Pathway: CD45

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Cell-Cell Contact

Details on the CD45 pathway:

Specificity Index HSPC as target: 0.264
HSPC as source: 0.484

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the CD45 pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Source CD45 Source NCAM NCAM Cell-Cell Contact 0.0972 0.029779705069578 Scatter Plot
Target CD45 Target AGT AGT Secreted Signaling 0.0979 0.0285701589730828 Scatter Plot
Target CD45 Target PECAM1 PECAM1 Cell-Cell Contact 0.0983 0.0280237853616738 Scatter Plot
Target CD45 Source PECAM1 PECAM1 Cell-Cell Contact 0.0983 0.0280237853616738 Scatter Plot
Target CD45 Target SELE SELE Cell-Cell Contact 0.0988 0.0272257566494254 Scatter Plot
Target CD45 Source LIGHT LIGHT Secreted Signaling 0.0989 0.0269762721584228 Scatter Plot
Target CD45 Source SEMA4 SEMA4 Cell-Cell Contact 0.0996 0.0259852921310431 Scatter Plot
Target CD45 Source ICOS ICOS Cell-Cell Contact 0.1027 0.021625725189778 Scatter Plot
Target CD45 Source SEMA7 SEMA7 Cell-Cell Contact 0.1053 0.0185324071337732 Scatter Plot
Target CD45 Target SEMA3 SEMA3 Secreted Signaling 0.1058 0.0179968777076446 Scatter Plot
Target CD45 Source CCL CCL Secreted Signaling 0.1115 0.0126134417693194 Scatter Plot
Source CD45 Source CXCL CXCL Secreted Signaling 0.1126 0.0117218946042165 Scatter Plot
Source CD45 Source CD34 CD34 Cell-Cell Contact 0.1137 0.0109593961873588 Scatter Plot
Target CD45 Target FN1 FN1 ECM-Receptor 0.1150 0.0100949564327108 Scatter Plot
Source CD45 Source OSM OSM Secreted Signaling 0.1182 0.00816431637054 Scatter Plot
Target CD45 Source PSAP PSAP Secreted Signaling 0.1182 0.0081613594753489 Scatter Plot
Target CD45 Target GDF GDF Secreted Signaling 0.1184 0.0080526396946093 Scatter Plot
Source CD45 Source PECAM1 PECAM1 Cell-Cell Contact 0.1187 0.0078742566287711 Scatter Plot
Target CD45 Source SPP1 SPP1 Secreted Signaling 0.1194 0.0075071800572628 Scatter Plot
Target CD45 Source CLEC CLEC Cell-Cell Contact 0.1236 0.0056329400541187 Scatter Plot
Target CD45 Source BAFF BAFF Secreted Signaling 0.1237 0.005604842927017 Scatter Plot
Target CD45 Target CSPG4 CSPG4 Cell-Cell Contact 0.1247 0.0052228536739203 Scatter Plot
Target CD45 Target LAMININ LAMININ ECM-Receptor 0.1268 0.0045065002240177 Scatter Plot
Target CD45 Target COLLAGEN COLLAGEN ECM-Receptor 0.1327 0.0029566322134972 Scatter Plot
Target CD45 Target GALECTIN GALECTIN Secreted Signaling 0.1346 0.0025652444500803 Scatter Plot
Target CD45 Target SPP1 SPP1 Secreted Signaling 0.1348 0.0025192483840035 Scatter Plot
Target CD45 Target CADM CADM Cell-Cell Contact 0.1364 0.0022331119619392 Scatter Plot
Target CD45 Source CADM CADM Cell-Cell Contact 0.1364 0.0022331119619392 Scatter Plot
Target CD45 Target SEMA6 SEMA6 Cell-Cell Contact 0.1374 0.0020733178790806 Scatter Plot
Target CD45 Target CCL CCL Secreted Signaling 0.1388 0.0018641666862661 Scatter Plot
Source CD45 Source ncWNT ncWNT Secreted Signaling 0.1457 0.0010871104345823 Scatter Plot
Source CD45 Source PTN PTN Secreted Signaling 0.1568 0.0004313236636339 Scatter Plot
