00000000000000000000020590767090750216 Scatter Plot
Target PTN Source SELL SELL Cell-Cell Contact -0.4120 0.0000000000000000000006560151180927614 Scatter Plot
Target PTN Source SEMA4 SEMA4 Cell-Cell Contact -0.4118 0.0000000000000000000006821174844379244 Scatter Plot
Target PTN Source COMPLEMENT COMPLEMENT Secreted Signaling -0.4111 0.0000000000000000000008102306001181826 Scatter Plot
Target PTN Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.3494 0.0000000000000008417642525534917 Scatter Plot
Target PTN Source SPP1 SPP1 Secreted Signaling -0.3338 0.000000000000017786061542974682 Scatter Plot
Target PTN Source APP APP Cell-Cell Contact -0.3266 0.00000000000006753803530527492 Scatter Plot
Target PTN Source PARs PARs Secreted Signaling -0.2968 0.000000000012481852718762728 Scatter Plot
Target PTN Target CXCL CXCL Secreted Signaling -0.2936 0.00000000002111910250306668 Scatter Plot
Target PTN Source GRN GRN Secreted Signaling -0.2866 0.00000000006586157229612 Scatter Plot
Target PTN Source NCAM NCAM Cell-Cell Contact -0.2798 0.00000000019101362931946735 Scatter Plot
Target PTN Source LAIR1 LAIR1 Cell-Cell Contact -0.2732 0.0000000005230992735712507 Scatter Plot
Target PTN Source TNF TNF Secreted Signaling -0.2371 0.00000008095414615497718 Scatter Plot
Target PTN Source CLEC CLEC Cell-Cell Contact -0.2328 0.0000001397971565844399 Scatter Plot
Target PTN Source BAFF BAFF Secreted Signaling -0.2162 0.0000010654257938606215 Scatter Plot
Target PTN Target NCAM NCAM Cell-Cell Contact -0.2074 0.000002909110625363955 Scatter Plot
Target PTN Target SEMA3 SEMA3 Secreted Signaling -0.1926 0.000014509885792512635 Scatter Plot
Target PTN Source CCL CCL Secreted Signaling -0.1924 0.00001474034184629537 Scatter Plot
Target PTN Target VEGF VEGF Secreted Signaling -0.1811 0.000046506935789533263 Scatter Plot
Source PTN Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.1751 0.00008273015549360436 Scatter Plot
Source PTN Source PARs PARs Secreted Signaling -0.1718 0.0001126861671837 Scatter Plot
Target PTN Source IL16 IL16 Secreted Signaling -0.1615 0.0002879147559252 Scatter Plot
Target PTN Target CSF CSF Secreted Signaling -0.1480 0.0009051558022594 Scatter Plot
Target PTN Source NKG2D NKG2D Cell-Cell Contact -0.1362 0.002270389095789 Scatter Plot
Target PTN Source CD45 CD45 Cell-Cell Contact -0.1327 0.0029582334451783 Scatter Plot
Target PTN Target SELE SELE Cell-Cell Contact -0.1316 0.0031967094387108 Scatter Plot
Source PTN Source IL6 IL6 Secreted Signaling -0.1179 0.0082910648225361 Scatter Plot
Target PTN Source IL2 IL2 Secreted Signaling -0.1119 0.0122518973962887 Scatter Plot
Source PTN Source ANGPTL ANGPTL Secreted Signaling -0.1108 0.0131695815570687 Scatter Plot
Target PTN Source SELPLG SELPLG Cell-Cell Contact -0.1036 0.0205589417286579 Scatter Plot
Source PTN Target TWEAK TWEAK Secreted Signaling 0.0971 0.0299934578744389 Scatter Plot
Source PTN Source IL1 IL1 Secreted Signaling 0.0979 0.0285964670860506 Scatter Plot
Source PTN Target COMPLEMENT COMPLEMENT Secreted Signaling 0.0980 0.0283813785277845 Scatter Plot
Target PTN Target NOTCH NOTCH Cell-Cell Contact 0.1014 0.0234223488852006 Scatter Plot
Source PTN Target ENHO ENHO Secreted Signaling 0.1023 0.0221587880814489 Scatter Plot
