Pathway: APP

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Cell-Cell Contact

Details on the APP pathway:

Specificity Index HSPC as target: 0.710
HSPC as source: 0.277

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the APP pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target APP Target PDGF PDGF Secreted Signaling 0.0965 0.0310346430340765 Scatter Plot
Target APP Target CD45 CD45 Cell-Cell Contact 0.0971 0.0299991536622759 Scatter Plot
Target APP Target GAS GAS Secreted Signaling 0.0987 0.0273051128437695 Scatter Plot
Target APP Source CD34 CD34 Cell-Cell Contact 0.1020 0.0226081247239203 Scatter Plot
Target APP Source GP1BA GP1BA Cell-Cell Contact 0.1026 0.0218043941432866 Scatter Plot
Target APP Source OSM OSM Secreted Signaling 0.1053 0.018472794606788 Scatter Plot
Source APP Source LAMININ LAMININ ECM-Receptor 0.1065 0.0171828045959117 Scatter Plot
Source APP Source CD45 CD45 Cell-Cell Contact 0.1121 0.0121100560597297 Scatter Plot
Source APP Source IL2 IL2 Secreted Signaling 0.1147 0.0102418997704765 Scatter Plot
Target APP Source AGRN AGRN ECM-Receptor 0.1279 0.0041702487379839 Scatter Plot
Target APP Source SEMA6 SEMA6 Cell-Cell Contact 0.1339 0.0027029582477994 Scatter Plot
Target APP Source IL6 IL6 Secreted Signaling 0.1379 0.0019943516244333 Scatter Plot
Source APP Source PSAP PSAP Secreted Signaling 0.1499 0.000775347948275 Scatter Plot
Target APP Source THBS THBS ECM-Receptor 0.1505 0.0007358532919166 Scatter Plot
Target APP Source APELIN APELIN Secreted Signaling 0.1549 0.0005109366326883 Scatter Plot
Target APP Source PTN PTN Secreted Signaling 0.1573 0.0004151865086114 Scatter Plot
Source APP Source VISFATIN VISFATIN Secreted Signaling 0.1695 0.0001401102423383 Scatter Plot
Target APP Target AGT AGT Secreted Signaling 0.1701 0.000131893310789 Scatter Plot
Target APP Target SEMA3 SEMA3 Secreted Signaling 0.1731 0.00009981304879647232 Scatter Plot
Target APP Source ICOS ICOS Cell-Cell Contact 0.1853 0.00003069188557520763 Scatter Plot
Target APP Target NOTCH NOTCH Cell-Cell Contact 0.1974 0.000008738498216346881 Scatter Plot
Source APP Source SEMA6 SEMA6 Cell-Cell Contact 0.2008 0.000006022367495325149 Scatter Plot
Target APP Target VEGF VEGF Secreted Signaling 0.2028 0.000004845754382607899 Scatter Plot
Target APP Target OSM OSM Secreted Signaling 0.2043 0.0000040936437102743815 Scatter Plot
Target APP Source ncWNT ncWNT Secreted Signaling 0.2053 0.0000036913298205943193 Scatter Plot
Target APP Target MK MK Secreted Signaling 0.2122 0.0000016902242471479202 Scatter Plot
Target APP Target CD23 CD23 Cell-Cell Contact 0.2156 0.0000011318790368202397 Scatter Plot
Target APP Target GALECTIN GALECTIN Secreted Signaling 0.2192 0.0000007461426891973102 Scatter Plot
Target APP Source ANGPTL ANGPTL Secreted Signaling 0.2256 0.0000003452561888570823 Scatter Plot
Target APP Target PTN PTN Secreted Signaling 0.2326 0.00000014359526038252998 Scatter Plot
Target APP Target RANKL RANKL Secreted Signaling 0.2366 0.0000000861834489054822 Scatter Plot
Target APP Target EPHA EPHA Cell-Cell Contact 0.2458 0.000000025892938806831082 Scatter Plot
Target APP Target NCAM NCAM Cell-Cell Contact 0.2473 0.000000021037638901766145 Scatter Plot
Target APP Target SPP1 SPP1 Secreted Signaling 0.2503 0.000000013931530153195932 Scatter Plot
Target APP Target FN1 FN1 ECM-Receptor 0.2513 0.000000012224289196474009 Scatter Plot
Source APP Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.2544 0.000000007890076780754172 Scatter Plot
Target APP Target NODAL NODAL Secreted Signaling 0.2546 0.000000007678618302931294 Scatter Plot
Source APP Source TNF TNF Secreted Signaling 0.2577 0.000000004995883082976772 Scatter Plot
Target APP Source GDF GDF Secreted Signaling 0.2639 0.0000000020643836744502332 Scatter Plot