Target CD45 Target ESAM ESAM Cell-Cell Contact 0.1583 0.0003802579570918 Scatter Plot
Target CD45 Source ESAM ESAM Cell-Cell Contact 0.1583 0.0003802579570918 Scatter Plot
Source CD45 Source SEMA3 SEMA3 Secreted Signaling 0.1655 0.0002020783552639 Scatter Plot
Target CD45 Source WNT WNT Secreted Signaling 0.1675 0.0001685190079698 Scatter Plot
Source CD45 Source NT NT Secreted Signaling 0.1854 0.00003033023459556997 Scatter Plot
Target CD45 Source SEMA3 SEMA3 Secreted Signaling 0.1897 0.000019530299220281044 Scatter Plot
Source CD45 Source WNT WNT Secreted Signaling 0.1985 0.000007736910820317817 Scatter Plot
Source CD45 Source CCL CCL Secreted Signaling 0.1993 0.000007081855749782569 Scatter Plot
Source CD45 Source CD46 CD46 Cell-Cell Contact 0.2023 0.00000511468336611232 Scatter Plot
Source CD45 Source GRN GRN Secreted Signaling 0.2071 0.000003014373442715584 Scatter Plot
Source CD45 Source CADM CADM Cell-Cell Contact 0.2185 0.0000008039196750612445 Scatter Plot
Source CD45 Source GDF GDF Secreted Signaling 0.2251 0.0000003671863246754067 Scatter Plot
Source CD45 Source IL2 IL2 Secreted Signaling 0.2459 0.00000002524978481442073 Scatter Plot
Source CD45 Source PROS PROS Secreted Signaling 0.2513 0.000000012220072352052373 Scatter Plot
Source CD45 Source RANKL RANKL Secreted Signaling 0.2628 0.000000002412637735233735 Scatter Plot
Source CD45 Source NOTCH NOTCH Cell-Cell Contact 0.2721 0.0000000006132698491033568 Scatter Plot
Source CD45 Source CD39 CD39 Cell-Cell Contact 0.2851 0.00000000008337315421770148 Scatter Plot
Source CD45 Source LIFR LIFR Secreted Signaling 0.2930 0.00000000002356724013136781 Scatter Plot
Source CD45 Source CDH CDH Cell-Cell Contact 0.2946 0.000000000018021539197535848 Scatter Plot
Source CD45 Source EPHB EPHB Cell-Cell Contact 0.3034 0.000000000004194865150918194 Scatter Plot
Source CD45 Source FLT3 FLT3 Secreted Signaling 0.3045 0.000000000003451278853583564 Scatter Plot
Source CD45 Source MK MK Secreted Signaling 0.3403 0.000000000000005074414402100237 Scatter Plot
Source CD45 Source PDGF PDGF Secreted Signaling 0.3405 0.0000000000000048987474788007 Scatter Plot
Source CD45 Source VEGF VEGF Secreted Signaling 0.3431 0.0000000000000029103958404640128 Scatter Plot
Source CD45 Source LAMININ LAMININ ECM-Receptor 0.3696 0.000000000000000012387050388341689 Scatter Plot
Source CD45 Source IL7 IL7 Secreted Signaling 0.4097 0.0000000000000000000011685774799706233 Scatter Plot
Source CD45 Source LIGHT LIGHT Secreted Signaling 0.4115 0.000000000000000000000743914603460769 Scatter Plot
Source CD45 Source BMP BMP Secreted Signaling 0.4221 0.000000000000000000000049648012905394243 Scatter Plot
Source CD45 Source TWEAK TWEAK Secreted Signaling 0.4420 0.00000000000000000000000024934386526039787 Scatter Plot
Source CD45 Source ESAM ESAM Cell-Cell Contact 0.4468 0.000000000000000000000000065256753499139 Scatter Plot
Source CD45 Source COLLAGEN COLLAGEN ECM-Receptor 0.4577 0.000000000000000000000000002902457572080121 Scatter Plot
