Pathway: KIT

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the KIT pathway:

Specificity Index HSPC as target: 0.907
HSPC as source: 0.160

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the KIT pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target KIT Target RANKL RANKL Secreted Signaling 0.0995 0.026063610133434 Scatter Plot
Target KIT Source AGRN AGRN ECM-Receptor 0.1090 0.0147725856838126 Scatter Plot
Target KIT Source WNT WNT Secreted Signaling 0.1310 0.0033361032552551 Scatter Plot
Target KIT Source OSM OSM Secreted Signaling 0.1506 0.0007310899224072 Scatter Plot
Target KIT Source SEMA3 SEMA3 Secreted Signaling 0.1566 0.0004409593976265 Scatter Plot
Target KIT Source GP1BA GP1BA Cell-Cell Contact 0.1577 0.0004017486177091 Scatter Plot
Target KIT Source PTN PTN Secreted Signaling 0.1583 0.000380109989148 Scatter Plot
Target KIT Source PROS PROS Secreted Signaling 0.1750 0.0000835408979482689 Scatter Plot
Target KIT Target VEGF VEGF Secreted Signaling 0.1825 0.00004021221414086654 Scatter Plot
Target KIT Source CD39 CD39 Cell-Cell Contact 0.1855 0.000029814860552007864 Scatter Plot
Target KIT Target GDF GDF Secreted Signaling 0.1921 0.000015201883145605527 Scatter Plot
Target KIT Source CD46 CD46 Cell-Cell Contact 0.2012 0.000005808940705362244 Scatter Plot
Target KIT Target CSPG4 CSPG4 Cell-Cell Contact 0.2064 0.000003248098882203313 Scatter Plot
Target KIT Source IL16 IL16 Secreted Signaling 0.2072 0.0000029679517569740986 Scatter Plot
Target KIT Source NOTCH NOTCH Cell-Cell Contact 0.2209 0.0000006046045943665482 Scatter Plot
Target KIT Source IL2 IL2 Secreted Signaling 0.2228 0.0000004825396928881699 Scatter Plot
Target KIT Source CSF CSF Secreted Signaling 0.2232 0.0000004573143574420567 Scatter Plot
Target KIT Source CADM CADM Cell-Cell Contact 0.2246 0.0000003887744554952382 Scatter Plot
Target KIT Source VEGF VEGF Secreted Signaling 0.2273 0.0000002792700769723613 Scatter Plot
Target KIT Source GDF GDF Secreted Signaling 0.2309 0.00000017905781114586505 Scatter Plot
Target KIT Source ANGPTL ANGPTL Secreted Signaling 0.2355 0.00000009913627290612075 Scatter Plot
Target KIT Source CD34 CD34 Cell-Cell Contact 0.2366 0.00000008659627912489855 Scatter Plot
Target KIT Source RANKL RANKL Secreted Signaling 0.2411 0.000000048184045061595046 Scatter Plot
Target KIT Source PSAP PSAP Secreted Signaling 0.2449 0.000000028928390121979677 Scatter Plot
Target KIT Source CCL CCL Secreted Signaling 0.2500 0.000000014522102011167494 Scatter Plot
Target KIT Source CD1D2 CD1D2 Cell-Cell Contact 0.2840 0.00000000009940816455715653 Scatter Plot
Target KIT Source CX3C CX3C Secreted Signaling 0.2871 0.00000000006050196038505391 Scatter Plot
Target KIT Source IGF IGF Secreted Signaling 0.2933 0.000000000022249628959152277 Scatter Plot
Target KIT Source PDGF PDGF Secreted Signaling 0.3023 0.0000000000049846634150037095 Scatter Plot
Target KIT Source MK MK Secreted Signaling 0.3140 0.0000000000006700788427399628 Scatter Plot
Target KIT Target THBS THBS ECM-Receptor 0.3158 0.000000000000479556824477806 Scatter Plot
Target KIT Source LIGHT LIGHT Secreted Signaling 0.3204 0.00000000000021095392409700371 Scatter Plot
