Pathway: SPP1

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the SPP1 pathway:

Specificity Index HSPC as target: 0.144
HSPC as source: 0.340

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the SPP1 pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target SPP1 Target SEMA3 SEMA3 Secreted Signaling 0.1014 0.0233763479019851 Scatter Plot
Target SPP1 Target ICAM ICAM Cell-Cell Contact 0.1037 0.0203756404392377 Scatter Plot
Target SPP1 Target NOTCH NOTCH Cell-Cell Contact 0.1049 0.0189451140093339 Scatter Plot
Target SPP1 Source CD34 CD34 Cell-Cell Contact 0.1052 0.0186544677745535 Scatter Plot
Target SPP1 Source AGRN AGRN ECM-Receptor 0.1075 0.016162999126527 Scatter Plot
Target SPP1 Target SELL SELL Cell-Cell Contact 0.1093 0.0144507600287986 Scatter Plot
Target SPP1 Target GAS GAS Secreted Signaling 0.1131 0.011374793771397 Scatter Plot
Target SPP1 Source CSF CSF Secreted Signaling 0.1163 0.009263818468855 Scatter Plot
Target SPP1 Source IL16 IL16 Secreted Signaling 0.1189 0.0077632609882638 Scatter Plot
Source SPP1 Source VISFATIN VISFATIN Secreted Signaling 0.1202 0.0071499122868948 Scatter Plot
Source SPP1 Source SELPLG SELPLG Cell-Cell Contact 0.1254 0.0049810766401314 Scatter Plot
Target SPP1 Source SELPLG SELPLG Cell-Cell Contact 0.1285 0.0040007948195875 Scatter Plot
Target SPP1 Source NOTCH NOTCH Cell-Cell Contact 0.1310 0.003328096893791 Scatter Plot
Target SPP1 Source RANKL RANKL Secreted Signaling 0.1311 0.0033149229882687 Scatter Plot
Target SPP1 Source CD39 CD39 Cell-Cell Contact 0.1357 0.0023512789418152 Scatter Plot
Target SPP1 Source ncWNT ncWNT Secreted Signaling 0.1374 0.0020787956944626 Scatter Plot
Target SPP1 Source LIGHT LIGHT Secreted Signaling 0.1380 0.0019866488552197 Scatter Plot
Target SPP1 Source PTN PTN Secreted Signaling 0.1407 0.0016161457681099 Scatter Plot
Target SPP1 Source OSM OSM Secreted Signaling 0.1440 0.0012481049255378 Scatter Plot
Target SPP1 Target AGT AGT Secreted Signaling 0.1464 0.0010234984466344 Scatter Plot
Target SPP1 Source SEMA4 SEMA4 Cell-Cell Contact 0.1468 0.0009927012919135 Scatter Plot
Target SPP1 Target GDF GDF Secreted Signaling 0.1504 0.0007400261982609 Scatter Plot
Target SPP1 Source SEMA3 SEMA3 Secreted Signaling 0.1528 0.0006078737122496 Scatter Plot
Target SPP1 Source ANGPTL ANGPTL Secreted Signaling 0.1535 0.0005716692908202 Scatter Plot
Target SPP1 Source PROS PROS Secreted Signaling 0.1542 0.0005414142461961 Scatter Plot
Target SPP1 Source LAMININ LAMININ ECM-Receptor 0.1569 0.0004307245674708 Scatter Plot
Target SPP1 Source CCL CCL Secreted Signaling 0.1646 0.0002180411023117 Scatter Plot
Target SPP1 Source PSAP PSAP Secreted Signaling 0.1648 0.0002145437228043 Scatter Plot
Target SPP1 Source CD46 CD46 Cell-Cell Contact 0.1695 0.0001393318614178 Scatter Plot
Target SPP1 Source IL2 IL2 Secreted Signaling 0.1723 0.0001074589935186 Scatter Plot
Target SPP1 Source VEGF VEGF Secreted Signaling 0.1787 0.000058459460200579207 Scatter Plot
Target SPP1 Source CD45 CD45 Cell-Cell Contact 0.1812 0.000046116460713013485 Scatter Plot
Target SPP1 Source CADM CADM Cell-Cell Contact 0.1836 0.0000363776153848652 Scatter Plot
Target SPP1 Source BST2 BST2 Cell-Cell Contact 0.1839 0.00003498592999564127 Scatter Plot
