Pathway: OSM

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the OSM pathway:

Specificity Index HSPC as target: 0.132
HSPC as source: 0.580

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the OSM pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target OSM Source AGRN AGRN ECM-Receptor 0.1006 0.0244218977809382 Scatter Plot
Source OSM Source EPHB EPHB Cell-Cell Contact 0.1008 0.024132822352478 Scatter Plot
Target OSM Source GDF GDF Secreted Signaling 0.1023 0.0220967065367689 Scatter Plot
Source OSM Source GDF GDF Secreted Signaling 0.1059 0.0178961455139813 Scatter Plot
Source OSM Source ANGPT ANGPT Secreted Signaling 0.1082 0.0154663247641315 Scatter Plot
Source OSM Source CXCL CXCL Secreted Signaling 0.1087 0.0149839063192495 Scatter Plot
Source OSM Source ANGPTL ANGPTL Secreted Signaling 0.1104 0.0134742683028093 Scatter Plot
Target OSM Source WNT WNT Secreted Signaling 0.1128 0.011593741783141 Scatter Plot
Target OSM Source PTN PTN Secreted Signaling 0.1142 0.0105939014303299 Scatter Plot
Target OSM Target CSPG4 CSPG4 Cell-Cell Contact 0.1151 0.0099933460693548 Scatter Plot
Target OSM Target NCAM NCAM Cell-Cell Contact 0.1152 0.0099429002686337 Scatter Plot
Target OSM Source IGF IGF Secreted Signaling 0.1176 0.0084875257549498 Scatter Plot
Target OSM Source CD1D2 CD1D2 Cell-Cell Contact 0.1216 0.0064723780981117 Scatter Plot
Target OSM Target EPHA EPHA Cell-Cell Contact 0.1221 0.0062482783632393 Scatter Plot
Target OSM Target MK MK Secreted Signaling 0.1241 0.0054476226853938 Scatter Plot
Target OSM Target GDF GDF Secreted Signaling 0.1248 0.0052013098999848 Scatter Plot
Target OSM Source IL16 IL16 Secreted Signaling 0.1300 0.0035941414781876 Scatter Plot
Source OSM Source COLLAGEN COLLAGEN ECM-Receptor 0.1306 0.0034501851447564 Scatter Plot
Target OSM Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.1325 0.0030020182237904 Scatter Plot
Target OSM Source CD86 CD86 Cell-Cell Contact 0.1353 0.0024311194464404 Scatter Plot
Target OSM Target VEGF VEGF Secreted Signaling 0.1359 0.0023245907893272 Scatter Plot
Target OSM Source SEMA3 SEMA3 Secreted Signaling 0.1370 0.002135030953773 Scatter Plot
Target OSM Source APELIN APELIN Secreted Signaling 0.1409 0.0015889767126353 Scatter Plot
Target OSM Source CXCL CXCL Secreted Signaling 0.1454 0.0011118076024364 Scatter Plot
Target OSM Target CD200 CD200 Cell-Cell Contact 0.1477 0.0009269547517665 Scatter Plot
Target OSM Source RANKL RANKL Secreted Signaling 0.1477 0.000925715655997 Scatter Plot
Target OSM Source IL2 IL2 Secreted Signaling 0.1485 0.0008665465330034 Scatter Plot
Target OSM Target ACTIVIN ACTIVIN Secreted Signaling 0.1493 0.0008121403609851 Scatter Plot
Target OSM Source SEMA6 SEMA6 Cell-Cell Contact 0.1499 0.0007749019069699 Scatter Plot
Target OSM Target COLLAGEN COLLAGEN ECM-Receptor 0.1499 0.0007738123680706 Scatter Plot
Target OSM Target CXCL CXCL Secreted Signaling 0.1513 0.0006854281226359 Scatter Plot
