Pathway: VWF

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: ECM-Receptor

Details on the VWF pathway:

Specificity Index HSPC as target: 0.462
HSPC as source: 0.883

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the VWF pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target VWF Source WNT WNT Secreted Signaling 0.1169 0.0089030856652461 Scatter Plot
Target VWF Source APELIN APELIN Secreted Signaling 0.1387 0.0018767447089295 Scatter Plot
Target VWF Source GDF GDF Secreted Signaling 0.1601 0.0003258916535553 Scatter Plot
Target VWF Source THBS THBS ECM-Receptor 0.1614 0.0002909340591162 Scatter Plot
Target VWF Source ANGPTL ANGPTL Secreted Signaling 0.1630 0.0002520212973889 Scatter Plot
Target VWF Source CD39 CD39 Cell-Cell Contact 0.1657 0.0001985856231693 Scatter Plot
Target VWF Source CD1D2 CD1D2 Cell-Cell Contact 0.1760 0.0000762803815259456 Scatter Plot
Target VWF Target GDF GDF Secreted Signaling 0.1760 0.00007576369964993364 Scatter Plot
Target VWF Source VEGF VEGF Secreted Signaling 0.1853 0.000030526159437433313 Scatter Plot
Target VWF Source ncWNT ncWNT Secreted Signaling 0.1945 0.000011851795111861374 Scatter Plot
Target VWF Source SEMA3 SEMA3 Secreted Signaling 0.1976 0.000008493008255010534 Scatter Plot
Target VWF Source VCAM VCAM Cell-Cell Contact 0.2348 0.00000010880825118219456 Scatter Plot
Target VWF Source CCL CCL Secreted Signaling 0.2356 0.00000009849681875031125 Scatter Plot
Target VWF Source IL2 IL2 Secreted Signaling 0.2418 0.00000004375354656197798 Scatter Plot
Target VWF Source CD86 CD86 Cell-Cell Contact 0.2532 0.00000000933270655798103 Scatter Plot
Target VWF Source IL1 IL1 Secreted Signaling 0.2597 0.000000003763442291862099 Scatter Plot
Target VWF Source CD46 CD46 Cell-Cell Contact 0.2601 0.000000003562005609636205 Scatter Plot
Target VWF Source NOTCH NOTCH Cell-Cell Contact 0.2609 0.000000003174656994710916 Scatter Plot
Target VWF Source CD45 CD45 Cell-Cell Contact 0.2626 0.0000000024898103273820033 Scatter Plot
Target VWF Source NT NT Secreted Signaling 0.2689 0.0000000009913872494717908 Scatter Plot
Target VWF Source PSAP PSAP Secreted Signaling 0.2691 0.0000000009618327642347016 Scatter Plot
Target VWF Source RANKL RANKL Secreted Signaling 0.2696 0.0000000008933729503798823 Scatter Plot
Target VWF Target CSPG4 CSPG4 Cell-Cell Contact 0.2698 0.0000000008730845887823357 Scatter Plot
Target VWF Source GALECTIN GALECTIN Secreted Signaling 0.2719 0.0000000006360689816895082 Scatter Plot
Target VWF Source CSF CSF Secreted Signaling 0.2725 0.0000000005784737579114836 Scatter Plot
Target VWF Source CADM CADM Cell-Cell Contact 0.2793 0.00000000020632093133508029 Scatter Plot
Target VWF Source PTN PTN Secreted Signaling 0.2857 0.00000000007616609735554541 Scatter Plot
Target VWF Source IGF IGF Secreted Signaling 0.3052 0.0000000000030515876838146614 Scatter Plot
Target VWF Source LAMININ LAMININ ECM-Receptor 0.3054 0.000000000002972374627330992 Scatter Plot
Target VWF Source CX3C CX3C Secreted Signaling 0.3131 0.0000000000007730440382370453 Scatter Plot
Target VWF Source THY1 THY1 Cell-Cell Contact 0.3175 0.00000000000035818775926540345 Scatter Plot
Target VWF Source ICAM ICAM Cell-Cell Contact 0.3329 0.000000000000020881214558807082 Scatter Plot
Target VWF Source LIGHT LIGHT Secreted Signaling 0.3390 0.000000000000006471269167119674 Scatter Plot
Target VWF Source FGF FGF Secreted Signaling 0.3449 0.0000000000000020575939728596828 Scatter Plot
Target VWF Source CDH CDH Cell-Cell Contact 0.3553 0.00000000000000025370856609130795 Scatter Plot