Source PTN Target COLLAGEN COLLAGEN ECM-Receptor 0.1026 0.0218060616901447 Scatter Plot
Source PTN Target GAS GAS Secreted Signaling 0.1028 0.0215352849213708 Scatter Plot
Source PTN Target IL1 IL1 Secreted Signaling 0.1045 0.0194220368405402 Scatter Plot
Source PTN Target PDGF PDGF Secreted Signaling 0.1046 0.0193302839258465 Scatter Plot
Source PTN Target SEMA3 SEMA3 Secreted Signaling 0.1048 0.0191128636900515 Scatter Plot
Source PTN Source GP1BA GP1BA Cell-Cell Contact 0.1055 0.0182669872571438 Scatter Plot
Source PTN Target EPHA EPHA Cell-Cell Contact 0.1064 0.0172764882455096 Scatter Plot
Source PTN Target CXCL CXCL Secreted Signaling 0.1082 0.0154628872610709 Scatter Plot
Source PTN Source PSAP PSAP Secreted Signaling 0.1093 0.0144610749588585 Scatter Plot
Source PTN Target NCAM NCAM Cell-Cell Contact 0.1124 0.0119103065223469 Scatter Plot
Source PTN Source CCL CCL Secreted Signaling 0.1138 0.0108708103622589 Scatter Plot
Source PTN Target OSM OSM Secreted Signaling 0.1142 0.0105939014303299 Scatter Plot
Target PTN Target NODAL NODAL Secreted Signaling 0.1143 0.0105330954235263 Scatter Plot
Source PTN Target RANKL RANKL Secreted Signaling 0.1161 0.0093623888822584 Scatter Plot
Source PTN Target CSPG4 CSPG4 Cell-Cell Contact 0.1198 0.0073437615379044 Scatter Plot
Source PTN Source SEMA4 SEMA4 Cell-Cell Contact 0.1233 0.0057632653383461 Scatter Plot
Source PTN Source SEMA3 SEMA3 Secreted Signaling 0.1247 0.0052422795470139 Scatter Plot
Source PTN Target NODAL NODAL Secreted Signaling 0.1251 0.0050869268103047 Scatter Plot
Source PTN Source SEMA7 SEMA7 Cell-Cell Contact 0.1254 0.0049948073759276 Scatter Plot
Source PTN Target AGT AGT Secreted Signaling 0.1256 0.0049246871181509 Scatter Plot
Source PTN Source BST2 BST2 Cell-Cell Contact 0.1262 0.0047001075163677 Scatter Plot
Source PTN Source ICOS ICOS Cell-Cell Contact 0.1266 0.0045651533368364 Scatter Plot
Source PTN Target VEGF VEGF Secreted Signaling 0.1268 0.0045222625352027 Scatter Plot
Source PTN Source CD1D2 CD1D2 Cell-Cell Contact 0.1270 0.0044656928807317 Scatter Plot
Source PTN Target SEMA6 SEMA6 Cell-Cell Contact 0.1283 0.0040507431507169 Scatter Plot
Target PTN Target SELL SELL Cell-Cell Contact 0.1298 0.0036346211464116 Scatter Plot
Source PTN Target GDF GDF Secreted Signaling 0.1305 0.0034564564101943 Scatter Plot
Source PTN Source ICAM ICAM Cell-Cell Contact 0.1313 0.0032557468686404 Scatter Plot
Target PTN Target IL6 IL6 Secreted Signaling 0.1330 0.0028840106150313 Scatter Plot
Target PTN Target EPHA EPHA Cell-Cell Contact 0.1331 0.0028594287509009 Scatter Plot
Source PTN Target SEMA7 SEMA7 Cell-Cell Contact 0.1339 0.0026893154652201 Scatter Plot
Source PTN Target CD200 CD200 Cell-Cell Contact 0.1347 0.0025458966932025 Scatter Plot
Source PTN Target THBS THBS ECM-Receptor 0.1370 0.0021434544715564 Scatter Plot
Source PTN Target ANGPTL ANGPTL Secreted Signaling 0.1376 0.0020487637796846 Scatter Plot
Source PTN Target SPP1 SPP1 Secreted Signaling 0.1407 0.0016161457681099 Scatter Plot
Source PTN Target SEMA5 SEMA5 Cell-Cell Contact 0.1424 0.0014073344365079 Scatter Plot
Source PTN Source CD39 CD39 Cell-Cell Contact 0.1440 0.0012479160369092 Scatter Plot
Source PTN Target BMP BMP Secreted Signaling 0.1452 0.0011264618820584 Scatter Plot