Target SPP1 Target OSM OSM Secreted Signaling 0.1872 0.000025305206599090984 Scatter Plot
Target SPP1 Source GDF GDF Secreted Signaling 0.1877 0.000023920002080643527 Scatter Plot
Target SPP1 Target SEMA6 SEMA6 Cell-Cell Contact 0.1903 0.00001843169150526767 Scatter Plot
Source SPP1 Source TNF TNF Secreted Signaling 0.1924 0.000014702454811627173 Scatter Plot
Target SPP1 Target SEMA5 SEMA5 Cell-Cell Contact 0.1936 0.000013012867849918907 Scatter Plot
Target SPP1 Source FGF FGF Secreted Signaling 0.1940 0.000012461847087394285 Scatter Plot
Target SPP1 Target CD200 CD200 Cell-Cell Contact 0.1948 0.000011537777825066962 Scatter Plot
Target SPP1 Source CD1D2 CD1D2 Cell-Cell Contact 0.1980 0.000008129612081132485 Scatter Plot
Target SPP1 Target VEGF VEGF Secreted Signaling 0.1989 0.0000074082761241992595 Scatter Plot
Target SPP1 Source CDH CDH Cell-Cell Contact 0.2054 0.000003636343629658278 Scatter Plot
Target SPP1 Source IL7 IL7 Secreted Signaling 0.2055 0.000003613410073810259 Scatter Plot
Target SPP1 Source NT NT Secreted Signaling 0.2056 0.000003549487000667328 Scatter Plot
Target SPP1 Target EPHB EPHB Cell-Cell Contact 0.2087 0.000002526085964446026 Scatter Plot
Target SPP1 Source CD86 CD86 Cell-Cell Contact 0.2165 0.0000010194583571522622 Scatter Plot
Source SPP1 Source NCAM NCAM Cell-Cell Contact 0.2178 0.0000008740001549750051 Scatter Plot
Source SPP1 Source PARs PARs Secreted Signaling 0.2191 0.0000007497301607629833 Scatter Plot
Target SPP1 Source IGF IGF Secreted Signaling 0.2277 0.00000026651582877421605 Scatter Plot
Target SPP1 Target BMP BMP Secreted Signaling 0.2295 0.0000002132733560917166 Scatter Plot
Source SPP1 Source GRN GRN Secreted Signaling 0.2300 0.0000001996910770039683 Scatter Plot
Target SPP1 Target ACTIVIN ACTIVIN Secreted Signaling 0.2353 0.00000010244591587077933 Scatter Plot
Target SPP1 Source PDGF PDGF Secreted Signaling 0.2409 0.000000049249231895167584 Scatter Plot
Target SPP1 Source THY1 THY1 Cell-Cell Contact 0.2413 0.00000004674210819963703 Scatter Plot
Source SPP1 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.2414 0.00000004618999097342793 Scatter Plot
Target SPP1 Source GP1BA GP1BA Cell-Cell Contact 0.2440 0.000000032603352620767846 Scatter Plot
Target SPP1 Source CXCL CXCL Secreted Signaling 0.2454 0.000000027283758886548315 Scatter Plot
Target SPP1 Source CX3C CX3C Secreted Signaling 0.2488 0.000000017249328025575964 Scatter Plot
Target SPP1 Source ICAM ICAM Cell-Cell Contact 0.2497 0.000000015259236692614024 Scatter Plot
Target SPP1 Source FLT3 FLT3 Secreted Signaling 0.2500 0.000000014574509259895346 Scatter Plot
Target SPP1 Target SLURP SLURP Secreted Signaling 0.2568 0.000000005672934799519079 Scatter Plot
Target SPP1 Source BMP BMP Secreted Signaling 0.2650 0.0000000017522713233862147 Scatter Plot
Target SPP1 Source EPHB EPHB Cell-Cell Contact 0.2681 0.0000000011070235482166934 Scatter Plot
Target SPP1 Source MK MK Secreted Signaling 0.2690 0.000000000975707784796016 Scatter Plot
Target SPP1 Source SEMA7 SEMA7 Cell-Cell Contact 0.2750 0.00000000039546335477407955 Scatter Plot
Target SPP1 Source GAS GAS Secreted Signaling 0.2888 0.000000000046398526461433055 Scatter Plot
