Pathway: IL17

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the IL17 pathway:

Specificity Index HSPC as target: 0.114
HSPC as source: 0.691

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the IL17 pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target IL17 Source IL2 IL2 Secreted Signaling 0.1372 0.0021068601303267 Scatter Plot
Target IL17 Source VISFATIN VISFATIN Secreted Signaling 0.1560 0.0004641748562359 Scatter Plot
Target IL17 Source LAIR1 LAIR1 Cell-Cell Contact 0.1563 0.000450217809974 Scatter Plot
Target IL17 Source SEMA4 SEMA4 Cell-Cell Contact 0.1602 0.0003214630937088 Scatter Plot
Target IL17 Source TGFb TGFb Secreted Signaling 0.1823 0.00004130995475825299 Scatter Plot
Target IL17 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1824 0.00004068819570298194 Scatter Plot
Target IL17 Source CLEC CLEC Cell-Cell Contact 0.1893 0.00002036248682657114 Scatter Plot
Target IL17 Source APP APP Cell-Cell Contact 0.1900 0.00001889432920180492 Scatter Plot
Target IL17 Source CD34 CD34 Cell-Cell Contact 0.2133 0.0000014887903504394866 Scatter Plot
Target IL17 Source ANNEXIN ANNEXIN Secreted Signaling 0.2135 0.000001459136377088469 Scatter Plot
Target IL17 Source ANGPTL ANGPTL Secreted Signaling 0.2232 0.0000004623859429684627 Scatter Plot
Target IL17 Source VISTA VISTA Cell-Cell Contact 0.2271 0.00000028419313269121815 Scatter Plot
Target IL17 Source COMPLEMENT COMPLEMENT Secreted Signaling 0.2327 0.00000014227209757219998 Scatter Plot
Target IL17 Source SELPLG SELPLG Cell-Cell Contact 0.2407 0.00000005040255564448728 Scatter Plot
Target IL17 Source CD52 CD52 Cell-Cell Contact 0.2510 0.000000012726207214962887 Scatter Plot
Target IL17 Source CCL CCL Secreted Signaling 0.2653 0.0000000016766222148376896 Scatter Plot
Target IL17 Source SELL SELL Cell-Cell Contact 0.3441 0.0000000000000024014257727519015 Scatter Plot
Target IL17 Source MIF MIF Secreted Signaling 0.3651 0.000000000000000032379676547528337 Scatter Plot
Target IL17 Source PARs PARs Secreted Signaling 0.3934 0.00000000000000000005887092609278925 Scatter Plot
Target IL17 Source MHC-I MHC-I Cell-Cell Contact -0.2801 0.00000000018083468761896936 Scatter Plot
Target IL17 Source JAM JAM Cell-Cell Contact -0.2641 0.0000000019981406395009907 Scatter Plot
Target IL17 Source ANGPT ANGPT Secreted Signaling -0.2600 0.0000000036003407961866612 Scatter Plot
Target IL17 Source ESAM ESAM Cell-Cell Contact -0.2550 0.000000007307745039804051 Scatter Plot
Target IL17 Source EPHB EPHB Cell-Cell Contact -0.2539 0.000000008555769020625437 Scatter Plot
Target IL17 Source FLT3 FLT3 Secreted Signaling -0.2498 0.000000015072007119494332 Scatter Plot
Target IL17 Source COLLAGEN COLLAGEN ECM-Receptor -0.2453 0.00000002742025753895397 Scatter Plot
Target IL17 Source CD45 CD45 Cell-Cell Contact -0.2400 0.00000005577946859445172 Scatter Plot
Target IL17 Source MHC-II MHC-II Cell-Cell Contact -0.2336 0.00000012596594588344326 Scatter Plot
