Pathway: FN1

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: ECM-Receptor

Details on the FN1 pathway:

Specificity Index HSPC as target: 0.143
HSPC as source: 0.207

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the FN1 pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target FN1 Source PECAM1 PECAM1 Cell-Cell Contact 0.0969 0.0302324833012306 Scatter Plot
Source FN1 Source PDGF PDGF Secreted Signaling 0.1011 0.0237789911059582 Scatter Plot
Source FN1 Source ANGPTL ANGPTL Secreted Signaling 0.1016 0.0230485328296654 Scatter Plot
Source FN1 Source ESAM ESAM Cell-Cell Contact 0.1045 0.0193867723322375 Scatter Plot
Source FN1 Source MK MK Secreted Signaling 0.1046 0.0193493552071018 Scatter Plot
Source FN1 Source NOTCH NOTCH Cell-Cell Contact 0.1057 0.0180318348996326 Scatter Plot
Target FN1 Target CXCL CXCL Secreted Signaling 0.1069 0.016831770845396 Scatter Plot
Source FN1 Source OSM OSM Secreted Signaling 0.1072 0.0165032058725938 Scatter Plot
Source FN1 Source GRN GRN Secreted Signaling 0.1082 0.0155135333837792 Scatter Plot
Target FN1 Target GAS GAS Secreted Signaling 0.1095 0.0143376066495235 Scatter Plot
Target FN1 Source TGFb TGFb Secreted Signaling 0.1095 0.0142997897249559 Scatter Plot
Target FN1 Source AGRN AGRN ECM-Receptor 0.1115 0.0125718825597869 Scatter Plot
Target FN1 Source IL16 IL16 Secreted Signaling 0.1207 0.0069131445503464 Scatter Plot
Source FN1 Source WNT WNT Secreted Signaling 0.1226 0.0060529927622916 Scatter Plot
Target FN1 Source WNT WNT Secreted Signaling 0.1249 0.0051647350974247 Scatter Plot
Target FN1 Target RANKL RANKL Secreted Signaling 0.1250 0.0051221556292208 Scatter Plot
Target FN1 Target AGT AGT Secreted Signaling 0.1250 0.0051182376184056 Scatter Plot
Source FN1 Source PROS PROS Secreted Signaling 0.1266 0.0045641135290907 Scatter Plot
Source FN1 Source SEMA6 SEMA6 Cell-Cell Contact 0.1271 0.0044312715161958 Scatter Plot
Target FN1 Source THBS THBS ECM-Receptor 0.1274 0.0043414345535003 Scatter Plot
Source FN1 Source APP APP Cell-Cell Contact 0.1304 0.0034900131657611 Scatter Plot
Target FN1 Source CD39 CD39 Cell-Cell Contact 0.1333 0.0028121156617883 Scatter Plot
Target FN1 Source CD34 CD34 Cell-Cell Contact 0.1344 0.0025999989401166 Scatter Plot
Target FN1 Source RANKL RANKL Secreted Signaling 0.1354 0.0024156258917802 Scatter Plot
Target FN1 Target GDF GDF Secreted Signaling 0.1408 0.0015931309723217 Scatter Plot
Target FN1 Source ANGPTL ANGPTL Secreted Signaling 0.1411 0.0015632658161349 Scatter Plot
Target FN1 Source OSM OSM Secreted Signaling 0.1434 0.0012999907524126 Scatter Plot
Target FN1 Source SEMA3 SEMA3 Secreted Signaling 0.1439 0.001255127432883 Scatter Plot
Target FN1 Source ncWNT ncWNT Secreted Signaling 0.1453 0.0011229415212992 Scatter Plot
Target FN1 Source CSF CSF Secreted Signaling 0.1458 0.0010764258035165 Scatter Plot
Target FN1 Source LIGHT LIGHT Secreted Signaling 0.1484 0.0008721267559254 Scatter Plot
Source FN1 Source IL6 IL6 Secreted Signaling 0.1535 0.0005725852264734 Scatter Plot
Target FN1 Source SEMA4 SEMA4 Cell-Cell Contact 0.1571 0.0004226067140669 Scatter Plot
Target FN1 Source VEGF VEGF Secreted Signaling 0.1589 0.0003596682734779 Scatter Plot
