Pathway: RANKL

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the RANKL pathway:

Specificity Index HSPC as target: 0.365
HSPC as source: 0.637

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the RANKL pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target RANKL Target NOTCH NOTCH Cell-Cell Contact 0.0984 0.0277999960687981 Scatter Plot
Target RANKL Source SEMA3 SEMA3 Secreted Signaling 0.0996 0.0260094363637706 Scatter Plot
Target RANKL Source AGRN AGRN ECM-Receptor 0.1045 0.0194147350482136 Scatter Plot
Target RANKL Source CD46 CD46 Cell-Cell Contact 0.1072 0.0164625159093295 Scatter Plot
Target RANKL Source IL16 IL16 Secreted Signaling 0.1097 0.0141517656753531 Scatter Plot
Target RANKL Source PTN PTN Secreted Signaling 0.1161 0.0093623888822584 Scatter Plot
Target RANKL Source LIFR LIFR Secreted Signaling 0.1167 0.0090153500384242 Scatter Plot
Target RANKL Source ANGPT ANGPT Secreted Signaling 0.1207 0.0068734667467414 Scatter Plot
Target RANKL Target GDF GDF Secreted Signaling 0.1228 0.0059623412391519 Scatter Plot
Target RANKL Target BMP BMP Secreted Signaling 0.1258 0.0048457266073528 Scatter Plot
Target RANKL Source LIGHT LIGHT Secreted Signaling 0.1269 0.0044681200795716 Scatter Plot
Target RANKL Target VWF VWF ECM-Receptor 0.1272 0.0043783264623534 Scatter Plot
Target RANKL Source CD1D2 CD1D2 Cell-Cell Contact 0.1275 0.0042895354677682 Scatter Plot
Target RANKL Target SEMA3 SEMA3 Secreted Signaling 0.1300 0.0036027673055202 Scatter Plot
Target RANKL Source THBS THBS ECM-Receptor 0.1302 0.0035374114386852 Scatter Plot
Target RANKL Source MK MK Secreted Signaling 0.1324 0.0030055537032178 Scatter Plot
Source RANKL Source ncWNT ncWNT Secreted Signaling 0.1332 0.002848774216119 Scatter Plot
Target RANKL Source GRN GRN Secreted Signaling 0.1355 0.0023968026228368 Scatter Plot
Target RANKL Source FLT3 FLT3 Secreted Signaling 0.1364 0.0022306369723765 Scatter Plot
Target RANKL Source LAMININ LAMININ ECM-Receptor 0.1403 0.001666852047604 Scatter Plot
Target RANKL Target SEMA6 SEMA6 Cell-Cell Contact 0.1431 0.0013325004870143 Scatter Plot
Target RANKL Source CX3C CX3C Secreted Signaling 0.1497 0.0007835374418993 Scatter Plot
Target RANKL Source NT NT Secreted Signaling 0.1534 0.0005783531758133 Scatter Plot
Target RANKL Target SPP1 SPP1 Secreted Signaling 0.1541 0.0005459556318638 Scatter Plot
Target RANKL Source IL2 IL2 Secreted Signaling 0.1541 0.0005442791303708 Scatter Plot
Target RANKL Target EPHA EPHA Cell-Cell Contact 0.1549 0.0005104892500231 Scatter Plot
Target RANKL Target BSP BSP ECM-Receptor 0.1594 0.0003445152360776 Scatter Plot
Target RANKL Source VCAM VCAM Cell-Cell Contact 0.1608 0.0003050935974706 Scatter Plot
Target RANKL Source NOTCH NOTCH Cell-Cell Contact 0.1640 0.0002297236650448 Scatter Plot
Target RANKL Target MK MK Secreted Signaling 0.1644 0.0002223716259976 Scatter Plot
Target RANKL Source CD86 CD86 Cell-Cell Contact 0.1655 0.0002009809096047 Scatter Plot
Target RANKL Source IGF IGF Secreted Signaling 0.1686 0.0001516937949685 Scatter Plot
Target RANKL Target ANGPTL ANGPTL Secreted Signaling 0.1690 0.0001465620615327 Scatter Plot
Target RANKL Target VEGF VEGF Secreted Signaling 0.1705 0.0001273061085512 Scatter Plot
