Pathway: IFN-II

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the IFN-II pathway:

Specificity Index HSPC as target:
HSPC as source:

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the IFN-II pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target IFN-II Source SEMA6 SEMA6 Cell-Cell Contact 0.1046 0.0193379112428514 Scatter Plot
Target IFN-II Target GRN GRN Secreted Signaling 0.1069 0.0168330744881915 Scatter Plot
Target IFN-II Target IL1 IL1 Secreted Signaling 0.1140 0.0107670706521476 Scatter Plot
Target IFN-II Target IL6 IL6 Secreted Signaling 0.1157 0.0096047826888003 Scatter Plot
Target IFN-II Source MIF MIF Secreted Signaling 0.1172 0.0086832579852583 Scatter Plot
Target IFN-II Source ANGPTL ANGPTL Secreted Signaling 0.1204 0.0070546793847112 Scatter Plot
Target IFN-II Target LAIR1 LAIR1 Cell-Cell Contact 0.1208 0.0068236624751325 Scatter Plot
Target IFN-II Target BST2 BST2 Cell-Cell Contact 0.1208 0.0068236624751325 Scatter Plot
Target IFN-II Source IL2 IL2 Secreted Signaling 0.1422 0.001435819059282 Scatter Plot
Target IFN-II Target COLLAGEN COLLAGEN ECM-Receptor 0.1676 0.0001672286897402 Scatter Plot
Target IFN-II Target SELE SELE Cell-Cell Contact 0.1927 0.000014310494684569768 Scatter Plot
Target IFN-II Source VISFATIN VISFATIN Secreted Signaling 0.1947 0.000011551398905809128 Scatter Plot
Target IFN-II Source NCAM NCAM Cell-Cell Contact 0.1959 0.00001025169376997044 Scatter Plot
Target IFN-II Target SELPLG SELPLG Cell-Cell Contact 0.1975 0.000008625514337387643 Scatter Plot
Target IFN-II Source TNF TNF Secreted Signaling 0.2027 0.000004897176543700987 Scatter Plot
Target IFN-II Source GRN GRN Secreted Signaling 0.2353 0.00000010177875951803557 Scatter Plot
Target IFN-II Source CLEC CLEC Cell-Cell Contact 0.2398 0.00000005706173349143554 Scatter Plot
Target IFN-II Source SELPLG SELPLG Cell-Cell Contact 0.2595 0.0000000038635398121463114 Scatter Plot
Target IFN-II Source SPP1 SPP1 Secreted Signaling 0.2682 0.0000000011066954899904658 Scatter Plot
Target IFN-II Target CXCL CXCL Secreted Signaling 0.2762 0.00000000033264968005408216 Scatter Plot
Target IFN-II Source LAIR1 LAIR1 Cell-Cell Contact 0.2927 0.00000000002474180982639464 Scatter Plot
Target IFN-II Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2997 0.000000000007753840062162257 Scatter Plot
Target IFN-II Target VEGF VEGF Secreted Signaling 0.3240 0.00000000000010952203824014281 Scatter Plot
Target IFN-II Target SEMA3 SEMA3 Secreted Signaling 0.3260 0.00000000000007628808198643085 Scatter Plot
Target IFN-II Target IL17 IL17 Secreted Signaling 0.3285 0.000000000000047483983390714665 Scatter Plot
Target IFN-II Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.3321 0.000000000000024363933409890528 Scatter Plot
Target IFN-II Target VCAM VCAM Cell-Cell Contact 0.3455 0.0000000000000018194461717732867 Scatter Plot
Target IFN-II Target CEACAM CEACAM Cell-Cell Contact 0.3492 0.0000000000000008686744672609157 Scatter Plot
Target IFN-II Target CCL CCL Secreted Signaling 0.3675 0.000000000000000019393645108385408 Scatter Plot
Target IFN-II Target ICAM ICAM Cell-Cell Contact 0.3743 0.0000000000000000044929388974761535 Scatter Plot
Target IFN-II Source SEMA4 SEMA4 Cell-Cell Contact 0.3980 0.00000000000000000001996373034661828 Scatter Plot
Target IFN-II Source APP APP Cell-Cell Contact 0.4065 0.0000000000000000000025637444995643326 Scatter Plot
Target IFN-II Source CCL CCL Secreted Signaling 0.4092 0.0000000000000000000012996769745084429 Scatter Plot
