Pathway: ACTIVIN

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the ACTIVIN pathway:

Specificity Index HSPC as target: 0.215
HSPC as source: 0.764

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the ACTIVIN pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target ACTIVIN Source OSM OSM Secreted Signaling 0.0992 0.0266050636337534 Scatter Plot
Target ACTIVIN Target NOTCH NOTCH Cell-Cell Contact 0.1142 0.0106222043563779 Scatter Plot
Target ACTIVIN Source ICOS ICOS Cell-Cell Contact 0.1156 0.0096548223369229 Scatter Plot
Target ACTIVIN Source SEMA6 SEMA6 Cell-Cell Contact 0.1265 0.0046029243565464 Scatter Plot
Target ACTIVIN Source NT NT Secreted Signaling 0.1296 0.0037026016755692 Scatter Plot
Target ACTIVIN Source APELIN APELIN Secreted Signaling 0.1349 0.002500660783889 Scatter Plot
Target ACTIVIN Source WNT WNT Secreted Signaling 0.1371 0.0021246784899754 Scatter Plot
Target ACTIVIN Source IL6 IL6 Secreted Signaling 0.1422 0.0014306900577258 Scatter Plot
Target ACTIVIN Target SEMA3 SEMA3 Secreted Signaling 0.1438 0.0012624021999845 Scatter Plot
Target ACTIVIN Source FGF FGF Secreted Signaling 0.1519 0.0006570171474976 Scatter Plot
Target ACTIVIN Target EPHA EPHA Cell-Cell Contact 0.1578 0.0003964417482182 Scatter Plot
Target ACTIVIN Source GDF GDF Secreted Signaling 0.1716 0.0001151408116654 Scatter Plot
Target ACTIVIN Source PTN PTN Secreted Signaling 0.1743 0.00008963626326529802 Scatter Plot
Target ACTIVIN Target ANGPTL ANGPTL Secreted Signaling 0.1840 0.000034907352299515674 Scatter Plot
Target ACTIVIN Source ANGPTL ANGPTL Secreted Signaling 0.1842 0.00003418064794161792 Scatter Plot
Target ACTIVIN Source CD34 CD34 Cell-Cell Contact 0.1946 0.000011708854124160127 Scatter Plot
Target ACTIVIN Source THY1 THY1 Cell-Cell Contact 0.2001 0.000006487847665622779 Scatter Plot
Target ACTIVIN Source CD1D2 CD1D2 Cell-Cell Contact 0.2097 0.000002249462974593095 Scatter Plot
Target ACTIVIN Source VCAM VCAM Cell-Cell Contact 0.2097 0.0000022489246925853192 Scatter Plot
Target ACTIVIN Source VEGF VEGF Secreted Signaling 0.2103 0.0000020915638778742627 Scatter Plot
Target ACTIVIN Source CD46 CD46 Cell-Cell Contact 0.2156 0.0000011426980407992238 Scatter Plot
Target ACTIVIN Target CSPG4 CSPG4 Cell-Cell Contact 0.2328 0.00000014088661114053412 Scatter Plot
Target ACTIVIN Source CCL CCL Secreted Signaling 0.2351 0.00000010499978309871361 Scatter Plot
Target ACTIVIN Source CD39 CD39 Cell-Cell Contact 0.2433 0.00000003569389239733082 Scatter Plot
Target ACTIVIN Source GP1BA GP1BA Cell-Cell Contact 0.2494 0.000000015879655161023752 Scatter Plot
Target ACTIVIN Source LIFR LIFR Secreted Signaling 0.2566 0.000000005805186606171442 Scatter Plot
Target ACTIVIN Source IGF IGF Secreted Signaling 0.2567 0.0000000057894729528825085 Scatter Plot
Target ACTIVIN Source NOTCH NOTCH Cell-Cell Contact 0.2601 0.000000003548262195265718 Scatter Plot
Target ACTIVIN Source RANKL RANKL Secreted Signaling 0.2612 0.0000000030570798501467893 Scatter Plot
Target ACTIVIN Source PROS PROS Secreted Signaling 0.2623 0.000000002600405421773071 Scatter Plot
Target ACTIVIN Target THBS THBS ECM-Receptor 0.2680 0.0000000011356000387285838 Scatter Plot
Target ACTIVIN Source CADM CADM Cell-Cell Contact 0.2687 0.0000000010210919086100531 Scatter Plot
Target ACTIVIN Source MK MK Secreted Signaling 0.2754 0.00000000037544095342224967 Scatter Plot
Target ACTIVIN Source SEMA3 SEMA3 Secreted Signaling 0.2784 0.00000000023625387734409645 Scatter Plot
Target ACTIVIN Source EPHB EPHB Cell-Cell Contact 0.2794 0.00000000020143569552871814 Scatter Plot
