Pathway: CD23

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Cell-Cell Contact

Details on the CD23 pathway:

Specificity Index HSPC as target: 0.370
HSPC as source: 0.285

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the CD23 pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target CD23 Source THBS THBS ECM-Receptor 0.1006 0.0245026788766564 Scatter Plot
Target CD23 Source ICOS ICOS Cell-Cell Contact 0.1032 0.0210580862293511 Scatter Plot
Target CD23 Target SELE SELE Cell-Cell Contact 0.1066 0.0171009279611469 Scatter Plot
Target CD23 Target BST2 BST2 Cell-Cell Contact 0.1089 0.0148700759580292 Scatter Plot
Target CD23 Target LAIR1 LAIR1 Cell-Cell Contact 0.1089 0.0148700759580292 Scatter Plot
Target CD23 Target CXCL CXCL Secreted Signaling 0.1089 0.0148349575522617 Scatter Plot
Target CD23 Source TNF TNF Secreted Signaling 0.1100 0.0138914685891358 Scatter Plot
Target CD23 Target SEMA6 SEMA6 Cell-Cell Contact 0.1124 0.0119078495152153 Scatter Plot
Target CD23 Source ANGPT ANGPT Secreted Signaling 0.1127 0.0116911165614535 Scatter Plot
Target CD23 Target VEGF VEGF Secreted Signaling 0.1185 0.0079682018810082 Scatter Plot
Target CD23 Target CSPG4 CSPG4 Cell-Cell Contact 0.1222 0.0062089112346238 Scatter Plot
Target CD23 Source VEGF VEGF Secreted Signaling 0.1260 0.0047808857094533 Scatter Plot
Target CD23 Target CLEC CLEC Cell-Cell Contact 0.1262 0.0047035105884839 Scatter Plot
Target CD23 Source RANKL RANKL Secreted Signaling 0.1292 0.0038066684677892 Scatter Plot
Target CD23 Target SEMA3 SEMA3 Secreted Signaling 0.1293 0.0037730027055153 Scatter Plot
Target CD23 Target EPHB EPHB Cell-Cell Contact 0.1305 0.0034593206102411 Scatter Plot
Target CD23 Source SPP1 SPP1 Secreted Signaling 0.1361 0.0022920490474389 Scatter Plot
Target CD23 Source NT NT Secreted Signaling 0.1389 0.001843851600525 Scatter Plot
Target CD23 Source CD46 CD46 Cell-Cell Contact 0.1396 0.0017542744949997 Scatter Plot
Target CD23 Source MHC-I MHC-I Cell-Cell Contact 0.1400 0.0017009427079996 Scatter Plot
Target CD23 Target CD34 CD34 Cell-Cell Contact 0.1438 0.0012641911895489 Scatter Plot
Target CD23 Target GDF GDF Secreted Signaling 0.1464 0.0010287397625606 Scatter Plot
Target CD23 Source CCL CCL Secreted Signaling 0.1469 0.0009844113366558 Scatter Plot
Target CD23 Target CCL CCL Secreted Signaling 0.1501 0.000762781218219 Scatter Plot
Target CD23 Source FLT3 FLT3 Secreted Signaling 0.1520 0.0006504907959536 Scatter Plot
Target CD23 Target TGFb TGFb Secreted Signaling 0.1521 0.0006414768252547 Scatter Plot
Target CD23 Source PROS PROS Secreted Signaling 0.1658 0.0001958031781062 Scatter Plot
Target CD23 Source LIFR LIFR Secreted Signaling 0.1684 0.000155074735613 Scatter Plot
Target CD23 Source CXCL CXCL Secreted Signaling 0.1697 0.0001367854664712 Scatter Plot
Target CD23 Source ICAM ICAM Cell-Cell Contact 0.1721 0.0001097475152521 Scatter Plot
Target CD23 Target ncWNT ncWNT Secreted Signaling 0.1727 0.0001040369132245 Scatter Plot
Target CD23 Target CD39 CD39 Cell-Cell Contact 0.1750 0.00008394770509867591 Scatter Plot
Target CD23 Target WNT WNT Secreted Signaling 0.1767 0.00007123219989271833 Scatter Plot
Target CD23 Source PDGF PDGF Secreted Signaling 0.1803 0.00005020768052987896 Scatter Plot
Target CD23 Source MHC-II MHC-II Cell-Cell Contact 0.1804 0.00004980398832464214 Scatter Plot
Target CD23 Target ACTIVIN ACTIVIN Secreted Signaling 0.1805 0.00004920753889383984 Scatter Plot
Target CD23 Source IL2 IL2 Secreted Signaling 0.1838 0.00003560497097146348 Scatter Plot
Target CD23 Source CSF CSF Secreted Signaling 0.1838 0.000035485106128885055 Scatter Plot
Target CD23 Source CD86 CD86 Cell-Cell Contact 0.1843 0.00003389830745884066 Scatter Plot
Target CD23 Source ncWNT ncWNT Secreted Signaling 0.1904 0.00001817870403404748 Scatter Plot
Target CD23 Source IGF IGF Secreted Signaling 0.1906 0.000017836281874282304 Scatter Plot
