Pathway: APELIN

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the APELIN pathway:

Specificity Index HSPC as target: 0.448
HSPC as source: 0.584

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the APELIN pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Source APELIN Source IGF IGF Secreted Signaling 0.1070 0.0167198673256463 Scatter Plot
Source APELIN Source VEGF VEGF Secreted Signaling 0.1220 0.0063159481612843 Scatter Plot
Source APELIN Source AGRN AGRN ECM-Receptor 0.1224 0.0061209293691824 Scatter Plot
Source APELIN Source LIGHT LIGHT Secreted Signaling 0.1320 0.0030939325383163 Scatter Plot
Source APELIN Source IL6 IL6 Secreted Signaling 0.1472 0.0009622263975991 Scatter Plot
Source APELIN Source COLLAGEN COLLAGEN ECM-Receptor 0.1561 0.0004583190578421 Scatter Plot
Source APELIN Source RANKL RANKL Secreted Signaling 0.1676 0.0001663178079276 Scatter Plot
Source APELIN Source TWEAK TWEAK Secreted Signaling 0.1797 0.00005308268123172123 Scatter Plot
Source APELIN Source ANGPT ANGPT Secreted Signaling 0.2017 0.000005457085708999603 Scatter Plot
Source APELIN Source LIFR LIFR Secreted Signaling 0.2626 0.0000000024893511093538446 Scatter Plot
Source APELIN Source PECAM1 PECAM1 Cell-Cell Contact -0.1444 0.0012009527545189 Scatter Plot
Source APELIN Source SELL SELL Cell-Cell Contact -0.1189 0.0077579378128259 Scatter Plot
Source APELIN Source CSF CSF Secreted Signaling 0.0967 0.0305390146738602 Scatter Plot
Source APELIN Target GAS GAS Secreted Signaling 0.1006 0.0245346618926485 Scatter Plot
Source APELIN Target DMP1 DMP1 ECM-Receptor 0.1024 0.0220767712311682 Scatter Plot
Source APELIN Source NT NT Secreted Signaling 0.1048 0.0190893384394321 Scatter Plot
Source APELIN Target BSP BSP ECM-Receptor 0.1064 0.0173197240283791 Scatter Plot
Source APELIN Source CD1D2 CD1D2 Cell-Cell Contact 0.1084 0.0153494080472732 Scatter Plot
Source APELIN Target IGF IGF Secreted Signaling 0.1108 0.0132022298135121 Scatter Plot
Source APELIN Target AGT AGT Secreted Signaling 0.1109 0.013069241466433 Scatter Plot
Source APELIN Target THBS THBS ECM-Receptor 0.1132 0.0113418972524266 Scatter Plot
Source APELIN Target VEGF VEGF Secreted Signaling 0.1137 0.0109775018409977 Scatter Plot
Source APELIN Target ANGPT ANGPT Secreted Signaling 0.1146 0.0103603138414194 Scatter Plot
Source APELIN Source EPHB EPHB Cell-Cell Contact 0.1150 0.0100944978209937 Scatter Plot
Source APELIN Source AGRN AGRN ECM-Receptor 0.1191 0.0076508896792464 Scatter Plot
Source APELIN Source ANGPTL ANGPTL Secreted Signaling 0.1192 0.0076305119073124 Scatter Plot
Source APELIN Target GDF GDF Secreted Signaling 0.1225 0.0061071888020651 Scatter Plot
Source APELIN Target MK MK Secreted Signaling 0.1229 0.0059123127081127 Scatter Plot
Source APELIN Target FGF FGF Secreted Signaling 0.1247 0.0052447679241944 Scatter Plot
Source APELIN Target NRG NRG Secreted Signaling 0.1255 0.0049572495183677 Scatter Plot
Source APELIN Target BAFF BAFF Secreted Signaling 0.1266 0.004588986815561 Scatter Plot
Source APELIN Source CCL CCL Secreted Signaling 0.1298 0.0036549693590181 Scatter Plot
Source APELIN Source MHC-I MHC-I Cell-Cell Contact 0.1300 0.003580966868992 Scatter Plot
Source APELIN Source NOTCH NOTCH Cell-Cell Contact 0.1320 0.0031108269063458 Scatter Plot
