Pathway: ADIPONECTIN

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the ADIPONECTIN pathway:

Specificity Index HSPC as target: 0.133
HSPC as source: 0.608

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the ADIPONECTIN pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target ADIPONECTIN Source OSM OSM Secreted Signaling 0.0971 0.0298670863204219 Scatter Plot
Target ADIPONECTIN Target SEMA3 SEMA3 Secreted Signaling 0.1024 0.0220183884829219 Scatter Plot
Target ADIPONECTIN Source WNT WNT Secreted Signaling 0.1078 0.0158581730771308 Scatter Plot
Target ADIPONECTIN Source ANGPTL ANGPTL Secreted Signaling 0.1086 0.01508773773993 Scatter Plot
Target ADIPONECTIN Source CD1D2 CD1D2 Cell-Cell Contact 0.1098 0.0140323314939077 Scatter Plot
Target ADIPONECTIN Target MK MK Secreted Signaling 0.1259 0.0048197243323882 Scatter Plot
Target ADIPONECTIN Source ncWNT ncWNT Secreted Signaling 0.1285 0.0040073140034453 Scatter Plot
Target ADIPONECTIN Target PECAM1 PECAM1 Cell-Cell Contact 0.1304 0.0034905171948748 Scatter Plot
Target ADIPONECTIN Source PECAM1 PECAM1 Cell-Cell Contact 0.1304 0.0034905171948748 Scatter Plot
Target ADIPONECTIN Target VEGF VEGF Secreted Signaling 0.1345 0.0025768267985657 Scatter Plot
Target ADIPONECTIN Source THY1 THY1 Cell-Cell Contact 0.1677 0.0001653310504209 Scatter Plot
Target ADIPONECTIN Source GDF GDF Secreted Signaling 0.1715 0.0001164663006451 Scatter Plot
Target ADIPONECTIN Target CSPG4 CSPG4 Cell-Cell Contact 0.1773 0.00006731274294001118 Scatter Plot
Target ADIPONECTIN Target COMPLEMENT COMPLEMENT Secreted Signaling 0.1826 0.00004000718452904317 Scatter Plot
Target ADIPONECTIN Target COLLAGEN COLLAGEN ECM-Receptor 0.1847 0.000032585376208831856 Scatter Plot
Target ADIPONECTIN Source CXCL CXCL Secreted Signaling 0.1864 0.00002730190451489421 Scatter Plot
Target ADIPONECTIN Source BAFF BAFF Secreted Signaling 0.1917 0.000015881350563835386 Scatter Plot
Target ADIPONECTIN Source CCL CCL Secreted Signaling 0.1926 0.00001442692777705903 Scatter Plot
Target ADIPONECTIN Target AGT AGT Secreted Signaling 0.1961 0.000010056127431480964 Scatter Plot
Target ADIPONECTIN Source NT NT Secreted Signaling 0.1978 0.00000831878505006678 Scatter Plot
Target ADIPONECTIN Source CADM CADM Cell-Cell Contact 0.1982 0.000008033495773788004 Scatter Plot
Target ADIPONECTIN Source CSF CSF Secreted Signaling 0.1999 0.000006658739216820952 Scatter Plot
Target ADIPONECTIN Source PROS PROS Secreted Signaling 0.2041 0.000004205792865511822 Scatter Plot
Target ADIPONECTIN Source VCAM VCAM Cell-Cell Contact 0.2052 0.0000037341615571658672 Scatter Plot
Target ADIPONECTIN Target ANGPTL ANGPTL Secreted Signaling 0.2121 0.0000017134806413192331 Scatter Plot
Target ADIPONECTIN Target GDF GDF Secreted Signaling 0.2136 0.0000014338774987117347 Scatter Plot
Target ADIPONECTIN Source ICAM ICAM Cell-Cell Contact 0.2140 0.0000013742861324979914 Scatter Plot
Target ADIPONECTIN Source IGF IGF Secreted Signaling 0.2210 0.000000598806353951889 Scatter Plot