Target OSM Target NOTCH NOTCH Cell-Cell Contact 0.1520 0.0006471598576586 Scatter Plot
Target OSM Source EPHB EPHB Cell-Cell Contact 0.1528 0.0006076669317329 Scatter Plot
Target OSM Target FN1 FN1 ECM-Receptor 0.1536 0.0005690491951611 Scatter Plot
Target OSM Target PTN PTN Secreted Signaling 0.1539 0.0005532311262966 Scatter Plot
Target OSM Source GRN GRN Secreted Signaling 0.1541 0.0005466207704265 Scatter Plot
Target OSM Source LIGHT LIGHT Secreted Signaling 0.1543 0.0005349096669428 Scatter Plot
Target OSM Target SEMA5 SEMA5 Cell-Cell Contact 0.1569 0.0004298396535199 Scatter Plot
Target OSM Source LCK LCK Cell-Cell Contact 0.1617 0.0002825237926442 Scatter Plot
Target OSM Source CCL CCL Secreted Signaling 0.1659 0.0001944467329009 Scatter Plot
Target OSM Source ICAM ICAM Cell-Cell Contact 0.1671 0.0001743643570445 Scatter Plot
Target OSM Target TGFb TGFb Secreted Signaling 0.1722 0.00010928830723 Scatter Plot
Target OSM Source IL7 IL7 Secreted Signaling 0.1750 0.00008328163548017146 Scatter Plot
Target OSM Source PECAM1 PECAM1 Cell-Cell Contact 0.1785 0.00005965879599844908 Scatter Plot
Target OSM Target PECAM1 PECAM1 Cell-Cell Contact 0.1785 0.00005965879599844908 Scatter Plot
Target OSM Source CSF CSF Secreted Signaling 0.1812 0.00004614461244364093 Scatter Plot
Target OSM Source COLLAGEN COLLAGEN ECM-Receptor 0.1833 0.00003735811859185019 Scatter Plot
Target OSM Target COMPLEMENT COMPLEMENT Secreted Signaling 0.1851 0.000031235926721290745 Scatter Plot
Target OSM Target SELPLG SELPLG Cell-Cell Contact 0.1863 0.000027731427156671148 Scatter Plot
Target OSM Source CD45 CD45 Cell-Cell Contact 0.1884 0.000022214729670038462 Scatter Plot
Target OSM Target CD22 CD22 Cell-Cell Contact 0.1884 0.000022214729670038462 Scatter Plot
Target OSM Target SEMA4 SEMA4 Cell-Cell Contact 0.1910 0.000017125154351800404 Scatter Plot
Target OSM Target RANKL RANKL Secreted Signaling 0.1976 0.000008528829112633855 Scatter Plot
Target OSM Source CDH CDH Cell-Cell Contact 0.1988 0.000007458373995318854 Scatter Plot
Target OSM Target CDH CDH Cell-Cell Contact 0.1988 0.000007458373995318854 Scatter Plot
Target OSM Target LAMININ LAMININ ECM-Receptor 0.2000 0.000006588481956609031 Scatter Plot
Target OSM Target THY1 THY1 Cell-Cell Contact 0.2021 0.000005240984387025243 Scatter Plot
Target OSM Target SEMA6 SEMA6 Cell-Cell Contact 0.2052 0.000003716863457660674 Scatter Plot
Target OSM Target SEMA3 SEMA3 Secreted Signaling 0.2056 0.000003557404354596829 Scatter Plot
Target OSM Source CD39 CD39 Cell-Cell Contact 0.2056 0.0000035563389523765955 Scatter Plot
Target OSM Target CD23 CD23 Cell-Cell Contact 0.2066 0.0000031798893552963894 Scatter Plot
Target OSM Target SEMA7 SEMA7 Cell-Cell Contact 0.2066 0.0000031730472585970804 Scatter Plot
Target OSM Target AGT AGT Secreted Signaling 0.2117 0.0000017911271966633215 Scatter Plot
Target OSM Target VWF VWF ECM-Receptor 0.2127 0.0000015948809202962765 Scatter Plot