Target IL17 Source GAS GAS Secreted Signaling -0.2326 0.00000014427920847486528 Scatter Plot
Target IL17 Source TWEAK TWEAK Secreted Signaling -0.2280 0.0000002545951930276869 Scatter Plot
Target IL17 Source BMP BMP Secreted Signaling -0.2276 0.00000026907224198927804 Scatter Plot
Target IL17 Source LIFR LIFR Secreted Signaling -0.2223 0.0000005119608751129899 Scatter Plot
Target IL17 Source IL2 IL2 Secreted Signaling -0.1962 0.000009885969814524362 Scatter Plot
Target IL17 Source IL7 IL7 Secreted Signaling -0.1962 0.000009885969814524362 Scatter Plot
Target IL17 Target BMP BMP Secreted Signaling -0.1869 0.000025919283508349898 Scatter Plot
Target IL17 Source VCAM VCAM Cell-Cell Contact -0.1808 0.00004783333818212654 Scatter Plot
Target IL17 Source SEMA7 SEMA7 Cell-Cell Contact -0.1792 0.00005584734063663366 Scatter Plot
Target IL17 Source CXCL CXCL Secreted Signaling -0.1791 0.00005611945121818086 Scatter Plot
Target IL17 Source CX3C CX3C Secreted Signaling -0.1731 0.0001005067990664 Scatter Plot
Target IL17 Source LCK LCK Cell-Cell Contact -0.1721 0.0001100909418404 Scatter Plot
Target IL17 Source CD46 CD46 Cell-Cell Contact -0.1596 0.0003397650897124 Scatter Plot
Target IL17 Source VEGF VEGF Secreted Signaling -0.1593 0.0003477575585264 Scatter Plot
Target IL17 Source GP1BA GP1BA Cell-Cell Contact -0.1480 0.0009034187611668 Scatter Plot
Target IL17 Source PDGF PDGF Secreted Signaling -0.1476 0.0009353562669608 Scatter Plot
Target IL17 Source CCL CCL Secreted Signaling -0.1456 0.0010987152364508 Scatter Plot
Target IL17 Source PSAP PSAP Secreted Signaling -0.1443 0.0012176180937994 Scatter Plot
Target IL17 Source LIGHT LIGHT Secreted Signaling -0.1424 0.0014070097758679 Scatter Plot
Target IL17 Source CDH CDH Cell-Cell Contact -0.1410 0.0015747018713542 Scatter Plot
Target IL17 Source GALECTIN GALECTIN Secreted Signaling -0.1330 0.0028760177080836 Scatter Plot
Target IL17 Source CD86 CD86 Cell-Cell Contact -0.1330 0.0028830377555786 Scatter Plot
Target IL17 Source MK MK Secreted Signaling -0.1292 0.0038038818402386 Scatter Plot
Target IL17 Source GDF GDF Secreted Signaling -0.1279 0.0041709034571148 Scatter Plot
Target IL17 Source CADM CADM Cell-Cell Contact -0.1276 0.004263785488236 Scatter Plot
Target IL17 Source ICAM ICAM Cell-Cell Contact -0.1206 0.006925120472506 Scatter Plot
Target IL17 Source IL16 IL16 Secreted Signaling -0.1168 0.00895578329889 Scatter Plot
Target IL17 Target BSP BSP ECM-Receptor -0.1131 0.0113624881686624 Scatter Plot
Target IL17 Target ANNEXIN ANNEXIN Secreted Signaling -0.1128 0.0116326869347191 Scatter Plot
Target IL17 Source IL1 IL1 Secreted Signaling -0.1032 0.0210532178843711 Scatter Plot
Target IL17 Source ANGPTL ANGPTL Secreted Signaling -0.1015 0.0231751328983848 Scatter Plot
Target IL17 Source PTN PTN Secreted Signaling -0.1003 0.0248503669954008 Scatter Plot
Target IL17 Source PROS PROS Secreted Signaling -0.1003 0.0248914460085566 Scatter Plot
