Pathway: CD22

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Cell-Cell Contact

Details on the CD22 pathway:

Specificity Index HSPC as target: 0.457
HSPC as source: 0.335

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the CD22 pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target CD22 Source NCAM NCAM Cell-Cell Contact 0.0972 0.029779705069578 Scatter Plot
Target CD22 Source APP APP Cell-Cell Contact 0.1121 0.0121100560597297 Scatter Plot
Target CD22 Source CD34 CD34 Cell-Cell Contact 0.1137 0.0109593961873588 Scatter Plot
Target CD22 Source OSM OSM Secreted Signaling 0.1182 0.0081643163705401 Scatter Plot
Target CD22 Target PECAM1 PECAM1 Cell-Cell Contact 0.1187 0.0078742566287711 Scatter Plot
Target CD22 Source PECAM1 PECAM1 Cell-Cell Contact 0.1187 0.0078742566287711 Scatter Plot
Target CD22 Source BAFF BAFF Secreted Signaling 0.1231 0.0058469809477965 Scatter Plot
Target CD22 Target SEMA3 SEMA3 Secreted Signaling 0.1304 0.0034929301300462 Scatter Plot
Target CD22 Source ncWNT ncWNT Secreted Signaling 0.1457 0.0010871104345823 Scatter Plot
Target CD22 Source PTN PTN Secreted Signaling 0.1568 0.0004313236636339 Scatter Plot
Target CD22 Target BST2 BST2 Cell-Cell Contact 0.1596 0.0003391979274005 Scatter Plot
Target CD22 Target LAIR1 LAIR1 Cell-Cell Contact 0.1596 0.0003391979274005 Scatter Plot
Target CD22 Target SEMA6 SEMA6 Cell-Cell Contact 0.1642 0.0002262194024301 Scatter Plot
Target CD22 Source ANGPTL ANGPTL Secreted Signaling 0.1647 0.0002159760608846 Scatter Plot
Target CD22 Source SEMA3 SEMA3 Secreted Signaling 0.1655 0.0002020783552639 Scatter Plot
Target CD22 Target SEMA5 SEMA5 Cell-Cell Contact 0.1656 0.0001998114345612 Scatter Plot
Target CD22 Target SELE SELE Cell-Cell Contact 0.1681 0.0001586296907708 Scatter Plot
Target CD22 Target RANKL RANKL Secreted Signaling 0.1715 0.0001166650386848 Scatter Plot
Target CD22 Target COLLAGEN COLLAGEN ECM-Receptor 0.1745 0.00008796318579749706 Scatter Plot
Target CD22 Target EPHA EPHA Cell-Cell Contact 0.1772 0.00006771309512291598 Scatter Plot
Target CD22 Target IL1 IL1 Secreted Signaling 0.1791 0.00005626354317025534 Scatter Plot
Target CD22 Target SPP1 SPP1 Secreted Signaling 0.1812 0.000046116460713013485 Scatter Plot
Target CD22 Source ICOS ICOS Cell-Cell Contact 0.1844 0.00003332169974401404 Scatter Plot
Target CD22 Source NT NT Secreted Signaling 0.1854 0.00003033023459556997 Scatter Plot
Target CD22 Target CSPG4 CSPG4 Cell-Cell Contact 0.1932 0.000013562117688471192 Scatter Plot
Target CD22 Source ANNEXIN ANNEXIN Secreted Signaling 0.1963 0.000009847093051674634 Scatter Plot
Target CD22 Source WNT WNT Secreted Signaling 0.1985 0.000007736910820317817 Scatter Plot
Target CD22 Source CD46 CD46 Cell-Cell Contact 0.2023 0.00000511468336611232 Scatter Plot
Target CD22 Target VEGF VEGF Secreted Signaling 0.2048 0.00000388637331037311 Scatter Plot
Target CD22 Source GRN GRN Secreted Signaling 0.2071 0.000003014373442715584 Scatter Plot
Target CD22 Source THY1 THY1 Cell-Cell Contact 0.2141 0.0000013583567860766124 Scatter Plot
