Pathway: PARs

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the PARs pathway:

Specificity Index HSPC as target: 0.684
HSPC as source: 0.979

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the PARs pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target PARs Target PECAM1 PECAM1 Cell-Cell Contact 0.0964 0.0310944277949151 Scatter Plot
Target PARs Source PECAM1 PECAM1 Cell-Cell Contact 0.0964 0.0310944277949151 Scatter Plot
Target PARs Source ncWNT ncWNT Secreted Signaling 0.0969 0.0302950957192388 Scatter Plot
Target PARs Source SEMA4 SEMA4 Cell-Cell Contact 0.1012 0.0236965725810746 Scatter Plot
Target PARs Target EPHA EPHA Cell-Cell Contact 0.1012 0.02356567659811 Scatter Plot
Source PARs Source CD34 CD34 Cell-Cell Contact 0.1064 0.0173363711604188 Scatter Plot
Source PARs Source VISFATIN VISFATIN Secreted Signaling 0.1227 0.0060098758641995 Scatter Plot
Target PARs Target PDGF PDGF Secreted Signaling 0.1308 0.0033987996649187 Scatter Plot
Target PARs Target COMPLEMENT COMPLEMENT Secreted Signaling 0.1336 0.0027606312862924 Scatter Plot
Target PARs Source THBS THBS ECM-Receptor 0.1364 0.002240553706486 Scatter Plot
Target PARs Source SEMA3 SEMA3 Secreted Signaling 0.1496 0.000794217340491 Scatter Plot
Target PARs Source CD39 CD39 Cell-Cell Contact 0.1525 0.0006215520381301 Scatter Plot
Target PARs Source APELIN APELIN Secreted Signaling 0.1538 0.000557585895861 Scatter Plot
Target PARs Target NODAL NODAL Secreted Signaling 0.1542 0.0005408417284155 Scatter Plot
Target PARs Source ANGPTL ANGPTL Secreted Signaling 0.1576 0.0004057290653001 Scatter Plot
Target PARs Target GDF GDF Secreted Signaling 0.1577 0.0004015959072798 Scatter Plot
Target PARs Source GDF GDF Secreted Signaling 0.1589 0.000360225342189 Scatter Plot
Source PARs Source TNF TNF Secreted Signaling 0.1651 0.0002087172540206 Scatter Plot
Target PARs Target COLLAGEN COLLAGEN ECM-Receptor 0.1701 0.0001320000974736 Scatter Plot
Source PARs Source TGFb TGFb Secreted Signaling 0.1761 0.00007531357626503316 Scatter Plot
Target PARs Source CD1D2 CD1D2 Cell-Cell Contact 0.1769 0.00006962031333607192 Scatter Plot
Target PARs Target OSM OSM Secreted Signaling 0.1819 0.00004282873348787814 Scatter Plot
Target PARs Source PTN PTN Secreted Signaling 0.1851 0.00003112785534992588 Scatter Plot
Target PARs Source CADM CADM Cell-Cell Contact 0.2006 0.000006147719516151697 Scatter Plot
Target PARs Target CADM CADM Cell-Cell Contact 0.2006 0.000006147719516151697 Scatter Plot
Target PARs Source VEGF VEGF Secreted Signaling 0.2196 0.0000007053293792239204 Scatter Plot
Target PARs Source NOTCH NOTCH Cell-Cell Contact 0.2263 0.0000003150669258810338 Scatter Plot
Source PARs Source ANGPTL ANGPTL Secreted Signaling 0.2281 0.0000002523154247572338 Scatter Plot
Target PARs Source CD86 CD86 Cell-Cell Contact 0.2295 0.0000002107396667483865 Scatter Plot
Target PARs Target AGT AGT Secreted Signaling 0.2303 0.0000001918613226626425 Scatter Plot
Source PARs Source SELPLG SELPLG Cell-Cell Contact 0.2317 0.00000016116209720822606 Scatter Plot
Target PARs Target CSPG4 CSPG4 Cell-Cell Contact 0.2334 0.00000012941456237956512 Scatter Plot
Target PARs Source LAMININ LAMININ ECM-Receptor 0.2432 0.00000003620126887269522 Scatter Plot
Target PARs Source CCL CCL Secreted Signaling 0.2453 0.00000002734246626841903 Scatter Plot
Target PARs Target SEMA6 SEMA6 Cell-Cell Contact 0.2502 0.000000014230450147961969 Scatter Plot
Target PARs Source PSAP PSAP Secreted Signaling 0.2537 0.000000008754820656490618 Scatter Plot
Target PARs Source IL1 IL1 Secreted Signaling 0.2586 0.000000004398857708574991 Scatter Plot
Target PARs Source THY1 THY1 Cell-Cell Contact 0.2587 0.000000004327216441023978 Scatter Plot
Target PARs Source CD45 CD45 Cell-Cell Contact 0.2589 0.000000004212764747408821 Scatter Plot
Target PARs Target ANGPTL ANGPTL Secreted Signaling 0.2631 0.000000002308275922436045 Scatter Plot
Target PARs Source LIGHT LIGHT Secreted Signaling 0.2649 0.000000001785309164899987 Scatter Plot