Target OSM Target SLURP SLURP Secreted Signaling 0.2137 0.000001421044079858492 Scatter Plot
Target OSM Target MIF MIF Secreted Signaling 0.2151 0.000001209256371824797 Scatter Plot
Target OSM Source NOTCH NOTCH Cell-Cell Contact 0.2159 0.0000011031263624373218 Scatter Plot
Target OSM Source LIFR LIFR Secreted Signaling 0.2172 0.0000009471221588778504 Scatter Plot
Target OSM Source CD46 CD46 Cell-Cell Contact 0.2179 0.00000086266050481285 Scatter Plot
Target OSM Source BST2 BST2 Cell-Cell Contact 0.2203 0.0000006510097275311859 Scatter Plot
Target OSM Source CADM CADM Cell-Cell Contact 0.2217 0.0000005484087108004105 Scatter Plot
Target OSM Target CADM CADM Cell-Cell Contact 0.2217 0.0000005484087108004105 Scatter Plot
Target OSM Target ANGPTL ANGPTL Secreted Signaling 0.2265 0.0000003086241933526343 Scatter Plot
Target OSM Target VTN VTN ECM-Receptor 0.2307 0.0000001816376257052121 Scatter Plot
Target OSM Target ncWNT ncWNT Secreted Signaling 0.2311 0.00000017344639150468072 Scatter Plot
Target OSM Source FN1 FN1 ECM-Receptor 0.2330 0.00000013621165773696321 Scatter Plot
Target OSM Target BMP BMP Secreted Signaling 0.2336 0.00000012610075836303646 Scatter Plot
Target OSM Target VISFATIN VISFATIN Secreted Signaling 0.2342 0.00000011694967953648657 Scatter Plot
Target OSM Source ANGPT ANGPT Secreted Signaling 0.2343 0.00000011579963232344381 Scatter Plot
Target OSM Source MHC-II MHC-II Cell-Cell Contact 0.2373 0.00000007876073634630993 Scatter Plot
Target OSM Source FLT3 FLT3 Secreted Signaling 0.2379 0.0000000730296316223562 Scatter Plot
Target OSM Target EPHB EPHB Cell-Cell Contact 0.2410 0.000000048750805145752055 Scatter Plot
Target OSM Source GAS GAS Secreted Signaling 0.2435 0.00000003474096724862825 Scatter Plot
Target OSM Source LAMININ LAMININ ECM-Receptor 0.2455 0.00000002662488448483309 Scatter Plot
Target OSM Target ANGPT ANGPT Secreted Signaling 0.2490 0.000000016703596228067448 Scatter Plot
Target OSM Target FGF FGF Secreted Signaling 0.2566 0.000000005824150152856925 Scatter Plot
Target OSM Target WNT WNT Secreted Signaling 0.2599 0.0000000036704843080527638 Scatter Plot
Target OSM Target THBS THBS ECM-Receptor 0.2611 0.0000000030940901010871036 Scatter Plot
Target OSM Target NPR2 NPR2 Secreted Signaling 0.2658 0.000000001556915832755359 Scatter Plot
Target OSM Source CX3C CX3C Secreted Signaling 0.2731 0.0000000005331107986726305 Scatter Plot
Target OSM Target IGF IGF Secreted Signaling 0.2806 0.00000000016902176309103267 Scatter Plot
Target OSM Source MHC-I MHC-I Cell-Cell Contact 0.2828 0.000000000119772173848898 Scatter Plot
Target OSM Source PDGF PDGF Secreted Signaling 0.2890 0.00000000004478041159798724 Scatter Plot
Target OSM Target TENASCIN TENASCIN ECM-Receptor 0.2911 0.00000000003190744981320133 Scatter Plot
Target OSM Target CD39 CD39 Cell-Cell Contact 0.2912 0.00000000003126273610709923 Scatter Plot
Target OSM Source PROS PROS Secreted Signaling 0.2927 0.000000000024488391851499664 Scatter Plot