Target FN1 Source NOTCH NOTCH Cell-Cell Contact 0.1603 0.0003202747524012 Scatter Plot
Target FN1 Target CD200 CD200 Cell-Cell Contact 0.1612 0.0002963280041144 Scatter Plot
Source FN1 Source SELPLG SELPLG Cell-Cell Contact 0.1619 0.0002767730888692 Scatter Plot
Target FN1 Source GDF GDF Secreted Signaling 0.1656 0.0001995638452342 Scatter Plot
Target FN1 Source CDH CDH Cell-Cell Contact 0.1664 0.000186095741024 Scatter Plot
Target FN1 Source LAMININ LAMININ ECM-Receptor 0.1670 0.0001755978147826 Scatter Plot
Target FN1 Source NT NT Secreted Signaling 0.1678 0.0001630501026855 Scatter Plot
Target FN1 Source CD1D2 CD1D2 Cell-Cell Contact 0.1701 0.0001327752825074 Scatter Plot
Target FN1 Target COMPLEMENT COMPLEMENT Secreted Signaling 0.1759 0.00007687501115436413 Scatter Plot
Target FN1 Source CD46 CD46 Cell-Cell Contact 0.1763 0.00007360932109596261 Scatter Plot
Target FN1 Target SEMA5 SEMA5 Cell-Cell Contact 0.1776 0.00006514471483824842 Scatter Plot
Source FN1 Source PSAP PSAP Secreted Signaling 0.1814 0.000045203874212684415 Scatter Plot
Target FN1 Target SEMA6 SEMA6 Cell-Cell Contact 0.1817 0.00004372216405277024 Scatter Plot
Target FN1 Source IGF IGF Secreted Signaling 0.1857 0.000029399403730811448 Scatter Plot
Target FN1 Source BST2 BST2 Cell-Cell Contact 0.1931 0.000013665985313742198 Scatter Plot
Target FN1 Source MK MK Secreted Signaling 0.1939 0.000012565559326480018 Scatter Plot
Target FN1 Source IL2 IL2 Secreted Signaling 0.1961 0.000009959500771338338 Scatter Plot
Target FN1 Source CCL CCL Secreted Signaling 0.1978 0.000008347774820945615 Scatter Plot
Target FN1 Source PTN PTN Secreted Signaling 0.1994 0.000006992503535384192 Scatter Plot
Target FN1 Target EPHB EPHB Cell-Cell Contact 0.2018 0.000005416160657664766 Scatter Plot
Target FN1 Target BMP BMP Secreted Signaling 0.2059 0.000003449631272426934 Scatter Plot
Target FN1 Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.2097 0.0000022364913177068327 Scatter Plot
Target FN1 Source SEMA7 SEMA7 Cell-Cell Contact 0.2160 0.0000010804907556364727 Scatter Plot
Target FN1 Source THY1 THY1 Cell-Cell Contact 0.2162 0.000001055565121453085 Scatter Plot
Target FN1 Source CX3C CX3C Secreted Signaling 0.2210 0.000000596377666302758 Scatter Plot
Target FN1 Source PROS PROS Secreted Signaling 0.2222 0.0000005173404597246242 Scatter Plot
Target FN1 Target VEGF VEGF Secreted Signaling 0.2244 0.000000397882582175405 Scatter Plot
Target FN1 Target ACTIVIN ACTIVIN Secreted Signaling 0.2276 0.0000002669328382559365 Scatter Plot
Target FN1 Source CD86 CD86 Cell-Cell Contact 0.2372 0.00000008007591108052438 Scatter Plot
Target FN1 Source CADM CADM Cell-Cell Contact 0.2400 0.000000055229803165740425 Scatter Plot
Target FN1 Source PSAP PSAP Secreted Signaling 0.2479 0.000000019252860742709546 Scatter Plot
Target FN1 Source GAS GAS Secreted Signaling 0.2524 0.000000010482507777657008 Scatter Plot
Target FN1 Source PDGF PDGF Secreted Signaling 0.2534 0.000000009113506115792704 Scatter Plot
Target FN1 Target SLURP SLURP Secreted Signaling 0.2566 0.000000005863031832801755 Scatter Plot
Target FN1 Source CD45 CD45 Cell-Cell Contact 0.2605 0.000000003341498924434451 Scatter Plot
Target FN1 Source IL7 IL7 Secreted Signaling 0.2665 0.0000000014172852426699151 Scatter Plot