Target PARs Source CSF CSF Secreted Signaling 0.2667 0.000000001379904632447939 Scatter Plot
Target PARs Source IL2 IL2 Secreted Signaling 0.2757 0.00000000035752669649021123 Scatter Plot
Target PARs Target CD200 CD200 Cell-Cell Contact 0.2769 0.00000000029852653785719565 Scatter Plot
Target PARs Source NT NT Secreted Signaling 0.2841 0.00000000009679790155761778 Scatter Plot
Target PARs Source MK MK Secreted Signaling 0.2959 0.000000000014674343787167637 Scatter Plot
Target PARs Source IGF IGF Secreted Signaling 0.3001 0.000000000007299658367761298 Scatter Plot
Target PARs Target PTN PTN Secreted Signaling 0.3081 0.0000000000018601139869965577 Scatter Plot
Target PARs Target BMP BMP Secreted Signaling 0.3084 0.0000000000017522322839691622 Scatter Plot
Target PARs Source CX3C CX3C Secreted Signaling 0.3118 0.0000000000009723763117498825 Scatter Plot
Target PARs Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.3164 0.0000000000004335157469530654 Scatter Plot
Target PARs Target SEMA5 SEMA5 Cell-Cell Contact 0.3182 0.0000000000003133554994588142 Scatter Plot
Target PARs Source ICAM ICAM Cell-Cell Contact 0.3242 0.00000000000010538081802932209 Scatter Plot
Target PARs Target ACTIVIN ACTIVIN Secreted Signaling 0.3250 0.00000000000009086599714448674 Scatter Plot
Target PARs Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.3281 0.000000000000051916200521676825 Scatter Plot
Target PARs Source CD46 CD46 Cell-Cell Contact 0.3302 0.000000000000034970304269795595 Scatter Plot
Target PARs Target VEGF VEGF Secreted Signaling 0.3338 0.000000000000017747202351936938 Scatter Plot
Target PARs Target PERIOSTIN PERIOSTIN Secreted Signaling 0.3342 0.000000000000016463393877484683 Scatter Plot
Target PARs Source RANKL RANKL Secreted Signaling 0.3381 0.000000000000007682820231217828 Scatter Plot
Source PARs Source MIF MIF Secreted Signaling 0.3483 0.0000000000000010468941275278416 Scatter Plot
Target PARs Target MIF MIF Secreted Signaling 0.3566 0.00000000000000019246115430154503 Scatter Plot
Target PARs Source FGF FGF Secreted Signaling 0.3661 0.000000000000000026123109264207004 Scatter Plot
Target PARs Target TGFb TGFb Secreted Signaling 0.3677 0.000000000000000018524461808782804 Scatter Plot
Target PARs Source LCK LCK Cell-Cell Contact 0.3681 0.000000000000000017008230739787938 Scatter Plot
Target PARs Source IL7 IL7 Secreted Signaling 0.3687 0.000000000000000014947113386725686 Scatter Plot
Target PARs Source CXCL CXCL Secreted Signaling 0.3699 0.000000000000000011708098254104289 Scatter Plot
Target PARs Source CDH CDH Cell-Cell Contact 0.3705 0.000000000000000010132600519100817 Scatter Plot
Target PARs Target CDH CDH Cell-Cell Contact 0.3705 0.000000000000000010132600519100817 Scatter Plot
Target PARs Target EPHB EPHB Cell-Cell Contact 0.3830 0.0000000000000000006472212587542506 Scatter Plot
Target PARs Target THBS THBS ECM-Receptor 0.3844 0.000000000000000000469743873473915 Scatter Plot
Target PARs Source BST2 BST2 Cell-Cell Contact 0.3851 0.00000000000000000039928106570798893 Scatter Plot
Target PARs Target SLURP SLURP Secreted Signaling 0.3939 0.00000000000000000005168546594665407 Scatter Plot
Target PARs Target SEMA4 SEMA4 Cell-Cell Contact 0.3945 0.00000000000000000004482747454515925 Scatter Plot
Source PARs Source APP APP Cell-Cell Contact 0.3997 0.000000000000000000013043554935149992 Scatter Plot
Target PARs Source VCAM VCAM Cell-Cell Contact 0.4056 0.000000000000000000003204981411971569 Scatter Plot
Target PARs Source SEMA7 SEMA7 Cell-Cell Contact 0.4061 0.0000000000000000000028068225740256027 Scatter Plot
Source PARs Source SEMA4 SEMA4 Cell-Cell Contact 0.4093 0.0000000000000000000012869198998753548 Scatter Plot
Target PARs Source GALECTIN GALECTIN Secreted Signaling 0.4131 0.00000000000000000000049238798678349475 Scatter Plot
Target PARs Target VISFATIN VISFATIN Secreted Signaling 0.4169 0.0000000000000000000001909054300434853 Scatter Plot
