Pathway: LAIR1

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Cell-Cell Contact

Details on the LAIR1 pathway:

Specificity Index HSPC as target:
HSPC as source:

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the LAIR1 pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target LAIR1 Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.0995 0.0260689756429559 Scatter Plot
Target LAIR1 Source MHC-II MHC-II Cell-Cell Contact 0.1018 0.0228653998393418 Scatter Plot
Target LAIR1 Target CXCL CXCL Secreted Signaling 0.1032 0.0210290097708253 Scatter Plot
Target LAIR1 Target SELE SELE Cell-Cell Contact 0.1043 0.0196753565956737 Scatter Plot
Target LAIR1 Target ANNEXIN ANNEXIN Secreted Signaling 0.1055 0.0183046887186878 Scatter Plot
Target LAIR1 Source MK MK Secreted Signaling 0.1062 0.0175463467041097 Scatter Plot
Target LAIR1 Source SELL SELL Cell-Cell Contact 0.1079 0.0157412112893728 Scatter Plot
Target LAIR1 Target FN1 FN1 ECM-Receptor 0.1091 0.0146684404785631 Scatter Plot
Target LAIR1 Source VISTA VISTA Cell-Cell Contact 0.1092 0.0145719558085868 Scatter Plot
Target LAIR1 Target NODAL NODAL Secreted Signaling 0.1099 0.0139745753478277 Scatter Plot
Target LAIR1 Target ICAM ICAM Cell-Cell Contact 0.1101 0.0137433232493763 Scatter Plot
Target LAIR1 Source SELPLG SELPLG Cell-Cell Contact 0.1106 0.0133084410273963 Scatter Plot
Source LAIR1 Source IL16 IL16 Secreted Signaling 0.1147 0.0102903435384453 Scatter Plot
Target LAIR1 Source PROS PROS Secreted Signaling 0.1166 0.0090609288486806 Scatter Plot
Target LAIR1 Source THBS THBS ECM-Receptor 0.1174 0.0086185399808347 Scatter Plot
Target LAIR1 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1191 0.0076628934693252 Scatter Plot
Target LAIR1 Source CD52 CD52 Cell-Cell Contact 0.1196 0.0074456989904464 Scatter Plot
Target LAIR1 Source CCL CCL Secreted Signaling 0.1208 0.0068619795319431 Scatter Plot
Source LAIR1 Source CD34 CD34 Cell-Cell Contact 0.1211 0.00669826444583 Scatter Plot
Source LAIR1 Source LAMININ LAMININ ECM-Receptor 0.1235 0.0056851659786751 Scatter Plot
Target LAIR1 Source PECAM1 PECAM1 Cell-Cell Contact 0.1247 0.0052286967682577 Scatter Plot
Target LAIR1 Target PECAM1 PECAM1 Cell-Cell Contact 0.1247 0.0052286967682577 Scatter Plot
Target LAIR1 Target COLLAGEN COLLAGEN ECM-Receptor 0.1262 0.0047252394981143 Scatter Plot
Source LAIR1 Source SEMA6 SEMA6 Cell-Cell Contact 0.1276 0.0042724093328303 Scatter Plot
Target LAIR1 Source GRN GRN Secreted Signaling 0.1286 0.0039697645323512 Scatter Plot
Target LAIR1 Source IL16 IL16 Secreted Signaling 0.1295 0.0037124617228381 Scatter Plot
Target LAIR1 Source VCAM VCAM Cell-Cell Contact 0.1324 0.0030196669163499 Scatter Plot
Target LAIR1 Target ANGPTL ANGPTL Secreted Signaling 0.1362 0.0022689668970528 Scatter Plot
Target LAIR1 Source CD86 CD86 Cell-Cell Contact 0.1503 0.0007489920042012 Scatter Plot
Target LAIR1 Source CD45 CD45 Cell-Cell Contact 0.1596 0.0003391979274005 Scatter Plot
Target LAIR1 Source ANNEXIN ANNEXIN Secreted Signaling 0.1654 0.0002036614629602 Scatter Plot
Source LAIR1 Source SPP1 SPP1 Secreted Signaling 0.1946 0.000011671399741626187 Scatter Plot
Source LAIR1 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1992 0.000007172711636531867 Scatter Plot
Source LAIR1 Source CCL CCL Secreted Signaling 0.2065 0.0000032222868181099405 Scatter Plot
Target LAIR1 Target GALECTIN GALECTIN Secreted Signaling 0.2099 0.000002193760166894943 Scatter Plot
