Pathway: CSPG4

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Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Cell-Cell Contact

Details on the CSPG4 pathway:

Specificity Index HSPC as target: 0.119
HSPC as source: 0.407

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the CSPG4 pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target CSPG4 Source ncWNT ncWNT Secreted Signaling 0.1141 0.0106852763080487 Scatter Plot
Target CSPG4 Source PTN PTN Secreted Signaling 0.1198 0.0073437615379044 Scatter Plot
Target CSPG4 Source ANGPTL ANGPTL Secreted Signaling 0.1311 0.0033120623242534 Scatter Plot
Target CSPG4 Source THY1 THY1 Cell-Cell Contact 0.1354 0.0024110433360872 Scatter Plot
Target CSPG4 Source SEMA6 SEMA6 Cell-Cell Contact 0.1359 0.0023222923858131 Scatter Plot
Target CSPG4 Source IL16 IL16 Secreted Signaling 0.1369 0.0021572565154345 Scatter Plot
Target CSPG4 Target GDF GDF Secreted Signaling 0.1384 0.0019159547878684 Scatter Plot
Target CSPG4 Source NT NT Secreted Signaling 0.1479 0.0009109622087499 Scatter Plot
Target CSPG4 Source LIGHT LIGHT Secreted Signaling 0.1631 0.0002497907359861 Scatter Plot
Target CSPG4 Target VEGF VEGF Secreted Signaling 0.1689 0.0001474325369836 Scatter Plot
Target CSPG4 Source CXCL CXCL Secreted Signaling 0.1776 0.00006523342842065921 Scatter Plot
Target CSPG4 Source PROS PROS Secreted Signaling 0.1807 0.00004808699645187975 Scatter Plot
Target CSPG4 Source CD45 CD45 Cell-Cell Contact 0.1932 0.000013562117688471192 Scatter Plot
Target CSPG4 Source CD86 CD86 Cell-Cell Contact 0.1995 0.000006932264384495567 Scatter Plot
Target CSPG4 Source AGRN AGRN ECM-Receptor 0.2010 0.000005909372249520705 Scatter Plot
Target CSPG4 Source CD39 CD39 Cell-Cell Contact 0.2037 0.000004381239096735658 Scatter Plot
Target CSPG4 Source CCL CCL Secreted Signaling 0.2128 0.000001564773460103694 Scatter Plot
Target CSPG4 Target NCAM NCAM Cell-Cell Contact 0.2163 0.0000010498728400240263 Scatter Plot
Target CSPG4 Source MK MK Secreted Signaling 0.2194 0.0000007261921522736894 Scatter Plot
Target CSPG4 Source PSAP PSAP Secreted Signaling 0.2272 0.0000002803014861641584 Scatter Plot
Target CSPG4 Target CD200 CD200 Cell-Cell Contact 0.2352 0.00000010332058138107481 Scatter Plot
Target CSPG4 Source ICAM ICAM Cell-Cell Contact 0.2405 0.00000005184351790476702 Scatter Plot
Target CSPG4 Target PTN PTN Secreted Signaling 0.2415 0.0000000457258595631413 Scatter Plot
Target CSPG4 Source VEGF VEGF Secreted Signaling 0.2416 0.0000000451551455621869 Scatter Plot
Target CSPG4 Source SEMA3 SEMA3 Secreted Signaling 0.2462 0.000000024514061769913423 Scatter Plot
Target CSPG4 Source CD46 CD46 Cell-Cell Contact 0.2487 0.000000017421388652070297 Scatter Plot
Target CSPG4 Source COLLAGEN COLLAGEN ECM-Receptor 0.2556 0.0000000067367448560557396 Scatter Plot
Target CSPG4 Source FLT3 FLT3 Secreted Signaling 0.2574 0.000000005226286979938991 Scatter Plot
Target CSPG4 Source EPHB EPHB Cell-Cell Contact 0.2614 0.0000000029577531734243403 Scatter Plot
Target CSPG4 Source LAMININ LAMININ ECM-Receptor 0.2632 0.000000002284251074619485 Scatter Plot