Target ADIPONECTIN Target EPHB EPHB Cell-Cell Contact 0.2227 0.0000004907599978172376 Scatter Plot
Target ADIPONECTIN Source VEGF VEGF Secreted Signaling 0.2287 0.0000002345986305101769 Scatter Plot
Target ADIPONECTIN Source NOTCH NOTCH Cell-Cell Contact 0.2323 0.00000014944278559524098 Scatter Plot
Target ADIPONECTIN Source BST2 BST2 Cell-Cell Contact 0.2357 0.00000009622490874233152 Scatter Plot
Target ADIPONECTIN Source PDGF PDGF Secreted Signaling 0.2394 0.00000005984269886853957 Scatter Plot
Target ADIPONECTIN Source LIFR LIFR Secreted Signaling 0.2417 0.00000004412446309990245 Scatter Plot
Target ADIPONECTIN Source CD86 CD86 Cell-Cell Contact 0.2448 0.000000029553366659805295 Scatter Plot
Target ADIPONECTIN Target VWF VWF ECM-Receptor 0.2448 0.00000002921138171837544 Scatter Plot
Target ADIPONECTIN Source SEMA3 SEMA3 Secreted Signaling 0.2467 0.000000022922986820688715 Scatter Plot
Target ADIPONECTIN Source RANKL RANKL Secreted Signaling 0.2583 0.000000004602318944797801 Scatter Plot
Target ADIPONECTIN Target SPP1 SPP1 Secreted Signaling 0.2605 0.000000003353774865582057 Scatter Plot
Target ADIPONECTIN Source IL2 IL2 Secreted Signaling 0.2606 0.000000003334238983431244 Scatter Plot
Target ADIPONECTIN Source CD39 CD39 Cell-Cell Contact 0.2696 0.0000000008941475749266102 Scatter Plot
Target ADIPONECTIN Target ANGPT ANGPT Secreted Signaling 0.2771 0.000000000286614307061128 Scatter Plot
Target ADIPONECTIN Source CD46 CD46 Cell-Cell Contact 0.2810 0.00000000015830634587277876 Scatter Plot
Target ADIPONECTIN Target TGFb TGFb Secreted Signaling 0.2861 0.00000000007065824634660412 Scatter Plot
Target ADIPONECTIN Source EPHB EPHB Cell-Cell Contact 0.2907 0.00000000003390240202700535 Scatter Plot
Target ADIPONECTIN Source LAMININ LAMININ ECM-Receptor 0.2943 0.000000000019029224997966108 Scatter Plot
Target ADIPONECTIN Source MK MK Secreted Signaling 0.2959 0.00000000001461963355084719 Scatter Plot
Target ADIPONECTIN Target ACTIVIN ACTIVIN Secreted Signaling 0.2987 0.000000000009222800382371729 Scatter Plot
Target ADIPONECTIN Source LIGHT LIGHT Secreted Signaling 0.3020 0.0000000000052512317997208426 Scatter Plot
Target ADIPONECTIN Source CX3C CX3C Secreted Signaling 0.3051 0.000000000003118571640480405 Scatter Plot
Target ADIPONECTIN Source IL7 IL7 Secreted Signaling 0.3079 0.0000000000019107302351748906 Scatter Plot
Target ADIPONECTIN Source LCK LCK Cell-Cell Contact 0.3090 0.0000000000015873167889001126 Scatter Plot
Target ADIPONECTIN Target NCAM NCAM Cell-Cell Contact 0.3091 0.0000000000015610110835331884 Scatter Plot
Target ADIPONECTIN Source FLT3 FLT3 Secreted Signaling 0.3167 0.00000000000041445019421176134 Scatter Plot
Target ADIPONECTIN Source PSAP PSAP Secreted Signaling 0.3185 0.0000000000002959187166988756 Scatter Plot
Target ADIPONECTIN Source CDH CDH Cell-Cell Contact 0.3215 0.00000000000017309461468070882 Scatter Plot
Target ADIPONECTIN Target BSP BSP ECM-Receptor 0.3443 0.0000000000000023080789329439997 Scatter Plot
Target ADIPONECTIN Target KIT KIT Secreted Signaling 0.3525 0.0000000000000004453591731641896 Scatter Plot
