Pathway: PROS

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the PROS pathway:

Specificity Index HSPC as target: 0.237
HSPC as source: 0.265

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the PROS pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Source PROS Source GDF GDF Secreted Signaling 0.1035 0.0205825705055237 Scatter Plot
Source PROS Source WNT WNT Secreted Signaling 0.1355 0.0023864306387687 Scatter Plot
Source PROS Source SEMA6 SEMA6 Cell-Cell Contact 0.1610 0.0003000426442435 Scatter Plot
Source PROS Source CADM CADM Cell-Cell Contact 0.1641 0.0002281932805558 Scatter Plot
Source PROS Source PTN PTN Secreted Signaling 0.1689 0.0001475767697613 Scatter Plot
Source PROS Source ncWNT ncWNT Secreted Signaling 0.1911 0.00001688773385126681 Scatter Plot
Source PROS Source LIGHT LIGHT Secreted Signaling 0.2004 0.000006339633314807896 Scatter Plot
Source PROS Source APELIN APELIN Secreted Signaling 0.2049 0.000003864478291978472 Scatter Plot
Source PROS Source VEGF VEGF Secreted Signaling 0.2415 0.000000045342506854087904 Scatter Plot
Source PROS Source CXCL CXCL Secreted Signaling 0.2694 0.0000000009145080152105093 Scatter Plot
Source PROS Source LAMININ LAMININ ECM-Receptor 0.2944 0.000000000018521057469702918 Scatter Plot
Source PROS Source NOTCH NOTCH Cell-Cell Contact 0.3192 0.0000000000002622725791815752 Scatter Plot
Source PROS Source RANKL RANKL Secreted Signaling 0.3446 0.0000000000000021627608959177185 Scatter Plot
Source PROS Source EPHB EPHB Cell-Cell Contact 0.3913 0.00000000000000000009552772394910706 Scatter Plot
Source PROS Source LIFR LIFR Secreted Signaling 0.4189 0.0000000000000000000001135049432043336 Scatter Plot
Source PROS Source CDH CDH Cell-Cell Contact 0.4251 0.000000000000000000000022879186222185414 Scatter Plot
Source PROS Source COLLAGEN COLLAGEN ECM-Receptor 0.4259 0.00000000000000000000001884955956086628 Scatter Plot
Source PROS Source ANGPT ANGPT Secreted Signaling 0.4356 0.0000000000000000000000014078906532631812 Scatter Plot
Source PROS Source TWEAK TWEAK Secreted Signaling 0.4430 0.0000000000000000000000001884711661257888 Scatter Plot
Source PROS Source PSAP PSAP Secreted Signaling 0.4580 0.0000000000000000000000000026784297257175395 Scatter Plot
Source PROS Source PDGF PDGF Secreted Signaling 0.4612 0.0000000000000000000000000010369977536117529 Scatter Plot
Source PROS Source BMP BMP Secreted Signaling 0.5283 0.00000000000000000000000000000000000027078732997991065 Scatter Plot
Source PROS Source SELL SELL Cell-Cell Contact -0.3181 0.00000000000032039998026415885 Scatter Plot
Source PROS Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.3092 0.000000000001532422397337677 Scatter Plot
Source PROS Source ANGPTL ANGPTL Secreted Signaling -0.2596 0.000000003817247503353143 Scatter Plot
Source PROS Source PARs PARs Secreted Signaling -0.2593 0.000000003983287987343568 Scatter Plot
Source PROS Source GALECTIN GALECTIN Secreted Signaling -0.1017 0.022896998156979 Scatter Plot
Source PROS Target CD86 CD86 Cell-Cell Contact 0.0989 0.0270684179887097 Scatter Plot
Source PROS Target CCL CCL Secreted Signaling 0.1008 0.0241459928805098 Scatter Plot
