Pathway: AGRN

Average Signaling Potential

Edge Color:
— HSCs as target
— HSCs as source

Pathway Category: ECM-Receptor

Details on the AGRN pathway:

KEGG:mmu04512

Specificity Index HSPC as target: 0.385
HSPC as source: 0.159

Graph Terms:

Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
HSC Percent: Proportion of HSCs that interact with the given cell type in the AGRN pathway.
Node Size: Node size refelcts percent of HSCs interacting
Node Color: Node color reflects Average Signaling Potential

Correlation Name	Pathway Name	Pathway Category	Correlation Score	-log10(adj. p-value)	Plot
Source AGRN Source RANKL	RANKL	Secreted Signaling	0.0997	0.0258575184385491	Scatter Plot
Source AGRN Source VCAM	VCAM	Cell-Cell Contact	0.1013	0.023558484585903	Scatter Plot
Source AGRN Source FGF	FGF	Secreted Signaling	0.1064	0.0173157742422599	Scatter Plot
Source AGRN Source VEGF	VEGF	Secreted Signaling	0.1069	0.0168228477305608	Scatter Plot
Source AGRN Source WNT	WNT	Secreted Signaling	0.1115	0.0126016045656805	Scatter Plot
Source AGRN Source LIFR	LIFR	Secreted Signaling	0.1138	0.0108662112246652	Scatter Plot
Source AGRN Source GAS	GAS	Secreted Signaling	0.1139	0.0108074387234027	Scatter Plot
Source AGRN Source JAM	JAM	Cell-Cell Contact	0.1173	0.0086305218426864	Scatter Plot
Source AGRN Source APELIN	APELIN	Secreted Signaling	0.1191	0.0076508896792464	Scatter Plot
Source AGRN Source PDGF	PDGF	Secreted Signaling	0.1223	0.0061577066969079	Scatter Plot
Source AGRN Source SEMA3	SEMA3	Secreted Signaling	0.1329	0.0029146079388125	Scatter Plot
Source AGRN Source ncWNT	ncWNT	Secreted Signaling	0.1341	0.0026505093003341	Scatter Plot
Source AGRN Source IL6	IL6	Secreted Signaling	0.1433	0.0013141066991588	Scatter Plot
Source AGRN Source ITGAL-ITGB2	ITGAL-ITGB2	Cell-Cell Contact	-0.1051	0.0187265376350105	Scatter Plot
Source AGRN Target DMP1	DMP1	ECM-Receptor	0.0968	0.0305047077872814	Scatter Plot
Source AGRN Target IGF	IGF	Secreted Signaling	0.0986	0.0274104136221785	Scatter Plot
Source AGRN Target OSM	OSM	Secreted Signaling	0.1006	0.0244218977809382	Scatter Plot
Source AGRN Target NODAL	NODAL	Secreted Signaling	0.1009	0.0240021478533462	Scatter Plot
Source AGRN Target COMPLEMENT	COMPLEMENT	Secreted Signaling	0.1019	0.0226864103137708	Scatter Plot
Source AGRN Target TWEAK	TWEAK	Secreted Signaling	0.1028	0.0215100265445641	Scatter Plot
Source AGRN Source CXCL	CXCL	Secreted Signaling	0.1028	0.0215074879827788	Scatter Plot
Source AGRN Source LAMININ	LAMININ	ECM-Receptor	0.1035	0.0205784156337562	Scatter Plot
Source AGRN Target TENASCIN	TENASCIN	ECM-Receptor	0.1040	0.0199874999136262	Scatter Plot
Source AGRN Source FLT3	FLT3	Secreted Signaling	0.1041	0.0199546772848817	Scatter Plot
Source AGRN Target RANKL	RANKL	Secreted Signaling	0.1045	0.0194147350482136	Scatter Plot
Source AGRN Source CD39	CD39	Cell-Cell Contact	0.1057	0.0180877970515018	Scatter Plot
Source AGRN Target ESAM	ESAM	Cell-Cell Contact	0.1062	0.0175093293027582	Scatter Plot
Source AGRN Source ESAM	ESAM	Cell-Cell Contact	0.1062	0.0175093293027582	Scatter Plot
Source AGRN Target TGFb	TGFb	Secreted Signaling	0.1067	0.0170478708525722	Scatter Plot
Source AGRN Source CX3C	CX3C	Secreted Signaling	0.1072	0.0164614109634478	Scatter Plot
Source AGRN Target SEMA3	SEMA3	Secreted Signaling	0.1073	0.016432230806125	Scatter Plot
Source AGRN Target SPP1	SPP1	Secreted Signaling	0.1075	0.016162999126527	Scatter Plot
Source AGRN Source IL2	IL2	Secreted Signaling	0.1076	0.0160984831069976	Scatter Plot
Source AGRN Source IL7	IL7	Secreted Signaling	0.1079	0.015768414272868	Scatter Plot
Source AGRN Target KIT	KIT	Secreted Signaling	0.1090	0.0147725856838126	Scatter Plot
Source AGRN Source CD46	CD46	Cell-Cell Contact	0.1097	0.0141043186995996	Scatter Plot