Target ADIPONECTIN Source BMP BMP Secreted Signaling 0.3548 0.00000000000000027742535346953983 Scatter Plot
Target ADIPONECTIN Source TWEAK TWEAK Secreted Signaling 0.3633 0.000000000000000047493372502513267 Scatter Plot
Target ADIPONECTIN Source SEMA7 SEMA7 Cell-Cell Contact 0.3635 0.00000000000000004590576869527225 Scatter Plot
Target ADIPONECTIN Source IL16 IL16 Secreted Signaling 0.3702 0.000000000000000011011706060069644 Scatter Plot
Target ADIPONECTIN Target SLURP SLURP Secreted Signaling 0.3723 0.000000000000000006955947445571308 Scatter Plot
Target ADIPONECTIN Source COLLAGEN COLLAGEN ECM-Receptor 0.3907 0.00000000000000000010970063029365637 Scatter Plot
Target ADIPONECTIN Target CD39 CD39 Cell-Cell Contact 0.3939 0.0000000000000000000523669902454914 Scatter Plot
Target ADIPONECTIN Source ESAM ESAM Cell-Cell Contact 0.3994 0.000000000000000000014029103475888067 Scatter Plot
Target ADIPONECTIN Source CD45 CD45 Cell-Cell Contact 0.4078 0.0000000000000000000018464238454281586 Scatter Plot
Target ADIPONECTIN Source GAS GAS Secreted Signaling 0.4110 0.0000000000000000000008352013353770601 Scatter Plot
Target ADIPONECTIN Source ANGPT ANGPT Secreted Signaling 0.4149 0.00000000000000000000031261119883743943 Scatter Plot
Target ADIPONECTIN Source JAM JAM Cell-Cell Contact 0.4235 0.00000000000000000000003503340070784664 Scatter Plot
Target ADIPONECTIN Target APP APP Cell-Cell Contact 0.4268 0.000000000000000000000014842990507906746 Scatter Plot
Target ADIPONECTIN Source MHC-II MHC-II Cell-Cell Contact 0.4274 0.000000000000000000000012676059453059437 Scatter Plot
Target ADIPONECTIN Target JAM JAM Cell-Cell Contact 0.4707 0.00000000000000000000000000006041098278139559 Scatter Plot
Target ADIPONECTIN Source MHC-I MHC-I Cell-Cell Contact 0.4883 0.0000000000000000000000000000002519151586416003 Scatter Plot
Target ADIPONECTIN Source MIF MIF Secreted Signaling -0.5618 0.0000000000000000000000000000000000000000005946051910652529 Scatter Plot
Target ADIPONECTIN Source ANGPTL ANGPTL Secreted Signaling -0.3930 0.00000000000000000006463645732144107 Scatter Plot
Target ADIPONECTIN Source TGFb TGFb Secreted Signaling -0.3638 0.00000000000000004273940598017442 Scatter Plot
Target ADIPONECTIN Source PARs PARs Secreted Signaling -0.3148 0.0000000000005750559821444126 Scatter Plot
Target ADIPONECTIN Source SELL SELL Cell-Cell Contact -0.2939 0.000000000020099306570308424 Scatter Plot
Target ADIPONECTIN Source CD52 CD52 Cell-Cell Contact -0.2720 0.000000000627725992158716 Scatter Plot
Target ADIPONECTIN Source CCL CCL Secreted Signaling -0.2633 0.00000000223528389575137 Scatter Plot
Target ADIPONECTIN Source COMPLEMENT COMPLEMENT Secreted Signaling -0.2621 0.000000002666046670794943 Scatter Plot
Target ADIPONECTIN Target IL17 IL17 Secreted Signaling -0.2511 0.000000012579356151067973 Scatter Plot
Target ADIPONECTIN Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.2462 0.000000024212258741886504 Scatter Plot
Target ADIPONECTIN Target CXCL CXCL Secreted Signaling -0.2028 0.000004866272929266748 Scatter Plot
