Pathway: IL16

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the IL16 pathway:

Specificity Index HSPC as target: 0.262
HSPC as source: 0.468

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the IL16 pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Source IL16 Source SELPLG SELPLG Cell-Cell Contact 0.0974 0.0295106140326355 Scatter Plot
Source IL16 Source PECAM1 PECAM1 Cell-Cell Contact 0.1042 0.0197367640437956 Scatter Plot
Source IL16 Source VISTA VISTA Cell-Cell Contact 0.1089 0.0148208435931771 Scatter Plot
Source IL16 Source NCAM NCAM Cell-Cell Contact 0.1091 0.0146235039903563 Scatter Plot
Source IL16 Source NT NT Secreted Signaling 0.1215 0.0065092921962637 Scatter Plot
Source IL16 Source WNT WNT Secreted Signaling 0.1222 0.0062164371253125 Scatter Plot
Source IL16 Source ANGPTL ANGPTL Secreted Signaling 0.1436 0.0012862206244154 Scatter Plot
Source IL16 Source LIFR LIFR Secreted Signaling 0.1498 0.0007817944857557 Scatter Plot
Source IL16 Source CD34 CD34 Cell-Cell Contact 0.1566 0.000439363548416 Scatter Plot
Source IL16 Source APP APP Cell-Cell Contact 0.1591 0.0003557393650371 Scatter Plot
Source IL16 Source SEMA3 SEMA3 Secreted Signaling 0.1613 0.000292271016568 Scatter Plot
Source IL16 Source VCAM VCAM Cell-Cell Contact 0.1628 0.0002558537710624 Scatter Plot
Source IL16 Source CADM CADM Cell-Cell Contact 0.1645 0.0002197604136244 Scatter Plot
Source IL16 Source CD46 CD46 Cell-Cell Contact 0.1685 0.0001531662844051 Scatter Plot
Source IL16 Source GDF GDF Secreted Signaling 0.1697 0.0001375275204432 Scatter Plot
Source IL16 Source EPHB EPHB Cell-Cell Contact 0.1760 0.00007626701567562626 Scatter Plot
Source IL16 Source CXCL CXCL Secreted Signaling 0.1844 0.00003334172487110571 Scatter Plot
Source IL16 Source RANKL RANKL Secreted Signaling 0.1953 0.000010848428065410016 Scatter Plot
Source IL16 Source PDGF PDGF Secreted Signaling 0.1962 0.000009941395887328004 Scatter Plot
Source IL16 Source NOTCH NOTCH Cell-Cell Contact 0.2008 0.000006039111431131975 Scatter Plot
Source IL16 Source PROS PROS Secreted Signaling 0.2131 0.00000151168643737607 Scatter Plot
Source IL16 Source CCL CCL Secreted Signaling 0.2236 0.0000004397851382794226 Scatter Plot
Source IL16 Source IGF IGF Secreted Signaling 0.2308 0.00000018026960340561875 Scatter Plot
Source IL16 Source GRN GRN Secreted Signaling 0.2336 0.0000001266641443696022 Scatter Plot
Source IL16 Source VEGF VEGF Secreted Signaling 0.2357 0.00000009689792650269434 Scatter Plot
Source IL16 Source CD39 CD39 Cell-Cell Contact 0.2363 0.0000000894190730026859 Scatter Plot
Source IL16 Source CDH CDH Cell-Cell Contact 0.2403 0.00000005297751100536284 Scatter Plot
Source IL16 Source LAMININ LAMININ ECM-Receptor 0.2834 0.00000000010952363694524421 Scatter Plot
Source IL16 Source LIGHT LIGHT Secreted Signaling 0.2856 0.0000000000766305788133719 Scatter Plot
Source IL16 Source JAM JAM Cell-Cell Contact 0.3123 0.0000000000008933691988628277 Scatter Plot
Source IL16 Source TWEAK TWEAK Secreted Signaling 0.3189 0.0000000000002789207366807509 Scatter Plot
Source IL16 Source BMP BMP Secreted Signaling 0.3207 0.00000000000019871948058487786 Scatter Plot
Source IL16 Source MK MK Secreted Signaling 0.3237 0.00000000000011578850997350281 Scatter Plot
Source IL16 Source ESAM ESAM Cell-Cell Contact 0.3248 0.00000000000009567756076798771 Scatter Plot