Source APELIN Target PTN PTN Secreted Signaling 0.1325 0.0030028784920177 Scatter Plot
Source APELIN Target VTN VTN ECM-Receptor 0.1325 0.0030012607917121 Scatter Plot
Source APELIN Target NOTCH NOTCH Cell-Cell Contact 0.1328 0.0029226773096259 Scatter Plot
Source APELIN Target ACTIVIN ACTIVIN Secreted Signaling 0.1349 0.002500660783889 Scatter Plot
Source APELIN Target VWF VWF ECM-Receptor 0.1387 0.0018767447089295 Scatter Plot
Source APELIN Target PDGF PDGF Secreted Signaling 0.1392 0.0018137519025734 Scatter Plot
Source APELIN Source CXCL CXCL Secreted Signaling 0.1395 0.0017689583540723 Scatter Plot
Source APELIN Source IL2 IL2 Secreted Signaling 0.1408 0.0015927173634699 Scatter Plot
Source APELIN Target OSM OSM Secreted Signaling 0.1409 0.0015889767126353 Scatter Plot
Source APELIN Source SEMA6 SEMA6 Cell-Cell Contact 0.1461 0.0010510602797577 Scatter Plot
Source APELIN Target ANGPTL ANGPTL Secreted Signaling 0.1463 0.0010312942313503 Scatter Plot
Source APELIN Source ICOS ICOS Cell-Cell Contact 0.1464 0.001022587620684 Scatter Plot
Source APELIN Source LAMININ LAMININ ECM-Receptor 0.1478 0.0009172579247938 Scatter Plot
Source APELIN Target CDH CDH Cell-Cell Contact 0.1500 0.0007684992626005 Scatter Plot
Source APELIN Source CDH CDH Cell-Cell Contact 0.1500 0.0007684992626005 Scatter Plot
Source APELIN Target CD39 CD39 Cell-Cell Contact 0.1538 0.0005579035173395 Scatter Plot
Source APELIN Target PARs PARs Secreted Signaling 0.1538 0.000557585895861 Scatter Plot
Source APELIN Target APP APP Cell-Cell Contact 0.1549 0.0005109366326883 Scatter Plot
Source APELIN Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1569 0.0004297564805798 Scatter Plot
Source APELIN Target SEMA6 SEMA6 Cell-Cell Contact 0.1569 0.0004275076056682 Scatter Plot
Source APELIN Source LCK LCK Cell-Cell Contact 0.1593 0.0003475760843322 Scatter Plot
Source APELIN Source SEMA7 SEMA7 Cell-Cell Contact 0.1599 0.0003314264343967 Scatter Plot
Source APELIN Target MIF MIF Secreted Signaling 0.1599 0.0003301885582434 Scatter Plot
Source APELIN Source PTN PTN Secreted Signaling 0.1665 0.0001834551191291 Scatter Plot
Source APELIN Source CD46 CD46 Cell-Cell Contact 0.1680 0.0001603295727376 Scatter Plot
Source APELIN Source THY1 THY1 Cell-Cell Contact 0.1681 0.0001594536888652 Scatter Plot
Source APELIN Source IL7 IL7 Secreted Signaling 0.1794 0.000054967672586923606 Scatter Plot
Source APELIN Source GAS GAS Secreted Signaling 0.1803 0.00004992392310401234 Scatter Plot
Source APELIN Target CADM CADM Cell-Cell Contact 0.1832 0.00003783169523518696 Scatter Plot
Source APELIN Source CADM CADM Cell-Cell Contact 0.1832 0.00003783169523518696 Scatter Plot
Source APELIN Target ESAM ESAM Cell-Cell Contact 0.1844 0.00003350495384212413 Scatter Plot
Source APELIN Source ESAM ESAM Cell-Cell Contact 0.1844 0.00003350495384212413 Scatter Plot
Source APELIN Source MHC-II MHC-II Cell-Cell Contact 0.1915 0.000016154555413336008 Scatter Plot
Source APELIN Target SEMA5 SEMA5 Cell-Cell Contact 0.1921 0.000015189441242500604 Scatter Plot
Source APELIN Target SLURP SLURP Secreted Signaling 0.1928 0.00001412800882870401 Scatter Plot
Source APELIN Target TENASCIN TENASCIN ECM-Receptor 0.1934 0.000013326881404439183 Scatter Plot
Source APELIN Target TGFb TGFb Secreted Signaling 0.1983 0.000007948745067801407 Scatter Plot