Target RANKL Source CD45 CD45 Cell-Cell Contact 0.1715 0.0001166650386848 Scatter Plot
Target RANKL Source ICAM ICAM Cell-Cell Contact 0.1746 0.0000872521515448252 Scatter Plot
Source RANKL Source LIGHT LIGHT Secreted Signaling 0.1768 0.00007027355760262958 Scatter Plot
Target RANKL Target NCAM NCAM Cell-Cell Contact 0.1793 0.00005508861209933962 Scatter Plot
Target RANKL Target SLURP SLURP Secreted Signaling 0.1859 0.00002882028685791688 Scatter Plot
Target RANKL Source CXCL CXCL Secreted Signaling 0.1922 0.000015083488769215655 Scatter Plot
Target RANKL Target FGF FGF Secreted Signaling 0.1973 0.000008768988780485954 Scatter Plot
Target RANKL Source CD39 CD39 Cell-Cell Contact 0.1977 0.000008413279913160776 Scatter Plot
Target RANKL Source EPHB EPHB Cell-Cell Contact 0.1981 0.000008104277326766343 Scatter Plot
Target RANKL Source CDH CDH Cell-Cell Contact 0.1984 0.00000783785988913419 Scatter Plot
Target RANKL Target CD34 CD34 Cell-Cell Contact 0.2010 0.000005940208233869769 Scatter Plot
Target RANKL Source COLLAGEN COLLAGEN ECM-Receptor 0.2021 0.000005222090382210972 Scatter Plot
Target RANKL Target CD39 CD39 Cell-Cell Contact 0.2030 0.000004729411942161606 Scatter Plot
Target RANKL Source IL7 IL7 Secreted Signaling 0.2037 0.000004405163849767194 Scatter Plot
Target RANKL Source SEMA7 SEMA7 Cell-Cell Contact 0.2085 0.000002573129474894764 Scatter Plot
Target RANKL Source CCL CCL Secreted Signaling 0.2098 0.000002228168444348856 Scatter Plot
Target RANKL Source GAS GAS Secreted Signaling 0.2121 0.0000017014772094965146 Scatter Plot
Target RANKL Target COLLAGEN COLLAGEN ECM-Receptor 0.2132 0.0000015059395519837365 Scatter Plot
Target RANKL Target IGF IGF Secreted Signaling 0.2138 0.0000014079882104276035 Scatter Plot
Target RANKL Target EPHB EPHB Cell-Cell Contact 0.2166 0.000001013959906128466 Scatter Plot
Target RANKL Source PROS PROS Secreted Signaling 0.2214 0.0000005705087287321529 Scatter Plot
Target RANKL Target WNT WNT Secreted Signaling 0.2227 0.0000004909125291668734 Scatter Plot
Target RANKL Target CD200 CD200 Cell-Cell Contact 0.2236 0.00000043724908201056073 Scatter Plot
Target RANKL Source TWEAK TWEAK Secreted Signaling 0.2258 0.0000003348062170757949 Scatter Plot
Target RANKL Source ESAM ESAM Cell-Cell Contact 0.2274 0.0000002740094937418492 Scatter Plot
Target RANKL Target CSPG4 CSPG4 Cell-Cell Contact 0.2295 0.0000002119525943335069 Scatter Plot
Target RANKL Source MHC-II MHC-II Cell-Cell Contact 0.2384 0.00000006842142109209586 Scatter Plot
Target RANKL Source MHC-I MHC-I Cell-Cell Contact 0.2419 0.000000043240244243669945 Scatter Plot
Target RANKL Source ncWNT ncWNT Secreted Signaling 0.2454 0.000000027011122880324977 Scatter Plot
Target RANKL Source JAM JAM Cell-Cell Contact 0.2460 0.000000024913160569045222 Scatter Plot
Target RANKL Source BST2 BST2 Cell-Cell Contact 0.2460 0.000000024891742916940763 Scatter Plot
Target RANKL Source PSAP PSAP Secreted Signaling 0.2465 0.000000023378764537054988 Scatter Plot
Target RANKL Source PDGF PDGF Secreted Signaling 0.2495 0.00000001556247625506181 Scatter Plot
Source RANKL Source WNT WNT Secreted Signaling 0.2791 0.00000000021167123763973558 Scatter Plot
Target RANKL Source BMP BMP Secreted Signaling 0.2871 0.00000000006063290736392159 Scatter Plot