Source PTN Target TGFb TGFb Secreted Signaling 0.1456 0.0010975671878181 Scatter Plot
Source PTN Target MK MK Secreted Signaling 0.1458 0.0010750581057171 Scatter Plot
Source PTN Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1476 0.0009281725137871 Scatter Plot
Target PTN Target CADM CADM Cell-Cell Contact 0.1505 0.0007362964695871 Scatter Plot
Source PTN Source CDH CDH Cell-Cell Contact 0.1512 0.0006936934764842 Scatter Plot
Source PTN Target CDH CDH Cell-Cell Contact 0.1512 0.0006936934764842 Scatter Plot
Target PTN Target BAFF BAFF Secreted Signaling 0.1521 0.0006452243701824 Scatter Plot
Source PTN Source FLT3 FLT3 Secreted Signaling 0.1521 0.0006417099091365 Scatter Plot
Target PTN Target OSM OSM Secreted Signaling 0.1539 0.0005532311262966 Scatter Plot
Source PTN Target CD22 CD22 Cell-Cell Contact 0.1568 0.0004313236636339 Scatter Plot
Source PTN Source CD45 CD45 Cell-Cell Contact 0.1568 0.0004313236636339 Scatter Plot
Source PTN Target APP APP Cell-Cell Contact 0.1573 0.0004151865086114 Scatter Plot
Source PTN Source TWEAK TWEAK Secreted Signaling 0.1579 0.0003922432700331 Scatter Plot
Source PTN Source BMP BMP Secreted Signaling 0.1582 0.0003838582359775 Scatter Plot
Source PTN Target KIT KIT Secreted Signaling 0.1583 0.000380109989148 Scatter Plot
Source PTN Target SELL SELL Cell-Cell Contact 0.1596 0.0003407174990151 Scatter Plot
Source PTN Source IL2 IL2 Secreted Signaling 0.1635 0.0002405947997009 Scatter Plot
Source PTN Target NRG NRG Secreted Signaling 0.1639 0.0002335228798294 Scatter Plot
Source PTN Source CX3C CX3C Secreted Signaling 0.1656 0.0001995390308786 Scatter Plot
Source PTN Target FGF FGF Secreted Signaling 0.1661 0.0001913884184407 Scatter Plot
Source PTN Target BAFF BAFF Secreted Signaling 0.1663 0.0001880295409613 Scatter Plot
Source PTN Source PROS PROS Secreted Signaling 0.1689 0.0001475767697613 Scatter Plot
Source PTN Target PERIOSTIN PERIOSTIN Secreted Signaling 0.1696 0.0001382265395531 Scatter Plot
Source PTN Target BSP BSP ECM-Receptor 0.1722 0.0001091807260993 Scatter Plot
Source PTN Target SLURP SLURP Secreted Signaling 0.1726 0.0001044125228738 Scatter Plot
Source PTN Source THBS THBS ECM-Receptor 0.1729 0.000101628678234 Scatter Plot
Source PTN Target ACTIVIN ACTIVIN Secreted Signaling 0.1743 0.00008963626326529802 Scatter Plot
Source PTN Target DMP1 DMP1 ECM-Receptor 0.1796 0.000053783390549047634 Scatter Plot
Source PTN Target NPR2 NPR2 Secreted Signaling 0.1833 0.00003719120661715597 Scatter Plot
Source PTN Source CXCL CXCL Secreted Signaling 0.1841 0.000034378291688363616 Scatter Plot
Source PTN Target PARs PARs Secreted Signaling 0.1851 0.00003112785534992588 Scatter Plot
Source PTN Target MIF MIF Secreted Signaling 0.1853 0.00003070371601824367 Scatter Plot
Source PTN Target JAM JAM Cell-Cell Contact 0.1857 0.00002923046973137299 Scatter Plot
Source PTN Source LCK LCK Cell-Cell Contact 0.1871 0.00002560508826561113 Scatter Plot
Source PTN Target EPHB EPHB Cell-Cell Contact 0.1883 0.000022474853192495927 Scatter Plot
Source PTN Target ANGPT ANGPT Secreted Signaling 0.1942 0.00001223394089106975 Scatter Plot
Target PTN Target VISFATIN VISFATIN Secreted Signaling 0.1960 0.000010096519507934894 Scatter Plot
