Pathway: LIFR

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the LIFR pathway:

Specificity Index HSPC as target: 0.131
HSPC as source: 0.707

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the LIFR pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Source LIFR Source IL6 IL6 Secreted Signaling 0.1324 0.003021114598057 Scatter Plot
Source LIFR Source GDF GDF Secreted Signaling 0.1620 0.0002760323469407 Scatter Plot
Source LIFR Source ncWNT ncWNT Secreted Signaling 0.1626 0.0002611231165554 Scatter Plot
Source LIFR Source VEGF VEGF Secreted Signaling 0.2310 0.0000001747469185350846 Scatter Plot
Source LIFR Source RANKL RANKL Secreted Signaling 0.2902 0.00000000003714256246246607 Scatter Plot
Source LIFR Source LIGHT LIGHT Secreted Signaling 0.3066 0.0000000000024089893474717235 Scatter Plot
Source LIFR Source CXCL CXCL Secreted Signaling 0.3195 0.0000000000002494276198389563 Scatter Plot
Source LIFR Source LAMININ LAMININ ECM-Receptor 0.3196 0.00000000000024660309662444733 Scatter Plot
Source LIFR Source COLLAGEN COLLAGEN ECM-Receptor 0.4221 0.00000000000000000000005009218737091507 Scatter Plot
Source LIFR Source TWEAK TWEAK Secreted Signaling 0.4970 0.000000000000000000000000000000014720165004233918 Scatter Plot
Source LIFR Source NCAM NCAM Cell-Cell Contact -0.1962 0.00000986154859218208 Scatter Plot
Source LIFR Source ANGPTL ANGPTL Secreted Signaling -0.1783 0.00006121370600441725 Scatter Plot
Source LIFR Source TGFb TGFb Secreted Signaling -0.1594 0.0003467173601545 Scatter Plot
Source LIFR Source SEMA6 SEMA6 Cell-Cell Contact 0.0996 0.0258852007607688 Scatter Plot
Source LIFR Target NODAL NODAL Secreted Signaling 0.1031 0.0210853758531814 Scatter Plot
Source LIFR Source AGRN AGRN ECM-Receptor 0.1138 0.0108662112246652 Scatter Plot
Source LIFR Target SEMA3 SEMA3 Secreted Signaling 0.1141 0.010689071751822 Scatter Plot
Source LIFR Source THBS THBS ECM-Receptor 0.1146 0.010338699436101 Scatter Plot
Source LIFR Target RANKL RANKL Secreted Signaling 0.1167 0.0090153500384242 Scatter Plot
Source LIFR Target NOTCH NOTCH Cell-Cell Contact 0.1333 0.0028116163753579 Scatter Plot
Source LIFR Source ANGPTL ANGPTL Secreted Signaling 0.1378 0.0020124402754928 Scatter Plot
Source LIFR Target GAS GAS Secreted Signaling 0.1382 0.0019486138376378 Scatter Plot
Source LIFR Source GALECTIN GALECTIN Secreted Signaling 0.1419 0.0014691233279477 Scatter Plot
Source LIFR Target THY1 THY1 Cell-Cell Contact 0.1425 0.0013985521317492 Scatter Plot
Source LIFR Source IL16 IL16 Secreted Signaling 0.1498 0.0007817944857557 Scatter Plot
Source LIFR Target EPHA EPHA Cell-Cell Contact 0.1532 0.0005859417960367 Scatter Plot
Source LIFR Source FGF FGF Secreted Signaling 0.1622 0.0002693894069279 Scatter Plot
Source LIFR Target CD23 CD23 Cell-Cell Contact 0.1684 0.000155074735613 Scatter Plot
Source LIFR Target COLLAGEN COLLAGEN ECM-Receptor 0.1695 0.0001404663518924 Scatter Plot
Source LIFR Target IL6 IL6 Secreted Signaling 0.1700 0.0001336928038617 Scatter Plot
Source LIFR Source SEMA3 SEMA3 Secreted Signaling 0.1748 0.00008529649316994214 Scatter Plot
Source LIFR Target GDF GDF Secreted Signaling 0.1755 0.00007956971105523995 Scatter Plot
Source LIFR Source PTN PTN Secreted Signaling 0.1799 0.00005240331148949862 Scatter Plot