Target IFN-II Target CLEC CLEC Cell-Cell Contact 0.4129 0.0000000000000000000005239125253819353 Scatter Plot
Target IFN-II Target CSF CSF Secreted Signaling 0.4388 0.00000000000000000000000060159515578958845 Scatter Plot
Target IFN-II Source CD52 CD52 Cell-Cell Contact 0.4463 0.0000000000000000000000000739065513888264 Scatter Plot
Target IFN-II Source VISTA VISTA Cell-Cell Contact 0.4627 0.00000000000000000000000000066631567494482565 Scatter Plot
Target IFN-II Source COMPLEMENT COMPLEMENT Secreted Signaling 0.4998 0.0000000000000000000000000000000057996437780395035 Scatter Plot
Target IFN-II Source SELL SELL Cell-Cell Contact 0.5007 0.000000000000000000000000000000004257509317427803 Scatter Plot
Target IFN-II Source ANNEXIN ANNEXIN Secreted Signaling 0.5156 0.00000000000000000000000000000000002610704226338268 Scatter Plot
Target IFN-II Source PARs PARs Secreted Signaling 0.5377 0.000000000000000000000000000000000000008077990935036792 Scatter Plot
Target IFN-II Target PARs PARs Secreted Signaling -0.5196 0.000000000000000000000000000000000006152797284368919 Scatter Plot
Target IFN-II Target VWF VWF ECM-Receptor -0.4925 0.00000000000000000000000000000006517449060472543 Scatter Plot
Target IFN-II Target TENASCIN TENASCIN ECM-Receptor -0.4900 0.00000000000000000000000000000014484569144851536 Scatter Plot
Target IFN-II Target MK MK Secreted Signaling -0.4506 0.00000000000000000000000002254136210876116 Scatter Plot
Target IFN-II Source ANGPT ANGPT Secreted Signaling -0.4171 0.00000000000000000000018017241282264261 Scatter Plot
Target IFN-II Target VTN VTN ECM-Receptor -0.4055 0.0000000000000000000032394917317454787 Scatter Plot
Target IFN-II Target CD34 CD34 Cell-Cell Contact -0.4018 0.00000000000000000000788657582720202 Scatter Plot
Target IFN-II Source GALECTIN GALECTIN Secreted Signaling -0.4017 0.000000000000000000008076174569942339 Scatter Plot
Target IFN-II Target IGF IGF Secreted Signaling -0.3834 0.0000000000000000005857192105133408 Scatter Plot
Target IFN-II Source LIFR LIFR Secreted Signaling -0.3763 0.0000000000000000029032596342916306 Scatter Plot
Target IFN-II Source JAM JAM Cell-Cell Contact -0.3762 0.0000000000000000029175940569844622 Scatter Plot
Target IFN-II Target SEMA7 SEMA7 Cell-Cell Contact -0.3509 0.0000000000000006214788828410625 Scatter Plot
Target IFN-II Target PTN PTN Secreted Signaling -0.3507 0.0000000000000006485516195683166 Scatter Plot
Target IFN-II Source FLT3 FLT3 Secreted Signaling -0.3484 0.0000000000000010150557170289784 Scatter Plot
Target IFN-II Target FN1 FN1 ECM-Receptor -0.3366 0.000000000000010365703912477455 Scatter Plot
Target IFN-II Target KIT KIT Secreted Signaling -0.3324 0.000000000000023005879711944353 Scatter Plot
Target IFN-II Source EPHB EPHB Cell-Cell Contact -0.3278 0.000000000000054481201106264105 Scatter Plot
Target IFN-II Source MHC-I MHC-I Cell-Cell Contact -0.3278 0.000000000000054734091559348255 Scatter Plot
Target IFN-II Target CD39 CD39 Cell-Cell Contact -0.3257 0.00000000000008004120719526874 Scatter Plot
Target IFN-II Source ESAM ESAM Cell-Cell Contact -0.3254 0.00000000000008465023577184366 Scatter Plot
Target IFN-II Target ESAM ESAM Cell-Cell Contact -0.3254 0.00000000000008465023577184366 Scatter Plot
Target IFN-II Source LCK LCK Cell-Cell Contact -0.3176 0.000000000000350911303391963 Scatter Plot
Target IFN-II Target JAM JAM Cell-Cell Contact -0.3158 0.0000000000004806136700231456 Scatter Plot
Target IFN-II Target ncWNT ncWNT Secreted Signaling -0.2970 0.000000000012234964003621888 Scatter Plot