Target ADIPONECTIN Source SEMA4 SEMA4 Cell-Cell Contact -0.1941 0.000012384173140544625 Scatter Plot
Target ADIPONECTIN Source CLEC CLEC Cell-Cell Contact -0.1775 0.00006571653180729509 Scatter Plot
Target ADIPONECTIN Target ICAM ICAM Cell-Cell Contact -0.1744 0.00008851171861438828 Scatter Plot
Target ADIPONECTIN Source VISFATIN VISFATIN Secreted Signaling -0.1602 0.000323182236063 Scatter Plot
Target ADIPONECTIN Target SEMA3 SEMA3 Secreted Signaling -0.1289 0.0038987055144575 Scatter Plot
Target ADIPONECTIN Source VISTA VISTA Cell-Cell Contact -0.1066 0.0170907475424891 Scatter Plot
Target ADIPONECTIN Source CD34 CD34 Cell-Cell Contact -0.1050 0.0189032763539405 Scatter Plot
Target ADIPONECTIN Source SPP1 SPP1 Secreted Signaling -0.1034 0.020750275119079 Scatter Plot
Target ADIPONECTIN Source NKG2D NKG2D Cell-Cell Contact -0.1008 0.0242099043183755 Scatter Plot
Target ADIPONECTIN Target BST2 BST2 Cell-Cell Contact 0.0995 0.0260689756429559 Scatter Plot
Target ADIPONECTIN Target LAIR1 LAIR1 Cell-Cell Contact 0.0995 0.0260689756429559 Scatter Plot
Target ADIPONECTIN Target VISFATIN VISFATIN Secreted Signaling 0.1008 0.0242210753143517 Scatter Plot
Target ADIPONECTIN Target EPHA EPHA Cell-Cell Contact 0.1123 0.0119913466601873 Scatter Plot
Target ADIPONECTIN Target IL1 IL1 Secreted Signaling 0.1261 0.0047536102021641 Scatter Plot
Target ADIPONECTIN Target OSM OSM Secreted Signaling 0.1325 0.0030020182237904 Scatter Plot
Target ADIPONECTIN Target NOTCH NOTCH Cell-Cell Contact 0.1884 0.000022226711501898855 Scatter Plot
Target ADIPONECTIN Target CADM CADM Cell-Cell Contact 0.1982 0.000008033495773788004 Scatter Plot
Target ADIPONECTIN Target AGT AGT Secreted Signaling 0.1992 0.000007158654058178344 Scatter Plot
Target ADIPONECTIN Target SEMA6 SEMA6 Cell-Cell Contact 0.2022 0.000005207587539421033 Scatter Plot
Target ADIPONECTIN Target FN1 FN1 ECM-Receptor 0.2097 0.0000022364913177068327 Scatter Plot
Target ADIPONECTIN Target NODAL NODAL Secreted Signaling 0.2128 0.0000015676970041187872 Scatter Plot
Target ADIPONECTIN Target LAMININ LAMININ ECM-Receptor 0.2315 0.00000016516295476965741 Scatter Plot
Target ADIPONECTIN Target SEMA5 SEMA5 Cell-Cell Contact 0.2354 0.00000010082555694871349 Scatter Plot
Target ADIPONECTIN Target GALECTIN GALECTIN Secreted Signaling 0.2520 0.000000011050134490549812 Scatter Plot
Target ADIPONECTIN Target VTN VTN ECM-Receptor 0.2537 0.00000000879706137114774 Scatter Plot
Target ADIPONECTIN Target SEMA4 SEMA4 Cell-Cell Contact 0.2635 0.000000002177472300651774 Scatter Plot
Target ADIPONECTIN Target BAFF BAFF Secreted Signaling 0.2681 0.0000000011220057810895583 Scatter Plot
Target ADIPONECTIN Target ANGPTL ANGPTL Secreted Signaling 0.2696 0.0000000008899003342865496 Scatter Plot
Target ADIPONECTIN Target THY1 THY1 Cell-Cell Contact 0.2705 0.0000000007823356824428401 Scatter Plot
Target ADIPONECTIN Target ANGPT ANGPT Secreted Signaling 0.2771 0.000000000286614307061128 Scatter Plot
Target ADIPONECTIN Target SEMA7 SEMA7 Cell-Cell Contact 0.2892 0.00000000004345915375939121 Scatter Plot
