Pathway: PSAP

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the PSAP pathway:

Specificity Index HSPC as target: 0.471
HSPC as source: 0.080

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the PSAP pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Source PSAP Source ncWNT ncWNT Secreted Signaling 0.1083 0.0154287728919616 Scatter Plot
Source PSAP Source PTN PTN Secreted Signaling 0.1093 0.0144610749588585 Scatter Plot
Source PSAP Source OSM OSM Secreted Signaling 0.1100 0.0138357678289576 Scatter Plot
Source PSAP Source PECAM1 PECAM1 Cell-Cell Contact 0.1389 0.0018498855800692 Scatter Plot
Source PSAP Source GDF GDF Secreted Signaling 0.1619 0.0002779577987758 Scatter Plot
Source PSAP Source SEMA6 SEMA6 Cell-Cell Contact 0.1866 0.000026780922499174564 Scatter Plot
Source PSAP Source SEMA3 SEMA3 Secreted Signaling 0.1999 0.00000663043792901612 Scatter Plot
Source PSAP Source WNT WNT Secreted Signaling 0.2101 0.000002156269682533269 Scatter Plot
Source PSAP Source CD34 CD34 Cell-Cell Contact 0.2156 0.000001141944196059879 Scatter Plot
Source PSAP Source GRN GRN Secreted Signaling 0.2345 0.0000001127524801929903 Scatter Plot
Source PSAP Source CXCL CXCL Secreted Signaling 0.2503 0.000000014037692550801561 Scatter Plot
Source PSAP Source VEGF VEGF Secreted Signaling 0.2647 0.0000000018445203051343023 Scatter Plot
Source PSAP Source LIFR LIFR Secreted Signaling 0.2725 0.0000000005788146915403988 Scatter Plot
Source PSAP Source EPHB EPHB Cell-Cell Contact 0.2758 0.00000000034964681654773 Scatter Plot
Source PSAP Source NT NT Secreted Signaling 0.2773 0.00000000028203238543243005 Scatter Plot
Source PSAP Source RANKL RANKL Secreted Signaling 0.2794 0.00000000020346238207433576 Scatter Plot
Source PSAP Source LIGHT LIGHT Secreted Signaling 0.3009 0.000000000006322779839853173 Scatter Plot
Source PSAP Source CCL CCL Secreted Signaling 0.3448 0.0000000000000020808488534331555 Scatter Plot
Source PSAP Source LAMININ LAMININ ECM-Receptor 0.3662 0.000000000000000025680555028115872 Scatter Plot
Source PSAP Source CDH CDH Cell-Cell Contact 0.3687 0.00000000000000001500207857216858 Scatter Plot
Source PSAP Source PDGF PDGF Secreted Signaling 0.3752 0.00000000000000000363103869694044 Scatter Plot
Source PSAP Source BMP BMP Secreted Signaling 0.4578 0.0000000000000000000000000028132644744797806 Scatter Plot
Source PSAP Source PROS PROS Secreted Signaling 0.4622 0.0000000000000000000000000007784801525560558 Scatter Plot
Source PSAP Source ANGPT ANGPT Secreted Signaling 0.4691 0.00000000000000000000000000009862248296620199 Scatter Plot
Source PSAP Source TWEAK TWEAK Secreted Signaling 0.4760 0.000000000000000000000000000012005709354569409 Scatter Plot
Source PSAP Source COLLAGEN COLLAGEN ECM-Receptor 0.4908 0.00000000000000000000000000000011049940632548896 Scatter Plot
Source PSAP Source CD45 CD45 Cell-Cell Contact 0.4969 0.000000000000000000000000000000015179757225314816 Scatter Plot
Source PSAP Source JAM JAM Cell-Cell Contact 0.5203 0.000000000000000000000000000000000004845457112518291 Scatter Plot
Source PSAP Source ANGPTL ANGPTL Secreted Signaling -0.3260 0.00000000000007623208749941725 Scatter Plot