Target IFN-II Source FGF FGF Secreted Signaling -0.2961 0.000000000014161172538091045 Scatter Plot
Target IFN-II Source BMP BMP Secreted Signaling -0.2864 0.00000000006780922597188938 Scatter Plot
Target IFN-II Target ANGPT ANGPT Secreted Signaling -0.2796 0.00000000019745139558046995 Scatter Plot
Target IFN-II Source TWEAK TWEAK Secreted Signaling -0.2795 0.00000000019933230536258912 Scatter Plot
Target IFN-II Source PDGF PDGF Secreted Signaling -0.2775 0.000000000270779240390767 Scatter Plot
Target IFN-II Target WNT WNT Secreted Signaling -0.2729 0.0000000005468972597506329 Scatter Plot
Target IFN-II Target SEMA5 SEMA5 Cell-Cell Contact -0.2725 0.0000000005786916443477256 Scatter Plot
Target IFN-II Target FGF FGF Secreted Signaling -0.2656 0.000000001608592744980917 Scatter Plot
Target IFN-II Target VEGF VEGF Secreted Signaling -0.2643 0.000000001947526343449645 Scatter Plot
Target IFN-II Source GP1BA GP1BA Cell-Cell Contact -0.2640 0.000000002016731223983521 Scatter Plot
Target IFN-II Source VEGF VEGF Secreted Signaling -0.2552 0.000000007083273834197093 Scatter Plot
Target IFN-II Target SEMA4 SEMA4 Cell-Cell Contact -0.2535 0.000000008979193942943797 Scatter Plot
Target IFN-II Target LAMININ LAMININ ECM-Receptor -0.2532 0.00000000936123825923893 Scatter Plot
Target IFN-II Target CDH CDH Cell-Cell Contact -0.2486 0.000000017561840586360937 Scatter Plot
Target IFN-II Source CDH CDH Cell-Cell Contact -0.2486 0.000000017561840586360937 Scatter Plot
Target IFN-II Source MHC-II MHC-II Cell-Cell Contact -0.2459 0.000000025374563171420665 Scatter Plot
Target IFN-II Target SPP1 SPP1 Secreted Signaling -0.2439 0.000000033194653907466034 Scatter Plot
Target IFN-II Source CXCL CXCL Secreted Signaling -0.2413 0.000000046642497306527835 Scatter Plot
Target IFN-II Target DMP1 DMP1 ECM-Receptor -0.2408 0.0000000502465606572328 Scatter Plot
Target IFN-II Target VISFATIN VISFATIN Secreted Signaling -0.2399 0.00000005649580024682737 Scatter Plot
Target IFN-II Target SEMA6 SEMA6 Cell-Cell Contact -0.2367 0.00000008508080906138224 Scatter Plot
Target IFN-II Target CSPG4 CSPG4 Cell-Cell Contact -0.2327 0.00000014154272817751858 Scatter Plot
Target IFN-II Source COLLAGEN COLLAGEN ECM-Receptor -0.2317 0.00000016047224554828924 Scatter Plot
Target IFN-II Source LIGHT LIGHT Secreted Signaling -0.2303 0.0000001918070035695867 Scatter Plot
Target IFN-II Target NRG NRG Secreted Signaling -0.2219 0.0000005403953999260838 Scatter Plot
Target IFN-II Source PTN PTN Secreted Signaling -0.2203 0.0000006548182055946153 Scatter Plot
Target IFN-II Target BSP BSP ECM-Receptor -0.2186 0.0000008021717088668155 Scatter Plot
Target IFN-II Source PROS PROS Secreted Signaling -0.2162 0.0000010582563610316215 Scatter Plot
Target IFN-II Source GAS GAS Secreted Signaling -0.2095 0.0000022923710385277075 Scatter Plot
Target IFN-II Source THY1 THY1 Cell-Cell Contact -0.2054 0.000003657541951427248 Scatter Plot
Target IFN-II Source BST2 BST2 Cell-Cell Contact -0.1979 0.00000828216420603611 Scatter Plot
Target IFN-II Target ANGPTL ANGPTL Secreted Signaling -0.1972 0.000008888555115756287 Scatter Plot
Target IFN-II Target NPR2 NPR2 Secreted Signaling -0.1967 0.00000942039265972568 Scatter Plot
Target IFN-II Source IL1 IL1 Secreted Signaling -0.1934 0.000013373240219273071 Scatter Plot
Target IFN-II Source CD46 CD46 Cell-Cell Contact -0.1901 0.00001883729153656707 Scatter Plot
Target IFN-II Target PERIOSTIN PERIOSTIN Secreted Signaling -0.1874 0.00002460923938395602 Scatter Plot
Target IFN-II Source CX3C CX3C Secreted Signaling -0.1860 0.000028349660713575728 Scatter Plot