Source RANKL Source COLLAGEN COLLAGEN ECM-Receptor 0.3513 0.0000000000000005645774968273201 Scatter Plot
Source RANKL Source TWEAK TWEAK Secreted Signaling 0.4351 0.0000000000000000000000016300583524801084 Scatter Plot
Source RANKL Source TGFb TGFb Secreted Signaling -0.2460 0.000000025130850095218157 Scatter Plot
Source RANKL Source SELPLG SELPLG Cell-Cell Contact -0.1952 0.00001097621919911261 Scatter Plot
Source RANKL Source SEMA4 SEMA4 Cell-Cell Contact -0.1598 0.0003341504683158 Scatter Plot
Target RANKL Source TGFb TGFb Secreted Signaling -0.1562 0.0004539034562107 Scatter Plot
Target RANKL Source MIF MIF Secreted Signaling -0.1525 0.0006227791081325 Scatter Plot
Source RANKL Source ANGPTL ANGPTL Secreted Signaling -0.1402 0.0016724738992053 Scatter Plot
Source RANKL Source TNF TNF Secreted Signaling -0.1353 0.002431343965357 Scatter Plot
Target RANKL Source CD52 CD52 Cell-Cell Contact -0.1298 0.0036396906363374 Scatter Plot
Target RANKL Source SEMA4 SEMA4 Cell-Cell Contact -0.1131 0.0114086019655635 Scatter Plot
Target RANKL Source ANGPTL ANGPTL Secreted Signaling -0.1098 0.0140256252293286 Scatter Plot
Target RANKL Target CXCL CXCL Secreted Signaling -0.1068 0.0168779412327271 Scatter Plot
Source RANKL Source ICOS ICOS Cell-Cell Contact 0.0975 0.0292640729139852 Scatter Plot
Source RANKL Target COMPLEMENT COMPLEMENT Secreted Signaling 0.0984 0.0278693204513776 Scatter Plot
Target RANKL Target KIT KIT Secreted Signaling 0.0995 0.026063610133434 Scatter Plot
Source RANKL Source AGRN AGRN ECM-Receptor 0.0997 0.0258575184385491 Scatter Plot
Source RANKL Target TWEAK TWEAK Secreted Signaling 0.1013 0.0235228542764414 Scatter Plot
Source RANKL Source SEMA6 SEMA6 Cell-Cell Contact 0.1037 0.0204272291242009 Scatter Plot
Source RANKL Target IL6 IL6 Secreted Signaling 0.1076 0.0160369756931362 Scatter Plot
Source RANKL Source THBS THBS ECM-Receptor 0.1090 0.0147922976868048 Scatter Plot
Source RANKL Target GAS GAS Secreted Signaling 0.1122 0.012079528100015 Scatter Plot
Source RANKL Source ANGPTL ANGPTL Secreted Signaling 0.1135 0.0110620312572065 Scatter Plot
Source RANKL Target CD86 CD86 Cell-Cell Contact 0.1204 0.0070543518369421 Scatter Plot
Target RANKL Target VTN VTN ECM-Receptor 0.1208 0.006848201140394 Scatter Plot
Source RANKL Source PTN PTN Secreted Signaling 0.1210 0.006765104512192 Scatter Plot
Target RANKL Target FN1 FN1 ECM-Receptor 0.1250 0.0051221556292208 Scatter Plot
Source RANKL Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1283 0.0040611563881749 Scatter Plot
Source RANKL Target CD23 CD23 Cell-Cell Contact 0.1292 0.0038066684677892 Scatter Plot
Target RANKL Target SEMA5 SEMA5 Cell-Cell Contact 0.1293 0.0037659807816999 Scatter Plot
Source RANKL Target SPP1 SPP1 Secreted Signaling 0.1311 0.0033149229882687 Scatter Plot
Source RANKL Target THY1 THY1 Cell-Cell Contact 0.1341 0.0026661390603532 Scatter Plot
Source RANKL Target GDF GDF Secreted Signaling 0.1346 0.0025553276537672 Scatter Plot
Source RANKL Source THY1 THY1 Cell-Cell Contact 0.1353 0.002436032402687 Scatter Plot
Source RANKL Target FN1 FN1 ECM-Receptor 0.1354 0.0024156258917802 Scatter Plot
Source RANKL Target PTN PTN Secreted Signaling 0.1420 0.0014606236901977 Scatter Plot
Source RANKL Target MK MK Secreted Signaling 0.1440 0.0012457198092627 Scatter Plot
