Pathway: DMP1

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: ECM-Receptor

Details on the DMP1 pathway:

Specificity Index HSPC as target: 0.271
HSPC as source: 0.734

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the DMP1 pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target DMP1 Source AGRN AGRN ECM-Receptor 0.0968 0.0305047077872814 Scatter Plot
Target DMP1 Source APELIN APELIN Secreted Signaling 0.1024 0.0220767712311682 Scatter Plot
Target DMP1 Source IL6 IL6 Secreted Signaling 0.1174 0.0086137069695175 Scatter Plot
Target DMP1 Source SEMA6 SEMA6 Cell-Cell Contact 0.1217 0.0064381859169211 Scatter Plot
Target DMP1 Source THBS THBS ECM-Receptor 0.1264 0.0046309462873536 Scatter Plot
Target DMP1 Source ANGPTL ANGPTL Secreted Signaling 0.1340 0.0026826035666195 Scatter Plot
Target DMP1 Source WNT WNT Secreted Signaling 0.1405 0.0016329808739672 Scatter Plot
Target DMP1 Source GDF GDF Secreted Signaling 0.1469 0.0009859690381154 Scatter Plot
Target DMP1 Target GAS GAS Secreted Signaling 0.1511 0.0006978401049907 Scatter Plot
Target DMP1 Target RANKL RANKL Secreted Signaling 0.1663 0.0001880202679004 Scatter Plot
Target DMP1 Source GP1BA GP1BA Cell-Cell Contact 0.1783 0.0000607433033667225 Scatter Plot
Target DMP1 Source PTN PTN Secreted Signaling 0.1796 0.000053783390549047634 Scatter Plot
Target DMP1 Source VCAM VCAM Cell-Cell Contact 0.1889 0.00002119627231149041 Scatter Plot
Target DMP1 Target VEGF VEGF Secreted Signaling 0.1912 0.00001672191843858891 Scatter Plot
Target DMP1 Source CD1D2 CD1D2 Cell-Cell Contact 0.1974 0.000008713837275452118 Scatter Plot
Target DMP1 Target SEMA3 SEMA3 Secreted Signaling 0.1998 0.000006731651796565465 Scatter Plot
Target DMP1 Target GDF GDF Secreted Signaling 0.2085 0.0000025657173394141705 Scatter Plot
Target DMP1 Target EPHA EPHA Cell-Cell Contact 0.2093 0.000002358488072068803 Scatter Plot
Target DMP1 Target NCAM NCAM Cell-Cell Contact 0.2166 0.0000010108901761122243 Scatter Plot
Target DMP1 Source CD39 CD39 Cell-Cell Contact 0.2316 0.0000001637271166988106 Scatter Plot
Target DMP1 Source CCL CCL Secreted Signaling 0.2436 0.000000034594081333028614 Scatter Plot
Target DMP1 Source THY1 THY1 Cell-Cell Contact 0.2509 0.000000012833416409868136 Scatter Plot
Target DMP1 Source IL2 IL2 Secreted Signaling 0.2544 0.000000007921829164908877 Scatter Plot
Target DMP1 Source SEMA3 SEMA3 Secreted Signaling 0.2641 0.000000002014567184281169 Scatter Plot
Target DMP1 Source ncWNT ncWNT Secreted Signaling 0.2655 0.0000000016343754625541256 Scatter Plot
Target DMP1 Target MK MK Secreted Signaling 0.2771 0.000000000289088183844677 Scatter Plot
Target DMP1 Source IL16 IL16 Secreted Signaling 0.2819 0.00000000013767851369376051 Scatter Plot
Target DMP1 Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2888 0.00000000004585126330096563 Scatter Plot
Target DMP1 Source RANKL RANKL Secreted Signaling 0.2945 0.00000000001834650256047447 Scatter Plot
Target DMP1 Source EPHB EPHB Cell-Cell Contact 0.2955 0.000000000015690785378788786 Scatter Plot
Target DMP1 Target CSPG4 CSPG4 Cell-Cell Contact 0.3059 0.000000000002722931384083355 Scatter Plot
Target DMP1 Target KIT KIT Secreted Signaling 0.3066 0.00000000000240867785188809 Scatter Plot
Target DMP1 Source CXCL CXCL Secreted Signaling 0.3070 0.0000000000022669941385293376 Scatter Plot