Target SPP1 Source LCK LCK Cell-Cell Contact 0.2901 0.00000000003752071601231264 Scatter Plot
Source SPP1 Source APP APP Cell-Cell Contact 0.3053 0.0000000000030047842905327007 Scatter Plot
Target SPP1 Source COLLAGEN COLLAGEN ECM-Receptor 0.3177 0.0000000000003437221168784177 Scatter Plot
Target SPP1 Target SEMA4 SEMA4 Cell-Cell Contact 0.3186 0.0000000000002935394941807473 Scatter Plot
Target SPP1 Source JAM JAM Cell-Cell Contact 0.3230 0.0000000000001324190990854572 Scatter Plot
Target SPP1 Target CD34 CD34 Cell-Cell Contact 0.3274 0.00000000000005921458950106007 Scatter Plot
Target SPP1 Source GALECTIN GALECTIN Secreted Signaling 0.3378 0.000000000000008240001396282283 Scatter Plot
Target SPP1 Source LIFR LIFR Secreted Signaling 0.3534 0.0000000000000003683854969207493 Scatter Plot
Target SPP1 Source TWEAK TWEAK Secreted Signaling 0.3545 0.0000000000000002992921979233393 Scatter Plot
Target SPP1 Source MHC-II MHC-II Cell-Cell Contact 0.3622 0.00000000000000006015933550385214 Scatter Plot
Source SPP1 Source SEMA4 SEMA4 Cell-Cell Contact 0.3654 0.00000000000000003027994417109643 Scatter Plot
Target SPP1 Source ESAM ESAM Cell-Cell Contact 0.3701 0.000000000000000011244517136731094 Scatter Plot
Source SPP1 Source SELL SELL Cell-Cell Contact 0.3756 0.000000000000000003332048403009595 Scatter Plot
Source SPP1 Source VISTA VISTA Cell-Cell Contact 0.3771 0.000000000000000002434206756453688 Scatter Plot
Target SPP1 Source ANGPT ANGPT Secreted Signaling 0.3803 0.0000000000000000011908749127466631 Scatter Plot
Source SPP1 Source CD52 CD52 Cell-Cell Contact 0.3966 0.00000000000000000002764335924264995 Scatter Plot
Target SPP1 Source MHC-I MHC-I Cell-Cell Contact 0.4268 0.000000000000000000000014963227866687194 Scatter Plot
Target SPP1 Source COMPLEMENT COMPLEMENT Secreted Signaling -0.4202 0.00000000000000000000008194560502480796 Scatter Plot
Target SPP1 Source CD52 CD52 Cell-Cell Contact -0.3867 0.00000000000000000027576550859216315 Scatter Plot
Target SPP1 Source VISTA VISTA Cell-Cell Contact -0.3749 0.000000000000000003909313586315506 Scatter Plot
Target SPP1 Source SELL SELL Cell-Cell Contact -0.3611 0.00000000000000007502383902813596 Scatter Plot
Source SPP1 Source ANGPT ANGPT Secreted Signaling -0.3132 0.0000000000007715687465538885 Scatter Plot
Target SPP1 Source NCAM NCAM Cell-Cell Contact -0.3044 0.0000000000035332580567702014 Scatter Plot
Target SPP1 Source SEMA4 SEMA4 Cell-Cell Contact -0.3041 0.000000000003723068223751697 Scatter Plot
Target SPP1 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.3029 0.000000000004513301868871413 Scatter Plot
Target SPP1 Source APP APP Cell-Cell Contact -0.3015 0.0000000000057169803740296274 Scatter Plot
Target SPP1 Target CD52 CD52 Cell-Cell Contact -0.3002 0.00000000000711342023104431 Scatter Plot
Target SPP1 Source ANNEXIN ANNEXIN Secreted Signaling -0.2961 0.000000000014121247491130242 Scatter Plot
Target SPP1 Source PARs PARs Secreted Signaling -0.2950 0.000000000016795864429538125 Scatter Plot
Target SPP1 Source CLEC CLEC Cell-Cell Contact -0.2699 0.0000000008602846358793483 Scatter Plot
Target SPP1 Target CCL CCL Secreted Signaling -0.2553 0.000000007032389158523153 Scatter Plot
Source SPP1 Source GAS GAS Secreted Signaling -0.2309 0.0000001785018908753768 Scatter Plot