Target RANKL Target PERIOSTIN PERIOSTIN Secreted Signaling 0.1462 0.0010394728389635 Scatter Plot
Source RANKL Target OSM OSM Secreted Signaling 0.1477 0.000925715655997 Scatter Plot
Target RANKL Target NRG NRG Secreted Signaling 0.1510 0.0007050909821815 Scatter Plot
Target RANKL Target ANGPT ANGPT Secreted Signaling 0.1530 0.0005976619112372 Scatter Plot
Target RANKL Target BAFF BAFF Secreted Signaling 0.1557 0.0004740304338832 Scatter Plot
Source RANKL Target SEMA3 SEMA3 Secreted Signaling 0.1565 0.0004424862555451 Scatter Plot
Source RANKL Target EPHA EPHA Cell-Cell Contact 0.1600 0.0003268609064364 Scatter Plot
Source RANKL Source GP1BA GP1BA Cell-Cell Contact 0.1615 0.0002868879441011 Scatter Plot
Source RANKL Target VEGF VEGF Secreted Signaling 0.1623 0.0002690383842122 Scatter Plot
Target RANKL Target SEMA4 SEMA4 Cell-Cell Contact 0.1659 0.0001952069184343 Scatter Plot
Target RANKL Target DMP1 DMP1 ECM-Receptor 0.1663 0.0001880202679004 Scatter Plot
Source RANKL Source APELIN APELIN Secreted Signaling 0.1676 0.0001663178079276 Scatter Plot
Target RANKL Target CD22 CD22 Cell-Cell Contact 0.1715 0.0001166650386848 Scatter Plot
Target RANKL Target PTN PTN Secreted Signaling 0.1733 0.00009783842350392832 Scatter Plot
Source RANKL Source CCL CCL Secreted Signaling 0.1836 0.00003608783013401739 Scatter Plot
Source RANKL Target COLLAGEN COLLAGEN ECM-Receptor 0.1888 0.00002140372317734401 Scatter Plot
Source RANKL Source LCK LCK Cell-Cell Contact 0.1889 0.00002113241172375796 Scatter Plot
Source RANKL Source CD86 CD86 Cell-Cell Contact 0.1929 0.000014036232836045248 Scatter Plot
Source RANKL Source IL16 IL16 Secreted Signaling 0.1953 0.000010848428065410016 Scatter Plot
Target RANKL Target OSM OSM Secreted Signaling 0.1976 0.000008528829112633855 Scatter Plot
Target RANKL Target CDH CDH Cell-Cell Contact 0.1984 0.00000783785988913419 Scatter Plot
Source RANKL Source SEMA3 SEMA3 Secreted Signaling 0.1997 0.000006780347955228688 Scatter Plot
Source RANKL Source VEGF VEGF Secreted Signaling 0.2050 0.00000381236909520565 Scatter Plot
Source RANKL Target NODAL NODAL Secreted Signaling 0.2094 0.0000023308651037519405 Scatter Plot
Source RANKL Source ICAM ICAM Cell-Cell Contact 0.2096 0.0000022733305773713348 Scatter Plot
Source RANKL Target AGT AGT Secreted Signaling 0.2124 0.0000016571373998858122 Scatter Plot
Target RANKL Target ncWNT ncWNT Secreted Signaling 0.2130 0.0000015382929731403726 Scatter Plot
Target RANKL Target LAMININ LAMININ ECM-Receptor 0.2159 0.0000010982448702035673 Scatter Plot
Source RANKL Target NCAM NCAM Cell-Cell Contact 0.2194 0.0000007261800402765748 Scatter Plot
Source RANKL Source CXCL CXCL Secreted Signaling 0.2206 0.0000006302774315102731 Scatter Plot
Source RANKL Target SEMA7 SEMA7 Cell-Cell Contact 0.2235 0.0000004443293845758362 Scatter Plot
Target RANKL Target ESAM ESAM Cell-Cell Contact 0.2274 0.0000002740094937418492 Scatter Plot
Target RANKL Target TENASCIN TENASCIN ECM-Receptor 0.2291 0.00000022377492827640205 Scatter Plot
Target RANKL Target THBS THBS ECM-Receptor 0.2303 0.0000001924405524153813 Scatter Plot
Source RANKL Target SEMA6 SEMA6 Cell-Cell Contact 0.2305 0.0000001875173722824483 Scatter Plot