Source PROS Target CXCL CXCL Secreted Signaling 0.1022 0.0222784987394877 Scatter Plot
Source PROS Source ANGPTL ANGPTL Secreted Signaling 0.1160 0.0094069953346339 Scatter Plot
Source PROS Target LAIR1 LAIR1 Cell-Cell Contact 0.1166 0.0090609288486806 Scatter Plot
Source PROS Target BST2 BST2 Cell-Cell Contact 0.1166 0.0090609288486806 Scatter Plot
Source PROS Source CD1D2 CD1D2 Cell-Cell Contact 0.1175 0.0085350155616829 Scatter Plot
Source PROS Target SELPLG SELPLG Cell-Cell Contact 0.1263 0.0046861687169328 Scatter Plot
Source PROS Source FN1 FN1 ECM-Receptor 0.1266 0.0045641135290907 Scatter Plot
Source PROS Source VCAM VCAM Cell-Cell Contact 0.1301 0.0035587972517432 Scatter Plot
Source PROS Source ICOS ICOS Cell-Cell Contact 0.1331 0.0028693067499838 Scatter Plot
Source PROS Source SEMA3 SEMA3 Secreted Signaling 0.1361 0.0022807077606346 Scatter Plot
Source PROS Target THY1 THY1 Cell-Cell Contact 0.1397 0.0017366411678103 Scatter Plot
Source PROS Target NOTCH NOTCH Cell-Cell Contact 0.1431 0.0013321698805362 Scatter Plot
Source PROS Source THBS THBS ECM-Receptor 0.1443 0.0012148423848907 Scatter Plot
Source PROS Source GP1BA GP1BA Cell-Cell Contact 0.1450 0.0011449442681091 Scatter Plot
Source PROS Target NODAL NODAL Secreted Signaling 0.1456 0.0010959483913247 Scatter Plot
Source PROS Source PTN PTN Secreted Signaling 0.1467 0.0010042536033096 Scatter Plot
Source PROS Target SPP1 SPP1 Secreted Signaling 0.1542 0.0005414142461961 Scatter Plot
Source PROS Target COLLAGEN COLLAGEN ECM-Receptor 0.1563 0.0004522918838593 Scatter Plot
Source PROS Target CADM CADM Cell-Cell Contact 0.1641 0.0002281932805558 Scatter Plot
Source PROS Target CD23 CD23 Cell-Cell Contact 0.1658 0.0001958031781062 Scatter Plot
Source PROS Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1749 0.00008416178943531555 Scatter Plot
Source PROS Target KIT KIT Secreted Signaling 0.1750 0.0000835408979482689 Scatter Plot
Source PROS Target CSPG4 CSPG4 Cell-Cell Contact 0.1807 0.00004808699645187975 Scatter Plot
Source PROS Target PTN PTN Secreted Signaling 0.1874 0.00002467586221261688 Scatter Plot
Source PROS Source CD39 CD39 Cell-Cell Contact 0.1886 0.00002191261293547629 Scatter Plot
Source PROS Target NCAM NCAM Cell-Cell Contact 0.1897 0.000019452243187278647 Scatter Plot
Source PROS Target AGT AGT Secreted Signaling 0.1927 0.000014255615809401256 Scatter Plot
Source PROS Target MK MK Secreted Signaling 0.1959 0.000010252581944629522 Scatter Plot
Source PROS Target SEMA3 SEMA3 Secreted Signaling 0.1981 0.000008105372621521322 Scatter Plot
Source PROS Target GDF GDF Secreted Signaling 0.2013 0.000005735656166728472 Scatter Plot
Source PROS Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.2041 0.000004205792865511822 Scatter Plot
Source PROS Target VEGF VEGF Secreted Signaling 0.2119 0.0000017384893710293017 Scatter Plot
Source PROS Source LCK LCK Cell-Cell Contact 0.2120 0.0000017178768117713156 Scatter Plot
Source PROS Source IL16 IL16 Secreted Signaling 0.2131 0.00000151168643737607 Scatter Plot
Source PROS Target EPHA EPHA Cell-Cell Contact 0.2164 0.0000010374158554448624 Scatter Plot