Target CD22 Source CADM CADM Cell-Cell Contact 0.2185 0.0000008039196750612445 Scatter Plot
Target CD22 Target CADM CADM Cell-Cell Contact 0.2185 0.0000008039196750612445 Scatter Plot
Target CD22 Source GDF GDF Secreted Signaling 0.2251 0.000000367186324675406 Scatter Plot
Target CD22 Target GDF GDF Secreted Signaling 0.2294 0.0000002150953227144349 Scatter Plot
Target CD22 Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2310 0.00000017652714934727585 Scatter Plot
Target CD22 Source VCAM VCAM Cell-Cell Contact 0.2345 0.0000001123440234155468 Scatter Plot
Target CD22 Target NOTCH NOTCH Cell-Cell Contact 0.2364 0.00000008897167910074603 Scatter Plot
Target CD22 Target VISFATIN VISFATIN Secreted Signaling 0.2367 0.00000008527294960670218 Scatter Plot
Target CD22 Source CXCL CXCL Secreted Signaling 0.2368 0.00000008422245285421135 Scatter Plot
Target CD22 Source CD1D2 CD1D2 Cell-Cell Contact 0.2369 0.00000008306874217050903 Scatter Plot
Target CD22 Source IL2 IL2 Secreted Signaling 0.2459 0.00000002524978481442073 Scatter Plot
Target CD22 Source PROS PROS Secreted Signaling 0.2513 0.000000012220072352052373 Scatter Plot
Target CD22 Target SEMA7 SEMA7 Cell-Cell Contact 0.2523 0.000000010638438238055076 Scatter Plot
Target CD22 Target PARs PARs Secreted Signaling 0.2589 0.000000004212764747408821 Scatter Plot
Target CD22 Target EPHB EPHB Cell-Cell Contact 0.2602 0.000000003515928886219151 Scatter Plot
Target CD22 Target FN1 FN1 ECM-Receptor 0.2605 0.000000003341498924434451 Scatter Plot
Target CD22 Target VWF VWF ECM-Receptor 0.2626 0.0000000024898103273820033 Scatter Plot
Target CD22 Source RANKL RANKL Secreted Signaling 0.2628 0.000000002412637735233735 Scatter Plot
Target CD22 Source CSF CSF Secreted Signaling 0.2632 0.000000002295607872171186 Scatter Plot
Target CD22 Source NOTCH NOTCH Cell-Cell Contact 0.2721 0.000000000613269849103357 Scatter Plot
Target CD22 Source IGF IGF Secreted Signaling 0.2800 0.00000000018468363365400058 Scatter Plot
Target CD22 Source CD39 CD39 Cell-Cell Contact 0.2851 0.00000000008337315421770148 Scatter Plot
Target CD22 Target VTN VTN ECM-Receptor 0.2855 0.00000000007777181450369302 Scatter Plot
Target CD22 Source CCL CCL Secreted Signaling 0.2900 0.000000000038200263625068935 Scatter Plot
Target CD22 Source LIFR LIFR Secreted Signaling 0.2930 0.00000000002356724013136781 Scatter Plot
Target CD22 Target NCAM NCAM Cell-Cell Contact 0.2936 0.00000000002111610609886069 Scatter Plot
Target CD22 Target CDH CDH Cell-Cell Contact 0.2946 0.000000000018021539197535848 Scatter Plot
Target CD22 Source CDH CDH Cell-Cell Contact 0.2946 0.000000000018021539197535848 Scatter Plot
Target CD22 Source EPHB EPHB Cell-Cell Contact 0.3034 0.000000000004194865150918194 Scatter Plot
Target CD22 Source FLT3 FLT3 Secreted Signaling 0.3045 0.000000000003451278853583564 Scatter Plot
Target CD22 Target NODAL NODAL Secreted Signaling 0.3091 0.0000000000015773922850100485 Scatter Plot
Target CD22 Source BST2 BST2 Cell-Cell Contact 0.3122 0.0000000000009193748998800874 Scatter Plot