Source SPP1 Source EPHB EPHB Cell-Cell Contact -0.2297 0.0000002068808608599275 Scatter Plot
Target SPP1 Source TNF TNF Secreted Signaling -0.2268 0.00000029713708308203337 Scatter Plot
Target SPP1 Target CSF CSF Secreted Signaling -0.2237 0.0000004337144427046923 Scatter Plot
Target SPP1 Target CXCL CXCL Secreted Signaling -0.2220 0.0000005334048561888414 Scatter Plot
Source SPP1 Source VEGF VEGF Secreted Signaling -0.2198 0.0000006920262111387661 Scatter Plot
Source SPP1 Source CDH CDH Cell-Cell Contact -0.2144 0.0000013071696271260902 Scatter Plot
Target SPP1 Source CCL CCL Secreted Signaling -0.2139 0.000001379742979737319 Scatter Plot
Source SPP1 Source GP1BA GP1BA Cell-Cell Contact -0.2125 0.0000016218601096004918 Scatter Plot
Source SPP1 Source COLLAGEN COLLAGEN ECM-Receptor -0.2108 0.0000019843107833675967 Scatter Plot
Source SPP1 Source ESAM ESAM Cell-Cell Contact -0.2073 0.000002947960453047304 Scatter Plot
Source SPP1 Source PDGF PDGF Secreted Signaling -0.2071 0.000003004676422301512 Scatter Plot
Target SPP1 Target CLEC CLEC Cell-Cell Contact -0.2052 0.000003739638193807024 Scatter Plot
Source SPP1 Source BMP BMP Secreted Signaling -0.2044 0.000004045791511985364 Scatter Plot
Source SPP1 Source LIFR LIFR Secreted Signaling -0.2021 0.000005239471117899355 Scatter Plot
Target SPP1 Source GRN GRN Secreted Signaling -0.1988 0.000007493369499542483 Scatter Plot
Source SPP1 Source TWEAK TWEAK Secreted Signaling -0.1937 0.000012955100040653794 Scatter Plot
Target SPP1 Source LAIR1 LAIR1 Cell-Cell Contact -0.1817 0.000043545254701529335 Scatter Plot
Target SPP1 Target VEGF VEGF Secreted Signaling -0.1777 0.00006440370681613214 Scatter Plot
Source SPP1 Source CD46 CD46 Cell-Cell Contact -0.1602 0.00032139024124 Scatter Plot
Source SPP1 Source SEMA7 SEMA7 Cell-Cell Contact -0.1555 0.0004841261663296 Scatter Plot
Target SPP1 Target SELPLG SELPLG Cell-Cell Contact -0.1533 0.0005836566730435 Scatter Plot
Target SPP1 Source MIF MIF Secreted Signaling -0.1441 0.001228874513622 Scatter Plot
Source SPP1 Source NT NT Secreted Signaling -0.1382 0.0019562675438396 Scatter Plot
Source SPP1 Source CCL CCL Secreted Signaling -0.1373 0.0020911889336868 Scatter Plot
Target SPP1 Target GRN GRN Secreted Signaling -0.1332 0.0028389698085211 Scatter Plot
Target SPP1 Source BAFF BAFF Secreted Signaling -0.1330 0.0028862704126194 Scatter Plot
Source SPP1 Source IGF IGF Secreted Signaling -0.1270 0.0044454241425086 Scatter Plot
Target SPP1 Target SEMA3 SEMA3 Secreted Signaling -0.1246 0.0052806425593381 Scatter Plot
Target SPP1 Target IL17 IL17 Secreted Signaling -0.1202 0.0071496260875114 Scatter Plot
Target SPP1 Source PDGF PDGF Secreted Signaling -0.1127 0.0116766770924049 Scatter Plot
Target SPP1 Source VISFATIN VISFATIN Secreted Signaling -0.1126 0.0117141698099289 Scatter Plot
Source SPP1 Source RANKL RANKL Secreted Signaling -0.1084 0.0153299380021763 Scatter Plot
Source SPP1 Source FGF FGF Secreted Signaling -0.1066 0.017142053038771 Scatter Plot
Source SPP1 Source GDF GDF Secreted Signaling -0.1058 0.0179860637406717 Scatter Plot
Target SPP1 Source ANGPTL ANGPTL Secreted Signaling -0.1019 0.0227186024863722 Scatter Plot