Target IL17 Source IGF IGF Secreted Signaling -0.0997 0.0257773012121824 Scatter Plot
Target IL17 Target EPHA EPHA Cell-Cell Contact 0.1054 0.0183586752211738 Scatter Plot
Target IL17 Target CCL CCL Secreted Signaling 0.1647 0.0002173995353201 Scatter Plot
Target IL17 Target VCAM VCAM Cell-Cell Contact 0.1695 0.0001396179713147 Scatter Plot
Target IL17 Target SEMA3 SEMA3 Secreted Signaling 0.1715 0.0001163610414015 Scatter Plot
Target IL17 Target ICAM ICAM Cell-Cell Contact 0.1819 0.00004268092501934196 Scatter Plot
Target IL17 Target SELL SELL Cell-Cell Contact 0.2008 0.000006069572944362995 Scatter Plot
Target IL17 Target SELPLG SELPLG Cell-Cell Contact 0.2091 0.0000024062881795037302 Scatter Plot
Target IL17 Target CXCL CXCL Secreted Signaling 0.2343 0.00000011520646916181323 Scatter Plot
Target IL17 Target VEGF VEGF Secreted Signaling 0.2503 0.00000001403111395565038 Scatter Plot
Target IL17 Target CLEC CLEC Cell-Cell Contact 0.2700 0.0000000008433329061346068 Scatter Plot
Target IL17 Target CD52 CD52 Cell-Cell Contact 0.3066 0.000000000002427803789815478 Scatter Plot
Target IL17 Target IFN-II IFN-II Secreted Signaling 0.3285 0.000000000000047483983390714665 Scatter Plot
Target IL17 Target CSF CSF Secreted Signaling 0.3431 0.000000000000002920333330952535 Scatter Plot
Target IL17 Target SEMA7 SEMA7 Cell-Cell Contact -0.3545 0.0000000000000002966302141887117 Scatter Plot
Target IL17 Target PARs PARs Secreted Signaling -0.3182 0.0000000000003164810408558141 Scatter Plot
Target IL17 Target JAM JAM Cell-Cell Contact -0.2729 0.0000000005464637261333096 Scatter Plot
Target IL17 Target ESAM ESAM Cell-Cell Contact -0.2550 0.000000007307745039804105 Scatter Plot
Target IL17 Target IGF IGF Secreted Signaling -0.2532 0.000000009417155728983271 Scatter Plot
Target IL17 Target ADIPONECTIN ADIPONECTIN Secreted Signaling -0.2511 0.000000012579356151067973 Scatter Plot
Target IL17 Target CD22 CD22 Cell-Cell Contact -0.2400 0.00000005577946859445172 Scatter Plot
Target IL17 Target FGF FGF Secreted Signaling -0.2353 0.00000010211801389496093 Scatter Plot
Target IL17 Target KIT KIT Secreted Signaling -0.2344 0.000000114174081541189 Scatter Plot
Target IL17 Target TENASCIN TENASCIN ECM-Receptor -0.2308 0.00000018012083781859667 Scatter Plot
Target IL17 Target ncWNT ncWNT Secreted Signaling -0.2285 0.0000002407065140143469 Scatter Plot
Target IL17 Target VWF VWF ECM-Receptor -0.2205 0.0000006377753543497501 Scatter Plot
Target IL17 Target ANGPT ANGPT Secreted Signaling -0.2166 0.0000010163598840442902 Scatter Plot
Target IL17 Target CD39 CD39 Cell-Cell Contact -0.2107 0.0000019994117894045173 Scatter Plot
Target IL17 Target SLURP SLURP Secreted Signaling -0.2052 0.0000037246166947798608 Scatter Plot
Target IL17 Target FN1 FN1 ECM-Receptor -0.2035 0.000004490727975610428 Scatter Plot
Target IL17 Target APP APP Cell-Cell Contact -0.2018 0.000005397352602163725 Scatter Plot