Target DMP1 Target SEMA7 SEMA7 Cell-Cell Contact 0.3111 0.0000000000011039910071828854 Scatter Plot
Target DMP1 Target CADM CADM Cell-Cell Contact 0.3149 0.000000000000565560840315424 Scatter Plot
Target DMP1 Source CADM CADM Cell-Cell Contact 0.3149 0.000000000000565560840315424 Scatter Plot
Target DMP1 Source NOTCH NOTCH Cell-Cell Contact 0.3159 0.0000000000004723693691899284 Scatter Plot
Target DMP1 Target SEMA6 SEMA6 Cell-Cell Contact 0.3177 0.0000000000003440557064452037 Scatter Plot
Target DMP1 Source VEGF VEGF Secreted Signaling 0.3191 0.0000000000002694590709004918 Scatter Plot
Target DMP1 Source NT NT Secreted Signaling 0.3199 0.0000000000002337313998388341 Scatter Plot
Target DMP1 Target EPHB EPHB Cell-Cell Contact 0.3200 0.0000000000002292652647474276 Scatter Plot
Target DMP1 Source CD46 CD46 Cell-Cell Contact 0.3210 0.00000000000019104173988588921 Scatter Plot
Target DMP1 Source CSF CSF Secreted Signaling 0.3396 0.000000000000005764769338116859 Scatter Plot
Target DMP1 Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.3435 0.000000000000002692659158643979 Scatter Plot
Target DMP1 Source CD86 CD86 Cell-Cell Contact 0.3471 0.000000000000001332732243948786 Scatter Plot
Target DMP1 Source LIGHT LIGHT Secreted Signaling 0.3561 0.00000000000000021283444334305687 Scatter Plot
Target DMP1 Target ACTIVIN ACTIVIN Secreted Signaling 0.3568 0.00000000000000018458791373168382 Scatter Plot
Target DMP1 Source IGF IGF Secreted Signaling 0.3610 0.00000000000000007713396659926369 Scatter Plot
Target DMP1 Target PARs PARs Secreted Signaling 0.3773 0.0000000000000000023150443088851343 Scatter Plot
Target DMP1 Source CD45 CD45 Cell-Cell Contact 0.3775 0.0000000000000000022100675976967603 Scatter Plot
Target DMP1 Source LCK LCK Cell-Cell Contact 0.3852 0.00000000000000000038785065632162975 Scatter Plot
Target DMP1 Source ICAM ICAM Cell-Cell Contact 0.3860 0.000000000000000000322306248477064 Scatter Plot
Target DMP1 Source CX3C CX3C Secreted Signaling 0.3869 0.0000000000000000002666606829398753 Scatter Plot
Target DMP1 Source LAMININ LAMININ ECM-Receptor 0.3954 0.00000000000000000003673430924103092 Scatter Plot
Target DMP1 Source FLT3 FLT3 Secreted Signaling 0.4043 0.000000000000000000004344640295988855 Scatter Plot
Target DMP1 Source PROS PROS Secreted Signaling 0.4072 0.00000000000000000000214426650340526 Scatter Plot
Target DMP1 Source BST2 BST2 Cell-Cell Contact 0.4090 0.0000000000000000000013777642970996217 Scatter Plot
Target DMP1 Source PSAP PSAP Secreted Signaling 0.4252 0.000000000000000000000022421115619085328 Scatter Plot
Target DMP1 Source MK MK Secreted Signaling 0.4361 0.0000000000000000000000012316064723115171 Scatter Plot
Target DMP1 Target SLURP SLURP Secreted Signaling 0.4574 0.0000000000000000000000000032028167838651728 Scatter Plot
Target DMP1 Source CDH CDH Cell-Cell Contact 0.4607 0.0000000000000000000000000012207082592911272 Scatter Plot
Target DMP1 Source PDGF PDGF Secreted Signaling 0.4636 0.0000000000000000000000000005132781789203375 Scatter Plot
Target DMP1 Source LIFR LIFR Secreted Signaling 0.4672 0.00000000000000000000000000017341588000633583 Scatter Plot
Target DMP1 Source COLLAGEN COLLAGEN ECM-Receptor 0.4675 0.00000000000000000000000000016296948061925707 Scatter Plot
Target DMP1 Source IL7 IL7 Secreted Signaling 0.4844 0.0000000000000000000000000000008697955076997664 Scatter Plot