Target OSM Target PERIOSTIN PERIOSTIN Secreted Signaling 0.2954 0.000000000015833985710890856 Scatter Plot
Target OSM Target ESAM ESAM Cell-Cell Contact 0.3007 0.000000000006558608519563482 Scatter Plot
Target OSM Source ESAM ESAM Cell-Cell Contact 0.3007 0.000000000006558608519563482 Scatter Plot
Target OSM Target DMP1 DMP1 ECM-Receptor 0.3103 0.0000000000012691821419172213 Scatter Plot
Target OSM Source BMP BMP Secreted Signaling 0.3120 0.000000000000938415393521738 Scatter Plot
Target OSM Target BSP BSP ECM-Receptor 0.3126 0.0000000000008464247866181057 Scatter Plot
Target OSM Source PSAP PSAP Secreted Signaling 0.3143 0.0000000000006344091753088504 Scatter Plot
Target OSM Target JAM JAM Cell-Cell Contact 0.3170 0.000000000000391098870968006 Scatter Plot
Target OSM Source TWEAK TWEAK Secreted Signaling 0.3173 0.00000000000037232986831732246 Scatter Plot
Target OSM Source SEMA7 SEMA7 Cell-Cell Contact 0.3264 0.0000000000000703625177674301 Scatter Plot
Target OSM Source MK MK Secreted Signaling 0.3289 0.000000000000044230518634442594 Scatter Plot
Target OSM Source JAM JAM Cell-Cell Contact 0.3296 0.00000000000003862948694575893 Scatter Plot
Target OSM Source NT NT Secreted Signaling 0.3476 0.0000000000000011934255661894858 Scatter Plot
Target OSM Target CD34 CD34 Cell-Cell Contact 0.3514 0.0000000000000005531228146439205 Scatter Plot
Target OSM Source CD52 CD52 Cell-Cell Contact -0.2246 0.0000003880981814459581 Scatter Plot
Target OSM Source SELL SELL Cell-Cell Contact -0.1996 0.000006848960001579829 Scatter Plot
Target OSM Source ANGPTL ANGPTL Secreted Signaling -0.1901 0.000018664248444037983 Scatter Plot
Target OSM Source SEMA4 SEMA4 Cell-Cell Contact -0.1810 0.00004692398528387954 Scatter Plot
Target OSM Source MIF MIF Secreted Signaling -0.1806 0.00004853853409836245 Scatter Plot
Target OSM Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.1798 0.00005290222599821486 Scatter Plot
Target OSM Target ICAM ICAM Cell-Cell Contact -0.1641 0.0002279393043704 Scatter Plot
Target OSM Source NKG2D NKG2D Cell-Cell Contact -0.1607 0.0003083238718276 Scatter Plot
Target OSM Source FGF FGF Secreted Signaling -0.1583 0.0003810506025124 Scatter Plot
Target OSM Source COMPLEMENT COMPLEMENT Secreted Signaling -0.1503 0.0007453630653507 Scatter Plot
Target OSM Target GRN GRN Secreted Signaling -0.1341 0.0026621546739631 Scatter Plot
Target OSM Source TGFb TGFb Secreted Signaling -0.1310 0.0033330594971949 Scatter Plot
Target OSM Target VCAM VCAM Cell-Cell Contact -0.1283 0.0040683939331689 Scatter Plot
Target OSM Target COLLAGEN COLLAGEN ECM-Receptor -0.1234 0.0057238880164272 Scatter Plot
Target OSM Target CD52 CD52 Cell-Cell Contact -0.1232 0.0057936476267994 Scatter Plot
Target OSM Source CLEC CLEC Cell-Cell Contact -0.1205 0.0069898665256972 Scatter Plot
Target OSM Target CXCL CXCL Secreted Signaling -0.1184 0.0080243063951588 Scatter Plot
Target OSM Source LAIR1 LAIR1 Cell-Cell Contact -0.1167 0.0089892080014794 Scatter Plot