Source IL16 Source ANGPT ANGPT Secreted Signaling 0.3356 0.000000000000012597268474738284 Scatter Plot
Source IL16 Source IL7 IL7 Secreted Signaling 0.3533 0.00000000000000037888205080558212 Scatter Plot
Source IL16 Source COLLAGEN COLLAGEN ECM-Receptor 0.3629 0.000000000000000051756500937029707 Scatter Plot
Source IL16 Source ICAM ICAM Cell-Cell Contact 0.3801 0.0000000000000000012441566649405772 Scatter Plot
Source IL16 Source GAS GAS Secreted Signaling 0.4194 0.00000000000000000000010039091597131944 Scatter Plot
Source IL16 Source MHC-II MHC-II Cell-Cell Contact 0.4803 0.000000000000000000000000000003201973135006516 Scatter Plot
Source IL16 Source PSAP PSAP Secreted Signaling 0.5148 0.000000000000000000000000000000000033679701842437407 Scatter Plot
Source IL16 Source CD45 CD45 Cell-Cell Contact 0.5476 0.0000000000000000000000000000000000000001788011258169628 Scatter Plot
Source IL16 Source MIF MIF Secreted Signaling -0.4783 0.000000000000000000000000000006005909368603294 Scatter Plot
Source IL16 Source TGFb TGFb Secreted Signaling -0.4059 0.0000000000000000000029268627585527037 Scatter Plot
Source IL16 Source ANGPTL ANGPTL Secreted Signaling -0.3305 0.00000000000003259912628739704 Scatter Plot
Source IL16 Source GALECTIN GALECTIN Secreted Signaling -0.2651 0.000000001739637566174803 Scatter Plot
Source IL16 Source SEMA4 SEMA4 Cell-Cell Contact -0.2232 0.0000004621728726242912 Scatter Plot
Source IL16 Source VEGF VEGF Secreted Signaling -0.1961 0.00001002205954882585 Scatter Plot
Source IL16 Source PARs PARs Secreted Signaling -0.1329 0.0029143340083549 Scatter Plot
Source IL16 Target NOTCH NOTCH Cell-Cell Contact 0.0984 0.0277562791766111 Scatter Plot
Source IL16 Target CCL CCL Secreted Signaling 0.0989 0.0269326471545246 Scatter Plot
Source IL16 Target SEMA5 SEMA5 Cell-Cell Contact 0.1007 0.0243182065966578 Scatter Plot
Source IL16 Target SEMA3 SEMA3 Secreted Signaling 0.1021 0.0224165944293157 Scatter Plot
Source IL16 Target PECAM1 PECAM1 Cell-Cell Contact 0.1042 0.0197367640437956 Scatter Plot
Source IL16 Target SEMA7 SEMA7 Cell-Cell Contact 0.1050 0.0188724740530315 Scatter Plot
Source IL16 Target SELPLG SELPLG Cell-Cell Contact 0.1066 0.0171272975561857 Scatter Plot
Source IL16 Target RANKL RANKL Secreted Signaling 0.1097 0.0141517656753531 Scatter Plot
Source IL16 Target VISFATIN VISFATIN Secreted Signaling 0.1142 0.0105858941715025 Scatter Plot
Source IL16 Source LAIR1 LAIR1 Cell-Cell Contact 0.1147 0.0102903435384453 Scatter Plot
Source IL16 Target SPP1 SPP1 Secreted Signaling 0.1189 0.0077632609882638 Scatter Plot
Source IL16 Target FN1 FN1 ECM-Receptor 0.1207 0.0069131445503464 Scatter Plot
Source IL16 Target LAIR1 LAIR1 Cell-Cell Contact 0.1295 0.0037124617228381 Scatter Plot
Source IL16 Target BST2 BST2 Cell-Cell Contact 0.1295 0.0037124617228381 Scatter Plot
Source IL16 Target OSM OSM Secreted Signaling 0.1300 0.0035941414781876 Scatter Plot
Source IL16 Target SEMA6 SEMA6 Cell-Cell Contact 0.1348 0.0025302989916081 Scatter Plot
Source IL16 Target CSPG4 CSPG4 Cell-Cell Contact 0.1369 0.0021572565154345 Scatter Plot
Source IL16 Target SELL SELL Cell-Cell Contact 0.1473 0.0009509436069096 Scatter Plot
Source IL16 Target VTN VTN ECM-Receptor 0.1520 0.000651456430444 Scatter Plot
Source IL16 Target ANNEXIN ANNEXIN Secreted Signaling 0.1529 0.000600316967773 Scatter Plot
Source IL16 Source THY1 THY1 Cell-Cell Contact 0.1534 0.0005781154483676 Scatter Plot
