Pathway: TNF

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the TNF pathway:

Specificity Index HSPC as target: 0.335
HSPC as source: 0.343

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the TNF pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Source TNF Source VISFATIN VISFATIN Secreted Signaling 0.1051 0.0186946054750511 Scatter Plot
Source TNF Source LAIR1 LAIR1 Cell-Cell Contact 0.1185 0.0080143285125659 Scatter Plot
Source TNF Source NCAM NCAM Cell-Cell Contact 0.1466 0.0010113414634053 Scatter Plot
Source TNF Source SELPLG SELPLG Cell-Cell Contact 0.1475 0.0009366970715313 Scatter Plot
Source TNF Source GRN GRN Secreted Signaling 0.2030 0.000004762414717623053 Scatter Plot
Source TNF Source VISTA VISTA Cell-Cell Contact 0.2578 0.000000004896208536876673 Scatter Plot
Source TNF Source SEMA4 SEMA4 Cell-Cell Contact 0.2877 0.00000000005475258045013191 Scatter Plot
Source TNF Source SELL SELL Cell-Cell Contact 0.3089 0.0000000000016227950222269665 Scatter Plot
Source TNF Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.3305 0.00000000000003263246604015743 Scatter Plot
Source TNF Source ESAM ESAM Cell-Cell Contact -0.2402 0.000000053695607676460057 Scatter Plot
Source TNF Source TWEAK TWEAK Secreted Signaling -0.2205 0.0000006401870120488975 Scatter Plot
Source TNF Source LIFR LIFR Secreted Signaling -0.2198 0.0000006946373328623818 Scatter Plot
Source TNF Source ANGPT ANGPT Secreted Signaling -0.2081 0.000002695616270889968 Scatter Plot
Source TNF Source JAM JAM Cell-Cell Contact -0.2080 0.0000027305091174781568 Scatter Plot
Source TNF Source PDGF PDGF Secreted Signaling -0.2023 0.000005129272279982214 Scatter Plot
Source TNF Source BMP BMP Secreted Signaling -0.1827 0.00003952980452903107 Scatter Plot
Source TNF Source EPHB EPHB Cell-Cell Contact -0.1762 0.00007459287469357353 Scatter Plot
Source TNF Source COLLAGEN COLLAGEN ECM-Receptor -0.1732 0.00009951870640363556 Scatter Plot
Source TNF Source GAS GAS Secreted Signaling -0.1562 0.0004542627725676 Scatter Plot
Source TNF Source NOTCH NOTCH Cell-Cell Contact -0.1461 0.0010497563642819 Scatter Plot
Source TNF Source IL7 IL7 Secreted Signaling -0.1307 0.0034028296657996 Scatter Plot
Source TNF Source NT NT Secreted Signaling -0.1280 0.0041536894485129 Scatter Plot
Source TNF Source LAMININ LAMININ ECM-Receptor -0.1214 0.006549474542685 Scatter Plot
Source TNF Source VEGF VEGF Secreted Signaling -0.1156 0.009690718912613 Scatter Plot
Source TNF Source PTN PTN Secreted Signaling -0.1151 0.0100046996167239 Scatter Plot
Source TNF Source CCL CCL Secreted Signaling -0.1138 0.0108693040226814 Scatter Plot
Source TNF Source CDH CDH Cell-Cell Contact -0.1123 0.0119790389698108 Scatter Plot
Source TNF Source VCAM VCAM Cell-Cell Contact -0.1091 0.014697353305816 Scatter Plot
Source TNF Target GRN GRN Secreted Signaling 0.1054 0.0183670778653308 Scatter Plot
Source TNF Target GALECTIN GALECTIN Secreted Signaling 0.1077 0.0160027612555665 Scatter Plot
Source TNF Source CLEC CLEC Cell-Cell Contact 0.1086 0.0151415122770208 Scatter Plot
Source TNF Target CD23 CD23 Cell-Cell Contact 0.1100 0.0138914685891358 Scatter Plot
Source TNF Target SELPLG SELPLG Cell-Cell Contact 0.1222 0.0062210332453574 Scatter Plot
Source TNF Target THY1 THY1 Cell-Cell Contact 0.1245 0.0053093814656745 Scatter Plot
Source TNF Source NKG2D NKG2D Cell-Cell Contact 0.1257 0.0048773009147766 Scatter Plot
Source TNF Target SEMA3 SEMA3 Secreted Signaling 0.1289 0.003880628056437 Scatter Plot
Source TNF Source CCL CCL Secreted Signaling 0.1292 0.0038039434789906 Scatter Plot