Target IFN-II Source SEMA7 SEMA7 Cell-Cell Contact -0.1815 0.00004443049092993264 Scatter Plot
Target IFN-II Source APELIN APELIN Secreted Signaling -0.1812 0.0000460004715911634 Scatter Plot
Target IFN-II Target AGT AGT Secreted Signaling -0.1763 0.00007384038691693661 Scatter Plot
Target IFN-II Target TGFb TGFb Secreted Signaling -0.1721 0.0001103336367003 Scatter Plot
Target IFN-II Source VCAM VCAM Cell-Cell Contact -0.1716 0.000115447204843 Scatter Plot
Target IFN-II Source IL7 IL7 Secreted Signaling -0.1676 0.0001658286615247 Scatter Plot
Target IFN-II Source IL2 IL2 Secreted Signaling -0.1676 0.0001658286615247 Scatter Plot
Target IFN-II Target APP APP Cell-Cell Contact -0.1597 0.0003377282349007 Scatter Plot
Target IFN-II Target EPHB EPHB Cell-Cell Contact -0.1567 0.0004364368073366 Scatter Plot
Target IFN-II Source ANGPTL ANGPTL Secreted Signaling -0.1560 0.0004651403393112 Scatter Plot
Target IFN-II Target ADIPONECTIN ADIPONECTIN Secreted Signaling -0.1534 0.0005753342379978 Scatter Plot
Target IFN-II Target CXCL CXCL Secreted Signaling -0.1478 0.0009201823440615 Scatter Plot
Target IFN-II Target SLURP SLURP Secreted Signaling -0.1355 0.0023864672087495 Scatter Plot
Target IFN-II Target BMP BMP Secreted Signaling -0.1299 0.0036164815465864 Scatter Plot
Target IFN-II Source CCL CCL Secreted Signaling -0.1272 0.0043832167924032 Scatter Plot
Target IFN-II Source LAMININ LAMININ ECM-Receptor -0.1271 0.0044281207976613 Scatter Plot
Target IFN-II Source ICAM ICAM Cell-Cell Contact -0.1261 0.0047310125850217 Scatter Plot
Target IFN-II Target COLLAGEN COLLAGEN ECM-Receptor -0.1258 0.0048442475637354 Scatter Plot
Target IFN-II Target MIF MIF Secreted Signaling -0.1247 0.0052405227259197 Scatter Plot
Target IFN-II Target GAS GAS Secreted Signaling -0.1217 0.0064209219444565 Scatter Plot
Target IFN-II Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.1198 0.0073260531688442 Scatter Plot
Target IFN-II Source MK MK Secreted Signaling -0.1193 0.0075849737910033 Scatter Plot
Target IFN-II Source IGF IGF Secreted Signaling -0.1181 0.0081881482110693 Scatter Plot
Target IFN-II Source RANKL RANKL Secreted Signaling -0.1157 0.0096327034555434 Scatter Plot
Target IFN-II Source ncWNT ncWNT Secreted Signaling -0.1150 0.0100404501278675 Scatter Plot
Target IFN-II Source NOTCH NOTCH Cell-Cell Contact -0.1096 0.0142458058857234 Scatter Plot
Target IFN-II Source NT NT Secreted Signaling -0.1060 0.0177204150164192 Scatter Plot
Target IFN-II Target CD22 CD22 Cell-Cell Contact -0.1056 0.0182096292874792 Scatter Plot
Target IFN-II Source CD45 CD45 Cell-Cell Contact -0.1056 0.0182096292874792 Scatter Plot
Target IFN-II Source CSF CSF Secreted Signaling -0.1054 0.0184408579813414 Scatter Plot
Target IFN-II Source CADM CADM Cell-Cell Contact -0.1038 0.0203101716344776 Scatter Plot
Target IFN-II Target CADM CADM Cell-Cell Contact -0.1038 0.0203101716344776 Scatter Plot
Target IFN-II Target GALECTIN GALECTIN Secreted Signaling 0.1137 0.010937722700119 Scatter Plot
Target IFN-II Target ICAM ICAM Cell-Cell Contact 0.3988 0.000000000000000000016544375099523598 Scatter Plot
Target IFN-II Target CD52 CD52 Cell-Cell Contact 0.4791 0.0000000000000000000000000000046729879509771265 Scatter Plot
Target IFN-II Target THBS THBS ECM-Receptor -0.2648 0.000000001817900379944913 Scatter Plot

Cells that are targets of IFN-II from HSCs*

    No cell populations

Cells that are source of IFN-II to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.