Pathway: ICOS

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Cell-Cell Contact

Details on the ICOS pathway:

Specificity Index HSPC as target: 0.303
HSPC as source: 0.147

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the ICOS pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Source ICOS Source RANKL RANKL Secreted Signaling 0.0975 0.0292640729139852 Scatter Plot
Source ICOS Source NOTCH NOTCH Cell-Cell Contact 0.1025 0.0219254474094919 Scatter Plot
Source ICOS Source MK MK Secreted Signaling 0.1120 0.0122160786210477 Scatter Plot
Source ICOS Source ANGPT ANGPT Secreted Signaling 0.1132 0.0112865417641376 Scatter Plot
Source ICOS Source CCL CCL Secreted Signaling 0.1142 0.0106283716968367 Scatter Plot
Source ICOS Source COLLAGEN COLLAGEN ECM-Receptor 0.1146 0.0103228814295212 Scatter Plot
Source ICOS Source BST2 BST2 Cell-Cell Contact 0.1155 0.0097260797278601 Scatter Plot
Source ICOS Source IL7 IL7 Secreted Signaling 0.1170 0.0088128130475074 Scatter Plot
Source ICOS Source GAS GAS Secreted Signaling 0.1188 0.0078290414074228 Scatter Plot
Source ICOS Source APP APP Cell-Cell Contact 0.1244 0.0053552131376493 Scatter Plot
Source ICOS Source PTN PTN Secreted Signaling 0.1266 0.0045651533368364 Scatter Plot
Source ICOS Source WNT WNT Secreted Signaling 0.1267 0.0045483429681687 Scatter Plot
Source ICOS Source CDH CDH Cell-Cell Contact 0.1278 0.0041996478336564 Scatter Plot
Source ICOS Source PROS PROS Secreted Signaling 0.1331 0.0028693067499838 Scatter Plot
Source ICOS Source PDGF PDGF Secreted Signaling 0.1379 0.0019993097059727 Scatter Plot
Source ICOS Source CXCL CXCL Secreted Signaling 0.1417 0.0014860529380078 Scatter Plot
Source ICOS Source VISFATIN VISFATIN Secreted Signaling 0.1418 0.0014784596721604 Scatter Plot
Source ICOS Source LIGHT LIGHT Secreted Signaling 0.1432 0.0013234930552319 Scatter Plot
Source ICOS Source CD86 CD86 Cell-Cell Contact 0.1462 0.0010425336109118 Scatter Plot
Source ICOS Source APELIN APELIN Secreted Signaling 0.1464 0.001022587620684 Scatter Plot
Source ICOS Source VEGF VEGF Secreted Signaling 0.1489 0.0008377296464983 Scatter Plot
Source ICOS Source CSF CSF Secreted Signaling 0.1506 0.0007298251959699 Scatter Plot
Source ICOS Source BMP BMP Secreted Signaling 0.1551 0.0005004999511535 Scatter Plot
Source ICOS Source SEMA7 SEMA7 Cell-Cell Contact 0.1619 0.000277692001665 Scatter Plot
Source ICOS Source IL16 IL16 Secreted Signaling 0.1753 0.00008089941091044904 Scatter Plot
Source ICOS Source MHC-II MHC-II Cell-Cell Contact 0.1798 0.000052418946387101375 Scatter Plot
Source ICOS Source CD45 CD45 Cell-Cell Contact 0.1844 0.00003332169974401404 Scatter Plot
Source ICOS Source IGF IGF Secreted Signaling 0.2016 0.000005507968698977427 Scatter Plot
Source ICOS Source PSAP PSAP Secreted Signaling 0.2486 0.000000017709760488409343 Scatter Plot
Source ICOS Source GALECTIN GALECTIN Secreted Signaling -0.2285 0.0000002393847116485 Scatter Plot
Source ICOS Source TGFb TGFb Secreted Signaling -0.1233 0.0057616671137525 Scatter Plot
Source ICOS Source ANGPTL ANGPTL Secreted Signaling -0.1172 0.0087002977320759 Scatter Plot
Source ICOS Target TWEAK TWEAK Secreted Signaling 0.0966 0.0308699816542722 Scatter Plot
Source ICOS Target CD39 CD39 Cell-Cell Contact 0.0966 0.0308389494770316 Scatter Plot
Source ICOS Target CLEC CLEC Cell-Cell Contact 0.1019 0.0226620246130686 Scatter Plot