Source TNF Target ANGPTL ANGPTL Secreted Signaling 0.1296 0.0036861115242359 Scatter Plot
Source TNF Source BAFF BAFF Secreted Signaling 0.1481 0.0008952890728107 Scatter Plot
Source TNF Target IL1 IL1 Secreted Signaling 0.1536 0.0005668895845494 Scatter Plot
Source TNF Target SELE SELE Cell-Cell Contact 0.1538 0.0005586278345573 Scatter Plot
Source TNF Source PARs PARs Secreted Signaling 0.1651 0.0002087172540206 Scatter Plot
Source TNF Target VCAM VCAM Cell-Cell Contact 0.1674 0.0001696214000193 Scatter Plot
Source TNF Target CD52 CD52 Cell-Cell Contact 0.1788 0.00005823476164140934 Scatter Plot
Source TNF Target COLLAGEN COLLAGEN ECM-Receptor 0.1862 0.000027862432789331525 Scatter Plot
Source TNF Target COMPLEMENT COMPLEMENT Secreted Signaling 0.1885 0.00002210658839949432 Scatter Plot
Source TNF Source SPP1 SPP1 Secreted Signaling 0.1924 0.000014702454811627173 Scatter Plot
Source TNF Target IFN-II IFN-II Secreted Signaling 0.2027 0.000004897176543700987 Scatter Plot
Source TNF Target CSF CSF Secreted Signaling 0.2032 0.000004666919040484646 Scatter Plot
Source TNF Source ANNEXIN ANNEXIN Secreted Signaling 0.2394 0.00000005992064456858384 Scatter Plot
Source TNF Target ANNEXIN ANNEXIN Secreted Signaling 0.2407 0.00000005027103248719857 Scatter Plot
Source TNF Target CEACAM CEACAM Cell-Cell Contact 0.2517 0.00000001148328973276606 Scatter Plot
Source TNF Source APP APP Cell-Cell Contact 0.2577 0.000000004995883082976772 Scatter Plot
Source TNF Target CXCL CXCL Secreted Signaling 0.2712 0.0000000007011652060800801 Scatter Plot
Source TNF Target CLEC CLEC Cell-Cell Contact 0.2781 0.0000000002491091425442617 Scatter Plot
Source TNF Target CCL CCL Secreted Signaling 0.2956 0.00000000001533378591146355 Scatter Plot
Source TNF Source COMPLEMENT COMPLEMENT Secreted Signaling 0.3079 0.000000000001927003040031784 Scatter Plot
Source TNF Target ICAM ICAM Cell-Cell Contact 0.3143 0.000000000000627532223659081 Scatter Plot
Source TNF Source CD52 CD52 Cell-Cell Contact 0.3499 0.0000000000000007529379937126393 Scatter Plot
Source TNF Target MK MK Secreted Signaling -0.2938 0.000000000020540665483659216 Scatter Plot
Source TNF Target PARs PARs Secreted Signaling -0.2574 0.0000000052234037066483735 Scatter Plot
Source TNF Source GALECTIN GALECTIN Secreted Signaling -0.2495 0.000000015646014355056238 Scatter Plot
Source TNF Target ESAM ESAM Cell-Cell Contact -0.2402 0.00000005369560767645947 Scatter Plot
Source TNF Target PTN PTN Secreted Signaling -0.2371 0.00000008095414615497718 Scatter Plot
Source TNF Source MHC-I MHC-I Cell-Cell Contact -0.2360 0.00000009348420706950905 Scatter Plot
Source TNF Target SPP1 SPP1 Secreted Signaling -0.2268 0.00000029713708308203337 Scatter Plot
Source TNF Target TENASCIN TENASCIN ECM-Receptor -0.2256 0.0000003452545066064258 Scatter Plot
Source TNF Target ANGPT ANGPT Secreted Signaling -0.2222 0.0000005173844178677806 Scatter Plot
Source TNF Source TWEAK TWEAK Secreted Signaling -0.2205 0.0000006401870120488975 Scatter Plot
Source TNF Target CD34 CD34 Cell-Cell Contact -0.2092 0.000002378922161777443 Scatter Plot
Source TNF Source FLT3 FLT3 Secreted Signaling -0.2043 0.000004104307761592196 Scatter Plot
Source TNF Source BST2 BST2 Cell-Cell Contact -0.1995 0.000006979500997009336 Scatter Plot
Source TNF Source GP1BA GP1BA Cell-Cell Contact -0.1989 0.000007385251366442178 Scatter Plot
Source TNF Target WNT WNT Secreted Signaling -0.1862 0.00002777686500422532 Scatter Plot
Source TNF Target JAM JAM Cell-Cell Contact -0.1785 0.0000595584885735856 Scatter Plot
Source TNF Target IGF IGF Secreted Signaling -0.1758 0.00007755447839872861 Scatter Plot