Target FN1 Source BMP BMP Secreted Signaling 0.2710 0.0000000007231236026005098 Scatter Plot
Target FN1 Source IL1 IL1 Secreted Signaling 0.2714 0.0000000006782188645375461 Scatter Plot
Target FN1 Source GP1BA GP1BA Cell-Cell Contact 0.2744 0.0000000004345170365686186 Scatter Plot
Target FN1 Source LCK LCK Cell-Cell Contact 0.2751 0.000000000390352698705943 Scatter Plot
Target FN1 Source ICAM ICAM Cell-Cell Contact 0.2787 0.00000000022646514172849507 Scatter Plot
Target FN1 Source FLT3 FLT3 Secreted Signaling 0.2961 0.000000000013991466222103809 Scatter Plot
Target FN1 Target FGF FGF Secreted Signaling 0.3078 0.000000000001975933351795597 Scatter Plot
Target FN1 Target WNT WNT Secreted Signaling 0.3085 0.000000000001725008125616581 Scatter Plot
Target FN1 Source CXCL CXCL Secreted Signaling 0.3112 0.000000000001085591627395605 Scatter Plot
Target FN1 Source FGF FGF Secreted Signaling 0.3137 0.0000000000007037459546543158 Scatter Plot
Target FN1 Source COLLAGEN COLLAGEN ECM-Receptor 0.3174 0.00000000000036591436199078273 Scatter Plot
Target FN1 Source GALECTIN GALECTIN Secreted Signaling 0.3195 0.00000000000024712398169059963 Scatter Plot
Target FN1 Source EPHB EPHB Cell-Cell Contact 0.3201 0.00000000000022414366199473162 Scatter Plot
Target FN1 Target ncWNT ncWNT Secreted Signaling 0.3232 0.0000000000001280207040146708 Scatter Plot
Target FN1 Source TWEAK TWEAK Secreted Signaling 0.3344 0.00000000000001563506319526209 Scatter Plot
Target FN1 Source JAM JAM Cell-Cell Contact 0.3453 0.0000000000000018824281696914517 Scatter Plot
Target FN1 Source ESAM ESAM Cell-Cell Contact 0.3501 0.0000000000000007288202969351404 Scatter Plot
Target FN1 Target KIT KIT Secreted Signaling 0.3556 0.0000000000000002392633049558489 Scatter Plot
Target FN1 Source LIFR LIFR Secreted Signaling 0.3559 0.0000000000000002241250612697193 Scatter Plot
Target FN1 Source MHC-II MHC-II Cell-Cell Contact 0.3973 0.0000000000000000000232561564729211 Scatter Plot
Target FN1 Source ANGPT ANGPT Secreted Signaling 0.3998 0.000000000000000000012800226716872948 Scatter Plot
Target FN1 Target CD39 CD39 Cell-Cell Contact 0.4336 0.00000000000000000000000244370472189382 Scatter Plot
Target FN1 Source MHC-I MHC-I Cell-Cell Contact 0.4390 0.0000000000000000000000005564980119673584 Scatter Plot
Target FN1 Target PARs PARs Secreted Signaling 0.5569 0.0000000000000000000000000000000000000000043598340638233546 Scatter Plot
Target FN1 Source COMPLEMENT COMPLEMENT Secreted Signaling -0.4136 0.0000000000000000000004352168923972 Scatter Plot
Target FN1 Source SELL SELL Cell-Cell Contact -0.3524 0.0000000000000004586970581514382 Scatter Plot
Target FN1 Source VISTA VISTA Cell-Cell Contact -0.3501 0.0000000000000007286166263366936 Scatter Plot
Target FN1 Source PARs PARs Secreted Signaling -0.3393 0.000000000000006112108658241722 Scatter Plot
Target FN1 Source ANNEXIN ANNEXIN Secreted Signaling -0.3187 0.0000000000002854602137720993 Scatter Plot
Target FN1 Source CD52 CD52 Cell-Cell Contact -0.3056 0.000000000002851203056078008 Scatter Plot
Target FN1 Source SEMA4 SEMA4 Cell-Cell Contact -0.2748 0.00000000041169893505970124 Scatter Plot
