Pathway: NPR2

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the NPR2 pathway:

Specificity Index HSPC as target: 0.508
HSPC as source: 0.471

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the NPR2 pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target NPR2 Source ANGPTL ANGPTL Secreted Signaling 0.1164 0.0091617796261298 Scatter Plot
Target NPR2 Source SEMA6 SEMA6 Cell-Cell Contact 0.1259 0.0048182264426499 Scatter Plot
Target NPR2 Target GAS GAS Secreted Signaling 0.1274 0.0043316271962786 Scatter Plot
Target NPR2 Source GDF GDF Secreted Signaling 0.1397 0.0017395717416211 Scatter Plot
Target NPR2 Source WNT WNT Secreted Signaling 0.1420 0.001451899653977 Scatter Plot
Target NPR2 Source GP1BA GP1BA Cell-Cell Contact 0.1427 0.0013739311547074 Scatter Plot
Target NPR2 Target SEMA3 SEMA3 Secreted Signaling 0.1442 0.0012268634341179 Scatter Plot
Target NPR2 Source THY1 THY1 Cell-Cell Contact 0.1543 0.000533391642201 Scatter Plot
Target NPR2 Source ICOS ICOS Cell-Cell Contact 0.1575 0.0004085321320023 Scatter Plot
Target NPR2 Target NOTCH NOTCH Cell-Cell Contact 0.1772 0.00006748058697605588 Scatter Plot
Target NPR2 Source PTN PTN Secreted Signaling 0.1833 0.00003719120661715597 Scatter Plot
Target NPR2 Source VCAM VCAM Cell-Cell Contact 0.2021 0.000005227009951007752 Scatter Plot
Target NPR2 Target NCAM NCAM Cell-Cell Contact 0.2083 0.000002637758294498707 Scatter Plot
Target NPR2 Target EPHA EPHA Cell-Cell Contact 0.2198 0.0000006958466886961199 Scatter Plot
Target NPR2 Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2208 0.0000006177865644408025 Scatter Plot
Target NPR2 Target VEGF VEGF Secreted Signaling 0.2273 0.0000002802565178811825 Scatter Plot
Target NPR2 Source CD1D2 CD1D2 Cell-Cell Contact 0.2277 0.0000002654359507361648 Scatter Plot
Target NPR2 Source APELIN APELIN Secreted Signaling 0.2289 0.0000002292812996222661 Scatter Plot
Target NPR2 Source CD39 CD39 Cell-Cell Contact 0.2314 0.00000016633938154367466 Scatter Plot
Target NPR2 Target SPP1 SPP1 Secreted Signaling 0.2325 0.00000014614875770972434 Scatter Plot
Target NPR2 Source ncWNT ncWNT Secreted Signaling 0.2336 0.00000012675857380246757 Scatter Plot
Target NPR2 Source CCL CCL Secreted Signaling 0.2393 0.00000006111893650421306 Scatter Plot
Target NPR2 Target RANKL RANKL Secreted Signaling 0.2431 0.00000003676253346550145 Scatter Plot
Target NPR2 Target MK MK Secreted Signaling 0.2437 0.000000034043779978499584 Scatter Plot
Target NPR2 Target PTN PTN Secreted Signaling 0.2461 0.00000002475020637691081 Scatter Plot
Target NPR2 Source CXCL CXCL Secreted Signaling 0.2488 0.000000017141164518318092 Scatter Plot
Target NPR2 Source IL16 IL16 Secreted Signaling 0.2602 0.00000000352361926086823 Scatter Plot
Target NPR2 Target FN1 FN1 ECM-Receptor 0.2639 0.000000002048153885366194 Scatter Plot
Target NPR2 Target CSPG4 CSPG4 Cell-Cell Contact 0.2744 0.00000000043753398865714174 Scatter Plot
Target NPR2 Target AGT AGT Secreted Signaling 0.2749 0.00000000040601817767778304 Scatter Plot
Target NPR2 Target SEMA7 SEMA7 Cell-Cell Contact 0.2811 0.0000000001550254436351122 Scatter Plot
