Pathway: NODAL

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the NODAL pathway:

Specificity Index HSPC as target: 0.217
HSPC as source: 0.924

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the NODAL pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target NODAL Target PDGF PDGF Secreted Signaling 0.0968 0.0305254188941528 Scatter Plot
Target NODAL Source AGRN AGRN ECM-Receptor 0.1009 0.0240021478533462 Scatter Plot
Target NODAL Source SELPLG SELPLG Cell-Cell Contact 0.1015 0.0232272092327383 Scatter Plot
Target NODAL Source LIFR LIFR Secreted Signaling 0.1031 0.0210853758531814 Scatter Plot
Target NODAL Source NT NT Secreted Signaling 0.1039 0.020140303679625 Scatter Plot
Target NODAL Target CADM CADM Cell-Cell Contact 0.1075 0.0161779094452663 Scatter Plot
Target NODAL Source CADM CADM Cell-Cell Contact 0.1075 0.0161779094452663 Scatter Plot
Target NODAL Target VISFATIN VISFATIN Secreted Signaling 0.1105 0.0133949977757257 Scatter Plot
Target NODAL Target PTN PTN Secreted Signaling 0.1143 0.0105330954235263 Scatter Plot
Target NODAL Target SEMA5 SEMA5 Cell-Cell Contact 0.1164 0.0091545395753022 Scatter Plot
Target NODAL Source GDF GDF Secreted Signaling 0.1165 0.009130912463464 Scatter Plot
Target NODAL Target VWF VWF ECM-Receptor 0.1184 0.0080464907894942 Scatter Plot
Target NODAL Source ANNEXIN ANNEXIN Secreted Signaling 0.1188 0.0078481990359667 Scatter Plot
Target NODAL Target THY1 THY1 Cell-Cell Contact 0.1212 0.0066826723323648 Scatter Plot
Target NODAL Target CD23 CD23 Cell-Cell Contact 0.1216 0.0064677141246305 Scatter Plot
Target NODAL Source OSM OSM Secreted Signaling 0.1239 0.0055317745101461 Scatter Plot
Target NODAL Source PTN PTN Secreted Signaling 0.1251 0.0050869268103047 Scatter Plot
Target NODAL Target MK MK Secreted Signaling 0.1254 0.004971500658781 Scatter Plot
Target NODAL Target OSM OSM Secreted Signaling 0.1325 0.0029869624229044 Scatter Plot
Target NODAL Target FN1 FN1 ECM-Receptor 0.1356 0.0023726938250857 Scatter Plot
Target NODAL Source IL6 IL6 Secreted Signaling 0.1362 0.0022791331216091 Scatter Plot
Target NODAL Source CD1D2 CD1D2 Cell-Cell Contact 0.1371 0.0021223320113608 Scatter Plot
Target NODAL Source SEMA6 SEMA6 Cell-Cell Contact 0.1418 0.0014798823516534 Scatter Plot
Target NODAL Source MK MK Secreted Signaling 0.1419 0.0014702602615468 Scatter Plot
Target NODAL Source CX3C CX3C Secreted Signaling 0.1424 0.0014095669390166 Scatter Plot
Target NODAL Source VCAM VCAM Cell-Cell Contact 0.1437 0.001271578806783 Scatter Plot
Target NODAL Source PROS PROS Secreted Signaling 0.1456 0.0010959483913247 Scatter Plot
Target NODAL Target VTN VTN ECM-Receptor 0.1496 0.000791812386318 Scatter Plot
Target NODAL Target NOTCH NOTCH Cell-Cell Contact 0.1576 0.0004024532942791 Scatter Plot
Target NODAL Source BST2 BST2 Cell-Cell Contact 0.1586 0.0003700348103845 Scatter Plot
Target NODAL Target SPP1 SPP1 Secreted Signaling 0.1590 0.0003574636351636 Scatter Plot
Target NODAL Source CD34 CD34 Cell-Cell Contact 0.1598 0.0003341135047736 Scatter Plot