Source CD45 Source ANGPT ANGPT Secreted Signaling 0.4757 0.00000000000000000000000000001312763625312542 Scatter Plot
Source CD45 Source JAM JAM Cell-Cell Contact 0.4792 0.0000000000000000000000000000044697707947358286 Scatter Plot
Source CD45 Source GAS GAS Secreted Signaling 0.5053 0.0000000000000000000000000000000009221415053154632 Scatter Plot
Source CD45 Source MIF MIF Secreted Signaling -0.5084 0.0000000000000000000000000000000003103206189656986 Scatter Plot
Source CD45 Source TGFb TGFb Secreted Signaling -0.3766 0.0000000000000000026818619107267372 Scatter Plot
Source CD45 Source PARs PARs Secreted Signaling -0.2462 0.000000024374766255573067 Scatter Plot
Source CD45 Source SEMA4 SEMA4 Cell-Cell Contact -0.2162 0.00000106024591062415 Scatter Plot
Source CD45 Source VISFATIN VISFATIN Secreted Signaling -0.1455 0.0010990308652563 Scatter Plot
Source CD45 Source CD52 CD52 Cell-Cell Contact -0.1278 0.0042003871281299 Scatter Plot
Source CD45 Source GALECTIN GALECTIN Secreted Signaling -0.1169 0.0089043921279613 Scatter Plot
Target CD45 Source ICAM ICAM Cell-Cell Contact -0.1017 0.0229685562127138 Scatter Plot
Target CD45 Source APELIN APELIN Secreted Signaling -0.0994 0.026220759314228 Scatter Plot
Target CD45 Target APP APP Cell-Cell Contact 0.0971 0.0299991536622759 Scatter Plot
Target CD45 Target SELPLG SELPLG Cell-Cell Contact 0.1101 0.0137794365221675 Scatter Plot
Source CD45 Source APP APP Cell-Cell Contact 0.1121 0.0121100560597297 Scatter Plot
Source CD45 Target SELL SELL Cell-Cell Contact 0.1128 0.0116161829010731 Scatter Plot
Source CD45 Target PECAM1 PECAM1 Cell-Cell Contact 0.1187 0.0078742566287711 Scatter Plot
Source CD45 Source BAFF BAFF Secreted Signaling 0.1231 0.0058469809477965 Scatter Plot
Source CD45 Target SEMA3 SEMA3 Secreted Signaling 0.1304 0.0034929301300462 Scatter Plot
Target CD45 Target BAFF BAFF Secreted Signaling 0.1391 0.0018221093639775 Scatter Plot
Source CD45 Target BST2 BST2 Cell-Cell Contact 0.1596 0.0003391979274005 Scatter Plot
Source CD45 Target LAIR1 LAIR1 Cell-Cell Contact 0.1596 0.0003391979274005 Scatter Plot
Source CD45 Target SEMA6 SEMA6 Cell-Cell Contact 0.1642 0.0002262194024301 Scatter Plot
Source CD45 Source ANGPTL ANGPTL Secreted Signaling 0.1647 0.0002159760608846 Scatter Plot
Source CD45 Target SEMA5 SEMA5 Cell-Cell Contact 0.1656 0.0001998114345612 Scatter Plot
Source CD45 Target SELE SELE Cell-Cell Contact 0.1681 0.0001586296907708 Scatter Plot
Source CD45 Target RANKL RANKL Secreted Signaling 0.1715 0.0001166650386848 Scatter Plot
Source CD45 Target COLLAGEN COLLAGEN ECM-Receptor 0.1745 0.00008796318579749731 Scatter Plot
Source CD45 Target EPHA EPHA Cell-Cell Contact 0.1772 0.00006771309512291598 Scatter Plot
Source CD45 Target IL1 IL1 Secreted Signaling 0.1791 0.00005626354317025534 Scatter Plot
Source CD45 Target SPP1 SPP1 Secreted Signaling 0.1812 0.000046116460713013485 Scatter Plot
Source CD45 Source ICOS ICOS Cell-Cell Contact 0.1844 0.00003332169974401404 Scatter Plot
Source CD45 Target OSM OSM Secreted Signaling 0.1884 0.000022214729670038462 Scatter Plot