Target CD22 Target BMP BMP Secreted Signaling 0.3148 0.0000000000005798246963557281 Scatter Plot
Target CD22 Target ANGPTL ANGPTL Secreted Signaling 0.3239 0.00000000000011163705186974483 Scatter Plot
Target CD22 Target THBS THBS ECM-Receptor 0.3377 0.000000000000008365017754101696 Scatter Plot
Target CD22 Source MK MK Secreted Signaling 0.3403 0.000000000000005074414402100291 Scatter Plot
Target CD22 Source PDGF PDGF Secreted Signaling 0.3405 0.000000000000004898747478800701 Scatter Plot
Target CD22 Source VEGF VEGF Secreted Signaling 0.3431 0.0000000000000029103958404640128 Scatter Plot
Target CD22 Source CX3C CX3C Secreted Signaling 0.3486 0.0000000000000009752773484982357 Scatter Plot
Target CD22 Target ACTIVIN ACTIVIN Secreted Signaling 0.3493 0.0000000000000008534149870640207 Scatter Plot
Target CD22 Target KIT KIT Secreted Signaling 0.3555 0.0000000000000002395267208033871 Scatter Plot
Target CD22 Target TENASCIN TENASCIN ECM-Receptor 0.3573 0.00000000000000016725728605279774 Scatter Plot
Target CD22 Source CD86 CD86 Cell-Cell Contact 0.3630 0.00000000000000005091721527634807 Scatter Plot
Target CD22 Source ICAM ICAM Cell-Cell Contact 0.3641 0.00000000000000003987186883640669 Scatter Plot
Target CD22 Target ANGPT ANGPT Secreted Signaling 0.3647 0.000000000000000035617022162864866 Scatter Plot
Target CD22 Target NPR2 NPR2 Secreted Signaling 0.3665 0.000000000000000024087455756106485 Scatter Plot
Target CD22 Source LAMININ LAMININ ECM-Receptor 0.3696 0.000000000000000012387050388341689 Scatter Plot
Target CD22 Target PERIOSTIN PERIOSTIN Secreted Signaling 0.3721 0.000000000000000007150541564410576 Scatter Plot
Target CD22 Target BSP BSP ECM-Receptor 0.3748 0.000000000000000004033670018951834 Scatter Plot
Target CD22 Target DMP1 DMP1 ECM-Receptor 0.3775 0.0000000000000000022100675976967603 Scatter Plot
Target CD22 Source LCK LCK Cell-Cell Contact 0.3811 0.0000000000000000009754940231930185 Scatter Plot
Target CD22 Target TGFb TGFb Secreted Signaling 0.3817 0.0000000000000000008663966664533873 Scatter Plot
Target CD22 Target CD34 CD34 Cell-Cell Contact 0.3902 0.00000000000000000012300822302821788 Scatter Plot
Target CD22 Target WNT WNT Secreted Signaling 0.4073 0.0000000000000000000020751508859836906 Scatter Plot
Target CD22 Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.4078 0.0000000000000000000018464238454281586 Scatter Plot
Target CD22 Source IL7 IL7 Secreted Signaling 0.4097 0.0000000000000000000011685774799706233 Scatter Plot
Target CD22 Source LIGHT LIGHT Secreted Signaling 0.4115 0.000000000000000000000743914603460769 Scatter Plot
Target CD22 Source SEMA7 SEMA7 Cell-Cell Contact 0.4162 0.0000000000000000000002274316447088247 Scatter Plot
Target CD22 Target IGF IGF Secreted Signaling 0.4179 0.0000000000000000000001488389207678452 Scatter Plot
Target CD22 Target FGF FGF Secreted Signaling 0.4218 0.00000000000000000000005362241395441491 Scatter Plot
Target CD22 Source BMP BMP Secreted Signaling 0.4221 0.000000000000000000000049648012905394243 Scatter Plot