Target NPR2 Source LIGHT LIGHT Secreted Signaling 0.2883 0.000000000050416205306740006 Scatter Plot
Target NPR2 Target GDF GDF Secreted Signaling 0.2883 0.000000000049827216370611326 Scatter Plot
Target NPR2 Source CD46 CD46 Cell-Cell Contact 0.2887 0.000000000047214978368465415 Scatter Plot
Target NPR2 Target BMP BMP Secreted Signaling 0.2897 0.00000000004012792999576116 Scatter Plot
Target NPR2 Target CADM CADM Cell-Cell Contact 0.2927 0.000000000024602989118740136 Scatter Plot
Target NPR2 Source CADM CADM Cell-Cell Contact 0.2927 0.000000000024602989118740136 Scatter Plot
Target NPR2 Source SEMA3 SEMA3 Secreted Signaling 0.2938 0.000000000020569853136592036 Scatter Plot
Target NPR2 Target SEMA6 SEMA6 Cell-Cell Contact 0.2992 0.000000000008473200054234493 Scatter Plot
Target NPR2 Source ICAM ICAM Cell-Cell Contact 0.2999 0.000000000007525693031264436 Scatter Plot
Target NPR2 Source RANKL RANKL Secreted Signaling 0.3013 0.000000000005912945275942203 Scatter Plot
Target NPR2 Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.3096 0.0000000000014236716885231292 Scatter Plot
Target NPR2 Source IL2 IL2 Secreted Signaling 0.3103 0.0000000000012626617288486222 Scatter Plot
Target NPR2 Target ANGPTL ANGPTL Secreted Signaling 0.3258 0.00000000000007835079949787086 Scatter Plot
Target NPR2 Source IGF IGF Secreted Signaling 0.3371 0.000000000000009327114200358195 Scatter Plot
Target NPR2 Source VEGF VEGF Secreted Signaling 0.3379 0.000000000000008120241298171255 Scatter Plot
Target NPR2 Target KIT KIT Secreted Signaling 0.3392 0.000000000000006255081704325204 Scatter Plot
Target NPR2 Target THBS THBS ECM-Receptor 0.3463 0.0000000000000015516657833062874 Scatter Plot
Target NPR2 Source CSF CSF Secreted Signaling 0.3487 0.0000000000000009610627783569948 Scatter Plot
Target NPR2 Source NT NT Secreted Signaling 0.3521 0.000000000000000489041860756529 Scatter Plot
Target NPR2 Target PARs PARs Secreted Signaling 0.3527 0.00000000000000042768412312440823 Scatter Plot
Target NPR2 Source CD86 CD86 Cell-Cell Contact 0.3534 0.0000000000000003721959745279592 Scatter Plot
Target NPR2 Target EPHB EPHB Cell-Cell Contact 0.3572 0.00000000000000017190183629337262 Scatter Plot
Target NPR2 Source EPHB EPHB Cell-Cell Contact 0.3576 0.00000000000000015808407387795834 Scatter Plot
Target NPR2 Target SEMA5 SEMA5 Cell-Cell Contact 0.3601 0.00000000000000009266330838046146 Scatter Plot
Target NPR2 Source CX3C CX3C Secreted Signaling 0.3604 0.00000000000000008720116369089474 Scatter Plot
Target NPR2 Target ACTIVIN ACTIVIN Secreted Signaling 0.3660 0.000000000000000027108623337674764 Scatter Plot
Target NPR2 Source CD45 CD45 Cell-Cell Contact 0.3665 0.000000000000000024087455756106485 Scatter Plot
Target NPR2 Source IL7 IL7 Secreted Signaling 0.3731 0.000000000000000005832949671555608 Scatter Plot
Target NPR2 Source MK MK Secreted Signaling 0.3795 0.0000000000000000014229366260839825 Scatter Plot
Target NPR2 Source LAMININ LAMININ ECM-Receptor 0.3803 0.0000000000000000011932695514350991 Scatter Plot