Source LIFR Source CD86 CD86 Cell-Cell Contact 0.1960 0.000010126252193277035 Scatter Plot
Source LIFR Source CD1D2 CD1D2 Cell-Cell Contact 0.2022 0.000005189585112260641 Scatter Plot
Source LIFR Target VEGF VEGF Secreted Signaling 0.2034 0.0000045416069527394205 Scatter Plot
Source LIFR Source CD39 CD39 Cell-Cell Contact 0.2037 0.00000441274164503743 Scatter Plot
Source LIFR Target NCAM NCAM Cell-Cell Contact 0.2151 0.0000012092034706142415 Scatter Plot
Source LIFR Target OSM OSM Secreted Signaling 0.2172 0.0000009471221588778504 Scatter Plot
Source LIFR Source THY1 THY1 Cell-Cell Contact 0.2372 0.00000007944760233302533 Scatter Plot
Source LIFR Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2408 0.000000049937147068229863 Scatter Plot
Source LIFR Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.2417 0.00000004412446309990245 Scatter Plot
Source LIFR Source IL2 IL2 Secreted Signaling 0.2426 0.000000039269171759560726 Scatter Plot
Source LIFR Source CSF CSF Secreted Signaling 0.2470 0.000000022018566256653932 Scatter Plot
Source LIFR Source CD46 CD46 Cell-Cell Contact 0.2488 0.00000001711891311073937 Scatter Plot
Source LIFR Source VCAM VCAM Cell-Cell Contact 0.2497 0.000000015118694627564722 Scatter Plot
Source LIFR Source GP1BA GP1BA Cell-Cell Contact 0.2538 0.000000008590901202425197 Scatter Plot
Source LIFR Target AGT AGT Secreted Signaling 0.2557 0.000000006653706997269644 Scatter Plot
Source LIFR Target ACTIVIN ACTIVIN Secreted Signaling 0.2566 0.000000005805186606171442 Scatter Plot
Source LIFR Source CADM CADM Cell-Cell Contact 0.2601 0.0000000035683352520599194 Scatter Plot
Source LIFR Target CADM CADM Cell-Cell Contact 0.2601 0.0000000035683352520599194 Scatter Plot
Source LIFR Source CCL CCL Secreted Signaling 0.2607 0.0000000032736365598174035 Scatter Plot
Source LIFR Source APELIN APELIN Secreted Signaling 0.2626 0.0000000024893511093538446 Scatter Plot
Source LIFR Target CSPG4 CSPG4 Cell-Cell Contact 0.2658 0.0000000015714468655981475 Scatter Plot
Source LIFR Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.2707 0.0000000007581719309300674 Scatter Plot
Source LIFR Source PSAP PSAP Secreted Signaling 0.2725 0.0000000005788146915403988 Scatter Plot
Source LIFR Target EPHB EPHB Cell-Cell Contact 0.2829 0.0000000001180895464962729 Scatter Plot
Source LIFR Target PTN PTN Secreted Signaling 0.2870 0.00000000006129638594174104 Scatter Plot
Source LIFR Source LIGHT LIGHT Secreted Signaling 0.2890 0.00000000004471512074162743 Scatter Plot
Source LIFR Source NT NT Secreted Signaling 0.2923 0.00000000002606150801832996 Scatter Plot
Source LIFR Source CD45 CD45 Cell-Cell Contact 0.2930 0.00000000002356724013136781 Scatter Plot
Source LIFR Target CD22 CD22 Cell-Cell Contact 0.2930 0.00000000002356724013136781 Scatter Plot
Source LIFR Target SEMA6 SEMA6 Cell-Cell Contact 0.2992 0.000000000008452087350259443 Scatter Plot
Source LIFR Source NOTCH NOTCH Cell-Cell Contact 0.3187 0.00000000000028706480949197743 Scatter Plot
Source LIFR Target ANGPTL ANGPTL Secreted Signaling 0.3200 0.00000000000022613488411575442 Scatter Plot
Source LIFR Target TGFb TGFb Secreted Signaling 0.3202 0.0000000000002202914408030317 Scatter Plot
Source LIFR Target SEMA5 SEMA5 Cell-Cell Contact 0.3283 0.000000000000049407555056214354 Scatter Plot