Source PROS Target RANKL RANKL Secreted Signaling 0.2214 0.0000005705087287321529 Scatter Plot
Source PROS Target FN1 FN1 ECM-Receptor 0.2222 0.0000005173404597246242 Scatter Plot
Source PROS Target SEMA5 SEMA5 Cell-Cell Contact 0.2271 0.00000028504666865914665 Scatter Plot
Source PROS Target SEMA6 SEMA6 Cell-Cell Contact 0.2310 0.0000001758796008909788 Scatter Plot
Source PROS Source CD46 CD46 Cell-Cell Contact 0.2332 0.00000013389962468690276 Scatter Plot
Source PROS Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2355 0.00000009878429544569813 Scatter Plot
Source PROS Source CD86 CD86 Cell-Cell Contact 0.2356 0.0000000976362685411238 Scatter Plot
Source PROS Source CCL CCL Secreted Signaling 0.2485 0.00000001789610355506343 Scatter Plot
Source PROS Source CD45 CD45 Cell-Cell Contact 0.2513 0.000000012220072352052373 Scatter Plot
Source PROS Target CD22 CD22 Cell-Cell Contact 0.2513 0.000000012220072352052373 Scatter Plot
Source PROS Source IL2 IL2 Secreted Signaling 0.2597 0.000000003755447044562606 Scatter Plot
Source PROS Target ACTIVIN ACTIVIN Secreted Signaling 0.2623 0.000000002600405421773071 Scatter Plot
Source PROS Target TGFb TGFb Secreted Signaling 0.2793 0.00000000020430050131120363 Scatter Plot
Source PROS Target LAMININ LAMININ ECM-Receptor 0.2868 0.00000000006334423830769918 Scatter Plot
Source PROS Target THBS THBS ECM-Receptor 0.2898 0.00000000003959768049310068 Scatter Plot
Source PROS Target OSM OSM Secreted Signaling 0.2927 0.000000000024488391851499664 Scatter Plot
Source PROS Target ANGPTL ANGPTL Secreted Signaling 0.2944 0.00000000001875125217974689 Scatter Plot
Source PROS Target BAFF BAFF Secreted Signaling 0.2975 0.000000000011243369219806536 Scatter Plot
Source PROS Source NT NT Secreted Signaling 0.3013 0.000000000005890631893774467 Scatter Plot
Source PROS Target EPHB EPHB Cell-Cell Contact 0.3130 0.0000000000007901926233179962 Scatter Plot
Source PROS Target SEMA7 SEMA7 Cell-Cell Contact 0.3143 0.0000000000006301979375969028 Scatter Plot
Source PROS Target BMP BMP Secreted Signaling 0.3178 0.00000000000033905493259969973 Scatter Plot
Source PROS Source CSF CSF Secreted Signaling 0.3241 0.00000000000010825075230903013 Scatter Plot
Source PROS Source IGF IGF Secreted Signaling 0.3370 0.000000000000009521416605456062 Scatter Plot
Source PROS Source CX3C CX3C Secreted Signaling 0.3374 0.000000000000008943193500017567 Scatter Plot
Source PROS Source ICAM ICAM Cell-Cell Contact 0.3420 0.000000000000003624178709089065 Scatter Plot
Source PROS Target IL6 IL6 Secreted Signaling 0.3496 0.0000000000000008004158757523387 Scatter Plot
Source PROS Target SEMA4 SEMA4 Cell-Cell Contact 0.3567 0.00000000000000018818037767452583 Scatter Plot
Source PROS Target CD200 CD200 Cell-Cell Contact 0.3637 0.00000000000000004360360441657949 Scatter Plot
Source PROS Target VISFATIN VISFATIN Secreted Signaling 0.3701 0.0000000000000000111869663970818 Scatter Plot
Source PROS Target IGF IGF Secreted Signaling 0.3764 0.000000000000000002827049276697833 Scatter Plot
Source PROS Target SLURP SLURP Secreted Signaling 0.3765 0.000000000000000002779041048556823 Scatter Plot