Source CD45 Target COMPLEMENT COMPLEMENT Secreted Signaling 0.1912 0.00001670829390239271 Scatter Plot
Source CD45 Target CSPG4 CSPG4 Cell-Cell Contact 0.1932 0.000013562117688471192 Scatter Plot
Source CD45 Source ANNEXIN ANNEXIN Secreted Signaling 0.1963 0.000009847093051674634 Scatter Plot
Source CD45 Target IL6 IL6 Secreted Signaling 0.1991 0.000007239452633905562 Scatter Plot
Source CD45 Source CD46 CD46 Cell-Cell Contact 0.2023 0.000005114683366112337 Scatter Plot
Source CD45 Target VEGF VEGF Secreted Signaling 0.2048 0.000003886373310373125 Scatter Plot
Source CD45 Source THY1 THY1 Cell-Cell Contact 0.2141 0.0000013583567860766105 Scatter Plot
Source CD45 Target CADM CADM Cell-Cell Contact 0.2185 0.0000008039196750612445 Scatter Plot
Source CD45 Source CADM CADM Cell-Cell Contact 0.2185 0.0000008039196750612445 Scatter Plot
Source CD45 Target GDF GDF Secreted Signaling 0.2294 0.0000002150953227144349 Scatter Plot
Source CD45 Source VCAM VCAM Cell-Cell Contact 0.2345 0.00000011234402341554647 Scatter Plot
Source CD45 Target NOTCH NOTCH Cell-Cell Contact 0.2364 0.00000008897167910074603 Scatter Plot
Source CD45 Target VISFATIN VISFATIN Secreted Signaling 0.2367 0.0000000852729496067036 Scatter Plot
Source CD45 Source CD1D2 CD1D2 Cell-Cell Contact 0.2369 0.00000008306874217050903 Scatter Plot
Source CD45 Target SEMA7 SEMA7 Cell-Cell Contact 0.2523 0.000000010638438238055076 Scatter Plot
Source CD45 Target PARs PARs Secreted Signaling 0.2589 0.000000004212764747408821 Scatter Plot
Source CD45 Target EPHB EPHB Cell-Cell Contact 0.2602 0.0000000035159288862190998 Scatter Plot
Source CD45 Target FN1 FN1 ECM-Receptor 0.2605 0.000000003341498924434451 Scatter Plot
Source CD45 Source CXCL CXCL Secreted Signaling 0.2608 0.0000000032008981385351892 Scatter Plot
Source CD45 Target VWF VWF ECM-Receptor 0.2626 0.0000000024898103273820033 Scatter Plot
Source CD45 Source CSF CSF Secreted Signaling 0.2632 0.000000002295607872171169 Scatter Plot
Source CD45 Source IGF IGF Secreted Signaling 0.2800 0.00000000018468363365400058 Scatter Plot
Source CD45 Source CD39 CD39 Cell-Cell Contact 0.2851 0.00000000008337315421770089 Scatter Plot
Source CD45 Target VTN VTN ECM-Receptor 0.2855 0.00000000007777181450369302 Scatter Plot
Source CD45 Target NCAM NCAM Cell-Cell Contact 0.2936 0.000000000021116106098860534 Scatter Plot
Source CD45 Source CDH CDH Cell-Cell Contact 0.2946 0.000000000018021539197535848 Scatter Plot
Source CD45 Target CDH CDH Cell-Cell Contact 0.2946 0.000000000018021539197535848 Scatter Plot
Source CD45 Target NODAL NODAL Secreted Signaling 0.3091 0.0000000000015773922850100485 Scatter Plot
Source CD45 Source BST2 BST2 Cell-Cell Contact 0.3122 0.0000000000009193748998800874 Scatter Plot
Source CD45 Target BMP BMP Secreted Signaling 0.3148 0.0000000000005798246963557344 Scatter Plot
Source CD45 Source CCL CCL Secreted Signaling 0.3192 0.00000000000026426215778694506 Scatter Plot
Source CD45 Target ANGPTL ANGPTL Secreted Signaling 0.3239 0.00000000000011163705186974723 Scatter Plot
