Pathway: NKG2D

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Cell-Cell Contact

Details on the NKG2D pathway:

Specificity Index HSPC as target: 0.437
HSPC as source: 0.398

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the NKG2D pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Source NKG2D Source FGF FGF Secreted Signaling 0.1164 0.0091743117061552 Scatter Plot
Source NKG2D Source SEMA4 SEMA4 Cell-Cell Contact 0.1250 0.0051203648347696 Scatter Plot
Source NKG2D Source TNF TNF Secreted Signaling 0.1257 0.0048773009147766 Scatter Plot
Source NKG2D Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1294 0.0037584679124882 Scatter Plot
Source NKG2D Source COMPLEMENT COMPLEMENT Secreted Signaling 0.1324 0.0030092139212849 Scatter Plot
Source NKG2D Source SELL SELL Cell-Cell Contact 0.1333 0.0028134034084072 Scatter Plot
Source NKG2D Source LAIR1 LAIR1 Cell-Cell Contact 0.2048 0.000003876427198304513 Scatter Plot
Source NKG2D Source TWEAK TWEAK Secreted Signaling -0.2145 0.0000012939226825799782 Scatter Plot
Source NKG2D Source CCL CCL Secreted Signaling -0.1815 0.000044762582219332895 Scatter Plot
Source NKG2D Source BMP BMP Secreted Signaling -0.1757 0.0000783931234696137 Scatter Plot
Source NKG2D Source RANKL RANKL Secreted Signaling -0.1710 0.0001220517508972 Scatter Plot
Source NKG2D Source BST2 BST2 Cell-Cell Contact -0.1697 0.0001378046949789 Scatter Plot
Source NKG2D Source CSF CSF Secreted Signaling -0.1688 0.0001486604609226 Scatter Plot
Source NKG2D Source CX3C CX3C Secreted Signaling -0.1637 0.0002377490353523 Scatter Plot
Source NKG2D Source ESAM ESAM Cell-Cell Contact -0.1635 0.0002418019791627 Scatter Plot
Source NKG2D Source JAM JAM Cell-Cell Contact -0.1531 0.0005907315236059 Scatter Plot
Source NKG2D Source ANGPT ANGPT Secreted Signaling -0.1530 0.0005951217933452 Scatter Plot
Source NKG2D Source SEMA7 SEMA7 Cell-Cell Contact -0.1488 0.0008453285651385 Scatter Plot
Source NKG2D Source PDGF PDGF Secreted Signaling -0.1472 0.0009607415648257 Scatter Plot
Source NKG2D Source GAS GAS Secreted Signaling -0.1432 0.0013221606555239 Scatter Plot
Source NKG2D Source FLT3 FLT3 Secreted Signaling -0.1407 0.0016091229570553 Scatter Plot
Source NKG2D Source NT NT Secreted Signaling -0.1356 0.002380028131546 Scatter Plot
Source NKG2D Source IGF IGF Secreted Signaling -0.1356 0.0023831352148018 Scatter Plot
Source NKG2D Source MHC-II MHC-II Cell-Cell Contact -0.1288 0.0039253014546425 Scatter Plot
Source NKG2D Source NOTCH NOTCH Cell-Cell Contact -0.1283 0.0040668109717443 Scatter Plot
Source NKG2D Source PSAP PSAP Secreted Signaling -0.1275 0.0042916520598771 Scatter Plot
Source NKG2D Source EPHB EPHB Cell-Cell Contact -0.1210 0.006764885549244 Scatter Plot
Source NKG2D Source CD45 CD45 Cell-Cell Contact -0.1201 0.0071776464335087 Scatter Plot
Source NKG2D Source CDH CDH Cell-Cell Contact -0.1140 0.0107092239064898 Scatter Plot
Source NKG2D Source CADM CADM Cell-Cell Contact -0.1091 0.0146990552021456 Scatter Plot
Source NKG2D Source IL7 IL7 Secreted Signaling -0.1070 0.0166601515928742 Scatter Plot
Source NKG2D Source PROS PROS Secreted Signaling -0.1039 0.0200798136136954 Scatter Plot
Source NKG2D Source LIFR LIFR Secreted Signaling -0.1010 0.0239525747707711 Scatter Plot
Source NKG2D Source SEMA3 SEMA3 Secreted Signaling -0.1001 0.0252597411212657 Scatter Plot
Source NKG2D Source THBS THBS ECM-Receptor -0.1000 0.0253732260649631 Scatter Plot
Source NKG2D Target COMPLEMENT COMPLEMENT Secreted Signaling 0.0988 0.0271520368883594 Scatter Plot
Source NKG2D Target CCL CCL Secreted Signaling 0.1161 0.0093719967572121 Scatter Plot
Source NKG2D Target VCAM VCAM Cell-Cell Contact 0.1182 0.0081503147666007 Scatter Plot
Source NKG2D Target GRN GRN Secreted Signaling 0.1257 0.0048950275047296 Scatter Plot
Source NKG2D Target CD52 CD52 Cell-Cell Contact 0.1307 0.003418308716394 Scatter Plot
Source NKG2D Target ICAM ICAM Cell-Cell Contact 0.1484 0.0008729633535437 Scatter Plot
Source NKG2D Source CD52 CD52 Cell-Cell Contact 0.2041 0.000004218144260248903 Scatter Plot
Source NKG2D Target CD34 CD34 Cell-Cell Contact -0.1780 0.00006264380253980611 Scatter Plot