Target KIT Source FGF FGF Secreted Signaling 0.3237 0.00000000000011507324256119536 Scatter Plot
Target KIT Source LAMININ LAMININ ECM-Receptor 0.3296 0.000000000000039105149442692186 Scatter Plot
Target KIT Source IL7 IL7 Secreted Signaling 0.3418 0.000000000000003739465977387682 Scatter Plot
Target KIT Source BST2 BST2 Cell-Cell Contact 0.3448 0.0000000000000021000394086344528 Scatter Plot
Target KIT Target BMP BMP Secreted Signaling 0.3498 0.00000000000000077028414292116 Scatter Plot
Target KIT Source GALECTIN GALECTIN Secreted Signaling 0.3502 0.0000000000000007104584267915353 Scatter Plot
Target KIT Source CD45 CD45 Cell-Cell Contact 0.3555 0.0000000000000002395267208033871 Scatter Plot
Target KIT Source THY1 THY1 Cell-Cell Contact 0.3593 0.00000000000000011078012516083332 Scatter Plot
Target KIT Source FLT3 FLT3 Secreted Signaling 0.3630 0.00000000000000005066040982587429 Scatter Plot
Target KIT Source CXCL CXCL Secreted Signaling 0.3646 0.000000000000000036275660283849095 Scatter Plot
Target KIT Source ICAM ICAM Cell-Cell Contact 0.3695 0.000000000000000012756875927898017 Scatter Plot
Target KIT Source LIFR LIFR Secreted Signaling 0.3719 0.000000000000000007619061998118838 Scatter Plot
Target KIT Source BMP BMP Secreted Signaling 0.3725 0.000000000000000006660621419243545 Scatter Plot
Target KIT Target VWF VWF ECM-Receptor 0.3784 0.0000000000000000017861859520996186 Scatter Plot
Target KIT Source CDH CDH Cell-Cell Contact 0.3873 0.00000000000000000024178692833673815 Scatter Plot
Target KIT Target SPP1 SPP1 Secreted Signaling 0.3874 0.0000000000000000002342054321276893 Scatter Plot
Target KIT Source CD86 CD86 Cell-Cell Contact 0.4104 0.0000000000000000000009620270794917046 Scatter Plot
Target KIT Source SEMA7 SEMA7 Cell-Cell Contact 0.4188 0.0000000000000000000001175743421389347 Scatter Plot
Target KIT Target SLURP SLURP Secreted Signaling 0.4286 0.00000000000000000000000912009518055073 Scatter Plot
Target KIT Source LCK LCK Cell-Cell Contact 0.4326 0.000000000000000000000003156314585378145 Scatter Plot
Target KIT Source TWEAK TWEAK Secreted Signaling 0.4645 0.0000000000000000000000000003926814694578423 Scatter Plot
Target KIT Target TGFb TGFb Secreted Signaling 0.4688 0.00000000000000000000000000010839526246719762 Scatter Plot
Target KIT Source EPHB EPHB Cell-Cell Contact 0.4728 0.000000000000000000000000000032691230428368577 Scatter Plot
Target KIT Source JAM JAM Cell-Cell Contact 0.4796 0.000000000000000000000000000003968556445589892 Scatter Plot
Target KIT Source VCAM VCAM Cell-Cell Contact 0.4868 0.0000000000000000000000000000004003892404712156 Scatter Plot
Target KIT Source GAS GAS Secreted Signaling 0.4905 0.00000000000000000000000000000012513552440016299 Scatter Plot
Target KIT Source ESAM ESAM Cell-Cell Contact 0.5066 0.00000000000000000000000000000000057389652947224775 Scatter Plot
Target KIT Source COLLAGEN COLLAGEN ECM-Receptor 0.5148 0.0000000000000000000000000000000000335978275687046 Scatter Plot
Target KIT Target WNT WNT Secreted Signaling 0.5382 0.000000000000000000000000000000000000006563369059036092 Scatter Plot
Target KIT Source MHC-II MHC-II Cell-Cell Contact 0.5875 0.00000000000000000000000000000000000000000000000944799364486924 Scatter Plot