Source CD45 Target THBS THBS ECM-Receptor 0.3377 0.000000000000008365017754101696 Scatter Plot
Source CD45 Target THY1 THY1 Cell-Cell Contact 0.3404 0.00000000000000492750725026171 Scatter Plot
Source CD45 Source CX3C CX3C Secreted Signaling 0.3486 0.0000000000000009752773484982357 Scatter Plot
Source CD45 Target LAMININ LAMININ ECM-Receptor 0.3491 0.0000000000000008877445003768247 Scatter Plot
Source CD45 Target ACTIVIN ACTIVIN Secreted Signaling 0.3493 0.0000000000000008534149870640207 Scatter Plot
Source CD45 Target KIT KIT Secreted Signaling 0.3555 0.0000000000000002395267208033871 Scatter Plot
Source CD45 Target TENASCIN TENASCIN ECM-Receptor 0.3573 0.00000000000000016725728605280144 Scatter Plot
Source CD45 Source CD86 CD86 Cell-Cell Contact 0.3630 0.00000000000000005091721527634807 Scatter Plot
Source CD45 Source ICAM ICAM Cell-Cell Contact 0.3641 0.00000000000000003987186883640754 Scatter Plot
Source CD45 Target ANGPT ANGPT Secreted Signaling 0.3647 0.000000000000000035617022162864866 Scatter Plot
Source CD45 Target NPR2 NPR2 Secreted Signaling 0.3665 0.000000000000000024087455756106485 Scatter Plot
Source CD45 Target NRG NRG Secreted Signaling 0.3693 0.00000000000000001338153615033816 Scatter Plot
Source CD45 Target CD23 CD23 Cell-Cell Contact 0.3696 0.000000000000000012301337709533798 Scatter Plot
Source CD45 Target PERIOSTIN PERIOSTIN Secreted Signaling 0.3721 0.000000000000000007150541564410576 Scatter Plot
Source CD45 Target BSP BSP ECM-Receptor 0.3748 0.00000000000000000403367001895198 Scatter Plot
Source CD45 Target DMP1 DMP1 ECM-Receptor 0.3775 0.0000000000000000022100675976967603 Scatter Plot
Source CD45 Source LCK LCK Cell-Cell Contact 0.3811 0.0000000000000000009754940231930185 Scatter Plot
Source CD45 Target TGFb TGFb Secreted Signaling 0.3817 0.0000000000000000008663966664533873 Scatter Plot
Source CD45 Target CD34 CD34 Cell-Cell Contact 0.3902 0.0000000000000000001230082230282152 Scatter Plot
Source CD45 Target SEMA4 SEMA4 Cell-Cell Contact 0.4025 0.000000000000000000006672884236261836 Scatter Plot
Source CD45 Target WNT WNT Secreted Signaling 0.4073 0.0000000000000000000020751508859836906 Scatter Plot
Source CD45 Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.4078 0.0000000000000000000018464238454281586 Scatter Plot
Source CD45 Source SEMA7 SEMA7 Cell-Cell Contact 0.4162 0.0000000000000000000002274316447088247 Scatter Plot
Source CD45 Target IGF IGF Secreted Signaling 0.4179 0.0000000000000000000001488389207678441 Scatter Plot
Source CD45 Target FGF FGF Secreted Signaling 0.4218 0.00000000000000000000005362241395441491 Scatter Plot
Source CD45 Target ncWNT ncWNT Secreted Signaling 0.4257 0.00000000000000000000001979268191842481 Scatter Plot
Source CD45 Target SLURP SLURP Secreted Signaling 0.4291 0.000000000000000000000008048350572191757 Scatter Plot
Source CD45 Target ESAM ESAM Cell-Cell Contact 0.4468 0.00000000000000000000000006525675349913572 Scatter Plot
Source CD45 Source COLLAGEN COLLAGEN ECM-Receptor 0.4534 0.000000000000000000000000009923290794058843 Scatter Plot