Source LIFR Source MK MK Secreted Signaling 0.3336 0.00000000000001841670259994751 Scatter Plot
Source LIFR Target THBS THBS ECM-Receptor 0.3451 0.000000000000001982908539000336 Scatter Plot
Source LIFR Source ICAM ICAM Cell-Cell Contact 0.3459 0.0000000000000016710438342461913 Scatter Plot
Source LIFR Source LAMININ LAMININ ECM-Receptor 0.3494 0.0000000000000008350843413354599 Scatter Plot
Source LIFR Target BAFF BAFF Secreted Signaling 0.3506 0.0000000000000006576087932402681 Scatter Plot
Source LIFR Target SPP1 SPP1 Secreted Signaling 0.3534 0.0000000000000003683854969207493 Scatter Plot
Source LIFR Target MK MK Secreted Signaling 0.3543 0.0000000000000003071806432609104 Scatter Plot
Source LIFR Target BMP BMP Secreted Signaling 0.3555 0.000000000000000242323604685349 Scatter Plot
Source LIFR Target FN1 FN1 ECM-Receptor 0.3559 0.0000000000000002241250612697193 Scatter Plot
Source LIFR Source IGF IGF Secreted Signaling 0.3562 0.0000000000000002083985884191819 Scatter Plot
Source LIFR Target CD200 CD200 Cell-Cell Contact 0.3581 0.00000000000000014131881857880827 Scatter Plot
Source LIFR Target LAMININ LAMININ ECM-Receptor 0.3637 0.00000000000000004391746219660261 Scatter Plot
Source LIFR Source CX3C CX3C Secreted Signaling 0.3697 0.000000000000000012116742809460719 Scatter Plot
Source LIFR Target KIT KIT Secreted Signaling 0.3719 0.000000000000000007619061998118838 Scatter Plot
Source LIFR Source LCK LCK Cell-Cell Contact 0.3752 0.000000000000000003661438538469272 Scatter Plot
Source LIFR Source IL7 IL7 Secreted Signaling 0.3874 0.00000000000000000023562130412592103 Scatter Plot
Source LIFR Target NPR2 NPR2 Secreted Signaling 0.3901 0.00000000000000000012589887604174999 Scatter Plot
Source LIFR Target MIF MIF Secreted Signaling 0.3904 0.00000000000000000011723915077766344 Scatter Plot
Source LIFR Target SEMA4 SEMA4 Cell-Cell Contact 0.3950 0.00000000000000000004048382157837796 Scatter Plot
Source LIFR Target VISFATIN VISFATIN Secreted Signaling 0.3998 0.000000000000000000012913594708378206 Scatter Plot
Source LIFR Target CDH CDH Cell-Cell Contact 0.4030 0.000000000000000000005940909560042194 Scatter Plot
Source LIFR Source CDH CDH Cell-Cell Contact 0.4030 0.000000000000000000005940909560042194 Scatter Plot
Source LIFR Target APP APP Cell-Cell Contact 0.4084 0.0000000000000000000016001011863125452 Scatter Plot
Source LIFR Source PROS PROS Secreted Signaling 0.4189 0.0000000000000000000001135049432043336 Scatter Plot
Source LIFR Source EPHB EPHB Cell-Cell Contact 0.4194 0.00000000000000000000010161839172687687 Scatter Plot
Source LIFR Target SLURP SLURP Secreted Signaling 0.4200 0.00000000000000000000008532241409198785 Scatter Plot
Source LIFR Target PERIOSTIN PERIOSTIN Secreted Signaling 0.4367 0.000000000000000000000001053424258936697 Scatter Plot
Source LIFR Source FLT3 FLT3 Secreted Signaling 0.4413 0.0000000000000000000000003007435773665852 Scatter Plot
Source LIFR Source BST2 BST2 Cell-Cell Contact 0.4472 0.0000000000000000000000000589086337177654 Scatter Plot
Source LIFR Target BSP BSP ECM-Receptor 0.4580 0.000000000000000000000000002667174298044998 Scatter Plot
Source LIFR Source GAS GAS Secreted Signaling 0.4638 0.0000000000000000000000000004788230364519671 Scatter Plot
Source LIFR Target DMP1 DMP1 ECM-Receptor 0.4672 0.00000000000000000000000000017341588000633583 Scatter Plot