Target VWF Source MK MK Secreted Signaling 0.3573 0.00000000000000016663815144046075 Scatter Plot
Target VWF Source BST2 BST2 Cell-Cell Contact 0.3573 0.0000000000000001662596897462018 Scatter Plot
Target VWF Source LCK LCK Cell-Cell Contact 0.3714 0.000000000000000008335170826084887 Scatter Plot
Target VWF Source CXCL CXCL Secreted Signaling 0.3861 0.0000000000000000003176957216451451 Scatter Plot
Target VWF Source SEMA7 SEMA7 Cell-Cell Contact 0.3867 0.00000000000000000027673672010661925 Scatter Plot
Target VWF Source GP1BA GP1BA Cell-Cell Contact 0.3996 0.000000000000000000013353165133390171 Scatter Plot
Target VWF Source EPHB EPHB Cell-Cell Contact 0.4075 0.0000000000000000000020066038402966323 Scatter Plot
Target VWF Source COLLAGEN COLLAGEN ECM-Receptor 0.4226 0.00000000000000000000004404651600385101 Scatter Plot
Target VWF Source IL7 IL7 Secreted Signaling 0.4294 0.000000000000000000000007394302588700326 Scatter Plot
Target VWF Source GAS GAS Secreted Signaling 0.4302 0.0000000000000000000000060563485436288775 Scatter Plot
Target VWF Source PROS PROS Secreted Signaling 0.4326 0.0000000000000000000000031970541215678607 Scatter Plot
Target VWF Source PDGF PDGF Secreted Signaling 0.4626 0.0000000000000000000000000006858775804702862 Scatter Plot
Target VWF Source FLT3 FLT3 Secreted Signaling 0.4760 0.000000000000000000000000000011949458478369827 Scatter Plot
Target VWF Source BMP BMP Secreted Signaling 0.4874 0.00000000000000000000000000000033498656664571908 Scatter Plot
Target VWF Source TWEAK TWEAK Secreted Signaling 0.5118 0.00000000000000000000000000000000009829436177443167 Scatter Plot
Target VWF Source MHC-II MHC-II Cell-Cell Contact 0.5178 0.000000000000000000000000000000000011999543469123184 Scatter Plot
Target VWF Source MHC-I MHC-I Cell-Cell Contact 0.5572 0.000000000000000000000000000000000000000003923326496386596 Scatter Plot
Target VWF Source LIFR LIFR Secreted Signaling 0.5705 0.000000000000000000000000000000000000000000015714888820432684 Scatter Plot
Target VWF Source ESAM ESAM Cell-Cell Contact 0.5899 0.000000000000000000000000000000000000000000000003245847259943436 Scatter Plot
Target VWF Source ANGPT ANGPT Secreted Signaling 0.6029 0.000000000000000000000000000000000000000000000000008047573753065467 Scatter Plot
Target VWF Source JAM JAM Cell-Cell Contact 0.6159 0.000000000000000000000000000000000000000000000000000014697170644992643 Scatter Plot
Target VWF Source CD52 CD52 Cell-Cell Contact -0.4968 0.000000000000000000000000000000015888722332014573 Scatter Plot
Target VWF Source SELL SELL Cell-Cell Contact -0.4919 0.00000000000000000000000000000007939125918602836 Scatter Plot
Target VWF Source COMPLEMENT COMPLEMENT Secreted Signaling -0.4603 0.0000000000000000000000000013426523793289938 Scatter Plot
Target VWF Source PARs PARs Secreted Signaling -0.4299 0.000000000000000000000006525857568687541 Scatter Plot
Target VWF Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.3911 0.00000000000000000010054108797985057 Scatter Plot
Target VWF Source CCL CCL Secreted Signaling -0.3778 0.000000000000000002067521605913716 Scatter Plot
Target VWF Source ANNEXIN ANNEXIN Secreted Signaling -0.3666 0.000000000000000023798844056614298 Scatter Plot
Target VWF Source VISTA VISTA Cell-Cell Contact -0.3592 0.0000000000000001133816469397855 Scatter Plot
Target VWF Source SEMA4 SEMA4 Cell-Cell Contact -0.3563 0.00000000000000020342571102229127 Scatter Plot