Target LAIR1 Source PSAP PSAP Secreted Signaling 0.2403 0.0000000530699133131853 Scatter Plot
Source LAIR1 Source GRN GRN Secreted Signaling 0.2619 0.000000002729930254372458 Scatter Plot
Source LAIR1 Source PARs PARs Secreted Signaling 0.2769 0.00000000029588360887850467 Scatter Plot
Source LAIR1 Source SEMA4 SEMA4 Cell-Cell Contact 0.2797 0.00000000019267795612847726 Scatter Plot
Source LAIR1 Source VISTA VISTA Cell-Cell Contact 0.3141 0.0000000000006495089158466372 Scatter Plot
Source LAIR1 Source SELL SELL Cell-Cell Contact 0.3176 0.0000000000003471781510745044 Scatter Plot
Source LAIR1 Source APP APP Cell-Cell Contact 0.3430 0.0000000000000030013646636285616 Scatter Plot
Source LAIR1 Source NCAM NCAM Cell-Cell Contact 0.3434 0.000000000000002778986773019781 Scatter Plot
Source LAIR1 Source CD52 CD52 Cell-Cell Contact 0.3610 0.00000000000000007705251433950091 Scatter Plot
Source LAIR1 Source COMPLEMENT COMPLEMENT Secreted Signaling 0.3923 0.00000000000000000007662294136689975 Scatter Plot
Source LAIR1 Source GALECTIN GALECTIN Secreted Signaling -0.3133 0.0000000000007453184742746699 Scatter Plot
Source LAIR1 Source EPHB EPHB Cell-Cell Contact -0.2223 0.0000005129858408783231 Scatter Plot
Source LAIR1 Source CCL CCL Secreted Signaling -0.2173 0.000000928042522968878 Scatter Plot
Source LAIR1 Source VCAM VCAM Cell-Cell Contact -0.2170 0.000000963356063531425 Scatter Plot
Source LAIR1 Source GP1BA GP1BA Cell-Cell Contact -0.2163 0.0000010474325813927942 Scatter Plot
Target LAIR1 Source MIF MIF Secreted Signaling -0.1818 0.00004329148683171368 Scatter Plot
Source LAIR1 Source SEMA4 SEMA4 Cell-Cell Contact -0.1729 0.0001016944638398 Scatter Plot
Source LAIR1 Source CD46 CD46 Cell-Cell Contact -0.1608 0.0003070645175844 Scatter Plot
Source LAIR1 Source IGF IGF Secreted Signaling -0.1542 0.0005415253095457 Scatter Plot
Source LAIR1 Source FLT3 FLT3 Secreted Signaling -0.1431 0.0013361614622566 Scatter Plot
Source LAIR1 Source BMP BMP Secreted Signaling -0.1424 0.0014089978257236 Scatter Plot
Target LAIR1 Target PDGF PDGF Secreted Signaling -0.1403 0.0016585128816172 Scatter Plot
Target LAIR1 Source ANGPTL ANGPTL Secreted Signaling -0.1374 0.0020819975631225 Scatter Plot
Source LAIR1 Source ANGPT ANGPT Secreted Signaling -0.1325 0.0029823510584208 Scatter Plot
Source LAIR1 Source ANGPTL ANGPTL Secreted Signaling -0.1275 0.0042937418055807 Scatter Plot
Source LAIR1 Source LIFR LIFR Secreted Signaling -0.1275 0.0042967402840624 Scatter Plot
Source LAIR1 Source TWEAK TWEAK Secreted Signaling -0.1227 0.0060138127786441 Scatter Plot
Source LAIR1 Source ESAM ESAM Cell-Cell Contact -0.1224 0.0061320442390094 Scatter Plot
Source LAIR1 Source JAM JAM Cell-Cell Contact -0.1198 0.0073098708303343 Scatter Plot
Source LAIR1 Source PDGF PDGF Secreted Signaling -0.1176 0.0084684162704761 Scatter Plot
Source LAIR1 Source PROS PROS Secreted Signaling -0.1164 0.0091569786911277 Scatter Plot
Target LAIR1 Source VEGF VEGF Secreted Signaling -0.1142 0.0105973966849988 Scatter Plot
Target LAIR1 Source VISFATIN VISFATIN Secreted Signaling -0.1091 0.0146886632202032 Scatter Plot
Source LAIR1 Source THBS THBS ECM-Receptor -0.1089 0.0148620908621225 Scatter Plot
Source LAIR1 Source NT NT Secreted Signaling -0.1063 0.0174566866781 Scatter Plot
Source LAIR1 Source CDH CDH Cell-Cell Contact -0.1045 0.0194811550238911 Scatter Plot
Target LAIR1 Source CDH CDH Cell-Cell Contact -0.1043 0.0196697290112374 Scatter Plot