Source LIFR Target SEMA7 SEMA7 Cell-Cell Contact 0.4705 0.00000000000000000000000000006491625966137794 Scatter Plot
Source LIFR Target NRG NRG Secreted Signaling 0.4713 0.00000000000000000000000000005046402131763885 Scatter Plot
Source LIFR Source SEMA7 SEMA7 Cell-Cell Contact 0.4811 0.00000000000000000000000000000245121038729185 Scatter Plot
Source LIFR Target CD39 CD39 Cell-Cell Contact 0.4830 0.0000000000000000000000000000013519119029352891 Scatter Plot
Source LIFR Target ANGPT ANGPT Secreted Signaling 0.4933 0.0000000000000000000000000000000491035111030057 Scatter Plot
Source LIFR Target ncWNT ncWNT Secreted Signaling 0.5026 0.000000000000000000000000000000002296188059756227 Scatter Plot
Source LIFR Target VTN VTN ECM-Receptor 0.5083 0.00000000000000000000000000000000032985926000175444 Scatter Plot
Source LIFR Source PDGF PDGF Secreted Signaling 0.5154 0.00000000000000000000000000000000002715468687662526 Scatter Plot
Source LIFR Target JAM JAM Cell-Cell Contact 0.5157 0.000000000000000000000000000000000025125864730571146 Scatter Plot
Source LIFR Target WNT WNT Secreted Signaling 0.5173 0.000000000000000000000000000000000014335396026262013 Scatter Plot
Source LIFR Target FGF FGF Secreted Signaling 0.5187 0.000000000000000000000000000000000008460965509880382 Scatter Plot
Source LIFR Source MHC-II MHC-II Cell-Cell Contact 0.5206 0.000000000000000000000000000000000004297501795395786 Scatter Plot
Source LIFR Source BMP BMP Secreted Signaling 0.5238 0.0000000000000000000000000000000000013674202048062812 Scatter Plot
Source LIFR Target ESAM ESAM Cell-Cell Contact 0.5425 0.0000000000000000000000000000000000000012937572075696009 Scatter Plot
Source LIFR Source ESAM ESAM Cell-Cell Contact 0.5425 0.0000000000000000000000000000000000000012937572075696009 Scatter Plot
Source LIFR Target IGF IGF Secreted Signaling 0.5430 0.0000000000000000000000000000000000000010698475070939568 Scatter Plot
Source LIFR Target CD34 CD34 Cell-Cell Contact 0.5514 0.00000000000000000000000000000000000000004033089753072131 Scatter Plot
Source LIFR Source ANGPT ANGPT Secreted Signaling 0.5533 0.000000000000000000000000000000000000000018816235077416768 Scatter Plot
Source LIFR Target VWF VWF ECM-Receptor 0.5705 0.000000000000000000000000000000000000000000015714888820432684 Scatter Plot
Source LIFR Target PARs PARs Secreted Signaling 0.5734 0.000000000000000000000000000000000000000000004667711947099261 Scatter Plot
Source LIFR Source MHC-I MHC-I Cell-Cell Contact 0.5799 0.00000000000000000000000000000000000000000000027724264648059697 Scatter Plot
Source LIFR Target TENASCIN TENASCIN ECM-Receptor 0.5815 0.0000000000000000000000000000000000000000000001393340511225104 Scatter Plot
Source LIFR Source JAM JAM Cell-Cell Contact 0.5998 0.00000000000000000000000000000000000000000000000003451907765783879 Scatter Plot
Source LIFR Source CD52 CD52 Cell-Cell Contact -0.5695 0.000000000000000000000000000000000000000000024670705264418455 Scatter Plot
Source LIFR Source SELL SELL Cell-Cell Contact -0.4706 0.00000000000000000000000000006234773527907986 Scatter Plot
Source LIFR Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.4579 0.0000000000000000000000000027614637835238955 Scatter Plot
Source LIFR Source COMPLEMENT COMPLEMENT Secreted Signaling -0.4300 0.0000000000000000000000063661539249566674 Scatter Plot