Target APP Source SEMA3 SEMA3 Secreted Signaling 0.2717 0.0000000006568889856394306 Scatter Plot
Target APP Source CD1D2 CD1D2 Cell-Cell Contact 0.2733 0.000000000514696298066246 Scatter Plot
Target APP Source THY1 THY1 Cell-Cell Contact 0.2782 0.0000000002423540132580255 Scatter Plot
Target APP Target ANGPTL ANGPTL Secreted Signaling 0.2791 0.00000000021182913194650767 Scatter Plot
Target APP Source CD46 CD46 Cell-Cell Contact 0.2801 0.00000000018139733191367067 Scatter Plot
Target APP Target GDF GDF Secreted Signaling 0.2802 0.00000000017895470009938238 Scatter Plot
Target APP Source LIGHT LIGHT Secreted Signaling 0.2844 0.00000000009226103505889682 Scatter Plot
Target APP Target COLLAGEN COLLAGEN ECM-Receptor 0.2866 0.00000000006548163559605881 Scatter Plot
Target APP Source CADM CADM Cell-Cell Contact 0.2883 0.00000000005011258375686716 Scatter Plot
Target APP Target CADM CADM Cell-Cell Contact 0.2883 0.00000000005011258375686716 Scatter Plot
Target APP Source NT NT Secreted Signaling 0.2919 0.000000000027917264072488457 Scatter Plot
Target APP Source VEGF VEGF Secreted Signaling 0.2924 0.00000000002581683685244693 Scatter Plot
Target APP Source WNT WNT Secreted Signaling 0.2989 0.000000000008878189776601671 Scatter Plot
Target APP Target SEMA7 SEMA7 Cell-Cell Contact 0.3024 0.000000000004955849884512966 Scatter Plot
Target APP Source VCAM VCAM Cell-Cell Contact 0.3100 0.0000000000013346305021345697 Scatter Plot
Target APP Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.3136 0.0000000000007122249728266574 Scatter Plot
Target APP Target SEMA5 SEMA5 Cell-Cell Contact 0.3227 0.00000000000013881229818386484 Scatter Plot
Target APP Target SEMA6 SEMA6 Cell-Cell Contact 0.3319 0.000000000000025519607912649516 Scatter Plot
Target APP Source IL2 IL2 Secreted Signaling 0.3319 0.00000000000002520247477199284 Scatter Plot
Target APP Target CSPG4 CSPG4 Cell-Cell Contact 0.3418 0.000000000000003806858004613198 Scatter Plot
Target APP Target PARs PARs Secreted Signaling 0.3471 0.0000000000000013203736472574337 Scatter Plot
Target APP Target VTN VTN ECM-Receptor 0.3479 0.0000000000000011397765814706534 Scatter Plot
Target APP Target VWF VWF ECM-Receptor 0.3488 0.0000000000000009489736554114324 Scatter Plot
Target APP Source EPHB EPHB Cell-Cell Contact 0.3509 0.000000000000000614086823052753 Scatter Plot
Target APP Source CXCL CXCL Secreted Signaling 0.3521 0.0000000000000004866480773384423 Scatter Plot
Target APP Source CCL CCL Secreted Signaling 0.3525 0.0000000000000004476988695873309 Scatter Plot
Target APP Source CD39 CD39 Cell-Cell Contact 0.3554 0.0000000000000002495428159776338 Scatter Plot
Source APP Source CD52 CD52 Cell-Cell Contact 0.3554 0.0000000000000002467054174292486 Scatter Plot
Target APP Target ACTIVIN ACTIVIN Secreted Signaling 0.3569 0.000000000000000180325977154186 Scatter Plot
Target APP Source CSF CSF Secreted Signaling 0.3694 0.000000000000000013052047418763608 Scatter Plot
Target APP Target THBS THBS ECM-Receptor 0.3756 0.000000000000000003379278612574249 Scatter Plot
Target APP Source RANKL RANKL Secreted Signaling 0.3782 0.0000000000000000018742477998619987 Scatter Plot
Target APP Source NOTCH NOTCH Cell-Cell Contact 0.3792 0.0000000000000000015250958438275521 Scatter Plot
Target APP Source LAMININ LAMININ ECM-Receptor 0.3799 0.0000000000000000012819828006335398 Scatter Plot
Target APP Target ANGPT ANGPT Secreted Signaling 0.3826 0.0000000000000000007018176795309523 Scatter Plot
Target APP Source LCK LCK Cell-Cell Contact 0.3873 0.0000000000000000002434502617680166 Scatter Plot
Target APP Source PROS PROS Secreted Signaling 0.3931 0.00000000000000000006337745227312127 Scatter Plot
Target APP Target KIT KIT Secreted Signaling 0.3932 0.00000000000000000006123497884603404 Scatter Plot