Target NPR2 Source PSAP PSAP Secreted Signaling 0.3827 0.0000000000000000006921292732203448 Scatter Plot
Target NPR2 Source PROS PROS Secreted Signaling 0.3843 0.0000000000000000004829536250538857 Scatter Plot
Target NPR2 Source LCK LCK Cell-Cell Contact 0.3847 0.000000000000000000433797314971031 Scatter Plot
Target NPR2 Source LIFR LIFR Secreted Signaling 0.3901 0.00000000000000000012589887604174999 Scatter Plot
Target NPR2 Target VWF VWF ECM-Receptor 0.3927 0.00000000000000000006857936788090641 Scatter Plot
Target NPR2 Source NOTCH NOTCH Cell-Cell Contact 0.3981 0.000000000000000000019360455197588422 Scatter Plot
Target NPR2 Source FLT3 FLT3 Secreted Signaling 0.4155 0.00000000000000000000026845017017879597 Scatter Plot
Target NPR2 Source CDH CDH Cell-Cell Contact 0.4236 0.0000000000000000000000340335345865902 Scatter Plot
Target NPR2 Target CDH CDH Cell-Cell Contact 0.4236 0.0000000000000000000000340335345865902 Scatter Plot
Target NPR2 Source BST2 BST2 Cell-Cell Contact 0.4257 0.000000000000000000000019641039567593562 Scatter Plot
Target NPR2 Source TWEAK TWEAK Secreted Signaling 0.4268 0.00000000000000000000001458984776495006 Scatter Plot
Target NPR2 Target CD200 CD200 Cell-Cell Contact 0.4290 0.000000000000000000000008237695870770857 Scatter Plot
Target NPR2 Target TENASCIN TENASCIN ECM-Receptor 0.4368 0.0000000000000000000000010126589117825726 Scatter Plot
Target NPR2 Target FGF FGF Secreted Signaling 0.4432 0.00000000000000000000000017720116684899048 Scatter Plot
Target NPR2 Target PERIOSTIN PERIOSTIN Secreted Signaling 0.4485 0.00000000000000000000000004074825993503907 Scatter Plot
Target NPR2 Source COLLAGEN COLLAGEN ECM-Receptor 0.4513 0.00000000000000000000000001815901460883448 Scatter Plot
Target NPR2 Target IGF IGF Secreted Signaling 0.4550 0.000000000000000000000000006366734861471702 Scatter Plot
Target NPR2 Target DMP1 DMP1 ECM-Receptor 0.4570 0.0000000000000000000000000035129016881796736 Scatter Plot
Target NPR2 Target BSP BSP ECM-Receptor 0.4586 0.000000000000000000000000002229009382096152 Scatter Plot
Target NPR2 Target SLURP SLURP Secreted Signaling 0.4620 0.0000000000000000000000000008313116978157816 Scatter Plot
Target NPR2 Source PDGF PDGF Secreted Signaling 0.4686 0.00000000000000000000000000011580256481322275 Scatter Plot
Target NPR2 Target MIF MIF Secreted Signaling 0.4717 0.000000000000000000000000000044648799466788913 Scatter Plot
Target NPR2 Source ANGPT ANGPT Secreted Signaling 0.4749 0.000000000000000000000000000017085883329128158 Scatter Plot
Target NPR2 Source GAS GAS Secreted Signaling 0.4821 0.000000000000000000000000000001788421140383866 Scatter Plot
Target NPR2 Target CD39 CD39 Cell-Cell Contact 0.4947 0.00000000000000000000000000000003174555475286477 Scatter Plot
Target NPR2 Target JAM JAM Cell-Cell Contact 0.5016 0.0000000000000000000000000000000031973720903414816 Scatter Plot
Target NPR2 Source ESAM ESAM Cell-Cell Contact 0.5053 0.0000000000000000000000000000000009016184400619876 Scatter Plot
Target NPR2 Source SEMA7 SEMA7 Cell-Cell Contact 0.5090 0.0000000000000000000000000000000002587784976472745 Scatter Plot