Target PARs Source PROS PROS Secreted Signaling 0.4177 0.0000000000000000000001563869346309021 Scatter Plot
Target PARs Source GP1BA GP1BA Cell-Cell Contact 0.4184 0.0000000000000000000001309110616061783 Scatter Plot
Target PARs Source GAS GAS Secreted Signaling 0.4298 0.000000000000000000000006630064634528774 Scatter Plot
Target PARs Target FGF FGF Secreted Signaling 0.4455 0.00000000000000000000000009473845763412869 Scatter Plot
Target PARs Source PDGF PDGF Secreted Signaling 0.4571 0.0000000000000000000000000034589107052270276 Scatter Plot
Target PARs Target SPP1 SPP1 Secreted Signaling 0.4613 0.0000000000000000000000000010198771798298471 Scatter Plot
Target PARs Target WNT WNT Secreted Signaling 0.4628 0.0000000000000000000000000006435118405319386 Scatter Plot
Target PARs Source BMP BMP Secreted Signaling 0.4813 0.0000000000000000000000000000023079185085580693 Scatter Plot
Target PARs Source COLLAGEN COLLAGEN ECM-Receptor 0.4877 0.00000000000000000000000000000030514478670338246 Scatter Plot
Target PARs Source FLT3 FLT3 Secreted Signaling 0.4956 0.00000000000000000000000000000002330586728660534 Scatter Plot
Source PARs Source VISTA VISTA Cell-Cell Contact 0.5046 0.0000000000000000000000000000000011431696114621932 Scatter Plot
Target PARs Source EPHB EPHB Cell-Cell Contact 0.5072 0.0000000000000000000000000000000004774391644910194 Scatter Plot
Target PARs Target MK MK Secreted Signaling 0.5150 0.000000000000000000000000000000000031231452579941563 Scatter Plot
Target PARs Target KIT KIT Secreted Signaling 0.5222 0.0000000000000000000000000000000000024532944873257562 Scatter Plot
Source PARs Source CD52 CD52 Cell-Cell Contact 0.5364 0.00000000000000000000000000000000000001327048499139054 Scatter Plot
Target PARs Source TWEAK TWEAK Secreted Signaling 0.5457 0.0000000000000000000000000000000000000003753502322760833 Scatter Plot
Target PARs Target ANGPT ANGPT Secreted Signaling 0.5466 0.00000000000000000000000000000000000000026721295343951676 Scatter Plot
Target PARs Source MHC-II MHC-II Cell-Cell Contact 0.5558 0.000000000000000000000000000000000000000006953512488332842 Scatter Plot
Target PARs Target CD39 CD39 Cell-Cell Contact 0.5597 0.0000000000000000000000000000000000000000014222099925343749 Scatter Plot
Target PARs Source LIFR LIFR Secreted Signaling 0.5734 0.000000000000000000000000000000000000000000004667711947099261 Scatter Plot
Target PARs Source ESAM ESAM Cell-Cell Contact 0.5887 0.000000000000000000000000000000000000000000000005712698088102653 Scatter Plot
Target PARs Target IGF IGF Secreted Signaling 0.5917 0.0000000000000000000000000000000000000000000000014698687529586652 Scatter Plot
Source PARs Source SELL SELL Cell-Cell Contact 0.5933 0.0000000000000000000000000000000000000000000000006841009158321659 Scatter Plot
Target PARs Source JAM JAM Cell-Cell Contact 0.5941 0.00000000000000000000000000000000000000000000000049177769905688966 Scatter Plot
Target PARs Target SEMA7 SEMA7 Cell-Cell Contact 0.6292 0.000000000000000000000000000000000000000000000000000000016766358136862013 Scatter Plot
Target PARs Target TENASCIN TENASCIN ECM-Receptor 0.6411 0.00000000000000000000000000000000000000000000000000000000003001608460697362 Scatter Plot
Target PARs Target VWF VWF ECM-Receptor 0.6742 0.00000000000000000000000000000000000000000000000000000000000000000013859769774614179 Scatter Plot
Target PARs Source MHC-I MHC-I Cell-Cell Contact 0.6760 0.00000000000000000000000000000000000000000000000000000000000000000004433131422486694 Scatter Plot
Target PARs Source ANGPT ANGPT Secreted Signaling 0.6789 0.000000000000000000000000000000000000000000000000000000000000000000007630265258816227 Scatter Plot
Target PARs Source COMPLEMENT COMPLEMENT Secreted Signaling -0.6400 0.00000000000000000000000000000000000000000000000000000000005324539790843177 Scatter Plot
Target PARs Source CD52 CD52 Cell-Cell Contact -0.6386 0.00000000000000000000000000000000000000000000000000000000011707378616649017 Scatter Plot