Source SPP1 Source AGRN AGRN ECM-Receptor -0.0983 0.0279359287191027 Scatter Plot
Source SPP1 Source NOTCH NOTCH Cell-Cell Contact -0.0979 0.0285340950449814 Scatter Plot
Source SPP1 Source ICAM ICAM Cell-Cell Contact -0.0978 0.0287913599754078 Scatter Plot
Target SPP1 Source NKG2D NKG2D Cell-Cell Contact -0.0968 0.0304115790640085 Scatter Plot
Source SPP1 Target SELE SELE Cell-Cell Contact 0.0991 0.0266802509152319 Scatter Plot
Target SPP1 Target SELL SELL Cell-Cell Contact 0.1044 0.019518314168619 Scatter Plot
Source SPP1 Target NCAM NCAM Cell-Cell Contact 0.1072 0.0164933251473574 Scatter Plot
Target SPP1 Target IL1 IL1 Secreted Signaling 0.1087 0.0150442407683911 Scatter Plot
Source SPP1 Target CD45 CD45 Cell-Cell Contact 0.1194 0.0075071800572628 Scatter Plot
Source SPP1 Source SELPLG SELPLG Cell-Cell Contact 0.1254 0.0049799862137143 Scatter Plot
Target SPP1 Target PDGF PDGF Secreted Signaling 0.1273 0.0043619727868152 Scatter Plot
Target SPP1 Target EPHA EPHA Cell-Cell Contact 0.1273 0.0043504653486059 Scatter Plot
Target SPP1 Target CD45 CD45 Cell-Cell Contact 0.1348 0.0025192483840035 Scatter Plot
Source SPP1 Target CD23 CD23 Cell-Cell Contact 0.1361 0.0022920490474389 Scatter Plot
Source SPP1 Target GALECTIN GALECTIN Secreted Signaling 0.1361 0.0022915145003995 Scatter Plot
Source SPP1 Target GRN GRN Secreted Signaling 0.1378 0.0020070082001532 Scatter Plot
Target SPP1 Target IL6 IL6 Secreted Signaling 0.1480 0.000900179806842 Scatter Plot
Source SPP1 Target VEGF VEGF Secreted Signaling 0.1491 0.0008219091996025 Scatter Plot
Source SPP1 Target THY1 THY1 Cell-Cell Contact 0.1492 0.0008186118319588 Scatter Plot
Target SPP1 Target RANKL RANKL Secreted Signaling 0.1541 0.0005459556318638 Scatter Plot
Target SPP1 Target NODAL NODAL Secreted Signaling 0.1590 0.0003574636351636 Scatter Plot
Source SPP1 Source BAFF BAFF Secreted Signaling 0.1655 0.0002008058806195 Scatter Plot
Source SPP1 Source CCL CCL Secreted Signaling 0.1678 0.0001638781027384 Scatter Plot
Target SPP1 Target SEMA6 SEMA6 Cell-Cell Contact 0.1689 0.0001472571663387 Scatter Plot
Target SPP1 Target CD22 CD22 Cell-Cell Contact 0.1812 0.000046116460713013485 Scatter Plot
Target SPP1 Target CADM CADM Cell-Cell Contact 0.1836 0.0000363776153848652 Scatter Plot
Source SPP1 Target COLLAGEN COLLAGEN ECM-Receptor 0.1878 0.000023724954920500728 Scatter Plot
Source SPP1 Target SEMA3 SEMA3 Secreted Signaling 0.1902 0.00001856864518837714 Scatter Plot
Target SPP1 Target SEMA5 SEMA5 Cell-Cell Contact 0.1926 0.000014523491742773286 Scatter Plot
Source SPP1 Source LAIR1 LAIR1 Cell-Cell Contact 0.1946 0.000011671399741626187 Scatter Plot
Target SPP1 Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1971 0.000008965006329983648 Scatter Plot
Target SPP1 Target CDH CDH Cell-Cell Contact 0.2054 0.000003636343629658278 Scatter Plot
Target SPP1 Target BAFF BAFF Secreted Signaling 0.2151 0.0000012082592067933245 Scatter Plot
Source SPP1 Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2177 0.0000008916291131630079 Scatter Plot
Source SPP1 Source CLEC CLEC Cell-Cell Contact 0.2259 0.0000003302627812753481 Scatter Plot
Source SPP1 Target VCAM VCAM Cell-Cell Contact 0.2270 0.0000002888435270007974 Scatter Plot