Source LIFR Target ICAM ICAM Cell-Cell Contact -0.4255 0.00000000000000000000002086468219746246 Scatter Plot
Source LIFR Source PARs PARs Secreted Signaling -0.4043 0.0000000000000000000043582393570575744 Scatter Plot
Source LIFR Target CD52 CD52 Cell-Cell Contact -0.3798 0.0000000000000000013222975074711404 Scatter Plot
Source LIFR Target IFN-II IFN-II Secreted Signaling -0.3763 0.0000000000000000029032596342916306 Scatter Plot
Source LIFR Source SEMA4 SEMA4 Cell-Cell Contact -0.3590 0.00000000000000011758129539073404 Scatter Plot
Source LIFR Target CCL CCL Secreted Signaling -0.3241 0.00000000000010841335541043053 Scatter Plot
Source LIFR Source VISTA VISTA Cell-Cell Contact -0.3204 0.00000000000020975670098487761 Scatter Plot
Source LIFR Source ANNEXIN ANNEXIN Secreted Signaling -0.2968 0.000000000012668843578727735 Scatter Plot
Source LIFR Target VCAM VCAM Cell-Cell Contact -0.2953 0.00000000001602890658222448 Scatter Plot
Source LIFR Target CSF CSF Secreted Signaling -0.2907 0.000000000034057265305440307 Scatter Plot
Source LIFR Target CXCL CXCL Secreted Signaling -0.2802 0.00000000018005473306451138 Scatter Plot
Source LIFR Source CCL CCL Secreted Signaling -0.2786 0.00000000022858733226665658 Scatter Plot
Source LIFR Source CLEC CLEC Cell-Cell Contact -0.2732 0.000000000518983030264966 Scatter Plot
Source LIFR Target CLEC CLEC Cell-Cell Contact -0.2684 0.0000000010656400142205475 Scatter Plot
Source LIFR Source SELPLG SELPLG Cell-Cell Contact -0.2660 0.0000000015268565854519366 Scatter Plot
Source LIFR Target CEACAM CEACAM Cell-Cell Contact -0.2592 0.000000004030352947998685 Scatter Plot
Source LIFR Source MIF MIF Secreted Signaling -0.2288 0.0000002325497690160072 Scatter Plot
Source LIFR Target IL17 IL17 Secreted Signaling -0.2223 0.0000005119608751129899 Scatter Plot
Source LIFR Source TNF TNF Secreted Signaling -0.2198 0.0000006946373328623818 Scatter Plot
Source LIFR Source SPP1 SPP1 Secreted Signaling -0.2021 0.000005239471117899355 Scatter Plot
Source LIFR Target COLLAGEN COLLAGEN ECM-Receptor -0.1994 0.000007048613623935656 Scatter Plot
Source LIFR Source APP APP Cell-Cell Contact -0.1791 0.00005662940161135336 Scatter Plot
Source LIFR Target VEGF VEGF Secreted Signaling -0.1604 0.0003155738729595 Scatter Plot
Source LIFR Target SELE SELE Cell-Cell Contact -0.1599 0.0003308904016253 Scatter Plot
Source LIFR Target COMPLEMENT COMPLEMENT Secreted Signaling -0.1368 0.0021636095099683 Scatter Plot
Source LIFR Source LAIR1 LAIR1 Cell-Cell Contact -0.1275 0.0042967402840624 Scatter Plot
Source LIFR Target ANNEXIN ANNEXIN Secreted Signaling -0.1260 0.0047687339816816 Scatter Plot
Source LIFR Source VISFATIN VISFATIN Secreted Signaling -0.1257 0.0048621573156407 Scatter Plot
Source LIFR Target GRN GRN Secreted Signaling -0.1247 0.0052448887013923 Scatter Plot
Source LIFR Target SEMA3 SEMA3 Secreted Signaling -0.1245 0.0052977300202159 Scatter Plot
Source LIFR Target IL1 IL1 Secreted Signaling -0.1197 0.0073599826465802 Scatter Plot
Source LIFR Source NKG2D NKG2D Cell-Cell Contact -0.1010 0.0239525747707711 Scatter Plot

Cells that are targets of LIFR from HSCs*

Cells that are source of LIFR to HSCs*

    No cell populations

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.