Source PSAP Source TGFb TGFb Secreted Signaling -0.2895 0.000000000041114644459297075 Scatter Plot
Source PSAP Source NCAM NCAM Cell-Cell Contact -0.1772 0.00006805169806175776 Scatter Plot
Source PSAP Source SEMA4 SEMA4 Cell-Cell Contact -0.1631 0.0002505305882787 Scatter Plot
Source PSAP Source PARs PARs Secreted Signaling -0.1536 0.00057012545302 Scatter Plot
Source PSAP Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.1509 0.000710918258475 Scatter Plot
Source PSAP Source VEGF VEGF Secreted Signaling -0.1287 0.0039572521785966 Scatter Plot
Source PSAP Target GAS GAS Secreted Signaling 0.1020 0.0226059563194141 Scatter Plot
Source PSAP Source PTN PTN Secreted Signaling 0.1159 0.0094773864519927 Scatter Plot
Source PSAP Target CD45 CD45 Cell-Cell Contact 0.1182 0.0081613594753489 Scatter Plot
Source PSAP Target NCAM NCAM Cell-Cell Contact 0.1279 0.0041863073813732 Scatter Plot
Source PSAP Target CCL CCL Secreted Signaling 0.1316 0.0031924578523632 Scatter Plot
Source PSAP Target PTN PTN Secreted Signaling 0.1316 0.0031851267316673 Scatter Plot
Source PSAP Target AGT AGT Secreted Signaling 0.1348 0.002530060554197 Scatter Plot
Source PSAP Target PECAM1 PECAM1 Cell-Cell Contact 0.1389 0.0018498855800692 Scatter Plot
Source PSAP Source CD1D2 CD1D2 Cell-Cell Contact 0.1492 0.0008175191921417 Scatter Plot
Source PSAP Source APP APP Cell-Cell Contact 0.1499 0.000775347948275 Scatter Plot
Source PSAP Target SELE SELE Cell-Cell Contact 0.1613 0.000292855801709 Scatter Plot
Source PSAP Target SEMA3 SEMA3 Secreted Signaling 0.1642 0.000225865939934 Scatter Plot
Source PSAP Target SPP1 SPP1 Secreted Signaling 0.1648 0.0002145437228043 Scatter Plot
Source PSAP Source ANGPTL ANGPTL Secreted Signaling 0.1730 0.0001013925312442 Scatter Plot
Source PSAP Source THY1 THY1 Cell-Cell Contact 0.1800 0.00005184671157781984 Scatter Plot
Source PSAP Source FN1 FN1 ECM-Receptor 0.1814 0.000045203874212684415 Scatter Plot
Source PSAP Target EPHA EPHA Cell-Cell Contact 0.1816 0.00004406794049107572 Scatter Plot
Source PSAP Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1911 0.000016877585250201445 Scatter Plot
Source PSAP Target NOTCH NOTCH Cell-Cell Contact 0.1969 0.000009229130226985263 Scatter Plot
Source PSAP Target VEGF VEGF Secreted Signaling 0.2019 0.000005377101764316892 Scatter Plot
Source PSAP Target CD86 CD86 Cell-Cell Contact 0.2086 0.0000025331432370321237 Scatter Plot
Source PSAP Target SELL SELL Cell-Cell Contact 0.2147 0.000001257089630596389 Scatter Plot
Source PSAP Target THY1 THY1 Cell-Cell Contact 0.2258 0.00000033536082218245685 Scatter Plot
Source PSAP Target CSPG4 CSPG4 Cell-Cell Contact 0.2272 0.0000002803014861641584 Scatter Plot
Source PSAP Target SEMA5 SEMA5 Cell-Cell Contact 0.2308 0.0000001795500522045653 Scatter Plot
Source PSAP Source SELPLG SELPLG Cell-Cell Contact 0.2335 0.00000012814104405700384 Scatter Plot
Source PSAP Target LAIR1 LAIR1 Cell-Cell Contact 0.2403 0.0000000530699133131853 Scatter Plot
Source PSAP Target BST2 BST2 Cell-Cell Contact 0.2403 0.0000000530699133131853 Scatter Plot