Target LAIR1 Target CDH CDH Cell-Cell Contact -0.1043 0.0196697290112374 Scatter Plot
Source LAIR1 Source TGFb TGFb Secreted Signaling -0.1020 0.0225276997340226 Scatter Plot
Source LAIR1 Source MK MK Secreted Signaling -0.1004 0.0247011358205368 Scatter Plot
Target LAIR1 Source SEMA4 SEMA4 Cell-Cell Contact -0.0970 0.030066772004552 Scatter Plot
Target LAIR1 Target THY1 THY1 Cell-Cell Contact 0.0977 0.0290112123629403 Scatter Plot
Target LAIR1 Target COMPLEMENT COMPLEMENT Secreted Signaling 0.1008 0.0241884502724867 Scatter Plot
Target LAIR1 Target MIF MIF Secreted Signaling 0.1009 0.0240289461743321 Scatter Plot
Target LAIR1 Target CD23 CD23 Cell-Cell Contact 0.1089 0.0148700759580292 Scatter Plot
Source LAIR1 Target SELL SELL Cell-Cell Contact 0.1128 0.0116282995139221 Scatter Plot
Source LAIR1 Source LAMININ LAMININ ECM-Receptor 0.1135 0.0110587035516518 Scatter Plot
Source LAIR1 Source TNF TNF Secreted Signaling 0.1185 0.0080143285125659 Scatter Plot
Target LAIR1 Target IFN-II IFN-II Secreted Signaling 0.1208 0.0068236624751325 Scatter Plot
Target LAIR1 Target CD200 CD200 Cell-Cell Contact 0.1287 0.0039379248854951 Scatter Plot
Source LAIR1 Target GALECTIN GALECTIN Secreted Signaling 0.1330 0.0028779799004766 Scatter Plot
Source LAIR1 Target BAFF BAFF Secreted Signaling 0.1341 0.0026497680157246 Scatter Plot
Source LAIR1 Target IL1 IL1 Secreted Signaling 0.1402 0.0016716703042109 Scatter Plot
Target LAIR1 Target GRN GRN Secreted Signaling 0.1424 0.0014110194660724 Scatter Plot
Target LAIR1 Target CLEC CLEC Cell-Cell Contact 0.1451 0.0011408750971234 Scatter Plot
Target LAIR1 Target CCL CCL Secreted Signaling 0.1508 0.0007194741343151 Scatter Plot
Source LAIR1 Target IL17 IL17 Secreted Signaling 0.1563 0.000450217809974 Scatter Plot
Target LAIR1 Target CD22 CD22 Cell-Cell Contact 0.1596 0.0003391979274005 Scatter Plot
Source LAIR1 Target GRN GRN Secreted Signaling 0.1721 0.0001102581175466 Scatter Plot
Source LAIR1 Target CCL CCL Secreted Signaling 0.1770 0.00006879515493178666 Scatter Plot
Source LAIR1 Source NKG2D NKG2D Cell-Cell Contact 0.2048 0.000003876427198304513 Scatter Plot
Source LAIR1 Target CLEC CLEC Cell-Cell Contact 0.2104 0.000002083691519864927 Scatter Plot
Source LAIR1 Target CXCL CXCL Secreted Signaling 0.2124 0.0000016493280263869226 Scatter Plot
Source LAIR1 Target CD23 CD23 Cell-Cell Contact 0.2193 0.0000007387105168495443 Scatter Plot
Source LAIR1 Target THY1 THY1 Cell-Cell Contact 0.2248 0.0000003781859680238094 Scatter Plot
Source LAIR1 Source IL2 IL2 Secreted Signaling 0.2295 0.0000002118667177757865 Scatter Plot
Source LAIR1 Target SEMA3 SEMA3 Secreted Signaling 0.2415 0.00000004554541342784631 Scatter Plot
Source LAIR1 Target VEGF VEGF Secreted Signaling 0.2453 0.000000027492431251133143 Scatter Plot
Source LAIR1 Target NCAM NCAM Cell-Cell Contact 0.2551 0.000000007252395587093513 Scatter Plot
Source LAIR1 Target CEACAM CEACAM Cell-Cell Contact 0.2926 0.000000000024849888127556424 Scatter Plot
Source LAIR1 Target IFN-II IFN-II Secreted Signaling 0.2927 0.00000000002474180982639464 Scatter Plot
Source LAIR1 Target ICAM ICAM Cell-Cell Contact 0.2959 0.000000000014509133719068467 Scatter Plot
Source LAIR1 Target COMPLEMENT COMPLEMENT Secreted Signaling 0.3230 0.00000000000013170387123712717 Scatter Plot
Source LAIR1 Target VCAM VCAM Cell-Cell Contact 0.3371 0.000000000000009447519552629608 Scatter Plot