Target CD23 Target CADM CADM Cell-Cell Contact 0.1907 0.000017691432823954493 Scatter Plot
Target CD23 Source CADM CADM Cell-Cell Contact 0.1907 0.000017691432823954493 Scatter Plot
Target CD23 Target SLURP SLURP Secreted Signaling 0.1918 0.000015739488414547382 Scatter Plot
Target CD23 Source COLLAGEN COLLAGEN ECM-Receptor 0.1919 0.000015639224319805377 Scatter Plot
Target CD23 Target NPR2 NPR2 Secreted Signaling 0.1947 0.000011641927550605207 Scatter Plot
Target CD23 Target ANGPT ANGPT Secreted Signaling 0.1959 0.00001021152623928832 Scatter Plot
Target CD23 Source ESAM ESAM Cell-Cell Contact 0.2001 0.000006549226370093716 Scatter Plot
Target CD23 Target ESAM ESAM Cell-Cell Contact 0.2001 0.000006549226370093716 Scatter Plot
Target CD23 Target VCAM VCAM Cell-Cell Contact 0.2026 0.000004954370882513306 Scatter Plot
Target CD23 Target BMP BMP Secreted Signaling 0.2034 0.000004567165707622712 Scatter Plot
Target CD23 Source SEMA3 SEMA3 Secreted Signaling 0.2098 0.000002215313513866823 Scatter Plot
Target CD23 Source IL7 IL7 Secreted Signaling 0.2141 0.000001361196374843378 Scatter Plot
Target CD23 Source NOTCH NOTCH Cell-Cell Contact 0.2146 0.000001283720710429317 Scatter Plot
Target CD23 Target CDH CDH Cell-Cell Contact 0.2147 0.0000012593003705235591 Scatter Plot
Target CD23 Source CDH CDH Cell-Cell Contact 0.2147 0.0000012593003705235591 Scatter Plot
Target CD23 Source MK MK Secreted Signaling 0.2173 0.0000009286394247010784 Scatter Plot
Target CD23 Source BMP BMP Secreted Signaling 0.2181 0.0000008421770026108825 Scatter Plot
Target CD23 Source LAIR1 LAIR1 Cell-Cell Contact 0.2193 0.0000007387105168495443 Scatter Plot
Target CD23 Target FGF FGF Secreted Signaling 0.2205 0.0000006384200001499715 Scatter Plot
Target CD23 Source NCAM NCAM Cell-Cell Contact 0.2241 0.0000004124409001921054 Scatter Plot
Target CD23 Target CD200 CD200 Cell-Cell Contact 0.2299 0.00000020217879319388226 Scatter Plot
Target CD23 Source LAMININ LAMININ ECM-Receptor 0.2299 0.00000020139588506334577 Scatter Plot
Target CD23 Source CD39 CD39 Cell-Cell Contact 0.2303 0.00000019120435084295427 Scatter Plot
Target CD23 Source CX3C CX3C Secreted Signaling 0.2308 0.00000017941962528444273 Scatter Plot
Target CD23 Source JAM JAM Cell-Cell Contact 0.2333 0.00000013218889606388554 Scatter Plot
Target CD23 Source COMPLEMENT COMPLEMENT Secreted Signaling 0.2340 0.000000119678661568389 Scatter Plot
Target CD23 Source TWEAK TWEAK Secreted Signaling 0.2343 0.00000011535860244445917 Scatter Plot
Target CD23 Source SEMA4 SEMA4 Cell-Cell Contact 0.2399 0.0000000565359482106653 Scatter Plot
Target CD23 Source SEMA7 SEMA7 Cell-Cell Contact 0.2414 0.00000004608738882733344 Scatter Plot
Target CD23 Source PSAP PSAP Secreted Signaling 0.2473 0.000000021094260931856792 Scatter Plot
Target CD23 Source GAS GAS Secreted Signaling 0.2662 0.0000000014812510395269574 Scatter Plot
Target CD23 Target CEACAM CEACAM Cell-Cell Contact 0.2749 0.00000000040626336909259814 Scatter Plot
Target CD23 Source VISTA VISTA Cell-Cell Contact 0.2795 0.00000000019927885897921412 Scatter Plot
Target CD23 Source LIGHT LIGHT Secreted Signaling 0.2799 0.00000000018661473581644046 Scatter Plot
Target CD23 Target ANNEXIN ANNEXIN Secreted Signaling 0.2849 0.00000000008572314083431654 Scatter Plot
Target CD23 Target MIF MIF Secreted Signaling 0.2917 0.0000000000287688068210878 Scatter Plot
Target CD23 Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.2929 0.000000000023693139140990125 Scatter Plot
Target CD23 Source APP APP Cell-Cell Contact 0.3541 0.00000000000000032046534746450847 Scatter Plot
Target CD23 Source ANNEXIN ANNEXIN Secreted Signaling 0.3560 0.00000000000000022047703153390806 Scatter Plot
Target CD23 Source IL16 IL16 Secreted Signaling 0.3649 0.000000000000000034235649821548123 Scatter Plot
Target CD23 Target CD22 CD22 Cell-Cell Contact 0.3696 0.000000000000000012301337709533798 Scatter Plot