Target NPR2 Target ncWNT ncWNT Secreted Signaling 0.5116 0.00000000000000000000000000000000010340308898172352 Scatter Plot
Target NPR2 Source BMP BMP Secreted Signaling 0.5205 0.000000000000000000000000000000000004587138293233659 Scatter Plot
Target NPR2 Target WNT WNT Secreted Signaling 0.5245 0.0000000000000000000000000000000000010745477552029224 Scatter Plot
Target NPR2 Source MHC-II MHC-II Cell-Cell Contact 0.5367 0.000000000000000000000000000000000000011877374718067832 Scatter Plot
Target NPR2 Source MHC-I MHC-I Cell-Cell Contact 0.5415 0.000000000000000000000000000000000000001903974242951669 Scatter Plot
Target NPR2 Source JAM JAM Cell-Cell Contact 0.5521 0.0000000000000000000000000000000000000000299869763001272 Scatter Plot
Target NPR2 Source CD52 CD52 Cell-Cell Contact -0.4167 0.0000000000000000000001995136692001125 Scatter Plot
Target NPR2 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.3774 0.000000000000000002235874385156432 Scatter Plot
Target NPR2 Source COMPLEMENT COMPLEMENT Secreted Signaling -0.3612 0.00000000000000007380637317404522 Scatter Plot
Target NPR2 Source TGFb TGFb Secreted Signaling -0.3035 0.000000000004091242714579735 Scatter Plot
Target NPR2 Source SELL SELL Cell-Cell Contact -0.3015 0.000000000005690627310040137 Scatter Plot
Target NPR2 Source PARs PARs Secreted Signaling -0.2511 0.000000012502464364154232 Scatter Plot
Target NPR2 Target CXCL CXCL Secreted Signaling -0.2429 0.00000003782253990735929 Scatter Plot
Target NPR2 Source MIF MIF Secreted Signaling -0.2267 0.0000003008254686238672 Scatter Plot
Target NPR2 Target CSF CSF Secreted Signaling -0.2183 0.0000008305246979724409 Scatter Plot
Target NPR2 Source CLEC CLEC Cell-Cell Contact -0.2138 0.0000013953100018328034 Scatter Plot
Target NPR2 Source ANGPTL ANGPTL Secreted Signaling -0.1877 0.000023966220461770703 Scatter Plot
Target NPR2 Source SPP1 SPP1 Secreted Signaling -0.1748 0.00008543835634014159 Scatter Plot
Target NPR2 Source SEMA4 SEMA4 Cell-Cell Contact -0.1743 0.00008905277772252675 Scatter Plot
Target NPR2 Target IL17 IL17 Secreted Signaling -0.1735 0.00009624451217412722 Scatter Plot
Target NPR2 Source CCL CCL Secreted Signaling -0.1707 0.0001251747018614 Scatter Plot
Target NPR2 Source TNF TNF Secreted Signaling -0.1648 0.00021530531805 Scatter Plot
Target NPR2 Source SELPLG SELPLG Cell-Cell Contact -0.1583 0.0003801369755434 Scatter Plot
Target NPR2 Source NCAM NCAM Cell-Cell Contact -0.1502 0.0007542747984345 Scatter Plot
Target NPR2 Source VISTA VISTA Cell-Cell Contact -0.1367 0.0021900347225121 Scatter Plot
Target NPR2 Source IL1 IL1 Secreted Signaling -0.1165 0.0091374875488933 Scatter Plot
Target NPR2 Source ANNEXIN ANNEXIN Secreted Signaling -0.1146 0.010340773178488 Scatter Plot
Target NPR2 Target COLLAGEN COLLAGEN ECM-Receptor -0.0987 0.0272874140726968 Scatter Plot
Target NPR2 Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1619 0.000276928111492 Scatter Plot
Target NPR2 Target NOTCH NOTCH Cell-Cell Contact 0.1771 0.00006831786409523592 Scatter Plot
Target NPR2 Target THY1 THY1 Cell-Cell Contact 0.1919 0.00001559918726670025 Scatter Plot