Target KIT Source MHC-I MHC-I Cell-Cell Contact 0.6143 0.00000000000000000000000000000000000000000000000000003275200950022846 Scatter Plot
Target KIT Source ANGPT ANGPT Secreted Signaling 0.6544 0.00000000000000000000000000000000000000000000000000000000000001830995325731781 Scatter Plot
Target KIT Source COMPLEMENT COMPLEMENT Secreted Signaling -0.5154 0.000000000000000000000000000000000028021658287204326 Scatter Plot
Target KIT Source CD52 CD52 Cell-Cell Contact -0.5009 0.000000000000000000000000000000003951428743485801 Scatter Plot
Target KIT Source VISTA VISTA Cell-Cell Contact -0.4997 0.000000000000000000000000000000005930814616840541 Scatter Plot
Target KIT Source SEMA4 SEMA4 Cell-Cell Contact -0.4869 0.0000000000000000000000000000003956495220628417 Scatter Plot
Target KIT Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.4634 0.0000000000000000000000000005401404415720292 Scatter Plot
Target KIT Source PARs PARs Secreted Signaling -0.4512 0.000000000000000000000000018870151033971955 Scatter Plot
Target KIT Source SELL SELL Cell-Cell Contact -0.4440 0.0000000000000000000000001418047863030671 Scatter Plot
Target KIT Source APP APP Cell-Cell Contact -0.3883 0.0000000000000000001921528570875225 Scatter Plot
Target KIT Source GRN GRN Secreted Signaling -0.2750 0.0000000003994148189517573 Scatter Plot
Target KIT Source ANNEXIN ANNEXIN Secreted Signaling -0.2699 0.0000000008490811694794724 Scatter Plot
Target KIT Source MIF MIF Secreted Signaling -0.2577 0.000000005007453275024128 Scatter Plot
Target KIT Source NCAM NCAM Cell-Cell Contact -0.2509 0.000000012854273581168224 Scatter Plot
Target KIT Source SPP1 SPP1 Secreted Signaling -0.2406 0.00000005124367259946189 Scatter Plot
Target KIT Target ANNEXIN ANNEXIN Secreted Signaling -0.2353 0.00000010171923687927835 Scatter Plot
Target KIT Target IL17 IL17 Secreted Signaling -0.2344 0.000000114174081541189 Scatter Plot
Target KIT Target SEMA3 SEMA3 Secreted Signaling -0.2339 0.00000012228667249506618 Scatter Plot
Target KIT Source BAFF BAFF Secreted Signaling -0.2312 0.0000001721874334783425 Scatter Plot
Target KIT Source CLEC CLEC Cell-Cell Contact -0.2275 0.00000027330482878510365 Scatter Plot
Target KIT Source CCL CCL Secreted Signaling -0.2203 0.0000006492159954517969 Scatter Plot
Target KIT Source VISFATIN VISFATIN Secreted Signaling -0.2032 0.000004631411068094184 Scatter Plot
Target KIT Source TNF TNF Secreted Signaling -0.1722 0.0001093672582542 Scatter Plot
Target KIT Source LAIR1 LAIR1 Cell-Cell Contact -0.1318 0.0031414674335652 Scatter Plot
Target KIT Source IL1 IL1 Secreted Signaling -0.1197 0.0073968148327148 Scatter Plot
Target KIT Source TGFb TGFb Secreted Signaling -0.1167 0.008999514463353 Scatter Plot
Target KIT Source ANGPTL ANGPTL Secreted Signaling -0.1116 0.0124957776569084 Scatter Plot
Target KIT Source NKG2D NKG2D Cell-Cell Contact -0.1081 0.0155763879785653 Scatter Plot
Target KIT Target GALECTIN GALECTIN Secreted Signaling 0.1124 0.0119170643082021 Scatter Plot
Target KIT Target AGT AGT Secreted Signaling 0.1421 0.0014486384817013 Scatter Plot
Target KIT Target COLLAGEN COLLAGEN ECM-Receptor 0.1542 0.0005415924915334 Scatter Plot
