Pathway: CX3C

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the CX3C pathway:

Specificity Index HSPC as target: 0.317
HSPC as source: 0.267

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the CX3C pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Source CX3C Source AGRN AGRN ECM-Receptor 0.1072 0.0164614109634478 Scatter Plot
Source CX3C Source SEMA6 SEMA6 Cell-Cell Contact 0.1293 0.0037732085172375 Scatter Plot
Source CX3C Source ncWNT ncWNT Secreted Signaling 0.1393 0.0017930781945966 Scatter Plot
Source CX3C Source ANGPTL ANGPTL Secreted Signaling 0.1495 0.0008008574925036 Scatter Plot
Source CX3C Source PTN PTN Secreted Signaling 0.1656 0.0001995390308786 Scatter Plot
Source CX3C Source GDF GDF Secreted Signaling 0.1762 0.00007438074126134305 Scatter Plot
Source CX3C Source CD46 CD46 Cell-Cell Contact 0.1804 0.0000495084489233165 Scatter Plot
Source CX3C Source THY1 THY1 Cell-Cell Contact 0.1894 0.00002011165528174008 Scatter Plot
Source CX3C Source NT NT Secreted Signaling 0.1904 0.000018185155636640704 Scatter Plot
Source CX3C Source CXCL CXCL Secreted Signaling 0.1957 0.000010476164053181422 Scatter Plot
Source CX3C Source APELIN APELIN Secreted Signaling 0.1984 0.000007839246599622918 Scatter Plot
Source CX3C Source WNT WNT Secreted Signaling 0.2115 0.0000018190423578194384 Scatter Plot
Source CX3C Source IL6 IL6 Secreted Signaling 0.2136 0.000001430537300161107 Scatter Plot
Source CX3C Source LIGHT LIGHT Secreted Signaling 0.2236 0.00000044081205604469 Scatter Plot
Source CX3C Source CSF CSF Secreted Signaling 0.2383 0.0000000695924158951423 Scatter Plot
Source CX3C Source RANKL RANKL Secreted Signaling 0.2525 0.000000010329057907341878 Scatter Plot
Source CX3C Source CD39 CD39 Cell-Cell Contact 0.2685 0.0000000010537299448325339 Scatter Plot
Source CX3C Source IGF IGF Secreted Signaling 0.2746 0.0000000004232684526765774 Scatter Plot
Source CX3C Source SEMA3 SEMA3 Secreted Signaling 0.2839 0.000000000100844307802022 Scatter Plot
Source CX3C Source NOTCH NOTCH Cell-Cell Contact 0.2897 0.000000000039818109437200935 Scatter Plot
Source CX3C Source CADM CADM Cell-Cell Contact 0.3114 0.0000000000010502485604267876 Scatter Plot
Source CX3C Source CCL CCL Secreted Signaling 0.3137 0.0000000000006997348264716165 Scatter Plot
Source CX3C Source VEGF VEGF Secreted Signaling 0.3142 0.0000000000006369224208972455 Scatter Plot
Source CX3C Source IL16 IL16 Secreted Signaling 0.3313 0.000000000000028338959279992632 Scatter Plot
Source CX3C Source EPHB EPHB Cell-Cell Contact 0.3339 0.00000000000001743184821594757 Scatter Plot
Source CX3C Source PROS PROS Secreted Signaling 0.3374 0.000000000000008943193500017567 Scatter Plot
Source CX3C Source LAMININ LAMININ ECM-Receptor 0.3403 0.0000000000000050264290887885314 Scatter Plot
Source CX3C Source CD45 CD45 Cell-Cell Contact 0.3486 0.0000000000000009752773484982357 Scatter Plot
Source CX3C Source FLT3 FLT3 Secreted Signaling 0.3576 0.00000000000000015757961984054738 Scatter Plot
Source CX3C Source SEMA7 SEMA7 Cell-Cell Contact 0.3629 0.000000000000000051334761959816 Scatter Plot
Source CX3C Source LIFR LIFR Secreted Signaling 0.3697 0.000000000000000012116742809460719 Scatter Plot
Source CX3C Source PSAP PSAP Secreted Signaling 0.3727 0.0000000000000000063131648153193365 Scatter Plot
Source CX3C Source BST2 BST2 Cell-Cell Contact 0.3923 0.00000000000000000007548486889502077 Scatter Plot
Source CX3C Source TWEAK TWEAK Secreted Signaling 0.4012 0.0000000000000000000091739596727461 Scatter Plot
Source CX3C Source CDH CDH Cell-Cell Contact 0.4060 0.000000000000000000002902313241976649 Scatter Plot
Source CX3C Source IL7 IL7 Secreted Signaling 0.4214 0.0000000000000000000000605843789843064 Scatter Plot