Target PARs Source SELL SELL Cell-Cell Contact -0.6261 0.00000000000000000000000000000000000000000000000000000008307927954015525 Scatter Plot
Target PARs Source VISTA VISTA Cell-Cell Contact -0.5452 0.0000000000000000000000000000000000000004613241784841442 Scatter Plot
Target PARs Source ANNEXIN ANNEXIN Secreted Signaling -0.5137 0.00000000000000000000000000000000004985638540576427 Scatter Plot
Target PARs Source SEMA4 SEMA4 Cell-Cell Contact -0.4885 0.0000000000000000000000000000002353904230930228 Scatter Plot
Target PARs Target VCAM VCAM Cell-Cell Contact -0.4719 0.0000000000000000000000000000421933225430266 Scatter Plot
Target PARs Source CCL CCL Secreted Signaling -0.4691 0.00000000000000000000000000010048162859490962 Scatter Plot
Source PARs Source ESAM ESAM Cell-Cell Contact -0.4325 0.000000000000000000000003287375919452906 Scatter Plot
Target PARs Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.4249 0.000000000000000000000023995420203398937 Scatter Plot
Target PARs Target CSF CSF Secreted Signaling -0.4221 0.00000000000000000000004985235613235003 Scatter Plot
Source PARs Source FLT3 FLT3 Secreted Signaling -0.4154 0.00000000000000000000027767724111907734 Scatter Plot
Target PARs Source APP APP Cell-Cell Contact -0.4092 0.000000000000000000001321907156298672 Scatter Plot
Source PARs Source LIFR LIFR Secreted Signaling -0.4043 0.0000000000000000000043582393570575744 Scatter Plot
Source PARs Source MHC-II MHC-II Cell-Cell Contact -0.4021 0.000000000000000000007359428452815773 Scatter Plot
Source PARs Source EPHB EPHB Cell-Cell Contact -0.3958 0.000000000000000000033672961543695166 Scatter Plot
Target PARs Target CXCL CXCL Secreted Signaling -0.3909 0.00000000000000000010508090682668024 Scatter Plot
Target PARs Target CEACAM CEACAM Cell-Cell Contact -0.3778 0.0000000000000000020733825338938735 Scatter Plot
Source PARs Source TWEAK TWEAK Secreted Signaling -0.3766 0.000000000000000002672197794329452 Scatter Plot
Source PARs Source GAS GAS Secreted Signaling -0.3609 0.00000000000000007957993795813371 Scatter Plot
Source PARs Source BMP BMP Secreted Signaling -0.3511 0.0000000000000005964952352367013 Scatter Plot
Target PARs Source LAIR1 LAIR1 Cell-Cell Contact -0.3494 0.0000000000000008326830931365716 Scatter Plot
Source PARs Source GALECTIN GALECTIN Secreted Signaling -0.3349 0.000000000000014192256298525652 Scatter Plot
Source PARs Source VCAM VCAM Cell-Cell Contact -0.3345 0.000000000000015567108788570084 Scatter Plot
Target PARs Source NCAM NCAM Cell-Cell Contact -0.3311 0.000000000000029561505565605825 Scatter Plot
Target PARs Source SPP1 SPP1 Secreted Signaling -0.3259 0.00000000000007744004418326534 Scatter Plot
Source PARs Source PDGF PDGF Secreted Signaling -0.3224 0.0000000000001468866982865751 Scatter Plot
Target PARs Target IL17 IL17 Secreted Signaling -0.3182 0.0000000000003164810408558141 Scatter Plot
Source PARs Source CDH CDH Cell-Cell Contact -0.3166 0.0000000000004197321190806886 Scatter Plot
Target PARs Source CLEC CLEC Cell-Cell Contact -0.3095 0.0000000000014557370276711396 Scatter Plot
Source PARs Source IL7 IL7 Secreted Signaling -0.3061 0.000000000002606519313160885 Scatter Plot
Target PARs Target SEMA3 SEMA3 Secreted Signaling -0.2895 0.00000000004140583974893672 Scatter Plot
Target PARs Source GRN GRN Secreted Signaling -0.2617 0.0000000028425604489843516 Scatter Plot
Source PARs Source PROS PROS Secreted Signaling -0.2592 0.0000000040311176450330295 Scatter Plot
Target PARs Source TNF TNF Secreted Signaling -0.2574 0.0000000052234037066483735 Scatter Plot
Target PARs Source MIF MIF Secreted Signaling -0.2470 0.000000021798239219707 Scatter Plot
Source PARs Source LIGHT LIGHT Secreted Signaling -0.2233 0.0000004525127462704489 Scatter Plot
Source PARs Source VEGF VEGF Secreted Signaling -0.2223 0.0000005124489753846194 Scatter Plot
Source PARs Source FGF FGF Secreted Signaling -0.2145 0.0000012871597359615326 Scatter Plot
Source PARs Source OSM OSM Secreted Signaling -0.2115 0.0000018217520445450117 Scatter Plot