Target NODAL Source IGF IGF Secreted Signaling 0.1609 0.0003023083179406 Scatter Plot
Target NODAL Source WNT WNT Secreted Signaling 0.1634 0.0002434536209815 Scatter Plot
Target NODAL Target IGF IGF Secreted Signaling 0.1646 0.0002177478259717 Scatter Plot
Target NODAL Target SELE SELE Cell-Cell Contact 0.1695 0.000139634632137 Scatter Plot
Target NODAL Source CD46 CD46 Cell-Cell Contact 0.1696 0.0001389623264086 Scatter Plot
Target NODAL Target TENASCIN TENASCIN ECM-Receptor 0.1696 0.0001389503210569 Scatter Plot
Target NODAL Target ANGPTL ANGPTL Secreted Signaling 0.1701 0.0001326775792733 Scatter Plot
Target NODAL Target THBS THBS ECM-Receptor 0.1728 0.0001024983353271 Scatter Plot
Target NODAL Target COLLAGEN COLLAGEN ECM-Receptor 0.1735 0.00009661182170532368 Scatter Plot
Target NODAL Source THY1 THY1 Cell-Cell Contact 0.1742 0.00008994571104396858 Scatter Plot
Target NODAL Source NOTCH NOTCH Cell-Cell Contact 0.1755 0.0000795848749524938 Scatter Plot
Target NODAL Source SEMA3 SEMA3 Secreted Signaling 0.1770 0.00006884319933212743 Scatter Plot
Target NODAL Target SEMA6 SEMA6 Cell-Cell Contact 0.1771 0.00006819059806043768 Scatter Plot
Target NODAL Source CSF CSF Secreted Signaling 0.1780 0.00006294584581780572 Scatter Plot
Target NODAL Target CSPG4 CSPG4 Cell-Cell Contact 0.1842 0.00003421452527190188 Scatter Plot
Target NODAL Target SEMA3 SEMA3 Secreted Signaling 0.1844 0.00003338411430019988 Scatter Plot
Target NODAL Target IL6 IL6 Secreted Signaling 0.1874 0.000024834430757011637 Scatter Plot
Target NODAL Source VEGF VEGF Secreted Signaling 0.1875 0.000024383653293587755 Scatter Plot
Target NODAL Source BMP BMP Secreted Signaling 0.1934 0.00001330186650783324 Scatter Plot
Target NODAL Source CD39 CD39 Cell-Cell Contact 0.1936 0.00001298656471879068 Scatter Plot
Target NODAL Source PDGF PDGF Secreted Signaling 0.1956 0.000010555859766741626 Scatter Plot
Target NODAL Source CCL CCL Secreted Signaling 0.1989 0.0000074484334872416896 Scatter Plot
Target NODAL Source FLT3 FLT3 Secreted Signaling 0.1993 0.000007105352694576632 Scatter Plot
Target NODAL Source IL2 IL2 Secreted Signaling 0.2002 0.000006442156274167031 Scatter Plot
Target NODAL Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2013 0.000005698174801624643 Scatter Plot
Target NODAL Source RANKL RANKL Secreted Signaling 0.2094 0.0000023308651037519405 Scatter Plot
Target NODAL Target FGF FGF Secreted Signaling 0.2104 0.000002070237112781573 Scatter Plot
Target NODAL Target NRG NRG Secreted Signaling 0.2127 0.000001593122949687248 Scatter Plot
Target NODAL Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.2128 0.0000015676970041187872 Scatter Plot
Target NODAL Source TWEAK TWEAK Secreted Signaling 0.2207 0.0000006226892766953999 Scatter Plot
Target NODAL Target NPR2 NPR2 Secreted Signaling 0.2265 0.0000003092121841828281 Scatter Plot
Target NODAL Target DMP1 DMP1 ECM-Receptor 0.2277 0.0000002642093714260851 Scatter Plot
Target NODAL Source CXCL CXCL Secreted Signaling 0.2289 0.00000022801521392293337 Scatter Plot
Target NODAL Target JAM JAM Cell-Cell Contact 0.2296 0.0000002082124901699706 Scatter Plot