Target PTN Target CD200 CD200 Cell-Cell Contact 0.1961 0.000010058421575011148 Scatter Plot
Source PTN Target CD39 CD39 Cell-Cell Contact 0.1967 0.000009365488029883764 Scatter Plot
Source PTN Source IL7 IL7 Secreted Signaling 0.1988 0.000007509389205605952 Scatter Plot
Source PTN Target FN1 FN1 ECM-Receptor 0.1994 0.000006992503535384192 Scatter Plot
Target PTN Target ANGPT ANGPT Secreted Signaling 0.2037 0.000004387702213697908 Scatter Plot
Target PTN Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.2045 0.00000400598023746483 Scatter Plot
Source PTN Source CSF CSF Secreted Signaling 0.2046 0.000003956992349345001 Scatter Plot
Source PTN Source ESAM ESAM Cell-Cell Contact 0.2076 0.0000028298856989549485 Scatter Plot
Source PTN Target ESAM ESAM Cell-Cell Contact 0.2076 0.0000028298856989549485 Scatter Plot
Source PTN Target SEMA4 SEMA4 Cell-Cell Contact 0.2110 0.000001936241033625519 Scatter Plot
Source PTN Target IGF IGF Secreted Signaling 0.2119 0.000001736661507558147 Scatter Plot
Source PTN Source COLLAGEN COLLAGEN ECM-Receptor 0.2127 0.0000015889554670460874 Scatter Plot
Source PTN Target VISFATIN VISFATIN Secreted Signaling 0.2133 0.0000014825019318076744 Scatter Plot
Source PTN Source PDGF PDGF Secreted Signaling 0.2164 0.0000010304881206912208 Scatter Plot
Target PTN Target AGT AGT Secreted Signaling 0.2186 0.0000007966618597957299 Scatter Plot
Source PTN Target WNT WNT Secreted Signaling 0.2199 0.0000006851349070388108 Scatter Plot
Source PTN Target CD34 CD34 Cell-Cell Contact 0.2205 0.0000006373517933172912 Scatter Plot
Source PTN Source MHC-I MHC-I Cell-Cell Contact 0.2217 0.0000005536701302813025 Scatter Plot
Source PTN Target ncWNT ncWNT Secreted Signaling 0.2270 0.0000002903743740915617 Scatter Plot
Target PTN Target TGFb TGFb Secreted Signaling 0.2306 0.00000018539067927288773 Scatter Plot
Target PTN Target APP APP Cell-Cell Contact 0.2326 0.00000014359526038252998 Scatter Plot
Target PTN Target CSPG4 CSPG4 Cell-Cell Contact 0.2415 0.0000000457258595631413 Scatter Plot
Target PTN Target NPR2 NPR2 Secreted Signaling 0.2461 0.00000002475020637691081 Scatter Plot
Target PTN Target SEMA4 SEMA4 Cell-Cell Contact 0.2649 0.000000001784482970659439 Scatter Plot
Source PTN Target LAMININ LAMININ ECM-Receptor 0.2666 0.0000000013860602738441544 Scatter Plot
Source PTN Target VTN VTN ECM-Receptor 0.2772 0.00000000028509061770639087 Scatter Plot
Source PTN Target VWF VWF ECM-Receptor 0.2857 0.00000000007616609735554541 Scatter Plot
Target PTN Target ESAM ESAM Cell-Cell Contact 0.2920 0.00000000002735963970765964 Scatter Plot
Source PTN Target TENASCIN TENASCIN ECM-Receptor 0.2935 0.000000000021732511642387185 Scatter Plot
Target PTN Target PARs PARs Secreted Signaling 0.3081 0.0000000000018601139869965577 Scatter Plot
Target PTN Target CD34 CD34 Cell-Cell Contact 0.3622 0.00000000000000005999212055546423 Scatter Plot
Target PTN Target ncWNT ncWNT Secreted Signaling 0.3697 0.000000000000000012250500349422305 Scatter Plot
Target PTN Target CD52 CD52 Cell-Cell Contact -0.3972 0.000000000000000000023907241317317542 Scatter Plot
Target PTN Target CEACAM CEACAM Cell-Cell Contact -0.3843 0.0000000000000000004833679408881077 Scatter Plot
Target PTN Target VCAM VCAM Cell-Cell Contact -0.3627 0.000000000000000053740434073471725 Scatter Plot