Source PARs Source CCL CCL Secreted Signaling -0.1983 0.000007877112542747864 Scatter Plot
Target PARs Source ANGPTL ANGPTL Secreted Signaling -0.1919 0.000015610595608335846 Scatter Plot
Source PARs Source SEMA3 SEMA3 Secreted Signaling -0.1882 0.000022690570032279345 Scatter Plot
Source PARs Source PTN PTN Secreted Signaling -0.1856 0.00002955018873950833 Scatter Plot
Source PARs Source NOTCH NOTCH Cell-Cell Contact -0.1833 0.00003735326594584235 Scatter Plot
Target PARs Target SELPLG SELPLG Cell-Cell Contact -0.1826 0.00003988100483278608 Scatter Plot
Target PARs Source BAFF BAFF Secreted Signaling -0.1826 0.00003989657302944873 Scatter Plot
Target PARs Target COLLAGEN COLLAGEN ECM-Receptor -0.1803 0.00005003384259464336 Scatter Plot
Source PARs Source RANKL RANKL Secreted Signaling -0.1736 0.00009566248797583532 Scatter Plot
Source PARs Source APELIN APELIN Secreted Signaling -0.1711 0.0001205273202636 Scatter Plot
Source PARs Source NT NT Secreted Signaling -0.1690 0.0001463688626705 Scatter Plot
Target PARs Source SELPLG SELPLG Cell-Cell Contact -0.1671 0.0001735915243159 Scatter Plot
Source PARs Source IL6 IL6 Secreted Signaling -0.1628 0.0002565934902149 Scatter Plot
Source PARs Source CADM CADM Cell-Cell Contact -0.1575 0.0004079935224575 Scatter Plot
Target PARs Source NKG2D NKG2D Cell-Cell Contact -0.1565 0.0004431224071176 Scatter Plot
Source PARs Source PSAP PSAP Secreted Signaling -0.1536 0.0005689556072994 Scatter Plot
Target PARs Target GRN GRN Secreted Signaling -0.1510 0.0007032910795533 Scatter Plot
Target PARs Source VISFATIN VISFATIN Secreted Signaling -0.1412 0.0015489506512898 Scatter Plot
Source PARs Source LAMININ LAMININ ECM-Receptor -0.1412 0.0015530078253047 Scatter Plot
Target PARs Target SELE SELE Cell-Cell Contact -0.1340 0.0026743557933327 Scatter Plot
Source PARs Source ncWNT ncWNT Secreted Signaling -0.1303 0.0035252278248056 Scatter Plot
Source PARs Source AGRN AGRN ECM-Receptor -0.1157 0.0096423202181154 Scatter Plot
Source PARs Source IL2 IL2 Secreted Signaling 0.0969 0.0302210173253905 Scatter Plot
Source PARs Target SELE SELE Cell-Cell Contact 0.1005 0.0245838786238203 Scatter Plot
Source PARs Target GRN GRN Secreted Signaling 0.1112 0.0128487495270923 Scatter Plot
Source PARs Target CD86 CD86 Cell-Cell Contact 0.1234 0.0057093290509204 Scatter Plot
Target PARs Target PDGF PDGF Secreted Signaling 0.1324 0.0030067010678287 Scatter Plot
Target PARs Target NOTCH NOTCH Cell-Cell Contact 0.1369 0.0021484515404204 Scatter Plot
Source PARs Target COLLAGEN COLLAGEN ECM-Receptor 0.1600 0.0003275933713373 Scatter Plot
Source PARs Target COMPLEMENT COMPLEMENT Secreted Signaling 0.1696 0.0001391439455183 Scatter Plot
Source PARs Source SPP1 SPP1 Secreted Signaling 0.2191 0.0000007497301607629833 Scatter Plot
Source PARs Target SEMA3 SEMA3 Secreted Signaling 0.2328 0.00000014040845037256113 Scatter Plot
Source PARs Source GRN GRN Secreted Signaling 0.2503 0.00000001394147934049022 Scatter Plot
Target PARs Target CD22 CD22 Cell-Cell Contact 0.2589 0.000000004212764747408821 Scatter Plot
Source PARs Target CEACAM CEACAM Cell-Cell Contact 0.2688 0.0000000010062463813429163 Scatter Plot
Source PARs Source LAIR1 LAIR1 Cell-Cell Contact 0.2769 0.00000000029588360887850467 Scatter Plot
Source PARs Target CCL CCL Secreted Signaling 0.2850 0.00000000008394300717977453 Scatter Plot
Source PARs Target CXCL CXCL Secreted Signaling 0.2931 0.000000000022931569455133688 Scatter Plot
Target PARs Target BAFF BAFF Secreted Signaling 0.2974 0.000000000011406473026339632 Scatter Plot
Source PARs Target SELPLG SELPLG Cell-Cell Contact 0.3006 0.000000000006688549333173969 Scatter Plot
Source PARs Source NCAM NCAM Cell-Cell Contact 0.3097 0.000000000001410689502925095 Scatter Plot
Target PARs Target PTN PTN Secreted Signaling 0.3131 0.000000000000776366897501763 Scatter Plot
Target PARs Target PERIOSTIN PERIOSTIN Secreted Signaling 0.3331 0.000000000000020241939515366965 Scatter Plot