Target ACTIVIN Source PDGF PDGF Secreted Signaling 0.2810 0.0000000001587317560910059 Scatter Plot
Target ACTIVIN Source IL2 IL2 Secreted Signaling 0.2961 0.00000000001406131054449232 Scatter Plot
Target ACTIVIN Source FLT3 FLT3 Secreted Signaling 0.2962 0.000000000013767846463753284 Scatter Plot
Target ACTIVIN Source CDH CDH Cell-Cell Contact 0.3035 0.000000000004101756625196289 Scatter Plot
Target ACTIVIN Source BST2 BST2 Cell-Cell Contact 0.3068 0.0000000000023185652479841705 Scatter Plot
Target ACTIVIN Source LAMININ LAMININ ECM-Receptor 0.3098 0.000000000001392365417372114 Scatter Plot
Target ACTIVIN Source CX3C CX3C Secreted Signaling 0.3196 0.0000000000002429278704026019 Scatter Plot
Target ACTIVIN Target KIT KIT Secreted Signaling 0.3201 0.00000000000022351288201071586 Scatter Plot
Target ACTIVIN Source CSF CSF Secreted Signaling 0.3215 0.0000000000001741815194611503 Scatter Plot
Target ACTIVIN Source CXCL CXCL Secreted Signaling 0.3228 0.0000000000001367922983977783 Scatter Plot
Target ACTIVIN Target VWF VWF ECM-Receptor 0.3327 0.000000000000021781154298939257 Scatter Plot
Target ACTIVIN Source IL16 IL16 Secreted Signaling 0.3336 0.0000000000000182000075989069 Scatter Plot
Target ACTIVIN Target TENASCIN TENASCIN ECM-Receptor 0.3472 0.0000000000000012984424709249785 Scatter Plot
Target ACTIVIN Source ICAM ICAM Cell-Cell Contact 0.3490 0.000000000000000911380025761297 Scatter Plot
Target ACTIVIN Source CD45 CD45 Cell-Cell Contact 0.3493 0.0000000000000008534149870640207 Scatter Plot
Target ACTIVIN Source LIGHT LIGHT Secreted Signaling 0.3500 0.0000000000000007376695813317359 Scatter Plot
Target ACTIVIN Source CD86 CD86 Cell-Cell Contact 0.3547 0.0000000000000002826607604208818 Scatter Plot
Target ACTIVIN Source SEMA7 SEMA7 Cell-Cell Contact 0.3553 0.0000000000000002527428709607126 Scatter Plot
Target ACTIVIN Source TWEAK TWEAK Secreted Signaling 0.3698 0.000000000000000012011517536895132 Scatter Plot
Target ACTIVIN Source PSAP PSAP Secreted Signaling 0.3700 0.000000000000000011285055571541653 Scatter Plot
Target ACTIVIN Source BMP BMP Secreted Signaling 0.3730 0.000000000000000005923988688493991 Scatter Plot
Target ACTIVIN Source LCK LCK Cell-Cell Contact 0.3841 0.0000000000000000005054257150278531 Scatter Plot
Target ACTIVIN Source GAS GAS Secreted Signaling 0.3928 0.00000000000000000006696917527768449 Scatter Plot
Target ACTIVIN Target CD39 CD39 Cell-Cell Contact 0.4052 0.000000000000000000003449036226783159 Scatter Plot
Target ACTIVIN Source ESAM ESAM Cell-Cell Contact 0.4130 0.0000000000000000000005071103369188361 Scatter Plot
Target ACTIVIN Source COLLAGEN COLLAGEN ECM-Receptor 0.4219 0.00000000000000000000005307997626837768 Scatter Plot
Target ACTIVIN Source JAM JAM Cell-Cell Contact 0.4261 0.000000000000000000000017929731987387778 Scatter Plot
Target ACTIVIN Source MHC-I MHC-I Cell-Cell Contact 0.4270 0.000000000000000000000013955327150385805 Scatter Plot
Target ACTIVIN Source IL7 IL7 Secreted Signaling 0.4278 0.000000000000000000000011469494141883881 Scatter Plot
Target ACTIVIN Target WNT WNT Secreted Signaling 0.4301 0.000000000000000000000006173357093708579 Scatter Plot
Target ACTIVIN Target APP APP Cell-Cell Contact 0.4437 0.00000000000000000000000015372798114422803 Scatter Plot
Target ACTIVIN Source ANGPT ANGPT Secreted Signaling 0.4595 0.0000000000000000000000000017144370440007654 Scatter Plot
Target ACTIVIN Source MHC-II MHC-II Cell-Cell Contact 0.4961 0.00000000000000000000000000000001990350971331073 Scatter Plot
Target ACTIVIN Source COMPLEMENT COMPLEMENT Secreted Signaling -0.2959 0.000000000014512157964557164 Scatter Plot
Target ACTIVIN Source SEMA4 SEMA4 Cell-Cell Contact -0.2785 0.00000000023299897836414516 Scatter Plot