Source NKG2D Target WNT WNT Secreted Signaling -0.1780 0.00006295420003756692 Scatter Plot
Source NKG2D Target BMP BMP Secreted Signaling -0.1642 0.0002260605165719 Scatter Plot
Source NKG2D Target ncWNT ncWNT Secreted Signaling -0.1635 0.0002407925998428 Scatter Plot
Source NKG2D Target ESAM ESAM Cell-Cell Contact -0.1635 0.0002418019791627 Scatter Plot
Source NKG2D Target JAM JAM Cell-Cell Contact -0.1620 0.0002751552820116 Scatter Plot
Source NKG2D Target OSM OSM Secreted Signaling -0.1607 0.0003083238718276 Scatter Plot
Source NKG2D Target ANGPT ANGPT Secreted Signaling -0.1593 0.000349675890281 Scatter Plot
Source NKG2D Target PARs PARs Secreted Signaling -0.1565 0.0004431224071176 Scatter Plot
Source NKG2D Target CD200 CD200 Cell-Cell Contact -0.1526 0.000616178294186 Scatter Plot
Source NKG2D Target CSPG4 CSPG4 Cell-Cell Contact -0.1511 0.0007014269046692 Scatter Plot
Source NKG2D Target MK MK Secreted Signaling -0.1443 0.0012166083712385 Scatter Plot
Source NKG2D Target NODAL NODAL Secreted Signaling -0.1420 0.0014512625999535 Scatter Plot
Source NKG2D Target AGT AGT Secreted Signaling -0.1418 0.0014739060617328 Scatter Plot
Source NKG2D Target ACTIVIN ACTIVIN Secreted Signaling -0.1418 0.0014828733319877 Scatter Plot
Source NKG2D Target VISFATIN VISFATIN Secreted Signaling -0.1412 0.001551844624664 Scatter Plot
Source NKG2D Target BAFF BAFF Secreted Signaling -0.1402 0.0016745963151937 Scatter Plot
Source NKG2D Target EPHB EPHB Cell-Cell Contact -0.1400 0.0016945777176626 Scatter Plot
Source NKG2D Target PTN PTN Secreted Signaling -0.1362 0.002270389095789 Scatter Plot
Source NKG2D Target MIF MIF Secreted Signaling -0.1350 0.0024796782744004 Scatter Plot
Source NKG2D Target APP APP Cell-Cell Contact -0.1349 0.0025036360139228 Scatter Plot
Source NKG2D Source CXCL CXCL Secreted Signaling -0.1296 0.0036882280626678 Scatter Plot
Source NKG2D Target IGF IGF Secreted Signaling -0.1288 0.0039140780173475 Scatter Plot
Source NKG2D Target THBS THBS ECM-Receptor -0.1239 0.0055185631325407 Scatter Plot
Source NKG2D Target SEMA6 SEMA6 Cell-Cell Contact -0.1215 0.0065352571862799 Scatter Plot
Source NKG2D Target NRG NRG Secreted Signaling -0.1211 0.0067116854345253 Scatter Plot
Source NKG2D Target CD22 CD22 Cell-Cell Contact -0.1201 0.0071776464335087 Scatter Plot
Source NKG2D Target TGFb TGFb Secreted Signaling -0.1156 0.0096787782168262 Scatter Plot
Source NKG2D Target BSP BSP ECM-Receptor -0.1156 0.0096867395512598 Scatter Plot
Source NKG2D Target TENASCIN TENASCIN ECM-Receptor -0.1144 0.0104728409333154 Scatter Plot
Source NKG2D Target CDH CDH Cell-Cell Contact -0.1140 0.0107092239064898 Scatter Plot
Source NKG2D Target DMP1 DMP1 ECM-Receptor -0.1116 0.012526055894661 Scatter Plot
Source NKG2D Target IL6 IL6 Secreted Signaling -0.1113 0.0127528464747992 Scatter Plot
Source NKG2D Target SEMA7 SEMA7 Cell-Cell Contact -0.1109 0.0130814329584168 Scatter Plot
Source NKG2D Target COLLAGEN COLLAGEN ECM-Receptor -0.1092 0.0145432799421795 Scatter Plot
Source NKG2D Target CADM CADM Cell-Cell Contact -0.1091 0.0146990552021456 Scatter Plot
Source NKG2D Target KIT KIT Secreted Signaling -0.1081 0.0155763879785653 Scatter Plot
Source NKG2D Source IL2 IL2 Secreted Signaling -0.1070 0.0166601515928742 Scatter Plot
Source NKG2D Target PERIOSTIN PERIOSTIN Secreted Signaling -0.1037 0.0204140351863579 Scatter Plot
Source NKG2D Target CD39 CD39 Cell-Cell Contact -0.1023 0.02210761090183 Scatter Plot
Source NKG2D Target ADIPONECTIN ADIPONECTIN Secreted Signaling -0.1008 0.0242099043183755 Scatter Plot
Source NKG2D Target ANGPTL ANGPTL Secreted Signaling -0.0994 0.0262906918177119 Scatter Plot
Source NKG2D Source LCK LCK Cell-Cell Contact -0.0984 0.027721080739941 Scatter Plot
Source NKG2D Target LAMININ LAMININ ECM-Receptor -0.0976 0.029130643798405 Scatter Plot
Source NKG2D Target VWF VWF ECM-Receptor -0.0970 0.0301631025031097 Scatter Plot
Source NKG2D Target SPP1 SPP1 Secreted Signaling -0.0968 0.0304115790640085 Scatter Plot

Cells that are targets of NKG2D from HSCs*

Cells that are source of NKG2D to HSCs*

    No cell populations

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.