Source APP Source NCAM NCAM Cell-Cell Contact 0.4036 0.000000000000000000005184745532010298 Scatter Plot
Target APP Source ICAM ICAM Cell-Cell Contact 0.4053 0.00000000000000000000344839862231649 Scatter Plot
Target APP Target EPHB EPHB Cell-Cell Contact 0.4075 0.0000000000000000000020056176426221672 Scatter Plot
Target APP Source LIFR LIFR Secreted Signaling 0.4084 0.0000000000000000000016001011863125452 Scatter Plot
Target APP Source FLT3 FLT3 Secreted Signaling 0.4106 0.0000000000000000000009318224019746696 Scatter Plot
Source APP Source SELL SELL Cell-Cell Contact 0.4106 0.0000000000000000000009208182677460042 Scatter Plot
Source APP Source SEMA4 SEMA4 Cell-Cell Contact 0.4146 0.0000000000000000000003403068547824758 Scatter Plot
Target APP Target PERIOSTIN PERIOSTIN Secreted Signaling 0.4173 0.00000000000000000000017349075666153193 Scatter Plot
Target APP Source IL16 IL16 Secreted Signaling 0.4202 0.00000000000000000000008217943794074034 Scatter Plot
Target APP Target BSP BSP ECM-Receptor 0.4254 0.0000000000000000000000212030786688241 Scatter Plot
Target APP Target DMP1 DMP1 ECM-Receptor 0.4271 0.000000000000000000000013540961129308737 Scatter Plot
Target APP Source CX3C CX3C Secreted Signaling 0.4469 0.00000000000000000000000006255593474470125 Scatter Plot
Target APP Target BMP BMP Secreted Signaling 0.4504 0.000000000000000000000000023724268325093807 Scatter Plot
Target APP Source CDH CDH Cell-Cell Contact 0.4506 0.00000000000000000000000002243932549519413 Scatter Plot
Target APP Target CDH CDH Cell-Cell Contact 0.4506 0.00000000000000000000000002243932549519381 Scatter Plot
Target APP Target IGF IGF Secreted Signaling 0.4538 0.000000000000000000000000008825804554410039 Scatter Plot
Target APP Target NPR2 NPR2 Secreted Signaling 0.4549 0.000000000000000000000000006519167741462753 Scatter Plot
Target APP Source IGF IGF Secreted Signaling 0.4596 0.0000000000000000000000000016640655625467933 Scatter Plot
Target APP Source MK MK Secreted Signaling 0.4750 0.000000000000000000000000000016601151080164618 Scatter Plot
Target APP Source CD45 CD45 Cell-Cell Contact 0.4802 0.0000000000000000000000000000033116232623584455 Scatter Plot
Target APP Source CD86 CD86 Cell-Cell Contact 0.4941 0.000000000000000000000000000000038698916945504416 Scatter Plot
Target APP Source PDGF PDGF Secreted Signaling 0.4954 0.00000000000000000000000000000002527705501219303 Scatter Plot
Source APP Source GRN GRN Secreted Signaling 0.4966 0.000000000000000000000000000000016791882352683682 Scatter Plot
Target APP Target TENASCIN TENASCIN ECM-Receptor 0.5028 0.0000000000000000000000000000000021458183403668565 Scatter Plot
Target APP Source TWEAK TWEAK Secreted Signaling 0.5426 0.000000000000000000000000000000000000001247376806306884 Scatter Plot
Target APP Target CD39 CD39 Cell-Cell Contact 0.5554 0.000000000000000000000000000000000000000008000812010126261 Scatter Plot
Target APP Source PSAP PSAP Secreted Signaling 0.5583 0.0000000000000000000000000000000000000000025451800685263266 Scatter Plot
Target APP Target FGF FGF Secreted Signaling 0.5591 0.0000000000000000000000000000000000000000017717638599579564 Scatter Plot
Target APP Target JAM JAM Cell-Cell Contact 0.5624 0.00000000000000000000000000000000000000000046713518620319865 Scatter Plot
Target APP Source ESAM ESAM Cell-Cell Contact 0.5673 0.00000000000000000000000000000000000000000006010575875823068 Scatter Plot
Target APP Target ESAM ESAM Cell-Cell Contact 0.5673 0.00000000000000000000000000000000000000000006010575875823068 Scatter Plot
Target APP Target ncWNT ncWNT Secreted Signaling 0.5678 0.00000000000000000000000000000000000000000004915951822207444 Scatter Plot
Target APP Source IL7 IL7 Secreted Signaling 0.5698 0.000000000000000000000000000000000000000000020939352022414962 Scatter Plot