Source CX3C Source COLLAGEN COLLAGEN ECM-Receptor 0.4342 0.000000000000000000000002055715527678789 Scatter Plot
Source CX3C Source BMP BMP Secreted Signaling 0.4464 0.00000000000000000000000007280172179372887 Scatter Plot
Source CX3C Source PDGF PDGF Secreted Signaling 0.4492 0.000000000000000000000000033521302140254256 Scatter Plot
Source CX3C Source ANGPT ANGPT Secreted Signaling 0.4503 0.000000000000000000000000023942986024099396 Scatter Plot
Source CX3C Source JAM JAM Cell-Cell Contact 0.4773 0.000000000000000000000000000008042907712611774 Scatter Plot
Source CX3C Source MHC-II MHC-II Cell-Cell Contact 0.4797 0.000000000000000000000000000003811515561831599 Scatter Plot
Source CX3C Source GAS GAS Secreted Signaling 0.4817 0.0000000000000000000000000000020488548555529345 Scatter Plot
Source CX3C Source ESAM ESAM Cell-Cell Contact 0.5012 0.0000000000000000000000000000000036625074810594376 Scatter Plot
Source CX3C Source CD52 CD52 Cell-Cell Contact -0.3562 0.00000000000000020761395873405307 Scatter Plot
Source CX3C Source TGFb TGFb Secreted Signaling -0.3481 0.000000000000001079092641417135 Scatter Plot
Source CX3C Source SELL SELL Cell-Cell Contact -0.3423 0.0000000000000034293819919547186 Scatter Plot
Source CX3C Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.3251 0.00000000000009008340934989832 Scatter Plot
Source CX3C Source MIF MIF Secreted Signaling -0.2946 0.00000000001816358015929887 Scatter Plot
Source CX3C Source COMPLEMENT COMPLEMENT Secreted Signaling -0.2839 0.00000000010035244053017196 Scatter Plot
Source CX3C Source PARs PARs Secreted Signaling -0.2577 0.0000000050270395211924065 Scatter Plot
Source CX3C Source CLEC CLEC Cell-Cell Contact -0.2051 0.0000037467424366419593 Scatter Plot
Source CX3C Source SEMA4 SEMA4 Cell-Cell Contact -0.1929 0.000014018671850387056 Scatter Plot
Source CX3C Source ANGPTL ANGPTL Secreted Signaling -0.1863 0.00002756029660650732 Scatter Plot
Source CX3C Source TNF TNF Secreted Signaling -0.1497 0.0007876513053033 Scatter Plot
Source CX3C Source VISTA VISTA Cell-Cell Contact -0.1313 0.0032590619439522 Scatter Plot
Source CX3C Source SPP1 SPP1 Secreted Signaling -0.1241 0.0054481006468612 Scatter Plot
Source CX3C Source VISFATIN VISFATIN Secreted Signaling -0.1020 0.0224953114797512 Scatter Plot
Source CX3C Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1020 0.0226095205305136 Scatter Plot
Source CX3C Target SEMA3 SEMA3 Secreted Signaling 0.1047 0.0192236658711053 Scatter Plot
Source CX3C Source THBS THBS ECM-Receptor 0.1249 0.0051662202868347 Scatter Plot
Source CX3C Target GAS GAS Secreted Signaling 0.1356 0.0023847731186788 Scatter Plot
Source CX3C Target NODAL NODAL Secreted Signaling 0.1424 0.0014095669390166 Scatter Plot
Source CX3C Target RANKL RANKL Secreted Signaling 0.1497 0.0007835374418993 Scatter Plot
Source CX3C Source GP1BA GP1BA Cell-Cell Contact 0.1556 0.0004792565877272 Scatter Plot
Source CX3C Target GALECTIN GALECTIN Secreted Signaling 0.1597 0.0003361976289225 Scatter Plot
Source CX3C Target PTN PTN Secreted Signaling 0.1681 0.000158904806131 Scatter Plot
Source CX3C Target VEGF VEGF Secreted Signaling 0.1737 0.00009466199604576226 Scatter Plot
Source CX3C Source CD86 CD86 Cell-Cell Contact 0.1739 0.00009281733997263268 Scatter Plot
Source CX3C Target THY1 THY1 Cell-Cell Contact 0.1854 0.00003032823365138686 Scatter Plot
Source CX3C Source VCAM VCAM Cell-Cell Contact 0.1923 0.000014872437662713075 Scatter Plot
Source CX3C Source CD1D2 CD1D2 Cell-Cell Contact 0.2115 0.00000181778595324856 Scatter Plot
Source CX3C Target MK MK Secreted Signaling 0.2149 0.000001234850609860991 Scatter Plot
Source CX3C Target EPHA EPHA Cell-Cell Contact 0.2209 0.0000006035850468284138 Scatter Plot