Target KIT Target IL1 IL1 Secreted Signaling 0.1656 0.0001997900114135 Scatter Plot
Target KIT Target TWEAK TWEAK Secreted Signaling 0.1786 0.00005916954204107503 Scatter Plot
Target KIT Target EPHA EPHA Cell-Cell Contact 0.1823 0.00004111760424564777 Scatter Plot
Target KIT Target CADM CADM Cell-Cell Contact 0.2246 0.0000003887744554952382 Scatter Plot
Target KIT Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2333 0.0000001319325187194517 Scatter Plot
Target KIT Target NOTCH NOTCH Cell-Cell Contact 0.2334 0.0000001302469492792849 Scatter Plot
Target KIT Target ANGPTL ANGPTL Secreted Signaling 0.2491 0.000000016514839880054475 Scatter Plot
Target KIT Target SELL SELL Cell-Cell Contact 0.2503 0.000000013944962388604882 Scatter Plot
Target KIT Target PDGF PDGF Secreted Signaling 0.2516 0.000000011754415473044716 Scatter Plot
Target KIT Target PTN PTN Secreted Signaling 0.2517 0.000000011492186466034921 Scatter Plot
Target KIT Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.2554 0.000000006935725265762416 Scatter Plot
Target KIT Target VISFATIN VISFATIN Secreted Signaling 0.2724 0.0000000005883329523725483 Scatter Plot
Target KIT Target PERIOSTIN PERIOSTIN Secreted Signaling 0.2769 0.00000000029572401601161763 Scatter Plot
Target KIT Target NODAL NODAL Secreted Signaling 0.2825 0.00000000012429463260720395 Scatter Plot
Target KIT Target BSP BSP ECM-Receptor 0.2959 0.000000000014481710864704531 Scatter Plot
Target KIT Target SEMA6 SEMA6 Cell-Cell Contact 0.2970 0.000000000012219599278382504 Scatter Plot
Target KIT Target DMP1 DMP1 ECM-Receptor 0.3066 0.00000000000240867785188809 Scatter Plot
Target KIT Target NRG NRG Secreted Signaling 0.3078 0.0000000000019722605283783896 Scatter Plot
Target KIT Target ACTIVIN ACTIVIN Secreted Signaling 0.3201 0.00000000000022351288201071586 Scatter Plot
Target KIT Target VTN VTN ECM-Receptor 0.3305 0.00000000000003308086063581244 Scatter Plot
Target KIT Target NPR2 NPR2 Secreted Signaling 0.3392 0.000000000000006255081704325204 Scatter Plot
Target KIT Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.3525 0.0000000000000004453591731641896 Scatter Plot
Target KIT Target JAM JAM Cell-Cell Contact 0.3526 0.0000000000000004379513697597989 Scatter Plot
Target KIT Target EPHB EPHB Cell-Cell Contact 0.3542 0.00000000000000031325945739980987 Scatter Plot
Target KIT Target CD22 CD22 Cell-Cell Contact 0.3555 0.0000000000000002395267208033871 Scatter Plot
Target KIT Target FN1 FN1 ECM-Receptor 0.3556 0.0000000000000002392633049558489 Scatter Plot
Target KIT Target SEMA5 SEMA5 Cell-Cell Contact 0.3576 0.00000000000000015534183312992495 Scatter Plot
Target KIT Target LAMININ LAMININ ECM-Receptor 0.3783 0.00000000000000000183874123762536 Scatter Plot
Target KIT Target CD34 CD34 Cell-Cell Contact 0.3811 0.0000000000000000009815059341106314 Scatter Plot
Target KIT Target MK MK Secreted Signaling 0.3826 0.0000000000000000007078445589027122 Scatter Plot
Target KIT Target CDH CDH Cell-Cell Contact 0.3873 0.00000000000000000024178692833673815 Scatter Plot
Target KIT Target APP APP Cell-Cell Contact 0.3932 0.00000000000000000006123497884603404 Scatter Plot