Target CSPG4 Source LIFR LIFR Secreted Signaling 0.2658 0.0000000015714468655981475 Scatter Plot
Target CSPG4 Source NOTCH NOTCH Cell-Cell Contact 0.2700 0.0000000008460273567317523 Scatter Plot
Target CSPG4 Source CX3C CX3C Secreted Signaling 0.2730 0.0000000005361160114163925 Scatter Plot
Target CSPG4 Source IGF IGF Secreted Signaling 0.2761 0.00000000033486117885456723 Scatter Plot
Target CSPG4 Source LCK LCK Cell-Cell Contact 0.2794 0.00000000020350096262085889 Scatter Plot
Target CSPG4 Source WNT WNT Secreted Signaling 0.2817 0.0000000001426841767971981 Scatter Plot
Target CSPG4 Source ANGPT ANGPT Secreted Signaling 0.2849 0.00000000008613744628837836 Scatter Plot
Target CSPG4 Target BSP BSP ECM-Receptor 0.2905 0.000000000035352485100007783 Scatter Plot
Target CSPG4 Source CDH CDH Cell-Cell Contact 0.2956 0.000000000015222521745222153 Scatter Plot
Target CSPG4 Target CDH CDH Cell-Cell Contact 0.2960 0.000000000014306012264551326 Scatter Plot
Target CSPG4 Source CSF CSF Secreted Signaling 0.2974 0.000000000011347335703199018 Scatter Plot
Target CSPG4 Target CD39 CD39 Cell-Cell Contact 0.2997 0.000000000007815439093081393 Scatter Plot
Target CSPG4 Source SEMA7 SEMA7 Cell-Cell Contact 0.3009 0.000000000006325479840837628 Scatter Plot
Target CSPG4 Target MIF MIF Secreted Signaling 0.3009 0.000000000006306397321670426 Scatter Plot
Target CSPG4 Source BST2 BST2 Cell-Cell Contact 0.3044 0.000000000003525475185279216 Scatter Plot
Target CSPG4 Source ESAM ESAM Cell-Cell Contact 0.3051 0.000000000003127277565668406 Scatter Plot
Target CSPG4 Source PDGF PDGF Secreted Signaling 0.3099 0.000000000001357947394073719 Scatter Plot
Target CSPG4 Source CADM CADM Cell-Cell Contact 0.3145 0.0000000000006059964090628643 Scatter Plot
Target CSPG4 Target CADM CADM Cell-Cell Contact 0.3145 0.0000000000006059964090628643 Scatter Plot
Target CSPG4 Source RANKL RANKL Secreted Signaling 0.3150 0.0000000000005596658602771173 Scatter Plot
Target CSPG4 Source MHC-II MHC-II Cell-Cell Contact 0.3289 0.000000000000044540321687898654 Scatter Plot
Target CSPG4 Source TWEAK TWEAK Secreted Signaling 0.3373 0.000000000000009104732561154476 Scatter Plot
Target CSPG4 Source MHC-I MHC-I Cell-Cell Contact 0.3391 0.0000000000000063859979107595086 Scatter Plot
Target CSPG4 Target CD34 CD34 Cell-Cell Contact 0.3395 0.000000000000005855583679406865 Scatter Plot
Target CSPG4 Source IL2 IL2 Secreted Signaling 0.3400 0.0000000000000053161639854311015 Scatter Plot
Target CSPG4 Source GAS GAS Secreted Signaling 0.3632 0.00000000000000004905596923652395 Scatter Plot
Target CSPG4 Source BMP BMP Secreted Signaling 0.3685 0.00000000000000001570380593782401 Scatter Plot
Target CSPG4 Target ncWNT ncWNT Secreted Signaling 0.3694 0.000000000000000012934472273907884 Scatter Plot
Target CSPG4 Source JAM JAM Cell-Cell Contact 0.3764 0.000000000000000002800768996462286 Scatter Plot
Target CSPG4 Source IL7 IL7 Secreted Signaling 0.4061 0.00000000000000000000278447926541142 Scatter Plot
Target CSPG4 Source CD52 CD52 Cell-Cell Contact -0.2958 0.000000000014899898560360508 Scatter Plot
Target CSPG4 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.2192 0.0000007464300536144233 Scatter Plot