Source SPP1 Target CEACAM CEACAM Cell-Cell Contact 0.2287 0.0000002331839730818865 Scatter Plot
Target SPP1 Target NPR2 NPR2 Secreted Signaling 0.2325 0.00000014614875770972434 Scatter Plot
Source SPP1 Target ANNEXIN ANNEXIN Secreted Signaling 0.2357 0.0000000964026035670707 Scatter Plot
Source SPP1 Target CXCL CXCL Secreted Signaling 0.2381 0.000000070632504284748 Scatter Plot
Source SPP1 Target CD52 CD52 Cell-Cell Contact 0.2444 0.000000030942625969055174 Scatter Plot
Target SPP1 Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2448 0.000000029562698425046163 Scatter Plot
Source SPP1 Target SELPLG SELPLG Cell-Cell Contact 0.2481 0.00000001896717667132629 Scatter Plot
Target SPP1 Target APP APP Cell-Cell Contact 0.2503 0.000000013931530153195932 Scatter Plot
Target SPP1 Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.2605 0.000000003353774865582057 Scatter Plot
Source SPP1 Target CLEC CLEC Cell-Cell Contact 0.2618 0.0000000027757391543191566 Scatter Plot
Source SPP1 Target IFN-II IFN-II Secreted Signaling 0.2682 0.0000000011066954899904658 Scatter Plot
Target SPP1 Target SEMA4 SEMA4 Cell-Cell Contact 0.2701 0.0000000008254534737850765 Scatter Plot
Source SPP1 Target CSF CSF Secreted Signaling 0.2719 0.0000000006295431632400925 Scatter Plot
Target SPP1 Target TGFb TGFb Secreted Signaling 0.2722 0.0000000006085220037853642 Scatter Plot
Source SPP1 Target ICAM ICAM Cell-Cell Contact 0.2805 0.000000000169903165588285 Scatter Plot
Target SPP1 Target SLURP SLURP Secreted Signaling 0.2946 0.000000000018149610308013856 Scatter Plot
Target SPP1 Target FGF FGF Secreted Signaling 0.2947 0.00000000001777756185669738 Scatter Plot
Source SPP1 Target CCL CCL Secreted Signaling 0.3155 0.0000000000005128627334766359 Scatter Plot
Target SPP1 Target WNT WNT Secreted Signaling 0.3331 0.000000000000020155277640427254 Scatter Plot
Target SPP1 Target ncWNT ncWNT Secreted Signaling 0.3343 0.000000000000015979904442332766 Scatter Plot
Target SPP1 Target CD39 CD39 Cell-Cell Contact 0.3379 0.000000000000008116899008489378 Scatter Plot
Source SPP1 Source ANNEXIN ANNEXIN Secreted Signaling 0.3423 0.0000000000000034347445144749388 Scatter Plot
Source SPP1 Source SEMA4 SEMA4 Cell-Cell Contact 0.3462 0.0000000000000015811941075029559 Scatter Plot
Target SPP1 Target ESAM ESAM Cell-Cell Contact 0.3701 0.000000000000000011244517136731094 Scatter Plot
Source SPP1 Source SELL SELL Cell-Cell Contact 0.3756 0.0000000000000000033304733410406657 Scatter Plot
Target SPP1 Target KIT KIT Secreted Signaling 0.3874 0.0000000000000000002342054321276893 Scatter Plot
Source SPP1 Source COMPLEMENT COMPLEMENT Secreted Signaling 0.4151 0.00000000000000000000030332039543730053 Scatter Plot
Target SPP1 Target PARs PARs Secreted Signaling 0.4613 0.0000000000000000000000000010198771798298471 Scatter Plot
Source SPP1 Target MK MK Secreted Signaling -0.3371 0.000000000000009423749974024072 Scatter Plot
Source SPP1 Target PTN PTN Secreted Signaling -0.3338 0.000000000000017786061542974682 Scatter Plot
Source SPP1 Target PARs PARs Secreted Signaling -0.3259 0.00000000000007744004418326534 Scatter Plot
Target SPP1 Target CEACAM CEACAM Cell-Cell Contact -0.2962 0.00000000001393862940296715 Scatter Plot