Target NPR2 Target CD23 CD23 Cell-Cell Contact 0.1947 0.000011641927550605207 Scatter Plot
Target NPR2 Target GALECTIN GALECTIN Secreted Signaling 0.1967 0.00000940846647200852 Scatter Plot
Target NPR2 Target COLLAGEN COLLAGEN ECM-Receptor 0.2074 0.000002897793121353467 Scatter Plot
Target NPR2 Target IL6 IL6 Secreted Signaling 0.2170 0.000000966864117128093 Scatter Plot
Target NPR2 Target NODAL NODAL Secreted Signaling 0.2265 0.0000003092121841828281 Scatter Plot
Target NPR2 Target OSM OSM Secreted Signaling 0.2658 0.000000001556915832755359 Scatter Plot
Target NPR2 Target VISFATIN VISFATIN Secreted Signaling 0.3395 0.0000000000000059013731442275436 Scatter Plot
Target NPR2 Target LAMININ LAMININ ECM-Receptor 0.3447 0.000000000000002124824841479733 Scatter Plot
Target NPR2 Target CD22 CD22 Cell-Cell Contact 0.3665 0.000000000000000024087455756106485 Scatter Plot
Target NPR2 Target TGFb TGFb Secreted Signaling 0.3682 0.000000000000000016681359492122098 Scatter Plot
Target NPR2 Target BAFF BAFF Secreted Signaling 0.3821 0.0000000000000000007916268089671786 Scatter Plot
Target NPR2 Target VTN VTN ECM-Receptor 0.3875 0.0000000000000000002324568567872681 Scatter Plot
Target NPR2 Target ANGPT ANGPT Secreted Signaling 0.3963 0.000000000000000000029554633534640584 Scatter Plot
Target NPR2 Target SEMA4 SEMA4 Cell-Cell Contact 0.4214 0.00000000000000000000005948686199325114 Scatter Plot
Target NPR2 Target NRG NRG Secreted Signaling 0.4317 0.0000000000000000000000040088869968860905 Scatter Plot
Target NPR2 Target APP APP Cell-Cell Contact 0.4549 0.000000000000000000000000006519167741462753 Scatter Plot
Target NPR2 Target ESAM ESAM Cell-Cell Contact 0.5053 0.0000000000000000000000000000000009016184400619876 Scatter Plot
Target NPR2 Target CD34 CD34 Cell-Cell Contact 0.5121 0.00000000000000000000000000000000008627148388974837 Scatter Plot
Target NPR2 Target ICAM ICAM Cell-Cell Contact -0.3459 0.000000000000001671490710311178 Scatter Plot
Target NPR2 Target CD52 CD52 Cell-Cell Contact -0.2778 0.0000000002607376593055321 Scatter Plot
Target NPR2 Target VCAM VCAM Cell-Cell Contact -0.2273 0.0000002778558129655009 Scatter Plot
Target NPR2 Target CCL CCL Secreted Signaling -0.2154 0.0000011659135183738903 Scatter Plot
Target NPR2 Target IFN-II IFN-II Secreted Signaling -0.1967 0.00000942039265972568 Scatter Plot
Target NPR2 Target CEACAM CEACAM Cell-Cell Contact -0.1808 0.00004780491928021766 Scatter Plot
Target NPR2 Target CLEC CLEC Cell-Cell Contact -0.1625 0.0002624855419342 Scatter Plot
Target NPR2 Target GRN GRN Secreted Signaling -0.1161 0.0093586358529515 Scatter Plot
Target NPR2 Target ANNEXIN ANNEXIN Secreted Signaling -0.1135 0.0110679902781953 Scatter Plot
Target NPR2 Target COMPLEMENT COMPLEMENT Secreted Signaling -0.1131 0.0113501694311685 Scatter Plot
Target NPR2 Target VEGF VEGF Secreted Signaling -0.1078 0.0159253638311011 Scatter Plot

Cells that are targets of NPR2 from HSCs*

    No cell populations

Cells that are source of NPR2 to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.