Source PROS Source FLT3 FLT3 Secreted Signaling 0.3800 0.0000000000000000012667722888313537 Scatter Plot
Source PROS Target PERIOSTIN PERIOSTIN Secreted Signaling 0.3819 0.0000000000000000008217385705867659 Scatter Plot
Source PROS Target NPR2 NPR2 Secreted Signaling 0.3843 0.0000000000000000004829536250538857 Scatter Plot
Source PROS Target APP APP Cell-Cell Contact 0.3931 0.00000000000000000006337745227312127 Scatter Plot
Source PROS Source IL7 IL7 Secreted Signaling 0.3957 0.000000000000000000034503455148525416 Scatter Plot
Source PROS Target CD39 CD39 Cell-Cell Contact 0.3959 0.00000000000000000003233423184284039 Scatter Plot
Source PROS Target BSP BSP ECM-Receptor 0.3992 0.000000000000000000014873586956976805 Scatter Plot
Source PROS Source GAS GAS Secreted Signaling 0.4032 0.000000000000000000005726496581344108 Scatter Plot
Source PROS Target DMP1 DMP1 ECM-Receptor 0.4072 0.00000000000000000000214426650340526 Scatter Plot
Source PROS Target ANGPT ANGPT Secreted Signaling 0.4073 0.000000000000000000002081224867364105 Scatter Plot
Source PROS Target PARs PARs Secreted Signaling 0.4177 0.0000000000000000000001563869346309021 Scatter Plot
Source PROS Target NRG NRG Secreted Signaling 0.4205 0.00000000000000000000007497515530185324 Scatter Plot
Source PROS Target VTN VTN ECM-Receptor 0.4212 0.00000000000000000000006332695504345074 Scatter Plot
Source PROS Source MK MK Secreted Signaling 0.4239 0.000000000000000000000031860242070091495 Scatter Plot
Source PROS Target CDH CDH Cell-Cell Contact 0.4251 0.000000000000000000000022879186222185414 Scatter Plot
Source PROS Target MIF MIF Secreted Signaling 0.4279 0.000000000000000000000010940871774741944 Scatter Plot
Source PROS Target VWF VWF ECM-Receptor 0.4326 0.0000000000000000000000031970541215678607 Scatter Plot
Source PROS Target WNT WNT Secreted Signaling 0.4327 0.0000000000000000000000031043740293364414 Scatter Plot
Source PROS Target ncWNT ncWNT Secreted Signaling 0.4337 0.000000000000000000000002367506205429431 Scatter Plot
Source PROS Source BST2 BST2 Cell-Cell Contact 0.4351 0.000000000000000000000001630065446634187 Scatter Plot
Source PROS Target FGF FGF Secreted Signaling 0.4481 0.00000000000000000000000004514124594497219 Scatter Plot
Source PROS Source PSAP PSAP Secreted Signaling 0.4622 0.0000000000000000000000000007784801525560558 Scatter Plot
Source PROS Source SEMA7 SEMA7 Cell-Cell Contact 0.4673 0.00000000000000000000000000017209163685028514 Scatter Plot
Source PROS Source PDGF PDGF Secreted Signaling 0.4712 0.00000000000000000000000000005213038917919385 Scatter Plot
Source PROS Source MHC-II MHC-II Cell-Cell Contact 0.4895 0.0000000000000000000000000000001723155671401816 Scatter Plot
Source PROS Source ESAM ESAM Cell-Cell Contact 0.4918 0.00000000000000000000000000000008136801251120063 Scatter Plot
Source PROS Target ESAM ESAM Cell-Cell Contact 0.4918 0.00000000000000000000000000000008136801251120063 Scatter Plot
Source PROS Target JAM JAM Cell-Cell Contact 0.4999 0.000000000000000000000000000000005656398245362253 Scatter Plot