Target SPP1 Target ICAM ICAM Cell-Cell Contact -0.2878 0.00000000005446047732241431 Scatter Plot
Source SPP1 Source MHC-I MHC-I Cell-Cell Contact -0.2854 0.00000000007994809974388907 Scatter Plot
Source SPP1 Target ncWNT ncWNT Secreted Signaling -0.2694 0.0000000009151541335098352 Scatter Plot
Source SPP1 Target WNT WNT Secreted Signaling -0.2694 0.0000000009187344454136471 Scatter Plot
Target SPP1 Target VCAM VCAM Cell-Cell Contact -0.2521 0.00000001088212341092964 Scatter Plot
Source SPP1 Source FLT3 FLT3 Secreted Signaling -0.2471 0.000000021691905575808524 Scatter Plot
Target SPP1 Target IFN-II IFN-II Secreted Signaling -0.2439 0.000000033194653907466034 Scatter Plot
Source SPP1 Source MHC-II MHC-II Cell-Cell Contact -0.2423 0.000000041181985213296935 Scatter Plot
Source SPP1 Target KIT KIT Secreted Signaling -0.2406 0.00000005124367259946189 Scatter Plot
Source SPP1 Source BST2 BST2 Cell-Cell Contact -0.2398 0.000000056665431836432396 Scatter Plot
Source SPP1 Target IGF IGF Secreted Signaling -0.2391 0.00000006260480560464014 Scatter Plot
Target SPP1 Target ANNEXIN ANNEXIN Secreted Signaling -0.2390 0.00000006355665452804991 Scatter Plot
Source SPP1 Source JAM JAM Cell-Cell Contact -0.2291 0.00000022260011087509337 Scatter Plot
Source SPP1 Target CDH CDH Cell-Cell Contact -0.2144 0.0000013071696271260902 Scatter Plot
Source SPP1 Target TENASCIN TENASCIN ECM-Receptor -0.2141 0.0000013589030873526195 Scatter Plot
Source SPP1 Target SEMA5 SEMA5 Cell-Cell Contact -0.2079 0.000002761225419790169 Scatter Plot
Source SPP1 Target ESAM ESAM Cell-Cell Contact -0.2073 0.000002947960453047304 Scatter Plot
Source SPP1 Source VCAM VCAM Cell-Cell Contact -0.2047 0.00000394354974260523 Scatter Plot
Source SPP1 Target CD39 CD39 Cell-Cell Contact -0.2036 0.000004464193585154247 Scatter Plot
Source SPP1 Target SEMA4 SEMA4 Cell-Cell Contact -0.2002 0.000006425200066965139 Scatter Plot
Source SPP1 Source GALECTIN GALECTIN Secreted Signaling -0.1991 0.00000723669445544662 Scatter Plot
Source SPP1 Target SLURP SLURP Secreted Signaling -0.1970 0.000009111237094506784 Scatter Plot
Source SPP1 Target JAM JAM Cell-Cell Contact -0.1897 0.00001957365438453704 Scatter Plot
Source SPP1 Target CD34 CD34 Cell-Cell Contact -0.1880 0.000023131933726434027 Scatter Plot
Source SPP1 Target EPHB EPHB Cell-Cell Contact -0.1873 0.00002487038635369979 Scatter Plot
Source SPP1 Target VWF VWF ECM-Receptor -0.1861 0.00002829563429004629 Scatter Plot
Source SPP1 Target THBS THBS ECM-Receptor -0.1818 0.0000431835025586288 Scatter Plot
Source SPP1 Target FN1 FN1 ECM-Receptor -0.1816 0.000044298280509386994 Scatter Plot
Source SPP1 Target APP APP Cell-Cell Contact -0.1753 0.00008116432382142017 Scatter Plot
Source SPP1 Target SEMA7 SEMA7 Cell-Cell Contact -0.1751 0.00008249051019959529 Scatter Plot
Source SPP1 Target NPR2 NPR2 Secreted Signaling -0.1748 0.00008543835634014159 Scatter Plot
Source SPP1 Source LCK LCK Cell-Cell Contact -0.1738 0.00009387132945366684 Scatter Plot
Source SPP1 Target NRG NRG Secreted Signaling -0.1720 0.0001112720123473 Scatter Plot
Target SPP1 Target COMPLEMENT COMPLEMENT Secreted Signaling -0.1657 0.0001987315156602 Scatter Plot
Source SPP1 Source LAMININ LAMININ ECM-Receptor -0.1651 0.0002088275163643 Scatter Plot