Source ICOS Target BAFF BAFF Secreted Signaling 0.1024 0.0220837785601446 Scatter Plot
Source ICOS Target CD45 CD45 Cell-Cell Contact 0.1027 0.021625725189778 Scatter Plot
Source ICOS Target CD23 CD23 Cell-Cell Contact 0.1032 0.0210580862293511 Scatter Plot
Source ICOS Source LCK LCK Cell-Cell Contact 0.1037 0.0203314277428728 Scatter Plot
Source ICOS Target COLLAGEN COLLAGEN ECM-Receptor 0.1045 0.0194440530060823 Scatter Plot
Source ICOS Target EPHA EPHA Cell-Cell Contact 0.1073 0.0163401859948693 Scatter Plot
Source ICOS Target THY1 THY1 Cell-Cell Contact 0.1107 0.0132225128610384 Scatter Plot
Source ICOS Target WNT WNT Secreted Signaling 0.1134 0.0111981091110582 Scatter Plot
Source ICOS Target COMPLEMENT COMPLEMENT Secreted Signaling 0.1152 0.0099355456284132 Scatter Plot
Source ICOS Target CD34 CD34 Cell-Cell Contact 0.1156 0.0096763017591493 Scatter Plot
Source ICOS Target ACTIVIN ACTIVIN Secreted Signaling 0.1156 0.0096548223369229 Scatter Plot
Source ICOS Target PDGF PDGF Secreted Signaling 0.1169 0.008907599044311 Scatter Plot
Source ICOS Source IL2 IL2 Secreted Signaling 0.1170 0.0088128130475074 Scatter Plot
Source ICOS Source IL7 IL7 Secreted Signaling 0.1170 0.0088128130475074 Scatter Plot
Source ICOS Target ANGPTL ANGPTL Secreted Signaling 0.1183 0.0081238435424841 Scatter Plot
Source ICOS Target IL6 IL6 Secreted Signaling 0.1186 0.0079271432884489 Scatter Plot
Source ICOS Target ncWNT ncWNT Secreted Signaling 0.1191 0.0076548306820542 Scatter Plot
Source ICOS Source JAM JAM Cell-Cell Contact 0.1203 0.0070942210316629 Scatter Plot
Source ICOS Target TGFb TGFb Secreted Signaling 0.1236 0.0056341090987837 Scatter Plot
Source ICOS Target GDF GDF Secreted Signaling 0.1239 0.0055344365969787 Scatter Plot
Source ICOS Target CDH CDH Cell-Cell Contact 0.1278 0.0041996478336564 Scatter Plot
Source ICOS Target JAM JAM Cell-Cell Contact 0.1325 0.0029919464868258 Scatter Plot
Source ICOS Target SELPLG SELPLG Cell-Cell Contact 0.1344 0.0025975851950335 Scatter Plot
Source ICOS Target CD200 CD200 Cell-Cell Contact 0.1352 0.0024552299958771 Scatter Plot
Source ICOS Target SEMA4 SEMA4 Cell-Cell Contact 0.1388 0.0018686369374973 Scatter Plot
Source ICOS Target EPHB EPHB Cell-Cell Contact 0.1469 0.0009892411856201 Scatter Plot
Source ICOS Target CD86 CD86 Cell-Cell Contact 0.1493 0.0008139995426725 Scatter Plot
Source ICOS Target CCL CCL Secreted Signaling 0.1509 0.0007140277469323 Scatter Plot
Source ICOS Target GALECTIN GALECTIN Secreted Signaling 0.1527 0.0006140236308983 Scatter Plot
Source ICOS Target SEMA3 SEMA3 Secreted Signaling 0.1549 0.0005094873997902 Scatter Plot
Source ICOS Target NPR2 NPR2 Secreted Signaling 0.1575 0.0004085321320023 Scatter Plot
Source ICOS Target CD22 CD22 Cell-Cell Contact 0.1844 0.00003332169974401404 Scatter Plot
Source ICOS Target APP APP Cell-Cell Contact 0.1853 0.00003069188557520763 Scatter Plot
Source ICOS Target MIF MIF Secreted Signaling 0.1949 0.00001139876933200328 Scatter Plot
Source ICOS Target GRN GRN Secreted Signaling -0.1144 0.0104902495464416 Scatter Plot
Source ICOS Target MK MK Secreted Signaling -0.0971 0.0298964030433793 Scatter Plot

Cells that are targets of ICOS from HSCs*

Cells that are source of ICOS to HSCs*

    No cell populations

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.