Target ADIPONECTIN Target CD23 CD23 Cell-Cell Contact 0.2929 0.000000000023693139140990125 Scatter Plot
Target ADIPONECTIN Target WNT WNT Secreted Signaling 0.2983 0.000000000009743484335352363 Scatter Plot
Target ADIPONECTIN Target TENASCIN TENASCIN ECM-Receptor 0.3064 0.0000000000024821440114080817 Scatter Plot
Target ADIPONECTIN Target NPR2 NPR2 Secreted Signaling 0.3096 0.0000000000014236716885231292 Scatter Plot
Target ADIPONECTIN Target THBS THBS ECM-Receptor 0.3100 0.000000000001334590610566334 Scatter Plot
Target ADIPONECTIN Target APP APP Cell-Cell Contact 0.3136 0.0000000000007122249728266574 Scatter Plot
Target ADIPONECTIN Target NRG NRG Secreted Signaling 0.3184 0.00000000000030394708818637004 Scatter Plot
Target ADIPONECTIN Target BMP BMP Secreted Signaling 0.3186 0.00000000000029387616258348543 Scatter Plot
Target ADIPONECTIN Target CDH CDH Cell-Cell Contact 0.3215 0.00000000000017309461468070698 Scatter Plot
Target ADIPONECTIN Target PERIOSTIN PERIOSTIN Secreted Signaling 0.3234 0.00000000000012213871900627333 Scatter Plot
Target ADIPONECTIN Target PARs PARs Secreted Signaling 0.3281 0.000000000000051916200521676825 Scatter Plot
Target ADIPONECTIN Target CD34 CD34 Cell-Cell Contact 0.3359 0.000000000000011818196302169855 Scatter Plot
Target ADIPONECTIN Target DMP1 DMP1 ECM-Receptor 0.3435 0.000000000000002692659158643979 Scatter Plot
Target ADIPONECTIN Target CD200 CD200 Cell-Cell Contact 0.3523 0.0000000000000004621437058968171 Scatter Plot
Target ADIPONECTIN Target ncWNT ncWNT Secreted Signaling 0.3555 0.0000000000000002413529332797308 Scatter Plot
Target ADIPONECTIN Target MIF MIF Secreted Signaling 0.3753 0.000000000000000003608121577879082 Scatter Plot
Target ADIPONECTIN Target ESAM ESAM Cell-Cell Contact 0.3994 0.000000000000000000014029103475888067 Scatter Plot
Target ADIPONECTIN Target CD22 CD22 Cell-Cell Contact 0.4078 0.0000000000000000000018464238454281586 Scatter Plot
Target ADIPONECTIN Target FGF FGF Secreted Signaling 0.4158 0.00000000000000000000024952800040779964 Scatter Plot
Target ADIPONECTIN Target IGF IGF Secreted Signaling 0.4438 0.00000000000000000000000015193036700998023 Scatter Plot
Target ADIPONECTIN Target CSF CSF Secreted Signaling -0.3371 0.000000000000009403697570531424 Scatter Plot
Target ADIPONECTIN Target CD52 CD52 Cell-Cell Contact -0.2841 0.0000000000977558209109008 Scatter Plot
Target ADIPONECTIN Target VEGF VEGF Secreted Signaling -0.2164 0.0000010361474183403956 Scatter Plot
Target ADIPONECTIN Target CLEC CLEC Cell-Cell Contact -0.2015 0.000005570757800831679 Scatter Plot
Target ADIPONECTIN Target IFN-II IFN-II Secreted Signaling -0.1534 0.0005753342379978 Scatter Plot
Target ADIPONECTIN Target CCL CCL Secreted Signaling -0.1454 0.0011155154105877 Scatter Plot
Target ADIPONECTIN Target VCAM VCAM Cell-Cell Contact -0.1154 0.009799988727144 Scatter Plot

Cells that are targets of ADIPONECTIN from HSCs*

    No cell populations

Cells that are source of ADIPONECTIN to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.