Target PTN Target IFN-II IFN-II Secreted Signaling -0.3507 0.0000000000000006485516195683166 Scatter Plot
Target PTN Target COMPLEMENT COMPLEMENT Secreted Signaling -0.3413 0.000000000000004145936562739795 Scatter Plot
Target PTN Target CCL CCL Secreted Signaling -0.3152 0.0000000000005405520848441267 Scatter Plot
Target PTN Target ANNEXIN ANNEXIN Secreted Signaling -0.2710 0.0000000007255241980863998 Scatter Plot
Target PTN Target GALECTIN GALECTIN Secreted Signaling -0.2530 0.000000009588864004289177 Scatter Plot
Target PTN Target CLEC CLEC Cell-Cell Contact -0.2466 0.00000002298046074467628 Scatter Plot
Target PTN Target IL1 IL1 Secreted Signaling -0.2281 0.0000002525223404903604 Scatter Plot
Source PTN Target IFN-II IFN-II Secreted Signaling -0.2203 0.0000006548182055946153 Scatter Plot
Source PTN Source CD52 CD52 Cell-Cell Contact -0.2062 0.0000033357348723652427 Scatter Plot
Source PTN Source PARs PARs Secreted Signaling -0.1856 0.00002955018873950833 Scatter Plot
Source PTN Source VISTA VISTA Cell-Cell Contact -0.1751 0.00008271302253222536 Scatter Plot
Source PTN Source COMPLEMENT COMPLEMENT Secreted Signaling -0.1724 0.0001072294490405 Scatter Plot
Source PTN Source SELL SELL Cell-Cell Contact -0.1722 0.0001093957699118 Scatter Plot
Source PTN Source SEMA4 SEMA4 Cell-Cell Contact -0.1591 0.0003555470605555 Scatter Plot
Source PTN Target CD52 CD52 Cell-Cell Contact -0.1430 0.0013431166031703 Scatter Plot
Source PTN Source CLEC CLEC Cell-Cell Contact -0.1405 0.0016325786131019 Scatter Plot
Target PTN Target GRN GRN Secreted Signaling -0.1352 0.0024429638481956 Scatter Plot
Target PTN Target CD22 CD22 Cell-Cell Contact -0.1327 0.0029582334451783 Scatter Plot
Source PTN Target ICAM ICAM Cell-Cell Contact -0.1296 0.0036962125414637 Scatter Plot
Source PTN Source ANNEXIN ANNEXIN Secreted Signaling -0.1252 0.005043974641871 Scatter Plot
Source PTN Target CEACAM CEACAM Cell-Cell Contact -0.1229 0.0059480911926799 Scatter Plot
Source PTN Target CLEC CLEC Cell-Cell Contact -0.1207 0.0068702397222464 Scatter Plot
Source PTN Target VCAM VCAM Cell-Cell Contact -0.1204 0.0070086664370988 Scatter Plot
Target PTN Target SELPLG SELPLG Cell-Cell Contact -0.1159 0.009487266922235 Scatter Plot
Source PTN Source TNF TNF Secreted Signaling -0.1151 0.0100046996167239 Scatter Plot
Source PTN Target CSF CSF Secreted Signaling -0.1144 0.0104343863939811 Scatter Plot
Source PTN Source CCL CCL Secreted Signaling -0.1096 0.0142270923700939 Scatter Plot
Source PTN Target CXCL CXCL Secreted Signaling -0.1073 0.0163360712833129 Scatter Plot
Source PTN Target CCL CCL Secreted Signaling -0.1063 0.0173947274933633 Scatter Plot
Source PTN Target GRN GRN Secreted Signaling -0.1025 0.0219207270243455 Scatter Plot
Source PTN Source NCAM NCAM Cell-Cell Contact -0.1005 0.0246209418685613 Scatter Plot
Source PTN Source SELPLG SELPLG Cell-Cell Contact -0.1005 0.0246704178705843 Scatter Plot
Source PTN Target IL17 IL17 Secreted Signaling -0.1003 0.0248503669954008 Scatter Plot
Source PTN Source APP APP Cell-Cell Contact -0.0962 0.0314373572324977 Scatter Plot

Cells that are targets of PTN from HSCs*

Cells that are source of PTN to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.