Target NODAL Target PERIOSTIN PERIOSTIN Secreted Signaling 0.2305 0.00000018749266624458442 Scatter Plot
Target NODAL Source CDH CDH Cell-Cell Contact 0.2315 0.00000016581395936528056 Scatter Plot
Target NODAL Target CDH CDH Cell-Cell Contact 0.2315 0.00000016581395936528056 Scatter Plot
Target NODAL Source EPHB EPHB Cell-Cell Contact 0.2337 0.00000012526491363171088 Scatter Plot
Target NODAL Target BSP BSP ECM-Receptor 0.2380 0.00000007208075153781566 Scatter Plot
Target NODAL Target LAMININ LAMININ ECM-Receptor 0.2461 0.000000024765460119648683 Scatter Plot
Target NODAL Source LIGHT LIGHT Secreted Signaling 0.2464 0.00000002369260179986784 Scatter Plot
Target NODAL Target ANGPT ANGPT Secreted Signaling 0.2490 0.000000016604053178217136 Scatter Plot
Target NODAL Source IL7 IL7 Secreted Signaling 0.2591 0.0000000041122337507987355 Scatter Plot
Target NODAL Source SEMA7 SEMA7 Cell-Cell Contact 0.2630 0.000000002349593787423192 Scatter Plot
Target NODAL Source JAM JAM Cell-Cell Contact 0.2631 0.000000002308518510319936 Scatter Plot
Target NODAL Source ESAM ESAM Cell-Cell Contact 0.2636 0.000000002141911569943009 Scatter Plot
Target NODAL Target ESAM ESAM Cell-Cell Contact 0.2636 0.000000002141911569943009 Scatter Plot
Target NODAL Target EPHB EPHB Cell-Cell Contact 0.2659 0.000000001544089578836815 Scatter Plot
Target NODAL Source IL16 IL16 Secreted Signaling 0.2685 0.000000001046242440823579 Scatter Plot
Target NODAL Target SLURP SLURP Secreted Signaling 0.2695 0.0000000009109384632075279 Scatter Plot
Target NODAL Source LAMININ LAMININ ECM-Receptor 0.2761 0.0000000003382509885923512 Scatter Plot
Target NODAL Target CD39 CD39 Cell-Cell Contact 0.2822 0.00000000013144124453572012 Scatter Plot
Target NODAL Target KIT KIT Secreted Signaling 0.2825 0.00000000012429463260720395 Scatter Plot
Target NODAL Source PSAP PSAP Secreted Signaling 0.2838 0.0000000001019888106328832 Scatter Plot
Target NODAL Source ICAM ICAM Cell-Cell Contact 0.2886 0.00000000004735446078771205 Scatter Plot
Target NODAL Target ncWNT ncWNT Secreted Signaling 0.2920 0.00000000002757253746269532 Scatter Plot
Target NODAL Source LCK LCK Cell-Cell Contact 0.2971 0.000000000011861136156513635 Scatter Plot
Target NODAL Target CD200 CD200 Cell-Cell Contact 0.3004 0.000000000006880255299207972 Scatter Plot
Target NODAL Source MHC-I MHC-I Cell-Cell Contact 0.3007 0.000000000006583744318390237 Scatter Plot
Target NODAL Source GAS GAS Secreted Signaling 0.3031 0.000000000004370491881387508 Scatter Plot
Target NODAL Source ANGPTL ANGPTL Secreted Signaling 0.3060 0.0000000000026936158647904345 Scatter Plot
Target NODAL Source CD45 CD45 Cell-Cell Contact 0.3091 0.0000000000015773922850100485 Scatter Plot
Target NODAL Target WNT WNT Secreted Signaling 0.3262 0.00000000000007289822927071657 Scatter Plot
Target NODAL Source CD86 CD86 Cell-Cell Contact 0.3392 0.0000000000000062782676076008766 Scatter Plot
Target NODAL Source MHC-II MHC-II Cell-Cell Contact 0.3419 0.000000000000003676583156513368 Scatter Plot
Target NODAL Source ANGPT ANGPT Secreted Signaling 0.3518 0.0000000000000005158040067030093 Scatter Plot