Source APELIN Source CX3C CX3C Secreted Signaling 0.1984 0.000007839246599622918 Scatter Plot
Source APELIN Target VISFATIN VISFATIN Secreted Signaling 0.1988 0.000007466371687658118 Scatter Plot
Source APELIN Source ANGPT ANGPT Secreted Signaling 0.2018 0.000005436750738318654 Scatter Plot
Source APELIN Source PROS PROS Secreted Signaling 0.2049 0.000003864478291978472 Scatter Plot
Source APELIN Target ncWNT ncWNT Secreted Signaling 0.2082 0.0000026457497540386507 Scatter Plot
Source APELIN Source ICAM ICAM Cell-Cell Contact 0.2129 0.000001560669408002614 Scatter Plot
Source APELIN Source BST2 BST2 Cell-Cell Contact 0.2215 0.0000005662150129074204 Scatter Plot
Source APELIN Target SEMA4 SEMA4 Cell-Cell Contact 0.2218 0.0000005473107949783166 Scatter Plot
Source APELIN Target JAM JAM Cell-Cell Contact 0.2230 0.0000004692414952803077 Scatter Plot
Source APELIN Target EPHB EPHB Cell-Cell Contact 0.2265 0.000000308621913785613 Scatter Plot
Source APELIN Target NPR2 NPR2 Secreted Signaling 0.2289 0.0000002292812996222661 Scatter Plot
Source APELIN Target CD34 CD34 Cell-Cell Contact 0.2345 0.00000011282402175824625 Scatter Plot
Source APELIN Target WNT WNT Secreted Signaling 0.2411 0.00000004812326855763699 Scatter Plot
Source APELIN Source PDGF PDGF Secreted Signaling 0.2413 0.00000004652064227786495 Scatter Plot
Source APELIN Source JAM JAM Cell-Cell Contact 0.2484 0.00000001822877515301753 Scatter Plot
Source APELIN Source BMP BMP Secreted Signaling 0.2493 0.000000015939811705461143 Scatter Plot
Source APELIN Target BMP BMP Secreted Signaling 0.2533 0.000000009302416308017162 Scatter Plot
Source APELIN Target IFN-II IFN-II Secreted Signaling -0.1812 0.0000460004715911634 Scatter Plot
Source APELIN Source PARs PARs Secreted Signaling -0.1711 0.0001205273202636 Scatter Plot
Source APELIN Source COMPLEMENT COMPLEMENT Secreted Signaling -0.1602 0.0003216028149926 Scatter Plot
Source APELIN Target PECAM1 PECAM1 Cell-Cell Contact -0.1444 0.0012009527545189 Scatter Plot
Source APELIN Target GRN GRN Secreted Signaling -0.1312 0.0032955642888475 Scatter Plot
Source APELIN Target COLLAGEN COLLAGEN ECM-Receptor -0.1302 0.0035324078051605 Scatter Plot
Source APELIN Source SEMA4 SEMA4 Cell-Cell Contact -0.1294 0.0037463724185019 Scatter Plot
Source APELIN Target CD52 CD52 Cell-Cell Contact -0.1288 0.0039252505944572 Scatter Plot
Source APELIN Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.1286 0.0039706077090403 Scatter Plot
Source APELIN Source CD52 CD52 Cell-Cell Contact -0.1230 0.005876722324489 Scatter Plot
Source APELIN Target ICAM ICAM Cell-Cell Contact -0.1209 0.0068095026938231 Scatter Plot
Source APELIN Source THBS THBS ECM-Receptor -0.1192 0.0076462426711692 Scatter Plot
Source APELIN Target VCAM VCAM Cell-Cell Contact -0.1128 0.0115909282089255 Scatter Plot
Source APELIN Source ANNEXIN ANNEXIN Secreted Signaling -0.1024 0.0220114804935501 Scatter Plot
Source APELIN Source CCL CCL Secreted Signaling -0.1003 0.0249779227859575 Scatter Plot
Source APELIN Source VISTA VISTA Cell-Cell Contact -0.1002 0.0250503656681393 Scatter Plot
Source APELIN Target CD45 CD45 Cell-Cell Contact -0.0994 0.026220759314228 Scatter Plot

Cells that are targets of APELIN from HSCs*

Cells that are source of APELIN to HSCs*

    No cell populations

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.