Source PSAP Target KIT KIT Secreted Signaling 0.2449 0.000000028928390121979677 Scatter Plot
Source PSAP Target RANKL RANKL Secreted Signaling 0.2465 0.000000023378764537054988 Scatter Plot
Source PSAP Target CD23 CD23 Cell-Cell Contact 0.2473 0.000000021094260931856792 Scatter Plot
Source PSAP Target FN1 FN1 ECM-Receptor 0.2479 0.000000019252860742709546 Scatter Plot
Source PSAP Source ICOS ICOS Cell-Cell Contact 0.2486 0.000000017709760488409343 Scatter Plot
Source PSAP Target COLLAGEN COLLAGEN ECM-Receptor 0.2497 0.000000015235674005261594 Scatter Plot
Source PSAP Source CD46 CD46 Cell-Cell Contact 0.2521 0.000000010948679846672313 Scatter Plot
Source PSAP Target SEMA6 SEMA6 Cell-Cell Contact 0.2532 0.00000000944041833570986 Scatter Plot
Source PSAP Target PARs PARs Secreted Signaling 0.2537 0.000000008754820656490618 Scatter Plot
Source PSAP Target SEMA7 SEMA7 Cell-Cell Contact 0.2583 0.000000004580380475844075 Scatter Plot
Source PSAP Target CADM CADM Cell-Cell Contact 0.2647 0.000000001836662840899705 Scatter Plot
Source PSAP Source CADM CADM Cell-Cell Contact 0.2647 0.000000001836662840899705 Scatter Plot
Source PSAP Source VCAM VCAM Cell-Cell Contact 0.2647 0.0000000018210954905465063 Scatter Plot
Source PSAP Target VISFATIN VISFATIN Secreted Signaling 0.2664 0.0000000014256406342728556 Scatter Plot
Source PSAP Target VWF VWF ECM-Receptor 0.2691 0.0000000009618327642347016 Scatter Plot
Source PSAP Source NOTCH NOTCH Cell-Cell Contact 0.2694 0.0000000009239167031056207 Scatter Plot
Source PSAP Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2762 0.00000000032908708004251586 Scatter Plot
Source PSAP Target IGF IGF Secreted Signaling 0.2766 0.000000000312220447036212 Scatter Plot
Source PSAP Target NODAL NODAL Secreted Signaling 0.2838 0.0000000001019888106328832 Scatter Plot
Source PSAP Source FLT3 FLT3 Secreted Signaling 0.2918 0.000000000028278310034553918 Scatter Plot
Source PSAP Target SELPLG SELPLG Cell-Cell Contact 0.2942 0.000000000019122833847110038 Scatter Plot
Source PSAP Target GDF GDF Secreted Signaling 0.3005 0.000000000006748865060081634 Scatter Plot
Source PSAP Source LCK LCK Cell-Cell Contact 0.3062 0.0000000000026029793484417298 Scatter Plot
Source PSAP Source IGF IGF Secreted Signaling 0.3119 0.0000000000009627001679254609 Scatter Plot
Source PSAP Target ANGPT ANGPT Secreted Signaling 0.3124 0.0000000000008771976829750244 Scatter Plot
Source PSAP Target OSM OSM Secreted Signaling 0.3143 0.0000000000006344091753088504 Scatter Plot
Source PSAP Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.3185 0.0000000000002959187166988756 Scatter Plot
Source PSAP Target ANGPTL ANGPTL Secreted Signaling 0.3208 0.00000000000019509429512141685 Scatter Plot
Source PSAP Target THBS THBS ECM-Receptor 0.3235 0.0000000000001196638328626313 Scatter Plot
Source PSAP Source CD39 CD39 Cell-Cell Contact 0.3239 0.00000000000011170775894311985 Scatter Plot
Source PSAP Target VTN VTN ECM-Receptor 0.3275 0.00000000000005814311678795573 Scatter Plot
Source PSAP Source CSF CSF Secreted Signaling 0.3297 0.000000000000037989730018007955 Scatter Plot