Target CD22 Target ncWNT ncWNT Secreted Signaling 0.4257 0.00000000000000000000001979268191842481 Scatter Plot
Target CD22 Target SLURP SLURP Secreted Signaling 0.4291 0.000000000000000000000008048350572191757 Scatter Plot
Target CD22 Source TWEAK TWEAK Secreted Signaling 0.4420 0.00000000000000000000000024934386526039787 Scatter Plot
Target CD22 Source ESAM ESAM Cell-Cell Contact 0.4468 0.000000000000000000000000065256753499139 Scatter Plot
Target CD22 Target ESAM ESAM Cell-Cell Contact 0.4468 0.000000000000000000000000065256753499139 Scatter Plot
Target CD22 Source COLLAGEN COLLAGEN ECM-Receptor 0.4547 0.000000000000000000000000006992240000671706 Scatter Plot
Target CD22 Source ANGPT ANGPT Secreted Signaling 0.4757 0.00000000000000000000000000001312763625312542 Scatter Plot
Target CD22 Source JAM JAM Cell-Cell Contact 0.4792 0.0000000000000000000000000000044697707947357 Scatter Plot
Target CD22 Target APP APP Cell-Cell Contact 0.4802 0.0000000000000000000000000000033116232623584455 Scatter Plot
Target CD22 Source PSAP PSAP Secreted Signaling 0.4969 0.000000000000000000000000000000015179757225314816 Scatter Plot
Target CD22 Source GAS GAS Secreted Signaling 0.5053 0.0000000000000000000000000000000009221415053154632 Scatter Plot
Target CD22 Target CD200 CD200 Cell-Cell Contact 0.5155 0.00000000000000000000000000000000002656158399776284 Scatter Plot
Target CD22 Target CD39 CD39 Cell-Cell Contact 0.5189 0.000000000000000000000000000000000008088907179721016 Scatter Plot
Target CD22 Target JAM JAM Cell-Cell Contact 0.5226 0.0000000000000000000000000000000000021291965694186348 Scatter Plot
Target CD22 Source MHC-I MHC-I Cell-Cell Contact 0.5306 0.00000000000000000000000000000000000011292548436878502 Scatter Plot
Target CD22 Source IL16 IL16 Secreted Signaling 0.5476 0.0000000000000000000000000000000000000001788011258169628 Scatter Plot
Target CD22 Target MIF MIF Secreted Signaling 0.5555 0.000000000000000000000000000000000000000007852201673253179 Scatter Plot
Target CD22 Source MHC-II MHC-II Cell-Cell Contact 0.5611 0.0000000000000000000000000000000000000000007938536296697809 Scatter Plot
Target CD22 Source MIF MIF Secreted Signaling -0.5084 0.0000000000000000000000000000000003103206189656676 Scatter Plot
Target CD22 Source TGFb TGFb Secreted Signaling -0.3766 0.0000000000000000026818619107267372 Scatter Plot
Target CD22 Source ANGPTL ANGPTL Secreted Signaling -0.3580 0.00000000000000014320914165973322 Scatter Plot
Target CD22 Source PARs PARs Secreted Signaling -0.2462 0.000000024374766255572617 Scatter Plot
Target CD22 Target IL17 IL17 Secreted Signaling -0.2400 0.00000005577946859445172 Scatter Plot
Target CD22 Target CSF CSF Secreted Signaling -0.2320 0.0000001553112367378984 Scatter Plot
Target CD22 Source SEMA4 SEMA4 Cell-Cell Contact -0.2162 0.0000010602459106241404 Scatter Plot
Target CD22 Source COMPLEMENT COMPLEMENT Secreted Signaling -0.1952 0.00001105508832337857 Scatter Plot
Target CD22 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.1811 0.0000464290461565844 Scatter Plot