Source CX3C Target FN1 FN1 ECM-Receptor 0.2210 0.000000596377666302758 Scatter Plot
Source CX3C Target AGT AGT Secreted Signaling 0.2221 0.0000005263878746798331 Scatter Plot
Source CX3C Target NCAM NCAM Cell-Cell Contact 0.2246 0.0000003894178386695662 Scatter Plot
Source CX3C Target COLLAGEN COLLAGEN ECM-Receptor 0.2246 0.00000038732390358481963 Scatter Plot
Source CX3C Target CD23 CD23 Cell-Cell Contact 0.2308 0.00000017941962528444273 Scatter Plot
Source CX3C Source IL2 IL2 Secreted Signaling 0.2387 0.00000006584498930787087 Scatter Plot
Source CX3C Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2487 0.000000017375697353506023 Scatter Plot
Source CX3C Target SPP1 SPP1 Secreted Signaling 0.2488 0.000000017249328025575964 Scatter Plot
Source CX3C Target SEMA5 SEMA5 Cell-Cell Contact 0.2668 0.000000001342779689402868 Scatter Plot
Source CX3C Target CSPG4 CSPG4 Cell-Cell Contact 0.2730 0.0000000005361160114163925 Scatter Plot
Source CX3C Target OSM OSM Secreted Signaling 0.2731 0.0000000005331107986726305 Scatter Plot
Source CX3C Target GDF GDF Secreted Signaling 0.2732 0.0000000005230473735172837 Scatter Plot
Source CX3C Target IL6 IL6 Secreted Signaling 0.2774 0.00000000027422294356950843 Scatter Plot
Source CX3C Target ANGPTL ANGPTL Secreted Signaling 0.2822 0.00000000013224482875262284 Scatter Plot
Source CX3C Target KIT KIT Secreted Signaling 0.2871 0.00000000006050196038505391 Scatter Plot
Source CX3C Target SEMA6 SEMA6 Cell-Cell Contact 0.2957 0.000000000015171554998697734 Scatter Plot
Source CX3C Source ICAM ICAM Cell-Cell Contact 0.2998 0.000000000007667054953638325 Scatter Plot
Source CX3C Target VISFATIN VISFATIN Secreted Signaling 0.3030 0.0000000000044263548113396594 Scatter Plot
Source CX3C Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.3051 0.000000000003118571640480405 Scatter Plot
Source CX3C Target CADM CADM Cell-Cell Contact 0.3114 0.0000000000010502485604267876 Scatter Plot
Source CX3C Target PARs PARs Secreted Signaling 0.3118 0.0000000000009723763117498825 Scatter Plot
Source CX3C Target VWF VWF ECM-Receptor 0.3131 0.0000000000007730440382370453 Scatter Plot
Source CX3C Target SEMA4 SEMA4 Cell-Cell Contact 0.3132 0.0000000000007655374066598376 Scatter Plot
Source CX3C Source CXCL CXCL Secreted Signaling 0.3133 0.0000000000007528167899927442 Scatter Plot
Source CX3C Target LAMININ LAMININ ECM-Receptor 0.3149 0.0000000000005625775023331654 Scatter Plot
Source CX3C Target ACTIVIN ACTIVIN Secreted Signaling 0.3196 0.0000000000002429278704026019 Scatter Plot
Source CX3C Target VTN VTN ECM-Receptor 0.3254 0.00000000000008432527935393781 Scatter Plot
Source CX3C Target SEMA7 SEMA7 Cell-Cell Contact 0.3343 0.000000000000016182760005966532 Scatter Plot
Source CX3C Target ANGPT ANGPT Secreted Signaling 0.3358 0.000000000000012044517007946976 Scatter Plot
Source CX3C Source LCK LCK Cell-Cell Contact 0.3478 0.000000000000001149649962542244 Scatter Plot
Source CX3C Target CD22 CD22 Cell-Cell Contact 0.3486 0.0000000000000009752773484982357 Scatter Plot
Source CX3C Source MK MK Secreted Signaling 0.3496 0.0000000000000007955141779045712 Scatter Plot
Source CX3C Target EPHB EPHB Cell-Cell Contact 0.3504 0.0000000000000006811505836339223 Scatter Plot
Source CX3C Target THBS THBS ECM-Receptor 0.3518 0.0000000000000005120171450581469 Scatter Plot
Source CX3C Target IGF IGF Secreted Signaling 0.3568 0.00000000000000018356201784618774 Scatter Plot
Source CX3C Source CCL CCL Secreted Signaling 0.3592 0.0000000000000001132040639861997 Scatter Plot
Source CX3C Target NPR2 NPR2 Secreted Signaling 0.3604 0.00000000000000008720116369089474 Scatter Plot
Source CX3C Target PERIOSTIN PERIOSTIN Secreted Signaling 0.3668 0.000000000000000022754749518411318 Scatter Plot