Source PSAP Target LAMININ LAMININ ECM-Receptor 0.3658 0.00000000000000002790601530608816 Scatter Plot
Source PSAP Target CDH CDH Cell-Cell Contact 0.3687 0.00000000000000001500207857216858 Scatter Plot
Source PSAP Target ACTIVIN ACTIVIN Secreted Signaling 0.3700 0.000000000000000011285055571541653 Scatter Plot
Source PSAP Target BMP BMP Secreted Signaling 0.3703 0.000000000000000010572255384458965 Scatter Plot
Source PSAP Source CX3C CX3C Secreted Signaling 0.3727 0.0000000000000000063131648153193365 Scatter Plot
Source PSAP Target GALECTIN GALECTIN Secreted Signaling 0.3782 0.0000000000000000019065225847848892 Scatter Plot
Source PSAP Source IL2 IL2 Secreted Signaling 0.3794 0.000000000000000001435750190556551 Scatter Plot
Source PSAP Target NPR2 NPR2 Secreted Signaling 0.3827 0.0000000000000000006921292732203448 Scatter Plot
Source PSAP Target EPHB EPHB Cell-Cell Contact 0.3835 0.0000000000000000005758824970213266 Scatter Plot
Source PSAP Target TENASCIN TENASCIN ECM-Receptor 0.3998 0.000000000000000000012731986429758023 Scatter Plot
Source PSAP Target TGFb TGFb Secreted Signaling 0.4058 0.000000000000000000003007853272478658 Scatter Plot
Source PSAP Target WNT WNT Secreted Signaling 0.4124 0.0000000000000000000005940716696117938 Scatter Plot
Source PSAP Source PDGF PDGF Secreted Signaling 0.4174 0.0000000000000000000001665603942176717 Scatter Plot
Source PSAP Source MK MK Secreted Signaling 0.4225 0.00000000000000000000004512970751974704 Scatter Plot
Source PSAP Target DMP1 DMP1 ECM-Receptor 0.4252 0.000000000000000000000022421115619085328 Scatter Plot
Source PSAP Target NRG NRG Secreted Signaling 0.4256 0.00000000000000000000002024744549349837 Scatter Plot
Source PSAP Target ncWNT ncWNT Secreted Signaling 0.4309 0.0000000000000000000000049669494109144124 Scatter Plot
Source PSAP Target BSP BSP ECM-Receptor 0.4344 0.000000000000000000000001982982188057845 Scatter Plot
Source PSAP Target PERIOSTIN PERIOSTIN Secreted Signaling 0.4396 0.0000000000000000000000004770444280211688 Scatter Plot
Source PSAP Target FGF FGF Secreted Signaling 0.4403 0.00000000000000000000000039399790940702638 Scatter Plot
Source PSAP Source CD86 CD86 Cell-Cell Contact 0.4441 0.0000000000000000000000001386641612528699 Scatter Plot
Source PSAP Source SEMA7 SEMA7 Cell-Cell Contact 0.4471 0.0000000000000000000000000603962124663264 Scatter Plot
Source PSAP Source PROS PROS Secreted Signaling 0.4580 0.0000000000000000000000000026784297257175395 Scatter Plot
Source PSAP Target CD34 CD34 Cell-Cell Contact 0.4672 0.00000000000000000000000000017478940406051767 Scatter Plot
Source PSAP Source ESAM ESAM Cell-Cell Contact 0.4791 0.000000000000000000000000000004640787569515732 Scatter Plot
Source PSAP Target ESAM ESAM Cell-Cell Contact 0.4791 0.000000000000000000000000000004640787569515732 Scatter Plot
Source PSAP Source IL7 IL7 Secreted Signaling 0.4823 0.000000000000000000000000000001719064768611683 Scatter Plot
Source PSAP Target BAFF BAFF Secreted Signaling 0.4825 0.0000000000000000000000000000015859011616057344 Scatter Plot
Source PSAP Source BST2 BST2 Cell-Cell Contact 0.4835 0.0000000000000000000000000000011691667985751452 Scatter Plot