Target VWF Source CLEC CLEC Cell-Cell Contact -0.2906 0.00000000003457173649161974 Scatter Plot
Target VWF Source NCAM NCAM Cell-Cell Contact -0.2245 0.00000039381797292514534 Scatter Plot
Target VWF Target IL17 IL17 Secreted Signaling -0.2205 0.0000006377753543497501 Scatter Plot
Target VWF Source ANGPTL ANGPTL Secreted Signaling -0.2124 0.0000016525696815656832 Scatter Plot
Target VWF Source APP APP Cell-Cell Contact -0.2079 0.000002757683285107017 Scatter Plot
Target VWF Source SPP1 SPP1 Secreted Signaling -0.1861 0.00002829563429004629 Scatter Plot
Target VWF Source LAIR1 LAIR1 Cell-Cell Contact -0.1767 0.000071406708659397 Scatter Plot
Target VWF Source TNF TNF Secreted Signaling -0.1744 0.00008811687737798565 Scatter Plot
Target VWF Source SELPLG SELPLG Cell-Cell Contact -0.1641 0.0002275733329531 Scatter Plot
Target VWF Source MIF MIF Secreted Signaling -0.1634 0.0002441495445594 Scatter Plot
Target VWF Source VISFATIN VISFATIN Secreted Signaling -0.1300 0.00358265771514 Scatter Plot
Target VWF Source GRN GRN Secreted Signaling -0.1080 0.0156892743806145 Scatter Plot
Target VWF Source NKG2D NKG2D Cell-Cell Contact -0.0970 0.0301631025031097 Scatter Plot
Target VWF Target EPHA EPHA Cell-Cell Contact 0.1093 0.014448060301446 Scatter Plot
Target VWF Target NODAL NODAL Secreted Signaling 0.1184 0.0080464907894942 Scatter Plot
Target VWF Target RANKL RANKL Secreted Signaling 0.1272 0.0043783264623534 Scatter Plot
Target VWF Target SEMA3 SEMA3 Secreted Signaling 0.1342 0.0026462047184967 Scatter Plot
Target VWF Target IL6 IL6 Secreted Signaling 0.1442 0.00122529366605 Scatter Plot
Target VWF Target CXCL CXCL Secreted Signaling 0.1556 0.0004777141566436 Scatter Plot
Target VWF Target GAS GAS Secreted Signaling 0.1692 0.0001434350421268 Scatter Plot
Target VWF Target COMPLEMENT COMPLEMENT Secreted Signaling 0.1953 0.000010853312347744483 Scatter Plot
Target VWF Target AGT AGT Secreted Signaling 0.2047 0.000003929026929544014 Scatter Plot
Target VWF Target OSM OSM Secreted Signaling 0.2127 0.0000015948809202962765 Scatter Plot
Target VWF Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.2448 0.00000002921138171837544 Scatter Plot
Target VWF Target CD22 CD22 Cell-Cell Contact 0.2626 0.0000000024898103273820033 Scatter Plot
Target VWF Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.2663 0.0000000014438827240467476 Scatter Plot
Target VWF Target CD200 CD200 Cell-Cell Contact 0.2725 0.0000000005753809178617285 Scatter Plot
Target VWF Target CADM CADM Cell-Cell Contact 0.2793 0.00000000020632093133508029 Scatter Plot
Target VWF Target VEGF VEGF Secreted Signaling 0.2881 0.000000000052078729827177936 Scatter Plot
Target VWF Target SEMA6 SEMA6 Cell-Cell Contact 0.3004 0.000000000006927845298841162 Scatter Plot
Target VWF Target EPHB EPHB Cell-Cell Contact 0.3016 0.000000000005605995666383797 Scatter Plot
Target VWF Target TGFb TGFb Secreted Signaling 0.3249 0.0000000000000933755832772949 Scatter Plot
Target VWF Target ACTIVIN ACTIVIN Secreted Signaling 0.3327 0.000000000000021781154298939257 Scatter Plot
Target VWF Target BAFF BAFF Secreted Signaling 0.3391 0.000000000000006399588049521023 Scatter Plot
Target VWF Target SEMA5 SEMA5 Cell-Cell Contact 0.3432 0.0000000000000028408748018430614 Scatter Plot
Target VWF Target APP APP Cell-Cell Contact 0.3488 0.0000000000000009489736554114324 Scatter Plot
Target VWF Target BMP BMP Secreted Signaling 0.3514 0.0000000000000005534965781969472 Scatter Plot
Target VWF Target CDH CDH Cell-Cell Contact 0.3553 0.00000000000000025370856609130795 Scatter Plot