Target KIT Target TENASCIN TENASCIN ECM-Receptor 0.3952 0.0000000000000000000383671118105588 Scatter Plot
Target KIT Target CD200 CD200 Cell-Cell Contact 0.4103 0.000000000000000000000987058182462799 Scatter Plot
Target KIT Target BAFF BAFF Secreted Signaling 0.4300 0.0000000000000000000000063515540232041325 Scatter Plot
Target KIT Target SEMA7 SEMA7 Cell-Cell Contact 0.4327 0.000000000000000000000003063080958685044 Scatter Plot
Target KIT Target ANGPT ANGPT Secreted Signaling 0.4430 0.0000000000000000000000001874457049135288 Scatter Plot
Target KIT Target MIF MIF Secreted Signaling 0.4506 0.00000000000000000000000002240516451771045 Scatter Plot
Target KIT Target SEMA4 SEMA4 Cell-Cell Contact 0.4682 0.00000000000000000000000000012990082399481876 Scatter Plot
Target KIT Target FGF FGF Secreted Signaling 0.4947 0.00000000000000000000000000000003132997064393863 Scatter Plot
Target KIT Target ESAM ESAM Cell-Cell Contact 0.5066 0.00000000000000000000000000000000057389652947224775 Scatter Plot
Target KIT Target IGF IGF Secreted Signaling 0.5139 0.000000000000000000000000000000000047356351595151 Scatter Plot
Target KIT Target PARs PARs Secreted Signaling 0.5222 0.0000000000000000000000000000000000024532944873257562 Scatter Plot
Target KIT Target ncWNT ncWNT Secreted Signaling 0.5392 0.0000000000000000000000000000000000000045884851706057545 Scatter Plot
Target KIT Target CD39 CD39 Cell-Cell Contact 0.5504 0.0000000000000000000000000000000000000000603156212373477 Scatter Plot
Target KIT Target ICAM ICAM Cell-Cell Contact -0.4365 0.0000000000000000000000011050921945988239 Scatter Plot
Target KIT Target CSF CSF Secreted Signaling -0.4180 0.00000000000000000000014507484870927926 Scatter Plot
Target KIT Target CLEC CLEC Cell-Cell Contact -0.3939 0.00000000000000000005159085466706011 Scatter Plot
Target KIT Target CD52 CD52 Cell-Cell Contact -0.3932 0.00000000000000000006187714784498549 Scatter Plot
Target KIT Target CCL CCL Secreted Signaling -0.3876 0.0000000000000000002227311081307527 Scatter Plot
Target KIT Target CEACAM CEACAM Cell-Cell Contact -0.3722 0.00000000000000000702824359215002 Scatter Plot
Target KIT Target VCAM VCAM Cell-Cell Contact -0.3560 0.00000000000000021950209376868711 Scatter Plot
Target KIT Target CXCL CXCL Secreted Signaling -0.3365 0.000000000000010463463269994246 Scatter Plot
Target KIT Target IFN-II IFN-II Secreted Signaling -0.3324 0.000000000000023005879711944353 Scatter Plot
Target KIT Target SELPLG SELPLG Cell-Cell Contact -0.2590 0.000000004173822807562475 Scatter Plot
Target KIT Target COMPLEMENT COMPLEMENT Secreted Signaling -0.1964 0.00000968838673326366 Scatter Plot
Target KIT Target VEGF VEGF Secreted Signaling -0.1789 0.000057450262820068464 Scatter Plot
Target KIT Target COLLAGEN COLLAGEN ECM-Receptor -0.1550 0.0005050734937022 Scatter Plot
Target KIT Target CD86 CD86 Cell-Cell Contact -0.1268 0.0044993274835365 Scatter Plot
Target KIT Target GRN GRN Secreted Signaling -0.1202 0.007129550145815 Scatter Plot
Target KIT Target IL1 IL1 Secreted Signaling -0.0976 0.0290956437632313 Scatter Plot

Cells that are targets of KIT from HSCs*

    No cell populations

Cells that are source of KIT to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.