Target IL17 Target WNT WNT Secreted Signaling -0.1872 0.000025138484276302977 Scatter Plot
Target IL17 Target CD34 CD34 Cell-Cell Contact -0.1872 0.000025167817845359396 Scatter Plot
Target IL17 Target MIF MIF Secreted Signaling -0.1864 0.00002742166051338238 Scatter Plot
Target IL17 Target LAMININ LAMININ ECM-Receptor -0.1787 0.00005886271840350104 Scatter Plot
Target IL17 Target SEMA5 SEMA5 Cell-Cell Contact -0.1754 0.0000804956642607264 Scatter Plot
Target IL17 Target NPR2 NPR2 Secreted Signaling -0.1735 0.00009624451217412722 Scatter Plot
Target IL17 Target VTN VTN ECM-Receptor -0.1648 0.0002146173855472 Scatter Plot
Target IL17 Target SEMA4 SEMA4 Cell-Cell Contact -0.1646 0.0002177044508946 Scatter Plot
Target IL17 Target MK MK Secreted Signaling -0.1643 0.0002245669607511 Scatter Plot
Target IL17 Target SEMA6 SEMA6 Cell-Cell Contact -0.1551 0.000502249633645 Scatter Plot
Target IL17 Target AGT AGT Secreted Signaling -0.1518 0.0006596887082957 Scatter Plot
Target IL17 Target VISFATIN VISFATIN Secreted Signaling -0.1505 0.0007375579596483 Scatter Plot
Target IL17 Target VEGF VEGF Secreted Signaling -0.1475 0.000942986881919 Scatter Plot
Target IL17 Target GALECTIN GALECTIN Secreted Signaling -0.1456 0.0010970592059022 Scatter Plot
Target IL17 Target NCAM NCAM Cell-Cell Contact -0.1455 0.0011035101234059 Scatter Plot
Target IL17 Target CDH CDH Cell-Cell Contact -0.1410 0.0015747018713542 Scatter Plot
Target IL17 Target THBS THBS ECM-Receptor -0.1357 0.0023541478753666 Scatter Plot
Target IL17 Target EPHB EPHB Cell-Cell Contact -0.1323 0.0030285084951658 Scatter Plot
Target IL17 Target ANGPTL ANGPTL Secreted Signaling -0.1316 0.0031890106215987 Scatter Plot
Target IL17 Target DMP1 DMP1 ECM-Receptor -0.1294 0.0037499577446605 Scatter Plot
Target IL17 Target CADM CADM Cell-Cell Contact -0.1276 0.004263785488236 Scatter Plot
Target IL17 Target CD200 CD200 Cell-Cell Contact -0.1210 0.0067292835405408 Scatter Plot
Target IL17 Target SPP1 SPP1 Secreted Signaling -0.1202 0.0071496260875114 Scatter Plot
Target IL17 Target NRG NRG Secreted Signaling -0.1187 0.0078795644241002 Scatter Plot
Target IL17 Target TGFb TGFb Secreted Signaling -0.1143 0.0105111404311092 Scatter Plot
Target IL17 Target CD23 CD23 Cell-Cell Contact -0.1135 0.0111266814476459 Scatter Plot
Target IL17 Target IL1 IL1 Secreted Signaling -0.1120 0.0121969977521367 Scatter Plot
Target IL17 Target ACTIVIN ACTIVIN Secreted Signaling -0.1095 0.0143352815521464 Scatter Plot
Target IL17 Target PERIOSTIN PERIOSTIN Secreted Signaling -0.1082 0.0155032919788871 Scatter Plot
Target IL17 Target NOTCH NOTCH Cell-Cell Contact -0.1063 0.0174225103051476 Scatter Plot
Target IL17 Target COLLAGEN COLLAGEN ECM-Receptor -0.0988 0.027211862131209 Scatter Plot

Cells that are targets of IL17 from HSCs*

    No cell populations

Cells that are source of IL17 to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.