Target DMP1 Target ncWNT ncWNT Secreted Signaling 0.4862 0.0000000000000000000000000000004874378841123078 Scatter Plot
Target DMP1 Source SEMA7 SEMA7 Cell-Cell Contact 0.4993 0.000000000000000000000000000000006740406635644123 Scatter Plot
Target DMP1 Target FGF FGF Secreted Signaling 0.4995 0.000000000000000000000000000000006431650799396655 Scatter Plot
Target DMP1 Source ANGPT ANGPT Secreted Signaling 0.5040 0.0000000000000000000000000000000014052247456738193 Scatter Plot
Target DMP1 Target MIF MIF Secreted Signaling 0.5041 0.0000000000000000000000000000000013607583468960268 Scatter Plot
Target DMP1 Source BMP BMP Secreted Signaling 0.5119 0.00000000000000000000000000000000009398231623242643 Scatter Plot
Target DMP1 Source GAS GAS Secreted Signaling 0.5245 0.0000000000000000000000000000000000010698463531534078 Scatter Plot
Target DMP1 Source TWEAK TWEAK Secreted Signaling 0.5308 0.00000000000000000000000000000000000010600255594581092 Scatter Plot
Target DMP1 Target WNT WNT Secreted Signaling 0.5358 0.000000000000000000000000000000000000016698571934939671 Scatter Plot
Target DMP1 Source MHC-II MHC-II Cell-Cell Contact 0.5364 0.000000000000000000000000000000000000013392114886409915 Scatter Plot
Target DMP1 Source ESAM ESAM Cell-Cell Contact 0.5486 0.00000000000000000000000000000000000000012102703378281635 Scatter Plot
Target DMP1 Source MHC-I MHC-I Cell-Cell Contact 0.5523 0.00000000000000000000000000000000000000002747223018597613 Scatter Plot
Target DMP1 Source JAM JAM Cell-Cell Contact 0.6030 0.000000000000000000000000000000000000000000000000007576386016055114 Scatter Plot
Target DMP1 Source CD52 CD52 Cell-Cell Contact -0.4015 0.000000000000000000008508991798514413 Scatter Plot
Target DMP1 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.3510 0.0000000000000006018638799360034 Scatter Plot
Target DMP1 Source SELL SELL Cell-Cell Contact -0.3384 0.000000000000007294508215981773 Scatter Plot
Target DMP1 Source COMPLEMENT COMPLEMENT Secreted Signaling -0.3039 0.000000000003849815398576503 Scatter Plot
Target DMP1 Source PARs PARs Secreted Signaling -0.2907 0.000000000033849862884991124 Scatter Plot
Target DMP1 Source TGFb TGFb Secreted Signaling -0.2812 0.00000000015307383789234102 Scatter Plot
Target DMP1 Source CLEC CLEC Cell-Cell Contact -0.2725 0.000000000575541218800829 Scatter Plot
Target DMP1 Source ANGPTL ANGPTL Secreted Signaling -0.2560 0.000000006341805443481441 Scatter Plot
Target DMP1 Source MIF MIF Secreted Signaling -0.2506 0.000000013462592405516412 Scatter Plot
Target DMP1 Source CCL CCL Secreted Signaling -0.2039 0.000004279364303838535 Scatter Plot
Target DMP1 Target VEGF VEGF Secreted Signaling -0.1850 0.00003155133300971854 Scatter Plot
Target DMP1 Source SEMA4 SEMA4 Cell-Cell Contact -0.1769 0.0000694700268271297 Scatter Plot
Target DMP1 Source VISTA VISTA Cell-Cell Contact -0.1696 0.0001390981768575 Scatter Plot
Target DMP1 Target CXCL CXCL Secreted Signaling -0.1651 0.0002094046152069 Scatter Plot
Target DMP1 Source SPP1 SPP1 Secreted Signaling -0.1620 0.0002760136069724 Scatter Plot
Target DMP1 Source NCAM NCAM Cell-Cell Contact -0.1563 0.0004518238831719 Scatter Plot
Target DMP1 Target CSF CSF Secreted Signaling -0.1558 0.0004722306573218 Scatter Plot
Target DMP1 Target IL17 IL17 Secreted Signaling -0.1294 0.0037499577446605 Scatter Plot
Target DMP1 Source ANNEXIN ANNEXIN Secreted Signaling -0.1140 0.0107453139895687 Scatter Plot