Target CD23 Source CD45 CD45 Cell-Cell Contact 0.3696 0.000000000000000012301337709533798 Scatter Plot
Target CD23 Source GRN GRN Secreted Signaling 0.4143 0.00000000000000000000036194362241135047 Scatter Plot
Target CD23 Source BAFF BAFF Secreted Signaling 0.4276 0.000000000000000000000012049333825976464 Scatter Plot
Target CD23 Target NCAM NCAM Cell-Cell Contact 0.4501 0.000000000000000000000000025705776493905815 Scatter Plot
Target CD23 Source MIF MIF Secreted Signaling -0.4753 0.000000000000000000000000000015043105503647244 Scatter Plot
Target CD23 Source TGFb TGFb Secreted Signaling -0.4166 0.00000000000000000000020639762060304336 Scatter Plot
Target CD23 Source ANGPTL ANGPTL Secreted Signaling -0.3914 0.00000000000000000009386136064908396 Scatter Plot
Target CD23 Source GALECTIN GALECTIN Secreted Signaling -0.3317 0.000000000000026068612580927663 Scatter Plot
Target CD23 Source CD34 CD34 Cell-Cell Contact -0.2600 0.000000003595003451943536 Scatter Plot
Target CD23 Source SEMA4 SEMA4 Cell-Cell Contact -0.2596 0.0000000038145294841242785 Scatter Plot
Target CD23 Target PDGF PDGF Secreted Signaling -0.2358 0.0000000952788068733459 Scatter Plot
Target CD23 Target MK MK Secreted Signaling -0.1689 0.0001475337045561 Scatter Plot
Target CD23 Target CCL CCL Secreted Signaling -0.1645 0.0002203892437082 Scatter Plot
Target CD23 Target TWEAK TWEAK Secreted Signaling -0.1625 0.0002634122085458 Scatter Plot
Target CD23 Source FGF FGF Secreted Signaling -0.1583 0.0003793918754893 Scatter Plot
Target CD23 Source VEGF VEGF Secreted Signaling -0.1425 0.001395315688084 Scatter Plot
Target CD23 Source SELPLG SELPLG Cell-Cell Contact -0.1399 0.0017092598635401 Scatter Plot
Target CD23 Target PECAM1 PECAM1 Cell-Cell Contact -0.1206 0.0069360474259251 Scatter Plot
Target CD23 Source PECAM1 PECAM1 Cell-Cell Contact -0.1206 0.0069360474259251 Scatter Plot
Target CD23 Source CCL CCL Secreted Signaling -0.1195 0.0074615885439491 Scatter Plot
Target CD23 Target IL17 IL17 Secreted Signaling -0.1135 0.0111266814476459 Scatter Plot
Target CD23 Source ICAM ICAM Cell-Cell Contact -0.1130 0.0114524469445447 Scatter Plot
Target CD23 Source VCAM VCAM Cell-Cell Contact -0.1057 0.0180550654283305 Scatter Plot
Target CD23 Source VISFATIN VISFATIN Secreted Signaling -0.1034 0.020783074633338 Scatter Plot
Target CD23 Target GRN GRN Secreted Signaling 0.1085 0.0151802089741495 Scatter Plot
Target CD23 Target IL6 IL6 Secreted Signaling 0.1124 0.0118863854986025 Scatter Plot
Target CD23 Target NODAL NODAL Secreted Signaling 0.1216 0.0064677141246305 Scatter Plot
Target CD23 Target CLEC CLEC Cell-Cell Contact 0.1262 0.0047035105884839 Scatter Plot
Target CD23 Target SEMA4 SEMA4 Cell-Cell Contact 0.1317 0.0031741255467087 Scatter Plot
Target CD23 Target CD34 CD34 Cell-Cell Contact 0.1438 0.0012641911895489 Scatter Plot
Target CD23 Target CCL CCL Secreted Signaling 0.1526 0.0006196083113548 Scatter Plot
Target CD23 Target BAFF BAFF Secreted Signaling 0.1593 0.0003499713978434 Scatter Plot
Target CD23 Target OSM OSM Secreted Signaling 0.2066 0.0000031798893552963894 Scatter Plot
Target CD23 Target APP APP Cell-Cell Contact 0.2156 0.0000011318790368202397 Scatter Plot
Target CD23 Target CD200 CD200 Cell-Cell Contact 0.2299 0.0000002028525191124948 Scatter Plot
Target CD23 Target CEACAM CEACAM Cell-Cell Contact 0.2749 0.00000000040626336909259814 Scatter Plot
Target CD23 Target GALECTIN GALECTIN Secreted Signaling 0.3320 0.00000000000002500269566173376 Scatter Plot
Target CD23 Target IL1 IL1 Secreted Signaling 0.3704 0.00000000000000001044064351133166 Scatter Plot
Target CD23 Target SELL SELL Cell-Cell Contact -0.2601 0.0000000035789059003596126 Scatter Plot
Target CD23 Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.1315 0.003227435288553 Scatter Plot

Cells that are targets of CD23 from HSCs*

    No cell populations

Cells that are source of CD23 to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.