Target CD22 Target VEGF VEGF Secreted Signaling -0.1511 0.0006993159093765 Scatter Plot
Target CD22 Source VISFATIN VISFATIN Secreted Signaling -0.1455 0.0010990308652563 Scatter Plot
Target CD22 Target CCL CCL Secreted Signaling -0.1445 0.0011945006051249 Scatter Plot
Target CD22 Source IL1 IL1 Secreted Signaling -0.1348 0.0025172175295835 Scatter Plot
Target CD22 Target PTN PTN Secreted Signaling -0.1327 0.0029582334451783 Scatter Plot
Target CD22 Source CD52 CD52 Cell-Cell Contact -0.1278 0.0042003871281299 Scatter Plot
Target CD22 Target VCAM VCAM Cell-Cell Contact -0.1269 0.0044984127607262 Scatter Plot
Target CD22 Source SELL SELL Cell-Cell Contact -0.1214 0.0065529637917457 Scatter Plot
Target CD22 Source NKG2D NKG2D Cell-Cell Contact -0.1201 0.0071776464335087 Scatter Plot
Target CD22 Target CXCL CXCL Secreted Signaling -0.1196 0.0074291842536948 Scatter Plot
Target CD22 Target CD52 CD52 Cell-Cell Contact -0.1185 0.0079795838704272 Scatter Plot
Target CD22 Source GALECTIN GALECTIN Secreted Signaling -0.1169 0.0089043921279613 Scatter Plot
Target CD22 Target ICAM ICAM Cell-Cell Contact -0.1126 0.0117698624413362 Scatter Plot
Target CD22 Target CLEC CLEC Cell-Cell Contact -0.1087 0.0149819536153502 Scatter Plot
Target CD22 Source CCL CCL Secreted Signaling -0.1038 0.0203161497425222 Scatter Plot
Target CD22 Target SELL SELL Cell-Cell Contact 0.1128 0.0116161829010731 Scatter Plot
Target CD22 Target COMPLEMENT COMPLEMENT Secreted Signaling 0.1508 0.0007153280126623 Scatter Plot
Target CD22 Target OSM OSM Secreted Signaling 0.1884 0.000022214729670038462 Scatter Plot
Target CD22 Target IL6 IL6 Secreted Signaling 0.1991 0.000007239452633905562 Scatter Plot
Target CD22 Target THY1 THY1 Cell-Cell Contact 0.3404 0.00000000000000492750725026171 Scatter Plot
Target CD22 Target LAMININ LAMININ ECM-Receptor 0.3491 0.0000000000000008877445003768247 Scatter Plot
Target CD22 Target NRG NRG Secreted Signaling 0.3693 0.00000000000000001338153615033816 Scatter Plot
Target CD22 Target CD23 CD23 Cell-Cell Contact 0.3696 0.000000000000000012301337709533798 Scatter Plot
Target CD22 Target CD34 CD34 Cell-Cell Contact 0.3902 0.00000000000000000012300822302821788 Scatter Plot
Target CD22 Target SEMA4 SEMA4 Cell-Cell Contact 0.4025 0.000000000000000000006672884236261836 Scatter Plot
Target CD22 Target BAFF BAFF Secreted Signaling 0.4692 0.00000000000000000000000000009615088108881136 Scatter Plot
Target CD22 Target CD200 CD200 Cell-Cell Contact 0.5159 0.00000000000000000000000000000000002337851611830868 Scatter Plot
Target CD22 Target CCL CCL Secreted Signaling -0.1211 0.0066918720619228 Scatter Plot
Target CD22 Target CD52 CD52 Cell-Cell Contact -0.1185 0.0079795838704272 Scatter Plot
Target CD22 Target CLEC CLEC Cell-Cell Contact -0.1087 0.0149819536153502 Scatter Plot
Target CD22 Target IFN-II IFN-II Secreted Signaling -0.1056 0.0182096292874792 Scatter Plot

Cells that are targets of CD22 from HSCs*

    No cell populations

Cells that are source of CD22 to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.