Target DMP1 Source NKG2D NKG2D Cell-Cell Contact -0.1116 0.012526055894661 Scatter Plot
Target DMP1 Source TNF TNF Secreted Signaling -0.1076 0.0161109581618082 Scatter Plot
Target DMP1 Source VISFATIN VISFATIN Secreted Signaling -0.1067 0.0169977144759882 Scatter Plot
Target DMP1 Target GALECTIN GALECTIN Secreted Signaling 0.1457 0.0010822723454319 Scatter Plot
Target DMP1 Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1501 0.0007565955626574 Scatter Plot
Target DMP1 Target AGT AGT Secreted Signaling 0.2046 0.000003983516192424805 Scatter Plot
Target DMP1 Target NODAL NODAL Secreted Signaling 0.2277 0.0000002642093714260851 Scatter Plot
Target DMP1 Target IL6 IL6 Secreted Signaling 0.2929 0.000000000023889324821987416 Scatter Plot
Target DMP1 Target OSM OSM Secreted Signaling 0.3103 0.0000000000012691821419172213 Scatter Plot
Target DMP1 Target SEMA5 SEMA5 Cell-Cell Contact 0.3160 0.0000000000004698362236390807 Scatter Plot
Target DMP1 Target VISFATIN VISFATIN Secreted Signaling 0.3491 0.0000000000000008911952513886548 Scatter Plot
Target DMP1 Target BAFF BAFF Secreted Signaling 0.3721 0.00000000000000000719774596406257 Scatter Plot
Target DMP1 Target TGFb TGFb Secreted Signaling 0.3752 0.00000000000000000364577699563496 Scatter Plot
Target DMP1 Target CD22 CD22 Cell-Cell Contact 0.3775 0.0000000000000000022100675976967603 Scatter Plot
Target DMP1 Target CD200 CD200 Cell-Cell Contact 0.3877 0.0000000000000000002187502646468888 Scatter Plot
Target DMP1 Target BMP BMP Secreted Signaling 0.3974 0.000000000000000000022850722296252198 Scatter Plot
Target DMP1 Target SEMA4 SEMA4 Cell-Cell Contact 0.4076 0.000000000000000000001945540476829836 Scatter Plot
Target DMP1 Target APP APP Cell-Cell Contact 0.4271 0.000000000000000000000013540961129308737 Scatter Plot
Target DMP1 Target ANGPT ANGPT Secreted Signaling 0.4477 0.00000000000000000000000005003207557789964 Scatter Plot
Target DMP1 Target NPR2 NPR2 Secreted Signaling 0.4570 0.0000000000000000000000000035129016881796736 Scatter Plot
Target DMP1 Target CDH CDH Cell-Cell Contact 0.4607 0.0000000000000000000000000012207082592911272 Scatter Plot
Target DMP1 Target CD39 CD39 Cell-Cell Contact 0.5120 0.00000000000000000000000000000000009087585289719071 Scatter Plot
Target DMP1 Target ESAM ESAM Cell-Cell Contact 0.5486 0.00000000000000000000000000000000000000012102703378281635 Scatter Plot
Target DMP1 Target CD34 CD34 Cell-Cell Contact 0.5554 0.000000000000000000000000000000000000000007984624299061826 Scatter Plot
Target DMP1 Target ICAM ICAM Cell-Cell Contact -0.3273 0.00000000000006027695365114217 Scatter Plot
Target DMP1 Target CD52 CD52 Cell-Cell Contact -0.2841 0.00000000009733096438377916 Scatter Plot
Target DMP1 Target VCAM VCAM Cell-Cell Contact -0.2419 0.00000004309211184234208 Scatter Plot
Target DMP1 Target IFN-II IFN-II Secreted Signaling -0.2408 0.0000000502465606572328 Scatter Plot
Target DMP1 Target CCL CCL Secreted Signaling -0.1923 0.000014988615121124853 Scatter Plot
Target DMP1 Target CEACAM CEACAM Cell-Cell Contact -0.1829 0.00003881140985799657 Scatter Plot
Target DMP1 Target GRN GRN Secreted Signaling -0.1190 0.0077435560355694 Scatter Plot

Cells that are targets of DMP1 from HSCs*

    No cell populations

Cells that are source of DMP1 to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.