Source TNF Target VWF VWF ECM-Receptor -0.1744 0.00008811687737798565 Scatter Plot
Source TNF Target ncWNT ncWNT Secreted Signaling -0.1743 0.00008960823772209578 Scatter Plot
Source TNF Target CD39 CD39 Cell-Cell Contact -0.1740 0.00009236116526340345 Scatter Plot
Source TNF Target VISFATIN VISFATIN Secreted Signaling -0.1734 0.00009771986381022125 Scatter Plot
Source TNF Target KIT KIT Secreted Signaling -0.1722 0.0001093672582542 Scatter Plot
Source TNF Source MHC-II MHC-II Cell-Cell Contact -0.1691 0.0001452896942613 Scatter Plot
Source TNF Target BAFF BAFF Secreted Signaling -0.1659 0.0001949454416314 Scatter Plot
Source TNF Target NPR2 NPR2 Secreted Signaling -0.1648 0.00021530531805 Scatter Plot
Source TNF Target THBS THBS ECM-Receptor -0.1637 0.0002370579981367 Scatter Plot
Source TNF Target SEMA4 SEMA4 Cell-Cell Contact -0.1611 0.0002972573777256 Scatter Plot
Source TNF Source SEMA7 SEMA7 Cell-Cell Contact -0.1549 0.0005071059606816 Scatter Plot
Source TNF Source LCK LCK Cell-Cell Contact -0.1534 0.0005758564043938 Scatter Plot
Source TNF Source IL2 IL2 Secreted Signaling -0.1511 0.0007021687941666 Scatter Plot
Source TNF Target SLURP SLURP Secreted Signaling -0.1502 0.0007543439482221 Scatter Plot
Source TNF Source CX3C CX3C Secreted Signaling -0.1497 0.0007876513053033 Scatter Plot
Source TNF Target FN1 FN1 ECM-Receptor -0.1493 0.0008101795296862 Scatter Plot
Source TNF Target VTN VTN ECM-Receptor -0.1470 0.0009743395337147 Scatter Plot
Source TNF Target ANGPTL ANGPTL Secreted Signaling -0.1386 0.0018996398424881 Scatter Plot
Source TNF Source RANKL RANKL Secreted Signaling -0.1353 0.002431343965357 Scatter Plot
Source TNF Target FGF FGF Secreted Signaling -0.1314 0.0032413611070575 Scatter Plot
Source TNF Target CD200 CD200 Cell-Cell Contact -0.1262 0.0047086804277846 Scatter Plot
Source TNF Source CD46 CD46 Cell-Cell Contact -0.1253 0.005033911233621 Scatter Plot
Source TNF Source CXCL CXCL Secreted Signaling -0.1243 0.0053860272323811 Scatter Plot
Source TNF Source IGF IGF Secreted Signaling -0.1224 0.0061354368996184 Scatter Plot
Source TNF Target NRG NRG Secreted Signaling -0.1222 0.0062175425644711 Scatter Plot
Source TNF Source CD1D2 CD1D2 Cell-Cell Contact -0.1222 0.0062344171183435 Scatter Plot
Source TNF Target APP APP Cell-Cell Contact -0.1178 0.0083805939568447 Scatter Plot
Source TNF Target SEMA7 SEMA7 Cell-Cell Contact -0.1166 0.0090471976051073 Scatter Plot
Source TNF Target BSP BSP ECM-Receptor -0.1161 0.0093441319324328 Scatter Plot
Source TNF Target CDH CDH Cell-Cell Contact -0.1123 0.0119790389698108 Scatter Plot
Source TNF Target ACTIVIN ACTIVIN Secreted Signaling -0.1106 0.0133256293909581 Scatter Plot
Source TNF Source MK MK Secreted Signaling -0.1090 0.01475356402005 Scatter Plot
Source TNF Target DMP1 DMP1 ECM-Receptor -0.1076 0.0161109581618082 Scatter Plot
Source TNF Target EPHB EPHB Cell-Cell Contact -0.1052 0.0186067560288661 Scatter Plot
Source TNF Target AGT AGT Secreted Signaling -0.1048 0.0191155104947647 Scatter Plot
Source TNF Target CADM CADM Cell-Cell Contact -0.1026 0.0216963008602489 Scatter Plot
Source TNF Source CADM CADM Cell-Cell Contact -0.1026 0.0216963008602489 Scatter Plot
Source TNF Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.0979 0.028656338761828 Scatter Plot
Source TNF Target BMP BMP Secreted Signaling -0.0973 0.0295395057256516 Scatter Plot
Source TNF Source ICAM ICAM Cell-Cell Contact -0.0963 0.0313900056694167 Scatter Plot

Cells that are targets of TNF from HSCs*

Cells that are source of TNF to HSCs*

    No cell populations

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.