Source IL16 Target SELE SELE Cell-Cell Contact 0.1569 0.0004281724744096 Scatter Plot
Source IL16 Target CADM CADM Cell-Cell Contact 0.1645 0.0002197604136244 Scatter Plot
Source IL16 Target COLLAGEN COLLAGEN ECM-Receptor 0.1704 0.0001291389352999 Scatter Plot
Source IL16 Source ICOS ICOS Cell-Cell Contact 0.1753 0.00008089941091044904 Scatter Plot
Source IL16 Source BAFF BAFF Secreted Signaling 0.1848 0.00003226246443476022 Scatter Plot
Source IL16 Target KIT KIT Secreted Signaling 0.2072 0.0000029679517569740986 Scatter Plot
Source IL16 Target TENASCIN TENASCIN ECM-Receptor 0.2129 0.0000015488059635597535 Scatter Plot
Source IL16 Target IL1 IL1 Secreted Signaling 0.2130 0.0000015320951159570035 Scatter Plot
Source IL16 Source FLT3 FLT3 Secreted Signaling 0.2135 0.0000014462000469777117 Scatter Plot
Source IL16 Target LAMININ LAMININ ECM-Receptor 0.2194 0.0000007289756971283371 Scatter Plot
Source IL16 Source CD1D2 CD1D2 Cell-Cell Contact 0.2205 0.0000006351134672946548 Scatter Plot
Source IL16 Source CSF CSF Secreted Signaling 0.2260 0.0000003270621235711592 Scatter Plot
Source IL16 Source IGF IGF Secreted Signaling 0.2351 0.0000001041616519746524 Scatter Plot
Source IL16 Target ANGPT ANGPT Secreted Signaling 0.2401 0.0000000547524232159762 Scatter Plot
Source IL16 Target CDH CDH Cell-Cell Contact 0.2403 0.00000005297751100536284 Scatter Plot
Source IL16 Target CD34 CD34 Cell-Cell Contact 0.2435 0.000000034806386128311646 Scatter Plot
Source IL16 Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2466 0.000000023018571483715464 Scatter Plot
Source IL16 Target EPHB EPHB Cell-Cell Contact 0.2480 0.00000001908684350818539 Scatter Plot
Source IL16 Target NCAM NCAM Cell-Cell Contact 0.2578 0.000000004907436446080375 Scatter Plot
Source IL16 Target GDF GDF Secreted Signaling 0.2589 0.000000004196398843915184 Scatter Plot
Source IL16 Source BST2 BST2 Cell-Cell Contact 0.2600 0.0000000036136366525620924 Scatter Plot
Source IL16 Target NPR2 NPR2 Secreted Signaling 0.2602 0.00000000352361926086823 Scatter Plot
Source IL16 Target SEMA4 SEMA4 Cell-Cell Contact 0.2644 0.0000000019035019273821103 Scatter Plot
Source IL16 Target IL6 IL6 Secreted Signaling 0.2650 0.000000001768833914249573 Scatter Plot
Source IL16 Target IGF IGF Secreted Signaling 0.2660 0.000000001510137757368208 Scatter Plot
Source IL16 Target NODAL NODAL Secreted Signaling 0.2685 0.000000001046242440823579 Scatter Plot
Source IL16 Target NRG NRG Secreted Signaling 0.2692 0.0000000009477284750462896 Scatter Plot
Source IL16 Source LCK LCK Cell-Cell Contact 0.2710 0.0000000007208597789651107 Scatter Plot
Source IL16 Target BMP BMP Secreted Signaling 0.2719 0.0000000006327643776282806 Scatter Plot
Source IL16 Target WNT WNT Secreted Signaling 0.2733 0.0000000005157122661018017 Scatter Plot
Source IL16 Source IL2 IL2 Secreted Signaling 0.2736 0.0000000004893139847894364 Scatter Plot
Source IL16 Target ANGPTL ANGPTL Secreted Signaling 0.2768 0.00000000030329101452527103 Scatter Plot
Source IL16 Target THBS THBS ECM-Receptor 0.2801 0.00000000018189789898344537 Scatter Plot
Source IL16 Target DMP1 DMP1 ECM-Receptor 0.2819 0.00000000013767851369376051 Scatter Plot
Source IL16 Target BSP BSP ECM-Receptor 0.2847 0.00000000008887247780851916 Scatter Plot
Source IL16 Target PERIOSTIN PERIOSTIN Secreted Signaling 0.2921 0.00000000002709341225304326 Scatter Plot