Target VWF Target KIT KIT Secreted Signaling 0.3784 0.0000000000000000017861859520996186 Scatter Plot
Target VWF Target SLURP SLURP Secreted Signaling 0.3855 0.0000000000000000003642964766771596 Scatter Plot
Target VWF Target NPR2 NPR2 Secreted Signaling 0.3927 0.00000000000000000006857936788090641 Scatter Plot
Target VWF Target MIF MIF Secreted Signaling 0.3974 0.00000000000000000002275003651334327 Scatter Plot
Target VWF Target SEMA4 SEMA4 Cell-Cell Contact 0.4142 0.0000000000000000000003774844603692414 Scatter Plot
Target VWF Target MK MK Secreted Signaling 0.4230 0.000000000000000000000039978312423025536 Scatter Plot
Target VWF Target ncWNT ncWNT Secreted Signaling 0.4478 0.000000000000000000000000049403523422385595 Scatter Plot
Target VWF Target VISFATIN VISFATIN Secreted Signaling 0.4556 0.0000000000000000000000000053244157500846645 Scatter Plot
Target VWF Target FGF FGF Secreted Signaling 0.4713 0.00000000000000000000000000005103617439614161 Scatter Plot
Target VWF Target WNT WNT Secreted Signaling 0.4740 0.000000000000000000000000000022131200099036966 Scatter Plot
Target VWF Target SEMA7 SEMA7 Cell-Cell Contact 0.4779 0.000000000000000000000000000006757064111022796 Scatter Plot
Target VWF Target CD39 CD39 Cell-Cell Contact 0.5442 0.00000000000000000000000000000000000000066535168372904 Scatter Plot
Target VWF Target ANGPT ANGPT Secreted Signaling 0.5482 0.00000000000000000000000000000000000000014137768882301146 Scatter Plot
Target VWF Target ESAM ESAM Cell-Cell Contact 0.5899 0.000000000000000000000000000000000000000000000003245847259943436 Scatter Plot
Target VWF Target CD34 CD34 Cell-Cell Contact 0.6235 0.00000000000000000000000000000000000000000000000000000031313263658787326 Scatter Plot
Target VWF Target PARs PARs Secreted Signaling 0.6742 0.00000000000000000000000000000000000000000000000000000000000000000013859769774614179 Scatter Plot
Target VWF Target IFN-II IFN-II Secreted Signaling -0.4925 0.00000000000000000000000000000006517449060472543 Scatter Plot
Target VWF Target CD52 CD52 Cell-Cell Contact -0.4066 0.0000000000000000000024529261893769438 Scatter Plot
Target VWF Target ICAM ICAM Cell-Cell Contact -0.3847 0.000000000000000000439398933336762 Scatter Plot
Target VWF Target VCAM VCAM Cell-Cell Contact -0.3458 0.0000000000000017293449685165933 Scatter Plot
Target VWF Target CCL CCL Secreted Signaling -0.3182 0.0000000000003136960393585422 Scatter Plot
Target VWF Target CSF CSF Secreted Signaling -0.2861 0.00000000007157511579934086 Scatter Plot
Target VWF Target CLEC CLEC Cell-Cell Contact -0.2757 0.00000000035565338969540626 Scatter Plot
Target VWF Target CEACAM CEACAM Cell-Cell Contact -0.2729 0.0000000005437722650761073 Scatter Plot
Target VWF Target CXCL CXCL Secreted Signaling -0.2664 0.0000000014215829350090307 Scatter Plot
Target VWF Target VEGF VEGF Secreted Signaling -0.2594 0.000000003909467534801964 Scatter Plot
Target VWF Target COMPLEMENT COMPLEMENT Secreted Signaling -0.1830 0.00003828631760445316 Scatter Plot
Target VWF Target SEMA3 SEMA3 Secreted Signaling -0.1386 0.0018947307485703 Scatter Plot
Target VWF Target SELE SELE Cell-Cell Contact -0.1266 0.0045719270012158 Scatter Plot
Target VWF Target GRN GRN Secreted Signaling -0.1258 0.0048302251403122 Scatter Plot
Target VWF Target ANNEXIN ANNEXIN Secreted Signaling -0.0996 0.0258901047514062 Scatter Plot

Cells that are targets of VWF from HSCs*

    No cell populations

Cells that are source of VWF to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.