Source SPP1 Target TGFb TGFb Secreted Signaling -0.1633 0.0002461918425102 Scatter Plot
Source SPP1 Target DMP1 DMP1 ECM-Receptor -0.1620 0.0002760136069724 Scatter Plot
Source SPP1 Target VTN VTN ECM-Receptor -0.1601 0.0003259560895356 Scatter Plot
Source SPP1 Target AGT AGT Secreted Signaling -0.1590 0.0003575225601028 Scatter Plot
Source SPP1 Source SEMA7 SEMA7 Cell-Cell Contact -0.1554 0.0004862860118799 Scatter Plot
Source SPP1 Source CD1D2 CD1D2 Cell-Cell Contact -0.1538 0.0005572536726039 Scatter Plot
Target SPP1 Target SELPLG SELPLG Cell-Cell Contact -0.1523 0.0006311595225725 Scatter Plot
Source SPP1 Target ANGPTL ANGPTL Secreted Signaling -0.1519 0.0006540182325141 Scatter Plot
Source SPP1 Target BSP BSP ECM-Receptor -0.1485 0.0008677187668807 Scatter Plot
Source SPP1 Source MK MK Secreted Signaling -0.1470 0.0009797372136835 Scatter Plot
Source SPP1 Source CD86 CD86 Cell-Cell Contact -0.1453 0.0011181716077076 Scatter Plot
Source SPP1 Target SEMA6 SEMA6 Cell-Cell Contact -0.1445 0.0011907858128229 Scatter Plot
Target SPP1 Target SEMA3 SEMA3 Secreted Signaling -0.1391 0.001823900237436 Scatter Plot
Source SPP1 Source CXCL CXCL Secreted Signaling -0.1384 0.0019168772904111 Scatter Plot
Source SPP1 Target ANGPT ANGPT Secreted Signaling -0.1382 0.0019545868355469 Scatter Plot
Source SPP1 Target FGF FGF Secreted Signaling -0.1380 0.0019884229570691 Scatter Plot
Source SPP1 Source CSF CSF Secreted Signaling -0.1338 0.002721063912342 Scatter Plot
Source SPP1 Target PERIOSTIN PERIOSTIN Secreted Signaling -0.1319 0.0031228500261305 Scatter Plot
Source SPP1 Target EPHA EPHA Cell-Cell Contact -0.1311 0.0033206042591708 Scatter Plot
Source SPP1 Target ACTIVIN ACTIVIN Secreted Signaling -0.1307 0.003422831599043 Scatter Plot
Source SPP1 Target LAMININ LAMININ ECM-Receptor -0.1288 0.0039283643698068 Scatter Plot
Source SPP1 Target MIF MIF Secreted Signaling -0.1284 0.0040327535134866 Scatter Plot
Source SPP1 Target COMPLEMENT COMPLEMENT Secreted Signaling -0.1270 0.0044473674162485 Scatter Plot
Source SPP1 Target BMP BMP Secreted Signaling -0.1256 0.0049097089165559 Scatter Plot
Source SPP1 Source CX3C CX3C Secreted Signaling -0.1241 0.0054481006468612 Scatter Plot
Source SPP1 Target CD200 CD200 Cell-Cell Contact -0.1209 0.0067862432422576 Scatter Plot
Source SPP1 Target NODAL NODAL Secreted Signaling -0.1189 0.0077556255813757 Scatter Plot
Source SPP1 Target VEGF VEGF Secreted Signaling -0.1159 0.0095168963113334 Scatter Plot
Source SPP1 Target VISFATIN VISFATIN Secreted Signaling -0.1111 0.01288965256521 Scatter Plot
Target SPP1 Target IL1 IL1 Secreted Signaling -0.1111 0.0129115543426874 Scatter Plot
Source SPP1 Target PDGF PDGF Secreted Signaling -0.1096 0.0142445739639995 Scatter Plot
Source SPP1 Source IL2 IL2 Secreted Signaling -0.1084 0.0153313800189933 Scatter Plot
Source SPP1 Source IL7 IL7 Secreted Signaling -0.1084 0.0153313800189933 Scatter Plot
Source SPP1 Target ADIPONECTIN ADIPONECTIN Secreted Signaling -0.1034 0.020750275119079 Scatter Plot
Source SPP1 Target GDF GDF Secreted Signaling -0.0976 0.0291095824351087 Scatter Plot

Cells that are targets of SPP1 from HSCs*

Cells that are source of SPP1 to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.