Source RANKL Target LAMININ LAMININ ECM-Receptor 0.2321 0.00000015367254186253352 Scatter Plot
Source RANKL Target ANGPTL ANGPTL Secreted Signaling 0.2336 0.00000012598381418522494 Scatter Plot
Target RANKL Target JAM JAM Cell-Cell Contact 0.2346 0.00000011186917760411729 Scatter Plot
Source RANKL Target VTN VTN ECM-Receptor 0.2361 0.00000009248300354314716 Scatter Plot
Target RANKL Target APP APP Cell-Cell Contact 0.2366 0.0000000861834489054822 Scatter Plot
Source RANKL Target SEMA5 SEMA5 Cell-Cell Contact 0.2374 0.00000007739152122873543 Scatter Plot
Target RANKL Target MIF MIF Secreted Signaling 0.2402 0.00000005418141862194979 Scatter Plot
Source RANKL Target BAFF BAFF Secreted Signaling 0.2408 0.00000004968317998270162 Scatter Plot
Source RANKL Target KIT KIT Secreted Signaling 0.2411 0.000000048184045061595046 Scatter Plot
Target RANKL Target NPR2 NPR2 Secreted Signaling 0.2431 0.00000003676253346550145 Scatter Plot
Source RANKL Source EPHB EPHB Cell-Cell Contact 0.2518 0.00000001144254722774058 Scatter Plot
Source RANKL Source CX3C CX3C Secreted Signaling 0.2525 0.000000010329057907341878 Scatter Plot
Source RANKL Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.2583 0.000000004602318944797801 Scatter Plot
Target RANKL Target VISFATIN VISFATIN Secreted Signaling 0.2594 0.00000000395451576358776 Scatter Plot
Source RANKL Target ACTIVIN ACTIVIN Secreted Signaling 0.2612 0.0000000030570798501467893 Scatter Plot
Source RANKL Source IL2 IL2 Secreted Signaling 0.2622 0.0000000026323377695728715 Scatter Plot
Source RANKL Target CD22 CD22 Cell-Cell Contact 0.2628 0.000000002412637735233735 Scatter Plot
Source RANKL Source CD45 CD45 Cell-Cell Contact 0.2628 0.000000002412637735233735 Scatter Plot
Source RANKL Target THBS THBS ECM-Receptor 0.2656 0.0000000016110511737522126 Scatter Plot
Source RANKL Source LAMININ LAMININ ECM-Receptor 0.2666 0.000000001395248555062789 Scatter Plot
Source RANKL Target PERIOSTIN PERIOSTIN Secreted Signaling 0.2667 0.000000001362857019120914 Scatter Plot
Source RANKL Target VWF VWF ECM-Receptor 0.2696 0.0000000008933729503798823 Scatter Plot
Source RANKL Target CADM CADM Cell-Cell Contact 0.2718 0.0000000006433550783837602 Scatter Plot
Source RANKL Source CADM CADM Cell-Cell Contact 0.2718 0.0000000006433550783837602 Scatter Plot
Source RANKL Target EPHB EPHB Cell-Cell Contact 0.2721 0.0000000006188272310460185 Scatter Plot
Source RANKL Target CD39 CD39 Cell-Cell Contact 0.2731 0.0000000005311636628804373 Scatter Plot
Source RANKL Target TGFb TGFb Secreted Signaling 0.2740 0.0000000004641820169044739 Scatter Plot
Target RANKL Target IL6 IL6 Secreted Signaling 0.2762 0.00000000033134025000393277 Scatter Plot
Target RANKL Target TGFb TGFb Secreted Signaling 0.2792 0.00000000020896210989823888 Scatter Plot
Source RANKL Source PSAP PSAP Secreted Signaling 0.2794 0.00000000020346238207433576 Scatter Plot
Source RANKL Target BMP BMP Secreted Signaling 0.2846 0.00000000008962299030998613 Scatter Plot
Source RANKL Target NRG NRG Secreted Signaling 0.2881 0.00000000005182789837182142 Scatter Plot
Source RANKL Target SEMA4 SEMA4 Cell-Cell Contact 0.2890 0.000000000044697819886196116 Scatter Plot
Source RANKL Source LIFR LIFR Secreted Signaling 0.2902 0.00000000003714256246246607 Scatter Plot