Target ACTIVIN Source CD52 CD52 Cell-Cell Contact -0.2631 0.000000002302078474532834 Scatter Plot
Target ACTIVIN Source CLEC CLEC Cell-Cell Contact -0.2313 0.0000001687301257580789 Scatter Plot
Target ACTIVIN Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.2308 0.00000017915396735362075 Scatter Plot
Target ACTIVIN Source PARs PARs Secreted Signaling -0.2184 0.0000008152833815306234 Scatter Plot
Target ACTIVIN Source SELL SELL Cell-Cell Contact -0.2073 0.0000029469657165354888 Scatter Plot
Target ACTIVIN Source VISTA VISTA Cell-Cell Contact -0.1728 0.0001030273600882 Scatter Plot
Target ACTIVIN Source TGFb TGFb Secreted Signaling -0.1600 0.0003283658279284 Scatter Plot
Target ACTIVIN Target CXCL CXCL Secreted Signaling -0.1587 0.0003683095221339 Scatter Plot
Target ACTIVIN Source MIF MIF Secreted Signaling -0.1534 0.0005788974660752 Scatter Plot
Target ACTIVIN Source ANGPTL ANGPTL Secreted Signaling -0.1493 0.0008141457975124 Scatter Plot
Target ACTIVIN Source NKG2D NKG2D Cell-Cell Contact -0.1418 0.0014828733319877 Scatter Plot
Target ACTIVIN Source NCAM NCAM Cell-Cell Contact -0.1401 0.0016927331404566 Scatter Plot
Target ACTIVIN Target ANNEXIN ANNEXIN Secreted Signaling -0.1356 0.0023774381632256 Scatter Plot
Target ACTIVIN Source SPP1 SPP1 Secreted Signaling -0.1307 0.003422831599043 Scatter Plot
Target ACTIVIN Source TNF TNF Secreted Signaling -0.1106 0.0133256293909581 Scatter Plot
Target ACTIVIN Target IL17 IL17 Secreted Signaling -0.1095 0.0143352815521464 Scatter Plot
Target ACTIVIN Target OSM OSM Secreted Signaling 0.1493 0.0008121403609851 Scatter Plot
Target ACTIVIN Target THY1 THY1 Cell-Cell Contact 0.1561 0.0004577199452287 Scatter Plot
Target ACTIVIN Target AGT AGT Secreted Signaling 0.1629 0.0002536683770942 Scatter Plot
Target ACTIVIN Target COLLAGEN COLLAGEN ECM-Receptor 0.1789 0.00005769648051284804 Scatter Plot
Target ACTIVIN Target CD23 CD23 Cell-Cell Contact 0.1805 0.00004920753889383984 Scatter Plot
Target ACTIVIN Target GALECTIN GALECTIN Secreted Signaling 0.1826 0.00003980305920772504 Scatter Plot
Target ACTIVIN Target SELL SELL Cell-Cell Contact 0.1916 0.000016105883879764304 Scatter Plot
Target ACTIVIN Target VISFATIN VISFATIN Secreted Signaling 0.2026 0.000004956865090031088 Scatter Plot
Target ACTIVIN Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.2068 0.000003120648061432336 Scatter Plot
Target ACTIVIN Target PTN PTN Secreted Signaling 0.2158 0.0000011066825088635706 Scatter Plot
Target ACTIVIN Target FN1 FN1 ECM-Receptor 0.2276 0.0000002669328382559365 Scatter Plot
Target ACTIVIN Target IL6 IL6 Secreted Signaling 0.2299 0.00000020062679656200346 Scatter Plot
Target ACTIVIN Target SPP1 SPP1 Secreted Signaling 0.2353 0.00000010244591587077933 Scatter Plot
Target ACTIVIN Target MK MK Secreted Signaling 0.2396 0.00000005820311456532261 Scatter Plot
Target ACTIVIN Target SEMA7 SEMA7 Cell-Cell Contact 0.2431 0.000000036652153256499366 Scatter Plot
Target ACTIVIN Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2624 0.0000000025470264934105446 Scatter Plot
Target ACTIVIN Target CADM CADM Cell-Cell Contact 0.2687 0.0000000010210919086100531 Scatter Plot
Target ACTIVIN Target ANGPTL ANGPTL Secreted Signaling 0.2712 0.0000000007004524202888852 Scatter Plot
Target ACTIVIN Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.2987 0.000000000009222800382371729 Scatter Plot
Target ACTIVIN Target CDH CDH Cell-Cell Contact 0.3035 0.000000000004101756625196289 Scatter Plot
Target ACTIVIN Target SEMA6 SEMA6 Cell-Cell Contact 0.3044 0.0000000000035129233729838538 Scatter Plot