Target PARs Target APP APP Cell-Cell Contact 0.3471 0.0000000000000013203736472574337 Scatter Plot
Target PARs Target NPR2 NPR2 Secreted Signaling 0.3527 0.00000000000000042768412312440823 Scatter Plot
Source PARs Target VEGF VEGF Secreted Signaling 0.3565 0.00000000000000019722885995646527 Scatter Plot
Source PARs Source CLEC CLEC Cell-Cell Contact 0.3572 0.0000000000000001695486706536504 Scatter Plot
Target PARs Target BSP BSP ECM-Receptor 0.3583 0.000000000000000134417966364344 Scatter Plot
Source PARs Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.3735 0.0000000000000000053383115551337946 Scatter Plot
Target PARs Target DMP1 DMP1 ECM-Receptor 0.3773 0.0000000000000000023150443088851343 Scatter Plot
Source PARs Target VCAM VCAM Cell-Cell Contact 0.3806 0.000000000000000001102999901088683 Scatter Plot
Target PARs Target NRG NRG Secreted Signaling 0.3809 0.0000000000000000010280365861623054 Scatter Plot
Source PARs Target ICAM ICAM Cell-Cell Contact 0.3925 0.00000000000000000007217692906561645 Scatter Plot
Source PARs Target IL17 IL17 Secreted Signaling 0.3934 0.00000000000000000005887092609278925 Scatter Plot
Source PARs Source CCL CCL Secreted Signaling 0.4087 0.0000000000000000000014669587155372046 Scatter Plot
Source PARs Target CLEC CLEC Cell-Cell Contact 0.4248 0.0000000000000000000000248123467356182 Scatter Plot
Source PARs Source ANNEXIN ANNEXIN Secreted Signaling 0.4420 0.00000000000000000000000024585189919974127 Scatter Plot
Target PARs Target JAM JAM Cell-Cell Contact 0.4750 0.00000000000000000000000000001631524775956254 Scatter Plot
Source PARs Source COMPLEMENT COMPLEMENT Secreted Signaling 0.4853 0.00000000000000000000000000000065705953782974235 Scatter Plot
Source PARs Target CSF CSF Secreted Signaling 0.4861 0.000000000000000000000000000000511867732406103 Scatter Plot
Target PARs Target ncWNT ncWNT Secreted Signaling 0.4895 0.00000000000000000000000000000016799305321526027 Scatter Plot
Target PARs Target LAMININ LAMININ ECM-Receptor 0.5216 0.0000000000000000000000000000000000030793261916001826 Scatter Plot
Source PARs Target IFN-II IFN-II Secreted Signaling 0.5377 0.000000000000000000000000000000000000008077990935036792 Scatter Plot
Source PARs Target CD52 CD52 Cell-Cell Contact 0.5490 0.0000000000000000000000000000000000000001036854807985582 Scatter Plot
Target PARs Target FN1 FN1 ECM-Receptor 0.5569 0.0000000000000000000000000000000000000000043598340638233546 Scatter Plot
Target PARs Target VTN VTN ECM-Receptor 0.5698 0.000000000000000000000000000000000000000000020995160982677158 Scatter Plot
Target PARs Target ESAM ESAM Cell-Cell Contact 0.5887 0.000000000000000000000000000000000000000000000005712698088102653 Scatter Plot
Target PARs Target CD34 CD34 Cell-Cell Contact 0.5918 0.0000000000000000000000000000000000000000000000014094093630767354 Scatter Plot
Target PARs Target CD52 CD52 Cell-Cell Contact -0.5545 0.000000000000000000000000000000000000000011618302183220458 Scatter Plot
Target PARs Target IFN-II IFN-II Secreted Signaling -0.5196 0.000000000000000000000000000000000006152797284368919 Scatter Plot
Source PARs Target SEMA7 SEMA7 Cell-Cell Contact -0.5195 0.000000000000000000000000000000000006425534848521191 Scatter Plot
Source PARs Source ANGPT ANGPT Secreted Signaling -0.5101 0.00000000000000000000000000000000017383329757938322 Scatter Plot
Source PARs Source MHC-I MHC-I Cell-Cell Contact -0.4698 0.000000000000000000000000000079562441639205 Scatter Plot
Target PARs Target ICAM ICAM Cell-Cell Contact -0.4555 0.000000000000000000000000005433859410425191 Scatter Plot
Source PARs Target KIT KIT Secreted Signaling -0.4512 0.000000000000000000000000018870151033971955 Scatter Plot
Source PARs Target TENASCIN TENASCIN ECM-Receptor -0.4438 0.00000000000000000000000014880154509283323 Scatter Plot
Source PARs Source JAM JAM Cell-Cell Contact -0.4361 0.0000000000000000000000012531824348079254 Scatter Plot
Source PARs Target FGF FGF Secreted Signaling -0.4351 0.0000000000000000000000016140118684523619 Scatter Plot