Source RANKL Source NOTCH NOTCH Cell-Cell Contact 0.2926 0.00000000002485872407956954 Scatter Plot
Source RANKL Target BSP BSP ECM-Receptor 0.2936 0.000000000021222280473620416 Scatter Plot
Source RANKL Target DMP1 DMP1 ECM-Receptor 0.2945 0.00000000001834650256047447 Scatter Plot
Source RANKL Source MK MK Secreted Signaling 0.2954 0.000000000015757728421682106 Scatter Plot
Source RANKL Target TENASCIN TENASCIN ECM-Receptor 0.2965 0.000000000013305882014459375 Scatter Plot
Source RANKL Target CD200 CD200 Cell-Cell Contact 0.3006 0.000000000006709061126836638 Scatter Plot
Source RANKL Target NPR2 NPR2 Secreted Signaling 0.3013 0.000000000005912945275942203 Scatter Plot
Source RANKL Source CD39 CD39 Cell-Cell Contact 0.3020 0.000000000005286118748425647 Scatter Plot
Source RANKL Source CD46 CD46 Cell-Cell Contact 0.3026 0.000000000004757184099888146 Scatter Plot
Source RANKL Target SLURP SLURP Secreted Signaling 0.3095 0.000000000001465191187908219 Scatter Plot
Source RANKL Target CSPG4 CSPG4 Cell-Cell Contact 0.3150 0.0000000000005596658602771173 Scatter Plot
Source RANKL Source NT NT Secreted Signaling 0.3196 0.00000000000024474951659806744 Scatter Plot
Source RANKL Source FLT3 FLT3 Secreted Signaling 0.3204 0.00000000000021029455863628534 Scatter Plot
Source RANKL Source IGF IGF Secreted Signaling 0.3292 0.000000000000041689852638785437 Scatter Plot
Source RANKL Target PARs PARs Secreted Signaling 0.3381 0.000000000000007682820231217828 Scatter Plot
Source RANKL Source PROS PROS Secreted Signaling 0.3446 0.0000000000000021627608959177185 Scatter Plot
Source RANKL Target IGF IGF Secreted Signaling 0.3503 0.0000000000000006937953483570213 Scatter Plot
Source RANKL Target FGF FGF Secreted Signaling 0.3516 0.0000000000000005317782661962782 Scatter Plot
Source RANKL Target VISFATIN VISFATIN Secreted Signaling 0.3555 0.0000000000000002416687357976865 Scatter Plot
Source RANKL Target ANGPT ANGPT Secreted Signaling 0.3627 0.00000000000000005406628843485096 Scatter Plot
Source RANKL Source IL7 IL7 Secreted Signaling 0.3649 0.000000000000000034328462280926215 Scatter Plot
Source RANKL Source PDGF PDGF Secreted Signaling 0.3713 0.000000000000000008631337317382294 Scatter Plot
Source RANKL Target APP APP Cell-Cell Contact 0.3782 0.0000000000000000018742477998619987 Scatter Plot
Source RANKL Source GAS GAS Secreted Signaling 0.3807 0.0000000000000000010807828897643961 Scatter Plot
Source RANKL Source CSF CSF Secreted Signaling 0.3808 0.0000000000000000010567873004479531 Scatter Plot
Source RANKL Source ESAM ESAM Cell-Cell Contact 0.3859 0.0000000000000000003321048872893098 Scatter Plot
Source RANKL Target ESAM ESAM Cell-Cell Contact 0.3859 0.0000000000000000003321048872893098 Scatter Plot
Source RANKL Target MIF MIF Secreted Signaling 0.3875 0.00000000000000000023168194782000605 Scatter Plot
Source RANKL Source ANGPT ANGPT Secreted Signaling 0.3893 0.00000000000000000015060877791517725 Scatter Plot
Source RANKL Target CD34 CD34 Cell-Cell Contact 0.3904 0.00000000000000000011835023923881097 Scatter Plot
Source RANKL Source CDH CDH Cell-Cell Contact 0.3941 0.00000000000000000004942000567764277 Scatter Plot
Source RANKL Target CDH CDH Cell-Cell Contact 0.3941 0.00000000000000000004942000567764277 Scatter Plot