Target CSPG4 Target CXCL CXCL Secreted Signaling -0.2033 0.00000458939882230117 Scatter Plot
Target CSPG4 Source SELL SELL Cell-Cell Contact -0.2017 0.00000546012217120143 Scatter Plot
Target CSPG4 Target CSF CSF Secreted Signaling -0.2004 0.0000063036423599235295 Scatter Plot
Target CSPG4 Source TGFb TGFb Secreted Signaling -0.1825 0.00004038229905056705 Scatter Plot
Target CSPG4 Source SEMA4 SEMA4 Cell-Cell Contact -0.1710 0.0001215725580149 Scatter Plot
Target CSPG4 Source COMPLEMENT COMPLEMENT Secreted Signaling -0.1688 0.0001492690612472 Scatter Plot
Target CSPG4 Source PARs PARs Secreted Signaling -0.1659 0.000194912194088 Scatter Plot
Target CSPG4 Source NKG2D NKG2D Cell-Cell Contact -0.1511 0.0007014269046692 Scatter Plot
Target CSPG4 Source ANNEXIN ANNEXIN Secreted Signaling -0.1504 0.0007435781918105 Scatter Plot
Target CSPG4 Source CCL CCL Secreted Signaling -0.1470 0.0009771383932547 Scatter Plot
Target CSPG4 Source VISTA VISTA Cell-Cell Contact -0.1366 0.0022077376471289 Scatter Plot
Target CSPG4 Source SELPLG SELPLG Cell-Cell Contact -0.1341 0.0026502474484907 Scatter Plot
Target CSPG4 Source MIF MIF Secreted Signaling -0.1255 0.0049566736709662 Scatter Plot
Target CSPG4 Source ANGPTL ANGPTL Secreted Signaling -0.1190 0.0077428474740254 Scatter Plot
Target CSPG4 Target CEACAM CEACAM Cell-Cell Contact -0.1153 0.0098786459469339 Scatter Plot
Target CSPG4 Source IL1 IL1 Secreted Signaling -0.1033 0.0209322479819531 Scatter Plot
Target CSPG4 Source LAIR1 LAIR1 Cell-Cell Contact -0.1010 0.0239754565318835 Scatter Plot
Target CSPG4 Source NCAM NCAM Cell-Cell Contact -0.0996 0.0260140678369225 Scatter Plot
Target CSPG4 Target OSM OSM Secreted Signaling 0.1151 0.0099933460693548 Scatter Plot
Target CSPG4 Target CD23 CD23 Cell-Cell Contact 0.1222 0.0062089112346238 Scatter Plot
Target CSPG4 Target CD45 CD45 Cell-Cell Contact 0.1247 0.0052228536739203 Scatter Plot
Target CSPG4 Target THY1 THY1 Cell-Cell Contact 0.1337 0.0027433639293 Scatter Plot
Target CSPG4 Target BAFF BAFF Secreted Signaling 0.1577 0.0003999291006082 Scatter Plot
Target CSPG4 Target IL6 IL6 Secreted Signaling 0.1588 0.0003637506298921 Scatter Plot
Target CSPG4 Target AGT AGT Secreted Signaling 0.1600 0.0003291405048883 Scatter Plot
Target CSPG4 Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.1773 0.00006731274294001118 Scatter Plot
Target CSPG4 Target SEMA5 SEMA5 Cell-Cell Contact 0.1805 0.00004900310925102406 Scatter Plot
Target CSPG4 Target NODAL NODAL Secreted Signaling 0.1842 0.00003421452527190188 Scatter Plot
Target CSPG4 Target EPHB EPHB Cell-Cell Contact 0.1903 0.00001839336288898054 Scatter Plot
Target CSPG4 Target CD22 CD22 Cell-Cell Contact 0.1932 0.000013562117688471192 Scatter Plot
Target CSPG4 Target EPHA EPHA Cell-Cell Contact 0.1989 0.000007424861481168582 Scatter Plot
Target CSPG4 Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.2013 0.00000573842638526432 Scatter Plot
Target CSPG4 Target KIT KIT Secreted Signaling 0.2064 0.000003248098882203313 Scatter Plot
Target CSPG4 Target RANKL RANKL Secreted Signaling 0.2295 0.0000002119525943335069 Scatter Plot