Source PARs Source COLLAGEN COLLAGEN ECM-Receptor -0.4330 0.0000000000000000000000028801358619055086 Scatter Plot
Source PARs Target ESAM ESAM Cell-Cell Contact -0.4325 0.000000000000000000000003287375919452906 Scatter Plot
Target PARs Target CCL CCL Secreted Signaling -0.4314 0.000000000000000000000004398329056222436 Scatter Plot
Source PARs Target VWF VWF ECM-Receptor -0.4299 0.000000000000000000000006525857568687541 Scatter Plot
Source PARs Target IGF IGF Secreted Signaling -0.4269 0.000000000000000000000014549382490106126 Scatter Plot
Target PARs Target CLEC CLEC Cell-Cell Contact -0.4231 0.00000000000000000000003868870871820052 Scatter Plot
Source PARs Target CD39 CD39 Cell-Cell Contact -0.4075 0.0000000000000000000020013139533487428 Scatter Plot
Source PARs Target ncWNT ncWNT Secreted Signaling -0.3955 0.000000000000000000035541832322519493 Scatter Plot
Source PARs Target JAM JAM Cell-Cell Contact -0.3897 0.00000000000000000013968164990555022 Scatter Plot
Source PARs Target WNT WNT Secreted Signaling -0.3877 0.00000000000000000021773947212151168 Scatter Plot
Source PARs Target MK MK Secreted Signaling -0.3863 0.00000000000000000030042999808786414 Scatter Plot
Source PARs Target CD34 CD34 Cell-Cell Contact -0.3805 0.0000000000000000011306365555174525 Scatter Plot
Source PARs Target ANGPT ANGPT Secreted Signaling -0.3797 0.0000000000000000013393038683003117 Scatter Plot
Source PARs Target SLURP SLURP Secreted Signaling -0.3433 0.000000000000002787246972701897 Scatter Plot
Source PARs Target VTN VTN ECM-Receptor -0.3413 0.00000000000000420082401580878 Scatter Plot
Source PARs Target FN1 FN1 ECM-Receptor -0.3393 0.000000000000006112108658241722 Scatter Plot
Source PARs Source SEMA7 SEMA7 Cell-Cell Contact -0.3364 0.000000000000010733648136832386 Scatter Plot
Source PARs Source PDGF PDGF Secreted Signaling -0.3209 0.00000000000019446780230295705 Scatter Plot
Target PARs Target COMPLEMENT COMPLEMENT Secreted Signaling -0.3196 0.00000000000024249971517394333 Scatter Plot
Source PARs Target CDH CDH Cell-Cell Contact -0.3166 0.0000000000004197321190806886 Scatter Plot
Source PARs Target ADIPONECTIN ADIPONECTIN Secreted Signaling -0.3148 0.0000000000005750559821444126 Scatter Plot
Source PARs Source GP1BA GP1BA Cell-Cell Contact -0.3106 0.0000000000012120066275487778 Scatter Plot
Source PARs Target LAMININ LAMININ ECM-Receptor -0.3041 0.000000000003712363361039164 Scatter Plot
Source PARs Source CXCL CXCL Secreted Signaling -0.3002 0.0000000000070799997698111174 Scatter Plot
Target PARs Target VEGF VEGF Secreted Signaling -0.2986 0.000000000009243682129769589 Scatter Plot
Source PARs Target PTN PTN Secreted Signaling -0.2968 0.000000000012481852718762728 Scatter Plot
Source PARs Source LCK LCK Cell-Cell Contact -0.2964 0.000000000013356103215997011 Scatter Plot
Source PARs Target APP APP Cell-Cell Contact -0.2952 0.000000000016462268228098254 Scatter Plot
Source PARs Target SPP1 SPP1 Secreted Signaling -0.2950 0.000000000016795864429538125 Scatter Plot
Source PARs Target EPHB EPHB Cell-Cell Contact -0.2919 0.000000000028207618596991425 Scatter Plot
Source PARs Target DMP1 DMP1 ECM-Receptor -0.2907 0.000000000033849862884991124 Scatter Plot
Source PARs Target VEGF VEGF Secreted Signaling -0.2831 0.00000000011327107114619274 Scatter Plot
Source PARs Target NRG NRG Secreted Signaling -0.2831 0.00000000011344539629626102 Scatter Plot
Source PARs Target BMP BMP Secreted Signaling -0.2819 0.00000000013690260295825935 Scatter Plot
Source PARs Target BSP BSP ECM-Receptor -0.2744 0.00000000043348219691571607 Scatter Plot
Source PARs Target SEMA4 SEMA4 Cell-Cell Contact -0.2742 0.00000000044738361642538335 Scatter Plot
Source PARs Target SEMA5 SEMA5 Cell-Cell Contact -0.2701 0.000000000832534298574 Scatter Plot
Source PARs Target TGFb TGFb Secreted Signaling -0.2618 0.000000002791593350772544 Scatter Plot
Source PARs Target MIF MIF Secreted Signaling -0.2599 0.000000003669960103303659 Scatter Plot