Source RANKL Source BST2 BST2 Cell-Cell Contact 0.3985 0.00000000000000000001763952977094172 Scatter Plot
Source RANKL Source SEMA7 SEMA7 Cell-Cell Contact 0.4077 0.000000000000000000001881387736641624 Scatter Plot
Source RANKL Source MHC-II MHC-II Cell-Cell Contact 0.4138 0.00000000000000000000041659824133236784 Scatter Plot
Source RANKL Source BMP BMP Secreted Signaling 0.4187 0.00000000000000000000011934169868672384 Scatter Plot
Source RANKL Source MHC-I MHC-I Cell-Cell Contact 0.4259 0.000000000000000000000018598567541330842 Scatter Plot
Source RANKL Target JAM JAM Cell-Cell Contact 0.4327 0.000000000000000000000003124209496516344 Scatter Plot
Source RANKL Target ncWNT ncWNT Secreted Signaling 0.4436 0.00000000000000000000000015757461878571077 Scatter Plot
Source RANKL Target WNT WNT Secreted Signaling 0.4539 0.000000000000000000000000008739849667829159 Scatter Plot
Source RANKL Source JAM JAM Cell-Cell Contact 0.4610 0.0000000000000000000000000011218367987856654 Scatter Plot
Source RANKL Source CD52 CD52 Cell-Cell Contact -0.3588 0.00000000000000012243315428685766 Scatter Plot
Source RANKL Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.2776 0.0000000002684997866419613 Scatter Plot
Source RANKL Target ICAM ICAM Cell-Cell Contact -0.2546 0.000000007691212272824982 Scatter Plot
Source RANKL Source SELL SELL Cell-Cell Contact -0.2475 0.000000020490893515695443 Scatter Plot
Source RANKL Source COMPLEMENT COMPLEMENT Secreted Signaling -0.2074 0.000002900604871603977 Scatter Plot
Source RANKL Target CD52 CD52 Cell-Cell Contact -0.1950 0.000011207559136384484 Scatter Plot
Source RANKL Target CXCL CXCL Secreted Signaling -0.1889 0.00002128719149303915 Scatter Plot
Source RANKL Target CCL CCL Secreted Signaling -0.1767 0.00007100127612307634 Scatter Plot
Source RANKL Source PARs PARs Secreted Signaling -0.1736 0.00009566248797583532 Scatter Plot
Source RANKL Source CLEC CLEC Cell-Cell Contact -0.1735 0.00009645167663752376 Scatter Plot
Source RANKL Source NKG2D NKG2D Cell-Cell Contact -0.1710 0.0001220517508972 Scatter Plot
Source RANKL Source MIF MIF Secreted Signaling -0.1628 0.0002568172303765 Scatter Plot
Source RANKL Target VCAM VCAM Cell-Cell Contact -0.1498 0.000776181265977 Scatter Plot
Source RANKL Target CSF CSF Secreted Signaling -0.1450 0.0011455919460875 Scatter Plot
Source RANKL Source CCL CCL Secreted Signaling -0.1396 0.0017510078549933 Scatter Plot
Source RANKL Target CEACAM CEACAM Cell-Cell Contact -0.1189 0.0077636655679534 Scatter Plot
Source RANKL Target CLEC CLEC Cell-Cell Contact -0.1174 0.0086242978479228 Scatter Plot
Source RANKL Target IFN-II IFN-II Secreted Signaling -0.1157 0.0096327034555434 Scatter Plot
Source RANKL Target COLLAGEN COLLAGEN ECM-Receptor -0.1118 0.0123626830736574 Scatter Plot
Source RANKL Source SPP1 SPP1 Secreted Signaling -0.1084 0.0153299380021763 Scatter Plot
Source RANKL Source CD34 CD34 Cell-Cell Contact -0.1083 0.0154387306877396 Scatter Plot
Source RANKL Target SELL SELL Cell-Cell Contact -0.1063 0.0173864884355579 Scatter Plot
Target RANKL Target ICAM ICAM Cell-Cell Contact -0.0978 0.0287008112012017 Scatter Plot

Cells that are targets of RANKL from HSCs*

Cells that are source of RANKL to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.