Target ACTIVIN Target IGF IGF Secreted Signaling 0.3051 0.0000000000031402639100084735 Scatter Plot
Target ACTIVIN Target LAMININ LAMININ ECM-Receptor 0.3150 0.0000000000005559550812019604 Scatter Plot
Target ACTIVIN Target VTN VTN ECM-Receptor 0.3195 0.0000000000002500048177520041 Scatter Plot
Target ACTIVIN Target PARs PARs Secreted Signaling 0.3250 0.00000000000009086599714448674 Scatter Plot
Target ACTIVIN Target SEMA5 SEMA5 Cell-Cell Contact 0.3309 0.00000000000003067685390007909 Scatter Plot
Target ACTIVIN Target NRG NRG Secreted Signaling 0.3402 0.00000000000000512855613911617 Scatter Plot
Target ACTIVIN Target EPHB EPHB Cell-Cell Contact 0.3417 0.0000000000000038208496050911945 Scatter Plot
Target ACTIVIN Target PERIOSTIN PERIOSTIN Secreted Signaling 0.3462 0.0000000000000015716171322291468 Scatter Plot
Target ACTIVIN Target CD22 CD22 Cell-Cell Contact 0.3493 0.0000000000000008534149870640207 Scatter Plot
Target ACTIVIN Target BSP BSP ECM-Receptor 0.3530 0.00000000000000040071798128862298 Scatter Plot
Target ACTIVIN Target DMP1 DMP1 ECM-Receptor 0.3568 0.00000000000000018458791373168382 Scatter Plot
Target ACTIVIN Target APP APP Cell-Cell Contact 0.3569 0.000000000000000180325977154186 Scatter Plot
Target ACTIVIN Target BAFF BAFF Secreted Signaling 0.3653 0.000000000000000031378778124044655 Scatter Plot
Target ACTIVIN Target NPR2 NPR2 Secreted Signaling 0.3660 0.000000000000000027108623337674764 Scatter Plot
Target ACTIVIN Target SEMA4 SEMA4 Cell-Cell Contact 0.3663 0.00000000000000002535903062927065 Scatter Plot
Target ACTIVIN Target ANGPT ANGPT Secreted Signaling 0.3708 0.000000000000000009537460386011829 Scatter Plot
Target ACTIVIN Target JAM JAM Cell-Cell Contact 0.3741 0.000000000000000004702157244499524 Scatter Plot
Target ACTIVIN Target ncWNT ncWNT Secreted Signaling 0.3931 0.00000000000000000006243801483125033 Scatter Plot
Target ACTIVIN Target FGF FGF Secreted Signaling 0.4004 0.000000000000000000011082303203929887 Scatter Plot
Target ACTIVIN Target ESAM ESAM Cell-Cell Contact 0.4130 0.0000000000000000000005071103369188361 Scatter Plot
Target ACTIVIN Target CD200 CD200 Cell-Cell Contact 0.4152 0.00000000000000000000029213011876991854 Scatter Plot
Target ACTIVIN Target CD34 CD34 Cell-Cell Contact 0.4163 0.00000000000000000000022172241223135863 Scatter Plot
Target ACTIVIN Target SLURP SLURP Secreted Signaling 0.4192 0.00000000000000000000010504391933268028 Scatter Plot
Target ACTIVIN Target MIF MIF Secreted Signaling 0.4368 0.000000000000000000000001012786586391772 Scatter Plot
Target ACTIVIN Target VCAM VCAM Cell-Cell Contact -0.2016 0.000005542716698137834 Scatter Plot
Target ACTIVIN Target ICAM ICAM Cell-Cell Contact -0.2016 0.000005562935547016261 Scatter Plot
Target ACTIVIN Target CD52 CD52 Cell-Cell Contact -0.1740 0.00009162394931403344 Scatter Plot
Target ACTIVIN Target CSF CSF Secreted Signaling -0.1631 0.0002501813515818 Scatter Plot
Target ACTIVIN Target VEGF VEGF Secreted Signaling -0.1527 0.0006106657465691 Scatter Plot
Target ACTIVIN Target CLEC CLEC Cell-Cell Contact -0.1511 0.0006976757209893 Scatter Plot
Target ACTIVIN Target ANNEXIN ANNEXIN Secreted Signaling -0.1356 0.0023774381632256 Scatter Plot
Target ACTIVIN Target CCL CCL Secreted Signaling -0.1325 0.0029819720626764 Scatter Plot
Target ACTIVIN Target CEACAM CEACAM Cell-Cell Contact -0.1234 0.0057158704134106 Scatter Plot
Target ACTIVIN Target GRN GRN Secreted Signaling -0.1144 0.0104479020211301 Scatter Plot

Cells that are targets of ACTIVIN from HSCs*

    No cell populations

Cells that are source of ACTIVIN to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.