Source CX3C Target NRG NRG Secreted Signaling 0.3692 0.000000000000000013598824549080862 Scatter Plot
Source CX3C Target CD34 CD34 Cell-Cell Contact 0.3694 0.000000000000000012918225530573215 Scatter Plot
Source CX3C Target BSP BSP ECM-Receptor 0.3782 0.0000000000000000018988393721844423 Scatter Plot
Source CX3C Target BMP BMP Secreted Signaling 0.3831 0.0000000000000000006322024652364086 Scatter Plot
Source CX3C Target DMP1 DMP1 ECM-Receptor 0.3869 0.0000000000000000002666606829398753 Scatter Plot
Source CX3C Target BAFF BAFF Secreted Signaling 0.3946 0.000000000000000000044298876493249726 Scatter Plot
Source CX3C Target CD39 CD39 Cell-Cell Contact 0.4029 0.000000000000000000006040434398076157 Scatter Plot
Source CX3C Target CDH CDH Cell-Cell Contact 0.4060 0.000000000000000000002902313241976649 Scatter Plot
Source CX3C Target TGFb TGFb Secreted Signaling 0.4099 0.0000000000000000000010888585689101057 Scatter Plot
Source CX3C Target ncWNT ncWNT Secreted Signaling 0.4129 0.0000000000000000000005268813881129752 Scatter Plot
Source CX3C Target FGF FGF Secreted Signaling 0.4199 0.00000000000000000000008754138609788547 Scatter Plot
Source CX3C Target TENASCIN TENASCIN ECM-Receptor 0.4253 0.00000000000000000000002177955875940353 Scatter Plot
Source CX3C Target CD200 CD200 Cell-Cell Contact 0.4256 0.000000000000000000000020044072586929602 Scatter Plot
Source CX3C Target SLURP SLURP Secreted Signaling 0.4276 0.000000000000000000000011869221276321586 Scatter Plot
Source CX3C Source COLLAGEN COLLAGEN ECM-Receptor 0.4368 0.0000000000000000000000010283424103174683 Scatter Plot
Source CX3C Target JAM JAM Cell-Cell Contact 0.4427 0.0000000000000000000000002026411219891016 Scatter Plot
Source CX3C Target APP APP Cell-Cell Contact 0.4469 0.00000000000000000000000006255593474470125 Scatter Plot
Source CX3C Target MIF MIF Secreted Signaling 0.4512 0.00000000000000000000000001898829802697728 Scatter Plot
Source CX3C Target WNT WNT Secreted Signaling 0.4592 0.0000000000000000000000000018959698369348862 Scatter Plot
Source CX3C Target ESAM ESAM Cell-Cell Contact 0.5012 0.0000000000000000000000000000000036625074810595416 Scatter Plot
Source CX3C Source MHC-I MHC-I Cell-Cell Contact 0.5092 0.00000000000000000000000000000000023864969551936033 Scatter Plot
Source CX3C Source CD52 CD52 Cell-Cell Contact -0.3562 0.00000000000000020761395873405307 Scatter Plot
Source CX3C Source COMPLEMENT COMPLEMENT Secreted Signaling -0.2839 0.00000000010035244053017196 Scatter Plot
Source CX3C Target ICAM ICAM Cell-Cell Contact -0.2732 0.0000000005191725926222357 Scatter Plot
Source CX3C Target CD52 CD52 Cell-Cell Contact -0.2480 0.000000019077815045777202 Scatter Plot
Source CX3C Target CXCL CXCL Secreted Signaling -0.2320 0.0000001552788862855457 Scatter Plot
Source CX3C Target IFN-II IFN-II Secreted Signaling -0.1860 0.000028349660713575728 Scatter Plot
Source CX3C Target CSF CSF Secreted Signaling -0.1766 0.00007188963228522297 Scatter Plot
Source CX3C Target IL17 IL17 Secreted Signaling -0.1731 0.0001005067990664 Scatter Plot
Source CX3C Source NKG2D NKG2D Cell-Cell Contact -0.1637 0.0002377490353523 Scatter Plot
Source CX3C Target CLEC CLEC Cell-Cell Contact -0.1551 0.0004983575500896 Scatter Plot
Source CX3C Source CCL CCL Secreted Signaling -0.1409 0.0015815432382963 Scatter Plot
Source CX3C Target CCL CCL Secreted Signaling -0.1407 0.0016075749889694 Scatter Plot
Source CX3C Target GRN GRN Secreted Signaling -0.1081 0.0155508114905997 Scatter Plot
Source CX3C Target VCAM VCAM Cell-Cell Contact -0.0986 0.0274391079319247 Scatter Plot

Cells that are targets of CX3C from HSCs*

Cells that are source of CX3C to HSCs*

    No cell populations

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.