Source CD45 Target BAFF BAFF Secreted Signaling 0.4692 0.00000000000000000000000000009615088108881136 Scatter Plot
Source CD45 Target APP APP Cell-Cell Contact 0.4802 0.0000000000000000000000000000033116232623584455 Scatter Plot
Source CD45 Source PSAP PSAP Secreted Signaling 0.4969 0.000000000000000000000000000000015179757225314816 Scatter Plot
Source CD45 Target CD200 CD200 Cell-Cell Contact 0.5155 0.00000000000000000000000000000000002618763023528923 Scatter Plot
Source CD45 Target CD39 CD39 Cell-Cell Contact 0.5189 0.000000000000000000000000000000000008088907179721016 Scatter Plot
Source CD45 Target JAM JAM Cell-Cell Contact 0.5226 0.0000000000000000000000000000000000021291965694186348 Scatter Plot
Source CD45 Source MHC-I MHC-I Cell-Cell Contact 0.5306 0.00000000000000000000000000000000000011292548436877857 Scatter Plot
Source CD45 Source IL16 IL16 Secreted Signaling 0.5476 0.0000000000000000000000000000000000000001788011258169628 Scatter Plot
Source CD45 Target MIF MIF Secreted Signaling 0.5555 0.000000000000000000000000000000000000000007852201673253741 Scatter Plot
Source CD45 Source MHC-II MHC-II Cell-Cell Contact 0.5611 0.0000000000000000000000000000000000000000007938536296697809 Scatter Plot
Source CD45 Source ANGPTL ANGPTL Secreted Signaling -0.3580 0.00000000000000014320914165973322 Scatter Plot
Source CD45 Target IL17 IL17 Secreted Signaling -0.2400 0.00000005577946859445172 Scatter Plot
Source CD45 Target CSF CSF Secreted Signaling -0.2320 0.0000001553112367378984 Scatter Plot
Source CD45 Source COMPLEMENT COMPLEMENT Secreted Signaling -0.1952 0.00001105508832337857 Scatter Plot
Source CD45 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.1811 0.00004642904615658449 Scatter Plot
Source CD45 Target VEGF VEGF Secreted Signaling -0.1511 0.0006993159093765 Scatter Plot
Source CD45 Source IL1 IL1 Secreted Signaling -0.1348 0.0025172175295835 Scatter Plot
Source CD45 Target CCL CCL Secreted Signaling -0.1328 0.0029194059800315 Scatter Plot
Source CD45 Target PTN PTN Secreted Signaling -0.1327 0.0029582334451783 Scatter Plot
Source CD45 Source CD52 CD52 Cell-Cell Contact -0.1278 0.0042003871281299 Scatter Plot
Source CD45 Target VCAM VCAM Cell-Cell Contact -0.1269 0.0044984127607262 Scatter Plot
Source CD45 Source SELL SELL Cell-Cell Contact -0.1214 0.0065529637917457 Scatter Plot
Source CD45 Source NKG2D NKG2D Cell-Cell Contact -0.1201 0.0071776464335087 Scatter Plot
Source CD45 Target CXCL CXCL Secreted Signaling -0.1196 0.0074291842536948 Scatter Plot
Source CD45 Target CD52 CD52 Cell-Cell Contact -0.1185 0.0079795838704272 Scatter Plot
Source CD45 Target ICAM ICAM Cell-Cell Contact -0.1126 0.0117698624413362 Scatter Plot
Source CD45 Target CLEC CLEC Cell-Cell Contact -0.1087 0.0149819536153502 Scatter Plot
Source CD45 Target IFN-II IFN-II Secreted Signaling -0.1056 0.0182096292874792 Scatter Plot
Source CD45 Source CCL CCL Secreted Signaling -0.1038 0.0203161497425222 Scatter Plot

Cells that are targets of CD45 from HSCs*

Cells that are source of CD45 to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.