Target FN1 Source APP APP Cell-Cell Contact -0.2744 0.00000000043846188641540847 Scatter Plot
Target FN1 Source NCAM NCAM Cell-Cell Contact -0.2740 0.0000000004623466260740829 Scatter Plot
Target FN1 Source CCL CCL Secreted Signaling -0.2598 0.000000003700954324968646 Scatter Plot
Target FN1 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.2380 0.00000007173573700589017 Scatter Plot
Target FN1 Source LAIR1 LAIR1 Cell-Cell Contact -0.2319 0.00000015639036389033706 Scatter Plot
Target FN1 Target CXCL CXCL Secreted Signaling -0.2086 0.0000025289195494257617 Scatter Plot
Target FN1 Target IL17 IL17 Secreted Signaling -0.2035 0.000004490727975610428 Scatter Plot
Target FN1 Source MIF MIF Secreted Signaling -0.1969 0.0000092194702677758 Scatter Plot
Target FN1 Target ANNEXIN ANNEXIN Secreted Signaling -0.1880 0.00002317405926285964 Scatter Plot
Target FN1 Source CLEC CLEC Cell-Cell Contact -0.1855 0.000029972317472484215 Scatter Plot
Target FN1 Source SPP1 SPP1 Secreted Signaling -0.1816 0.000044298280509386994 Scatter Plot
Target FN1 Source GRN GRN Secreted Signaling -0.1524 0.0006287508549241 Scatter Plot
Target FN1 Target SEMA3 SEMA3 Secreted Signaling -0.1494 0.0008046099276238 Scatter Plot
Target FN1 Source TNF TNF Secreted Signaling -0.1493 0.0008101795296862 Scatter Plot
Target FN1 Source BAFF BAFF Secreted Signaling -0.1430 0.0013408893708148 Scatter Plot
Target FN1 Source ANGPTL ANGPTL Secreted Signaling -0.1348 0.0025193638201999 Scatter Plot
Target FN1 Source VISFATIN VISFATIN Secreted Signaling -0.1219 0.0063596049138392 Scatter Plot
Source FN1 Source EPHB EPHB Cell-Cell Contact -0.1100 0.0138304325169826 Scatter Plot
Target FN1 Target PECAM1 PECAM1 Cell-Cell Contact 0.0969 0.0302324833012306 Scatter Plot
Source FN1 Target ENHO ENHO Secreted Signaling 0.0977 0.0289207747387538 Scatter Plot
Target FN1 Target PDGF PDGF Secreted Signaling 0.1005 0.0245663590750286 Scatter Plot
Source FN1 Target BMP BMP Secreted Signaling 0.1016 0.0230961352859628 Scatter Plot
Source FN1 Target VEGF VEGF Secreted Signaling 0.1023 0.0221256865504945 Scatter Plot
Source FN1 Target ESAM ESAM Cell-Cell Contact 0.1045 0.0193867723322375 Scatter Plot
Source FN1 Target CXCL CXCL Secreted Signaling 0.1059 0.0178204457914465 Scatter Plot
Target FN1 Target NOTCH NOTCH Cell-Cell Contact 0.1060 0.0177556558343525 Scatter Plot
Target FN1 Target BST2 BST2 Cell-Cell Contact 0.1091 0.0146684404785631 Scatter Plot
Target FN1 Target LAIR1 LAIR1 Cell-Cell Contact 0.1091 0.0146684404785631 Scatter Plot
Target FN1 Target CD45 CD45 Cell-Cell Contact 0.1150 0.0100949564327108 Scatter Plot
Target FN1 Target EPHA EPHA Cell-Cell Contact 0.1174 0.008604666592602 Scatter Plot
Target FN1 Target SELL SELL Cell-Cell Contact 0.1225 0.0060833472169293 Scatter Plot
Source FN1 Target SELPLG SELPLG Cell-Cell Contact 0.1226 0.0060719589382435 Scatter Plot
Target FN1 Target IL6 IL6 Secreted Signaling 0.1341 0.0026537705830463 Scatter Plot
Source FN1 Source CCL CCL Secreted Signaling 0.1355 0.0023973484254349 Scatter Plot
Target FN1 Target NODAL NODAL Secreted Signaling 0.1356 0.0023726938250857 Scatter Plot
Source FN1 Target CSF CSF Secreted Signaling 0.1445 0.001196172163612 Scatter Plot
Target FN1 Target OSM OSM Secreted Signaling 0.1536 0.0005690491951611 Scatter Plot