Source PROS Source MHC-I MHC-I Cell-Cell Contact 0.5002 0.0000000000000000000000000000000050859885622288274 Scatter Plot
Source PROS Target TENASCIN TENASCIN ECM-Receptor 0.5299 0.00000000000000000000000000000000000014667592956345757 Scatter Plot
Source PROS Target CD34 CD34 Cell-Cell Contact 0.5448 0.0000000000000000000000000000000000000005369711007525486 Scatter Plot
Source PROS Source JAM JAM Cell-Cell Contact 0.5537 0.000000000000000000000000000000000000000015861224669896216 Scatter Plot
Source PROS Source CD52 CD52 Cell-Cell Contact -0.4045 0.000000000000000000004148284119902919 Scatter Plot
Source PROS Target ICAM ICAM Cell-Cell Contact -0.3283 0.00000000000004951463047102738 Scatter Plot
Source PROS Target CD52 CD52 Cell-Cell Contact -0.2929 0.000000000023749211404031597 Scatter Plot
Source PROS Source COMPLEMENT COMPLEMENT Secreted Signaling -0.2859 0.00000000007281730850721739 Scatter Plot
Source PROS Target VCAM VCAM Cell-Cell Contact -0.2650 0.000000001768463064051273 Scatter Plot
Source PROS Source PARs PARs Secreted Signaling -0.2592 0.0000000040311176450330295 Scatter Plot
Source PROS Source SEMA4 SEMA4 Cell-Cell Contact -0.2399 0.00000005585853913230993 Scatter Plot
Source PROS Target IFN-II IFN-II Secreted Signaling -0.2162 0.0000010582563610316215 Scatter Plot
Source PROS Source TGFb TGFb Secreted Signaling -0.2122 0.0000016913917620074236 Scatter Plot
Source PROS Source CLEC CLEC Cell-Cell Contact -0.2023 0.000005101661182866964 Scatter Plot
Source PROS Source MIF MIF Secreted Signaling -0.1805 0.00004908076673144822 Scatter Plot
Source PROS Source ANNEXIN ANNEXIN Secreted Signaling -0.1664 0.0001864738723593 Scatter Plot
Source PROS Target COLLAGEN COLLAGEN ECM-Receptor -0.1516 0.000671057649241 Scatter Plot
Source PROS Target CEACAM CEACAM Cell-Cell Contact -0.1475 0.0009430368274945 Scatter Plot
Source PROS Target CXCL CXCL Secreted Signaling -0.1440 0.0012408304018293 Scatter Plot
Source PROS Source NCAM NCAM Cell-Cell Contact -0.1399 0.0017102650103569 Scatter Plot
Source PROS Target CCL CCL Secreted Signaling -0.1333 0.0028263218664355 Scatter Plot
Source PROS Source CCL CCL Secreted Signaling -0.1313 0.0032604020909921 Scatter Plot
Source PROS Target VEGF VEGF Secreted Signaling -0.1197 0.0073747701837826 Scatter Plot
Source PROS Source LAIR1 LAIR1 Cell-Cell Contact -0.1164 0.0091569786911277 Scatter Plot
Source PROS Source SELPLG SELPLG Cell-Cell Contact -0.1114 0.0127172467520858 Scatter Plot
Source PROS Source VISTA VISTA Cell-Cell Contact -0.1099 0.0139212533429467 Scatter Plot
Source PROS Target GRN GRN Secreted Signaling -0.1069 0.0167567563612741 Scatter Plot
Source PROS Source NKG2D NKG2D Cell-Cell Contact -0.1039 0.0200798136136954 Scatter Plot
Source PROS Target IL17 IL17 Secreted Signaling -0.1003 0.0248914460085566 Scatter Plot
Source PROS Target PDGF PDGF Secreted Signaling -0.0996 0.0259178609151594 Scatter Plot
Source PROS Target COMPLEMENT COMPLEMENT Secreted Signaling -0.0993 0.0264276362899227 Scatter Plot

Cells that are targets of PROS from HSCs*

Cells that are source of PROS to HSCs*

    No cell populations

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.