Source AGRN Target FN1	FN1	ECM-Receptor	0.1115	0.0125718825597869	Scatter Plot
Source AGRN Target JAM	JAM	Cell-Cell Contact	0.1123	0.0119539682571803	Scatter Plot
Source AGRN Target BMP	BMP	Secreted Signaling	0.1127	0.0116413222786546	Scatter Plot
Source AGRN Target ncWNT	ncWNT	Secreted Signaling	0.1129	0.0115520560048751	Scatter Plot
Source AGRN Source ANGPTL	ANGPTL	Secreted Signaling	0.1178	0.0083931662000529	Scatter Plot
Source AGRN Target SEMA5	SEMA5	Cell-Cell Contact	0.1183	0.0080783957314456	Scatter Plot
Source AGRN Target VEGF	VEGF	Secreted Signaling	0.1201	0.0071790572283019	Scatter Plot
Source AGRN Source APELIN	APELIN	Secreted Signaling	0.1224	0.0061209293691824	Scatter Plot
Source AGRN Source THY1	THY1	Cell-Cell Contact	0.1232	0.0058058340447677	Scatter Plot
Source AGRN Target ANGPTL	ANGPTL	Secreted Signaling	0.1239	0.0055322430952575	Scatter Plot
Source AGRN Target CD34	CD34	Cell-Cell Contact	0.1254	0.0049882037501046	Scatter Plot
Source AGRN Target APP	APP	Cell-Cell Contact	0.1279	0.0041702487379839	Scatter Plot
Source AGRN Source BST2	BST2	Cell-Cell Contact	0.1314	0.0032329972680812	Scatter Plot
Source AGRN Source LCK	LCK	Cell-Cell Contact	0.1316	0.0031982674737839	Scatter Plot
Source AGRN Target THBS	THBS	ECM-Receptor	0.1345	0.002579663056098	Scatter Plot
Source AGRN Source NOTCH	NOTCH	Cell-Cell Contact	0.1353	0.0024269964640189	Scatter Plot
Source AGRN Target ENHO	ENHO	Secreted Signaling	0.1371	0.0021271965707617	Scatter Plot
Source AGRN Target AGT	AGT	Secreted Signaling	0.1386	0.0018900823724282	Scatter Plot
Source AGRN Target IL1	IL1	Secreted Signaling	0.1404	0.0016439550752931	Scatter Plot
Source AGRN Target SEMA6	SEMA6	Cell-Cell Contact	0.1405	0.0016342079401153	Scatter Plot
Source AGRN Target CADM	CADM	Cell-Cell Contact	0.1540	0.0005474118196226	Scatter Plot
Source AGRN Source CADM	CADM	Cell-Cell Contact	0.1540	0.0005474118196226	Scatter Plot
Source AGRN Target WNT	WNT	Secreted Signaling	0.1763	0.00007389738051790255	Scatter Plot
Source AGRN Target MK	MK	Secreted Signaling	0.1865	0.00002704157709969156	Scatter Plot
Source AGRN Target COLLAGEN	COLLAGEN	ECM-Receptor	0.1970	0.000009129680461280731	Scatter Plot
Source AGRN Target CSPG4	CSPG4	Cell-Cell Contact	0.2010	0.000005909372249520705	Scatter Plot
Source AGRN Target PTN	PTN	Secreted Signaling	0.2119	0.000001745171921688032	Scatter Plot
Source AGRN Source BAFF	BAFF	Secreted Signaling	-0.1676	0.0001659515303416	Scatter Plot
Source AGRN Source ANNEXIN	ANNEXIN	Secreted Signaling	-0.1339	0.0026930468707943	Scatter Plot
Source AGRN Source VISTA	VISTA	Cell-Cell Contact	-0.1219	0.0063425325885652	Scatter Plot
Source AGRN Target ICAM	ICAM	Cell-Cell Contact	-0.1183	0.0081036654798737	Scatter Plot
Source AGRN Source PARs	PARs	Secreted Signaling	-0.1157	0.0096423202181154	Scatter Plot
Source AGRN Source SEMA4	SEMA4	Cell-Cell Contact	-0.1149	0.0101123530568799	Scatter Plot
Source AGRN Target CXCL	CXCL	Secreted Signaling	-0.1104	0.0134935401788601	Scatter Plot
Source AGRN Source CD52	CD52	Cell-Cell Contact	-0.1073	0.0163583652837384	Scatter Plot
Source AGRN Source SELL	SELL	Cell-Cell Contact	-0.1057	0.018023987179297	Scatter Plot
Source AGRN Source ESAM	ESAM	Cell-Cell Contact	-0.1029	0.0213196369511184	Scatter Plot
Source AGRN Target ESAM	ESAM	Cell-Cell Contact	-0.1029	0.0213196369511184	Scatter Plot
Source AGRN Source SPP1	SPP1	Secreted Signaling	-0.0983	0.0279359287191027	Scatter Plot

Cells that are targets of AGRN from HSCs*

Cells that are source of AGRN to HSCs*

No cell populations

Ligands:

Agrn

Receptors:

Dag1

*Cell types are filtered such that they interact with at least 5% of HSCs.

Select HSPC Type

Cell-Cell Signaling Value

Pathway: AGRN