Source LAIR1 Target CD52 CD52 Cell-Cell Contact 0.4644 0.0000000000000000000000000004092030734043913 Scatter Plot
Source LAIR1 Source ANNEXIN ANNEXIN Secreted Signaling 0.4857 0.0000000000000000000000000000005772544677908936 Scatter Plot
Source LAIR1 Target PARs PARs Secreted Signaling -0.3494 0.0000000000000008326830931365716 Scatter Plot
Source LAIR1 Target MK MK Secreted Signaling -0.3209 0.00000000000019385384521154466 Scatter Plot
Source LAIR1 Target SEMA7 SEMA7 Cell-Cell Contact -0.3122 0.0000000000009066883535128526 Scatter Plot
Source LAIR1 Target PTN PTN Secreted Signaling -0.2732 0.0000000005230992735712507 Scatter Plot
Source LAIR1 Target FN1 FN1 ECM-Receptor -0.2319 0.00000015639036389033706 Scatter Plot
Source LAIR1 Source IL1 IL1 Secreted Signaling -0.2104 0.000002074142115803648 Scatter Plot
Source LAIR1 Target AGT AGT Secreted Signaling -0.2012 0.000005792909744655195 Scatter Plot
Source LAIR1 Target CD34 CD34 Cell-Cell Contact -0.1906 0.000017880407463170628 Scatter Plot
Source LAIR1 Target IGF IGF Secreted Signaling -0.1872 0.000025232122379767024 Scatter Plot
Source LAIR1 Target SPP1 SPP1 Secreted Signaling -0.1817 0.000043545254701529335 Scatter Plot
Source LAIR1 Target THBS THBS ECM-Receptor -0.1790 0.00005666651640094696 Scatter Plot
Source LAIR1 Target VWF VWF ECM-Receptor -0.1767 0.000071406708659397 Scatter Plot
Source LAIR1 Target TENASCIN TENASCIN ECM-Receptor -0.1680 0.0001603579544346 Scatter Plot
Source LAIR1 Source MHC-I MHC-I Cell-Cell Contact -0.1678 0.0001631700660843 Scatter Plot
Source LAIR1 Target PDGF PDGF Secreted Signaling -0.1651 0.0002090834416806 Scatter Plot
Source LAIR1 Target LAMININ LAMININ ECM-Receptor -0.1557 0.0004764288071243 Scatter Plot
Source LAIR1 Target ncWNT ncWNT Secreted Signaling -0.1461 0.001051229626984 Scatter Plot
Source LAIR1 Target VISFATIN VISFATIN Secreted Signaling -0.1420 0.0014531463130185 Scatter Plot
Source LAIR1 Target CXCL CXCL Secreted Signaling -0.1363 0.0022478743259899 Scatter Plot
Source LAIR1 Target KIT KIT Secreted Signaling -0.1318 0.0031414674335652 Scatter Plot
Source LAIR1 Target ESAM ESAM Cell-Cell Contact -0.1224 0.0061320442390094 Scatter Plot
Source LAIR1 Target VTN VTN ECM-Receptor -0.1194 0.0075085982513068 Scatter Plot
Source LAIR1 Target ANGPT ANGPT Secreted Signaling -0.1193 0.0075716784112595 Scatter Plot
Source LAIR1 Target VEGF VEGF Secreted Signaling -0.1181 0.008187256421465 Scatter Plot
Source LAIR1 Target OSM OSM Secreted Signaling -0.1167 0.0089892080014794 Scatter Plot
Source LAIR1 Target BMP BMP Secreted Signaling -0.1137 0.0109805581835422 Scatter Plot
Source LAIR1 Target EPHB EPHB Cell-Cell Contact -0.1118 0.0123412059026803 Scatter Plot
Source LAIR1 Target SEMA5 SEMA5 Cell-Cell Contact -0.1095 0.0142783016121055 Scatter Plot
Source LAIR1 Target WNT WNT Secreted Signaling -0.1072 0.0164904654089391 Scatter Plot
Source LAIR1 Target SEMA6 SEMA6 Cell-Cell Contact -0.1062 0.0175692317969339 Scatter Plot
Source LAIR1 Target CDH CDH Cell-Cell Contact -0.1045 0.0194811550238911 Scatter Plot
Source LAIR1 Target CSPG4 CSPG4 Cell-Cell Contact -0.1010 0.0239754565318835 Scatter Plot
Source LAIR1 Target SEMA4 SEMA4 Cell-Cell Contact -0.0969 0.0302894267020578 Scatter Plot
Source LAIR1 Target JAM JAM Cell-Cell Contact -0.0966 0.0307690649332855 Scatter Plot

Cells that are targets of LAIR1 from HSCs*

Cells that are source of LAIR1 to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.