Target OSM Source VEGF VEGF Secreted Signaling -0.1050 0.0188420453494416 Scatter Plot
Source OSM Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.0971 0.0298670863204219 Scatter Plot
Source OSM Source MHC-I MHC-I Cell-Cell Contact 0.0980 0.02850382152193 Scatter Plot
Source OSM Target LAMININ LAMININ ECM-Receptor 0.0987 0.0273869570467442 Scatter Plot
Source OSM Target ACTIVIN ACTIVIN Secreted Signaling 0.0992 0.0266050636337534 Scatter Plot
Source OSM Source SEMA3 SEMA3 Secreted Signaling 0.1026 0.0217088788818644 Scatter Plot
Source OSM Source VISFATIN VISFATIN Secreted Signaling 0.1029 0.0213824376652983 Scatter Plot
Source OSM Target NOTCH NOTCH Cell-Cell Contact 0.1041 0.0199499735413938 Scatter Plot
Source OSM Target APP APP Cell-Cell Contact 0.1053 0.018472794606788 Scatter Plot
Source OSM Target IL1 IL1 Secreted Signaling 0.1065 0.0172298348495726 Scatter Plot
Source OSM Source GAS GAS Secreted Signaling 0.1069 0.0167853891096266 Scatter Plot
Source OSM Target SEMA6 SEMA6 Cell-Cell Contact 0.1070 0.0166487179559475 Scatter Plot
Source OSM Source FN1 FN1 ECM-Receptor 0.1072 0.0165032058725938 Scatter Plot
Source OSM Target MIF MIF Secreted Signaling 0.1075 0.0162090917623715 Scatter Plot
Source OSM Target COLLAGEN COLLAGEN ECM-Receptor 0.1079 0.015751594696707 Scatter Plot
Source OSM Target SELE SELE Cell-Cell Contact 0.1082 0.0155338674268362 Scatter Plot
Source OSM Target CD200 CD200 Cell-Cell Contact 0.1086 0.0151008481392035 Scatter Plot
Source OSM Source PSAP PSAP Secreted Signaling 0.1100 0.0138357678289576 Scatter Plot
Source OSM Source CD1D2 CD1D2 Cell-Cell Contact 0.1108 0.0131828215273216 Scatter Plot
Target OSM Target CCL CCL Secreted Signaling 0.1153 0.0098460964032524 Scatter Plot
Source OSM Source FGF FGF Secreted Signaling 0.1164 0.0091766089340844 Scatter Plot
Source OSM Target CD39 CD39 Cell-Cell Contact 0.1168 0.0089636233632486 Scatter Plot
Source OSM Source CCL CCL Secreted Signaling 0.1180 0.0082360160846395 Scatter Plot
Source OSM Target CD22 CD22 Cell-Cell Contact 0.1182 0.0081643163705401 Scatter Plot
Source OSM Source CD45 CD45 Cell-Cell Contact 0.1182 0.00816431637054 Scatter Plot
Source OSM Source GALECTIN GALECTIN Secreted Signaling 0.1191 0.0076911698854303 Scatter Plot
Source OSM Target BMP BMP Secreted Signaling 0.1210 0.0067657305495465 Scatter Plot
Source OSM Target GDF GDF Secreted Signaling 0.1217 0.0064408247864568 Scatter Plot
Source OSM Target NODAL NODAL Secreted Signaling 0.1239 0.0055317745101461 Scatter Plot
Source OSM Source LCK LCK Cell-Cell Contact 0.1270 0.0044515966083984 Scatter Plot
Source OSM Target ncWNT ncWNT Secreted Signaling 0.1273 0.0043647911057183 Scatter Plot
Source OSM Source SEMA4 SEMA4 Cell-Cell Contact 0.1307 0.0034117555063043 Scatter Plot
Source OSM Target SEMA4 SEMA4 Cell-Cell Contact 0.1309 0.0033738681694092 Scatter Plot
Target OSM Target NODAL NODAL Secreted Signaling 0.1325 0.0029869624229044 Scatter Plot