Source IL16 Target ncWNT ncWNT Secreted Signaling 0.2930 0.000000000023549835983654137 Scatter Plot
Source IL16 Source SEMA7 SEMA7 Cell-Cell Contact 0.3042 0.0000000000036324157784331497 Scatter Plot
Source IL16 Source ANNEXIN ANNEXIN Secreted Signaling 0.3151 0.0000000000005437201466581213 Scatter Plot
Source IL16 Target FGF FGF Secreted Signaling 0.3204 0.0000000000002109111493752428 Scatter Plot
Source IL16 Target ESAM ESAM Cell-Cell Contact 0.3248 0.00000000000009567756076798771 Scatter Plot
Source IL16 Target TGFb TGFb Secreted Signaling 0.3292 0.00000000000004199052649571106 Scatter Plot
Source IL16 Source CX3C CX3C Secreted Signaling 0.3313 0.000000000000028338959279992632 Scatter Plot
Source IL16 Target THY1 THY1 Cell-Cell Contact 0.3316 0.00000000000002661413864803554 Scatter Plot
Source IL16 Target ACTIVIN ACTIVIN Secreted Signaling 0.3336 0.0000000000000182000075989069 Scatter Plot
Source IL16 Target BAFF BAFF Secreted Signaling 0.3464 0.0000000000000015361322522715449 Scatter Plot
Source IL16 Source IL7 IL7 Secreted Signaling 0.3533 0.00000000000000037888205080558212 Scatter Plot
Source IL16 Target CD23 CD23 Cell-Cell Contact 0.3649 0.000000000000000034235649821548123 Scatter Plot
Source IL16 Target CD39 CD39 Cell-Cell Contact 0.3696 0.0000000000000000122916525368755 Scatter Plot
Source IL16 Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.3702 0.000000000000000011011706060069644 Scatter Plot
Source IL16 Source ICAM ICAM Cell-Cell Contact 0.3801 0.00000000000000000124415666494055 Scatter Plot
Source IL16 Source CD86 CD86 Cell-Cell Contact 0.3865 0.0000000000000000002904493700412741 Scatter Plot
Source IL16 Target JAM JAM Cell-Cell Contact 0.3930 0.00000000000000000006424335206302921 Scatter Plot
Source IL16 Target APP APP Cell-Cell Contact 0.4202 0.00000000000000000000008217943794074034 Scatter Plot
Source IL16 Target SLURP SLURP Secreted Signaling 0.4356 0.0000000000000000000000014296272153114592 Scatter Plot
Source IL16 Source MHC-I MHC-I Cell-Cell Contact 0.4465 0.00000000000000000000000006994217203526714 Scatter Plot
Source IL16 Target GALECTIN GALECTIN Secreted Signaling 0.4571 0.0000000000000000000000000034159233371804934 Scatter Plot
Source IL16 Target MIF MIF Secreted Signaling 0.5108 0.00000000000000000000000000000000013917495068997758 Scatter Plot
Source IL16 Target CD200 CD200 Cell-Cell Contact 0.5330 0.00000000000000000000000000000000000004720192844223958 Scatter Plot
Source IL16 Target CD22 CD22 Cell-Cell Contact 0.5476 0.0000000000000000000000000000000000000001788011258169628 Scatter Plot
Source IL16 Source IL1 IL1 Secreted Signaling -0.1774 0.0000665111791098952 Scatter Plot
Source IL16 Target PTN PTN Secreted Signaling -0.1615 0.0002879147559252 Scatter Plot
Source IL16 Target VEGF VEGF Secreted Signaling -0.1414 0.0015303449835272 Scatter Plot
Source IL16 Target CCL CCL Secreted Signaling -0.1406 0.0016250905181908 Scatter Plot
Source IL16 Target CSF CSF Secreted Signaling -0.1381 0.0019732151946667 Scatter Plot
Source IL16 Target MK MK Secreted Signaling -0.1314 0.0032334943008384 Scatter Plot
Source IL16 Target IL17 IL17 Secreted Signaling -0.1168 0.00895578329889 Scatter Plot
Source IL16 Target ENHO ENHO Secreted Signaling -0.0986 0.0275525931367218 Scatter Plot

Cells that are targets of IL16 from HSCs*

Cells that are source of IL16 to HSCs*

    No cell populations

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.