Source PARs Source PROS PROS Secreted Signaling -0.2593 0.000000003983287987343568 Scatter Plot
Source PARs Target AGT AGT Secreted Signaling -0.2588 0.000000004298485420638405 Scatter Plot
Source PARs Source MK MK Secreted Signaling -0.2582 0.000000004657589451045441 Scatter Plot
Source PARs Source CX3C CX3C Secreted Signaling -0.2577 0.0000000050270395211924065 Scatter Plot
Source PARs Target THBS THBS ECM-Receptor -0.2544 0.000000007987939998618343 Scatter Plot
Source PARs Target NPR2 NPR2 Secreted Signaling -0.2511 0.000000012502464364154232 Scatter Plot
Source PARs Target PERIOSTIN PERIOSTIN Secreted Signaling -0.2508 0.000000012969122816113045 Scatter Plot
Source PARs Target CD22 CD22 Cell-Cell Contact -0.2462 0.000000024374766255572617 Scatter Plot
Source PARs Source CD45 CD45 Cell-Cell Contact -0.2462 0.000000024374766255573067 Scatter Plot
Source PARs Source CD46 CD46 Cell-Cell Contact -0.2409 0.00000004946944265175357 Scatter Plot
Source PARs Target SEMA6 SEMA6 Cell-Cell Contact -0.2363 0.00000009014904094727805 Scatter Plot
Source PARs Source THY1 THY1 Cell-Cell Contact -0.2338 0.00000012259227727911198 Scatter Plot
Source PARs Source IGF IGF Secreted Signaling -0.2336 0.00000012721569619047664 Scatter Plot
Target PARs Target ANNEXIN ANNEXIN Secreted Signaling -0.2241 0.00000041118895893875 Scatter Plot
Source PARs Target ANGPTL ANGPTL Secreted Signaling -0.2210 0.0000006027881710723616 Scatter Plot
Source PARs Target ACTIVIN ACTIVIN Secreted Signaling -0.2184 0.0000008152833815306234 Scatter Plot
Source PARs Target IL1 IL1 Secreted Signaling -0.2151 0.000001200254109419039 Scatter Plot
Source PARs Source BST2 BST2 Cell-Cell Contact -0.2130 0.0000015440353574903715 Scatter Plot
Source PARs Source ICAM ICAM Cell-Cell Contact -0.2107 0.000002003633124479968 Scatter Plot
Source PARs Source IL2 IL2 Secreted Signaling -0.2047 0.000003934024040271716 Scatter Plot
Source PARs Target VISFATIN VISFATIN Secreted Signaling -0.2032 0.000004625742798725546 Scatter Plot
Source PARs Target NODAL NODAL Secreted Signaling -0.1953 0.00001088934519679642 Scatter Plot
Source PARs Source ANGPTL ANGPTL Secreted Signaling -0.1947 0.000011560291134290654 Scatter Plot
Source PARs Source GDF GDF Secreted Signaling -0.1929 0.000014065726846519807 Scatter Plot
Target PARs Target IL1 IL1 Secreted Signaling -0.1880 0.000023181460154000645 Scatter Plot
Source PARs Source CD86 CD86 Cell-Cell Contact -0.1871 0.000025584083743814866 Scatter Plot
Source PARs Target GAS GAS Secreted Signaling -0.1803 0.00005025457229148696 Scatter Plot
Source PARs Source PTN PTN Secreted Signaling -0.1718 0.0001126861671837 Scatter Plot
Source PARs Target CSPG4 CSPG4 Cell-Cell Contact -0.1659 0.000194912194088 Scatter Plot
Source PARs Source CSF CSF Secreted Signaling -0.1612 0.0002945523073464 Scatter Plot
Source PARs Target CADM CADM Cell-Cell Contact -0.1575 0.0004079935224575 Scatter Plot
Source PARs Source PSAP PSAP Secreted Signaling -0.1536 0.00057012545302 Scatter Plot
Source PARs Target CD200 CD200 Cell-Cell Contact -0.1527 0.0006107290704297 Scatter Plot
Source PARs Source CD1D2 CD1D2 Cell-Cell Contact -0.1386 0.0018950254829246 Scatter Plot
Source PARs Target COMPLEMENT COMPLEMENT Secreted Signaling -0.1376 0.0020425756905601 Scatter Plot
Source PARs Target COLLAGEN COLLAGEN ECM-Receptor -0.1365 0.0022203571614063 Scatter Plot
Source PARs Source IL16 IL16 Secreted Signaling -0.1329 0.0029143340083549 Scatter Plot
Source PARs Target GDF GDF Secreted Signaling -0.1316 0.0031873946331325 Scatter Plot
Source PARs Target BAFF BAFF Secreted Signaling -0.1173 0.0086638907114031 Scatter Plot
Source PARs Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.1087 0.0150051963013975 Scatter Plot
Source PARs Target NOTCH NOTCH Cell-Cell Contact -0.1008 0.0242023903100317 Scatter Plot

Cells that are targets of PARs from HSCs*

Cells that are source of PARs to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.