Target CSPG4 Target ACTIVIN ACTIVIN Secreted Signaling 0.2328 0.00000014088661114053412 Scatter Plot
Target CSPG4 Target PARs PARs Secreted Signaling 0.2334 0.00000012941456237956512 Scatter Plot
Target CSPG4 Target SEMA6 SEMA6 Cell-Cell Contact 0.2336 0.00000012672730426235166 Scatter Plot
Target CSPG4 Target SEMA4 SEMA4 Cell-Cell Contact 0.2351 0.00000010488105845129719 Scatter Plot
Target CSPG4 Target CD200 CD200 Cell-Cell Contact 0.2354 0.00000010073958034066745 Scatter Plot
Target CSPG4 Target SLURP SLURP Secreted Signaling 0.2581 0.000000004703470546882679 Scatter Plot
Target CSPG4 Target VWF VWF ECM-Receptor 0.2698 0.0000000008730845887823357 Scatter Plot
Target CSPG4 Target NPR2 NPR2 Secreted Signaling 0.2744 0.00000000043753398865714174 Scatter Plot
Target CSPG4 Target PERIOSTIN PERIOSTIN Secreted Signaling 0.2815 0.00000000014695204747429928 Scatter Plot
Target CSPG4 Target NRG NRG Secreted Signaling 0.2823 0.00000000012879734455911612 Scatter Plot
Target CSPG4 Target IGF IGF Secreted Signaling 0.2828 0.00000000011992635194979922 Scatter Plot
Target CSPG4 Target CDH CDH Cell-Cell Contact 0.2948 0.000000000017446174886472376 Scatter Plot
Target CSPG4 Target TGFb TGFb Secreted Signaling 0.2971 0.000000000012013913709377144 Scatter Plot
Target CSPG4 Target CD39 CD39 Cell-Cell Contact 0.2997 0.000000000007815439093081393 Scatter Plot
Target CSPG4 Target ESAM ESAM Cell-Cell Contact 0.3051 0.000000000003127277565668406 Scatter Plot
Target CSPG4 Target DMP1 DMP1 ECM-Receptor 0.3059 0.000000000002722931384083355 Scatter Plot
Target CSPG4 Target FGF FGF Secreted Signaling 0.3102 0.0000000000012847426434664894 Scatter Plot
Target CSPG4 Target CADM CADM Cell-Cell Contact 0.3145 0.0000000000006059964090628643 Scatter Plot
Target CSPG4 Target CD34 CD34 Cell-Cell Contact 0.3395 0.000000000000005855583679406993 Scatter Plot
Target CSPG4 Target APP APP Cell-Cell Contact 0.3418 0.000000000000003806858004613198 Scatter Plot
Target CSPG4 Target BMP BMP Secreted Signaling 0.3618 0.00000000000000006495232745828331 Scatter Plot
Target CSPG4 Target WNT WNT Secreted Signaling 0.4009 0.000000000000000000009782197035219336 Scatter Plot
Target CSPG4 Target IFN-II IFN-II Secreted Signaling -0.2327 0.00000014154272817751858 Scatter Plot
Target CSPG4 Target ICAM ICAM Cell-Cell Contact -0.2083 0.0000026347845129367675 Scatter Plot
Target CSPG4 Target CXCL CXCL Secreted Signaling -0.2042 0.000004156953661827736 Scatter Plot
Target CSPG4 Target CSF CSF Secreted Signaling -0.2004 0.0000063036423599235295 Scatter Plot
Target CSPG4 Target CD52 CD52 Cell-Cell Contact -0.1772 0.00006751412372226304 Scatter Plot
Target CSPG4 Target SEMA3 SEMA3 Secreted Signaling -0.1226 0.0060472738989172 Scatter Plot
Target CSPG4 Target CEACAM CEACAM Cell-Cell Contact -0.1153 0.0098786459469339 Scatter Plot
Target CSPG4 Target CCL CCL Secreted Signaling -0.1123 0.0119996024895251 Scatter Plot
Target CSPG4 Target COMPLEMENT COMPLEMENT Secreted Signaling -0.1012 0.0236370995809138 Scatter Plot

Cells that are targets of CSPG4 from HSCs*

    No cell populations

Cells that are source of CSPG4 to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.