Target NODAL Source COLLAGEN COLLAGEN ECM-Receptor 0.3519 0.0000000000000005043428233318832 Scatter Plot
Target NODAL Source TGFb TGFb Secreted Signaling -0.2059 0.0000034340497995083955 Scatter Plot
Target NODAL Source PARs PARs Secreted Signaling -0.1953 0.00001088934519679642 Scatter Plot
Target NODAL Target CSF CSF Secreted Signaling -0.1738 0.00009332109505550532 Scatter Plot
Target NODAL Source MIF MIF Secreted Signaling -0.1724 0.0001072954321165 Scatter Plot
Target NODAL Source COMPLEMENT COMPLEMENT Secreted Signaling -0.1708 0.0001240957645109 Scatter Plot
Target NODAL Source CLEC CLEC Cell-Cell Contact -0.1694 0.0001408120731759 Scatter Plot
Target NODAL Target CXCL CXCL Secreted Signaling -0.1522 0.0006359035028696 Scatter Plot
Target NODAL Source VISFATIN VISFATIN Secreted Signaling -0.1440 0.001247635023483 Scatter Plot
Target NODAL Source NKG2D NKG2D Cell-Cell Contact -0.1420 0.0014512625999535 Scatter Plot
Target NODAL Source SEMA4 SEMA4 Cell-Cell Contact -0.1305 0.0034680732307184 Scatter Plot
Target NODAL Source ANGPTL ANGPTL Secreted Signaling -0.1244 0.0053561204266654 Scatter Plot
Target NODAL Source SPP1 SPP1 Secreted Signaling -0.1189 0.0077556255813757 Scatter Plot
Target NODAL Target CCL CCL Secreted Signaling -0.1134 0.0111972509833907 Scatter Plot
Target NODAL Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.1075 0.0161889615573424 Scatter Plot
Target NODAL Source VISTA VISTA Cell-Cell Contact -0.1066 0.0171237916981421 Scatter Plot
Target NODAL Source CD52 CD52 Cell-Cell Contact -0.1052 0.0186115985658192 Scatter Plot
Target NODAL Source SELL SELL Cell-Cell Contact -0.0992 0.026486156363314 Scatter Plot
Target NODAL Target LAIR1 LAIR1 Cell-Cell Contact 0.1099 0.0139745753478277 Scatter Plot
Target NODAL Target BST2 BST2 Cell-Cell Contact 0.1099 0.0139745753478277 Scatter Plot
Target NODAL Target SELL SELL Cell-Cell Contact 0.1523 0.0006329806499823 Scatter Plot
Target NODAL Target PARs PARs Secreted Signaling 0.1542 0.0005408417284155 Scatter Plot
Target NODAL Target CD34 CD34 Cell-Cell Contact 0.1852 0.00003071401359508825 Scatter Plot
Target NODAL Target NRG NRG Secreted Signaling 0.2127 0.000001593122949687248 Scatter Plot
Target NODAL Target APP APP Cell-Cell Contact 0.2546 0.000000007678618302931294 Scatter Plot
Target NODAL Target GALECTIN GALECTIN Secreted Signaling 0.2645 0.0000000018912989380736454 Scatter Plot
Target NODAL Target BAFF BAFF Secreted Signaling 0.2938 0.000000000020574769889505763 Scatter Plot
Target NODAL Target IL1 IL1 Secreted Signaling 0.3005 0.000000000006758862770874193 Scatter Plot
Target NODAL Target SEMA4 SEMA4 Cell-Cell Contact 0.3059 0.0000000000026988005706554888 Scatter Plot
Target NODAL Target CD22 CD22 Cell-Cell Contact 0.3091 0.0000000000015773922850100485 Scatter Plot
Target NODAL Target MIF MIF Secreted Signaling 0.3303 0.000000000000034426321810906315 Scatter Plot

Cells that are targets of NODAL from HSCs*

    No cell populations

Cells that are source of NODAL to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.