Source OSM Source SELPLG SELPLG Cell-Cell Contact 0.1336 0.0027546216900826 Scatter Plot
Source OSM Target GALECTIN GALECTIN Secreted Signaling 0.1356 0.0023696050056937 Scatter Plot
Source OSM Source ICAM ICAM Cell-Cell Contact 0.1371 0.0021250139484627 Scatter Plot
Source OSM Target WNT WNT Secreted Signaling 0.1389 0.0018447723469752 Scatter Plot
Source OSM Target MK MK Secreted Signaling 0.1401 0.001680801735633 Scatter Plot
Source OSM Source THY1 THY1 Cell-Cell Contact 0.1414 0.001525582132596 Scatter Plot
Source OSM Source MHC-II MHC-II Cell-Cell Contact 0.1415 0.0015141617611386 Scatter Plot
Source OSM Target FN1 FN1 ECM-Receptor 0.1434 0.0012999907524126 Scatter Plot
Source OSM Target SPP1 SPP1 Secreted Signaling 0.1440 0.0012481049255378 Scatter Plot
Source OSM Source CD86 CD86 Cell-Cell Contact 0.1463 0.001037105888448 Scatter Plot
Source OSM Target KIT KIT Secreted Signaling 0.1506 0.0007310899224072 Scatter Plot
Source OSM Target TGFb TGFb Secreted Signaling 0.1653 0.0002043846564549 Scatter Plot
Target OSM Target BAFF BAFF Secreted Signaling 0.1686 0.0001523470913543 Scatter Plot
Source OSM Target SELL SELL Cell-Cell Contact 0.1735 0.0000965352718705436 Scatter Plot
Source OSM Source CD34 CD34 Cell-Cell Contact 0.1770 0.00006921194865679938 Scatter Plot
Target OSM Target PARs PARs Secreted Signaling 0.1819 0.00004282873348787814 Scatter Plot
Source OSM Target PDGF PDGF Secreted Signaling 0.1830 0.000038571371338991566 Scatter Plot
Target OSM Target SPP1 SPP1 Secreted Signaling 0.1872 0.000025305206599090984 Scatter Plot
Target OSM Target APP APP Cell-Cell Contact 0.2043 0.0000040936437102743815 Scatter Plot
Source OSM Source VCAM VCAM Cell-Cell Contact 0.2589 0.000000004230904891554029 Scatter Plot
Target OSM Target NRG NRG Secreted Signaling 0.2965 0.000000000013194647901263848 Scatter Plot
Source OSM Source PARs PARs Secreted Signaling -0.2115 0.0000018217520445450117 Scatter Plot
Source OSM Target VCAM VCAM Cell-Cell Contact -0.1952 0.000011038791956611674 Scatter Plot
Source OSM Source VISTA VISTA Cell-Cell Contact -0.1716 0.0001148707404027 Scatter Plot
Source OSM Target NCAM NCAM Cell-Cell Contact -0.1534 0.000575868866158 Scatter Plot
Source OSM Source APP APP Cell-Cell Contact -0.1256 0.0049193880510141 Scatter Plot
Source OSM Target VEGF VEGF Secreted Signaling -0.1236 0.0056621861762476 Scatter Plot
Source OSM Source COMPLEMENT COMPLEMENT Secreted Signaling -0.1232 0.0058176205944685 Scatter Plot
Source OSM Source NCAM NCAM Cell-Cell Contact -0.1231 0.0058586165792169 Scatter Plot
Source OSM Target CD52 CD52 Cell-Cell Contact -0.1155 0.0097542307812452 Scatter Plot
Source OSM Source SEMA4 SEMA4 Cell-Cell Contact -0.1118 0.0123671837379637 Scatter Plot
Source OSM Target CEACAM CEACAM Cell-Cell Contact -0.1080 0.0156727334414839 Scatter Plot

Cells that are targets of OSM from HSCs*

Cells that are source of OSM to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.