Source PSAP Source ICAM ICAM Cell-Cell Contact 0.4849 0.0000000000000000000000000000007372244058590847 Scatter Plot
Source PSAP Target SEMA4 SEMA4 Cell-Cell Contact 0.4860 0.0000000000000000000000000000005301811206918456 Scatter Plot
Source PSAP Target CD22 CD22 Cell-Cell Contact 0.4969 0.000000000000000000000000000000015179757225314816 Scatter Plot
Source PSAP Target SLURP SLURP Secreted Signaling 0.4972 0.000000000000000000000000000000013885744313861948 Scatter Plot
Source PSAP Target CD200 CD200 Cell-Cell Contact 0.4985 0.000000000000000000000000000000008992792768207723 Scatter Plot
Source PSAP Target IL6 IL6 Secreted Signaling 0.4996 0.0000000000000000000000000000000061596940530663964 Scatter Plot
Source PSAP Source GAS GAS Secreted Signaling 0.5079 0.0000000000000000000000000000000003757229359662622 Scatter Plot
Source PSAP Target CD39 CD39 Cell-Cell Contact 0.5096 0.00000000000000000000000000000000020680093034786152 Scatter Plot
Source PSAP Target JAM JAM Cell-Cell Contact 0.5099 0.00000000000000000000000000000000018871840605972043 Scatter Plot
Source PSAP Source IL16 IL16 Secreted Signaling 0.5148 0.000000000000000000000000000000000033679701842437407 Scatter Plot
Source PSAP Target APP APP Cell-Cell Contact 0.5583 0.0000000000000000000000000000000000000000025451800685263266 Scatter Plot
Source PSAP Source MHC-I MHC-I Cell-Cell Contact 0.5694 0.000000000000000000000000000000000000000000025281160754214164 Scatter Plot
Source PSAP Target MIF MIF Secreted Signaling 0.6365 0.00000000000000000000000000000000000000000000000000000000034946423254178815 Scatter Plot
Source PSAP Source MHC-II MHC-II Cell-Cell Contact 0.6367 0.0000000000000000000000000000000000000000000000000000000003282002902381421 Scatter Plot
Source PSAP Source MIF MIF Secreted Signaling -0.3230 0.00000000000013142054514216062 Scatter Plot
Source PSAP Target VCAM VCAM Cell-Cell Contact -0.2925 0.00000000002527929283031589 Scatter Plot
Source PSAP Source GALECTIN GALECTIN Secreted Signaling -0.2569 0.000000005609219062130642 Scatter Plot
Source PSAP Source COMPLEMENT COMPLEMENT Secreted Signaling -0.2274 0.0000002736493649182648 Scatter Plot
Source PSAP Target VEGF VEGF Secreted Signaling -0.1781 0.00006202702943162654 Scatter Plot
Source PSAP Source CD52 CD52 Cell-Cell Contact -0.1585 0.0003751488165626 Scatter Plot
Source PSAP Target CEACAM CEACAM Cell-Cell Contact -0.1540 0.0005485345450972 Scatter Plot
Source PSAP Source PARs PARs Secreted Signaling -0.1536 0.0005689556072994 Scatter Plot
Source PSAP Target CD52 CD52 Cell-Cell Contact -0.1522 0.0006384559026558 Scatter Plot
Source PSAP Target ICAM ICAM Cell-Cell Contact -0.1466 0.0010090267194836 Scatter Plot
Source PSAP Target IL17 IL17 Secreted Signaling -0.1443 0.0012176180937994 Scatter Plot
Source PSAP Source IL1 IL1 Secreted Signaling -0.1428 0.0013656814214648 Scatter Plot
Source PSAP Source NKG2D NKG2D Cell-Cell Contact -0.1275 0.0042916520598771 Scatter Plot

Cells that are targets of PSAP from HSCs*

Cells that are source of PSAP to HSCs*

    No cell populations

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.