Target FN1 Target CDH CDH Cell-Cell Contact 0.1664 0.000186095741024 Scatter Plot
Source FN1 Target SEMA4 SEMA4 Cell-Cell Contact 0.1736 0.00009540491952910756 Scatter Plot
Source FN1 Target CCL CCL Secreted Signaling 0.1952 0.000010970258527824469 Scatter Plot
Target FN1 Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1981 0.00000808359204717299 Scatter Plot
Source FN1 Target IL6 IL6 Secreted Signaling 0.2075 0.0000028890745351034702 Scatter Plot
Source FN1 Target OSM OSM Secreted Signaling 0.2330 0.00000013621165773696321 Scatter Plot
Target FN1 Target CADM CADM Cell-Cell Contact 0.2400 0.000000055229803165740425 Scatter Plot
Target FN1 Target APP APP Cell-Cell Contact 0.2513 0.000000012224289196474009 Scatter Plot
Target FN1 Target BAFF BAFF Secreted Signaling 0.2592 0.000000004045362861347519 Scatter Plot
Target FN1 Target CD22 CD22 Cell-Cell Contact 0.2605 0.000000003341498924434451 Scatter Plot
Target FN1 Target NPR2 NPR2 Secreted Signaling 0.2639 0.000000002048153885366194 Scatter Plot
Target FN1 Target TGFb TGFb Secreted Signaling 0.2823 0.0000000001299776715170543 Scatter Plot
Target FN1 Target FGF FGF Secreted Signaling 0.2845 0.00000000009114873381733507 Scatter Plot
Target FN1 Target SEMA4 SEMA4 Cell-Cell Contact 0.3070 0.000000000002237999460390024 Scatter Plot
Target FN1 Target CD34 CD34 Cell-Cell Contact 0.3483 0.0000000000000010484706971071237 Scatter Plot
Target FN1 Target ESAM ESAM Cell-Cell Contact 0.3501 0.0000000000000007288202969351404 Scatter Plot
Target FN1 Target IFN-II IFN-II Secreted Signaling -0.3366 0.000000000000010365703912477455 Scatter Plot
Target FN1 Target CD52 CD52 Cell-Cell Contact -0.2998 0.000000000007652581380106073 Scatter Plot
Target FN1 Target VCAM VCAM Cell-Cell Contact -0.2932 0.000000000022831215590617388 Scatter Plot
Target FN1 Target VEGF VEGF Secreted Signaling -0.2539 0.000000008473965990956966 Scatter Plot
Target FN1 Target CLEC CLEC Cell-Cell Contact -0.2527 0.00000001012075111125228 Scatter Plot
Target FN1 Target CEACAM CEACAM Cell-Cell Contact -0.2349 0.0000001070555633587078 Scatter Plot
Target FN1 Target CCL CCL Secreted Signaling -0.2195 0.0000007139997163319237 Scatter Plot
Target FN1 Target ICAM ICAM Cell-Cell Contact -0.2192 0.0000007456639720655814 Scatter Plot
Target FN1 Target CSF CSF Secreted Signaling -0.2074 0.000002916637140171082 Scatter Plot
Target FN1 Target COMPLEMENT COMPLEMENT Secreted Signaling -0.1597 0.0003382738449936 Scatter Plot
Target FN1 Target SELPLG SELPLG Cell-Cell Contact -0.1482 0.0008859917271271 Scatter Plot
Target FN1 Target IL1 IL1 Secreted Signaling -0.1384 0.0019188445233555 Scatter Plot
Target FN1 Target GRN GRN Secreted Signaling -0.1354 0.0024108893987127 Scatter Plot
Source FN1 Source CD1D2 CD1D2 Cell-Cell Contact -0.1222 0.0062124977058264 Scatter Plot
Target FN1 Target NCAM NCAM Cell-Cell Contact -0.1078 0.0159151859214161 Scatter Plot
Source FN1 Target THBS THBS ECM-Receptor -0.1070 0.0166687175899809 Scatter Plot
Source FN1 Source CXCL CXCL Secreted Signaling -0.0971 0.0299003080296108 Scatter Plot

Cells that are targets of FN1 from HSCs*

Cells that are source of FN1 to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.