Target APP Source BST2 BST2 Cell-Cell Contact 0.5708 0.000000000000000000000000000000000000000000014108126402318618 Scatter Plot
Target APP Target CD200 CD200 Cell-Cell Contact 0.5734 0.000000000000000000000000000000000000000000004543508504479122 Scatter Plot
Target APP Source SEMA7 SEMA7 Cell-Cell Contact 0.5783 0.00000000000000000000000000000000000000000000056720075243014395 Scatter Plot
Target APP Target WNT WNT Secreted Signaling 0.5804 0.0000000000000000000000000000000000000000000002234619535247154 Scatter Plot
Source APP Source VISTA VISTA Cell-Cell Contact 0.5812 0.00000000000000000000000000000000000000000000015554920455758344 Scatter Plot
Target APP Source COLLAGEN COLLAGEN ECM-Receptor 0.5820 0.00000000000000000000000000000000000000000000011300074992313971 Scatter Plot
Target APP Source ANGPT ANGPT Secreted Signaling 0.5862 0.000000000000000000000000000000000000000000000016896728714582663 Scatter Plot
Target APP Source BMP BMP Secreted Signaling 0.5898 0.000000000000000000000000000000000000000000000003415131302138515 Scatter Plot
Target APP Target SLURP SLURP Secreted Signaling 0.6025 0.000000000000000000000000000000000000000000000000009458257752865696 Scatter Plot
Target APP Source JAM JAM Cell-Cell Contact 0.6277 0.00000000000000000000000000000000000000000000000000000003694317393912732 Scatter Plot
Target APP Source GAS GAS Secreted Signaling 0.6410 0.000000000000000000000000000000000000000000000000000000000032034675163398164 Scatter Plot
Target APP Source MHC-I MHC-I Cell-Cell Contact 0.7157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000010181466397376622 Scatter Plot
Target APP Source MHC-II MHC-II Cell-Cell Contact 0.7922 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005901729234328215 Scatter Plot
Source APP Source GALECTIN GALECTIN Secreted Signaling -0.5803 0.00000000000000000000000000000000000000000000023372458387913145 Scatter Plot
Target APP Source TGFb TGFb Secreted Signaling -0.4254 0.00000000000000000000002126435176777175 Scatter Plot
Source APP Source VCAM VCAM Cell-Cell Contact -0.4230 0.00000000000000000000003960889167283218 Scatter Plot
Target APP Source CD52 CD52 Cell-Cell Contact -0.3873 0.0000000000000000002388181608841616 Scatter Plot
Target APP Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.3816 0.0000000000000000008900524245667395 Scatter Plot
Target APP Source COMPLEMENT COMPLEMENT Secreted Signaling -0.3307 0.000000000000031720249852777586 Scatter Plot
Target APP Source MIF MIF Secreted Signaling -0.3127 0.0000000000008296605511492165 Scatter Plot
Source APP Source FGF FGF Secreted Signaling -0.3039 0.000000000003827455648092714 Scatter Plot
Target APP Source PARs PARs Secreted Signaling -0.2952 0.000000000016462268228098254 Scatter Plot
Source APP Source ANGPT ANGPT Secreted Signaling -0.2920 0.000000000027364673449508562 Scatter Plot
Target APP Source SELL SELL Cell-Cell Contact -0.2754 0.00000000037133463157937766 Scatter Plot
Source APP Source SEMA4 SEMA4 Cell-Cell Contact -0.2683 0.0000000010820933387653884 Scatter Plot
Source APP Source EPHB EPHB Cell-Cell Contact -0.2590 0.000000004174543729998518 Scatter Plot
Target APP Source ANGPTL ANGPTL Secreted Signaling -0.2373 0.00000007870446307410498 Scatter Plot
Source APP Source VEGF VEGF Secreted Signaling -0.2282 0.00000024934325185892944 Scatter Plot
Target APP Source CLEC CLEC Cell-Cell Contact -0.2272 0.0000002825658759339821 Scatter Plot
Target APP Target CXCL CXCL Secreted Signaling -0.2221 0.000000523503579107525 Scatter Plot
Target APP Source SEMA4 SEMA4 Cell-Cell Contact -0.2147 0.000001267674264048973 Scatter Plot
Target APP Target CSF CSF Secreted Signaling -0.2113 0.0000018641478357079216 Scatter Plot
Source APP Source TGFb TGFb Secreted Signaling -0.2047 0.000003937239814656118 Scatter Plot
Target APP Source NCAM NCAM Cell-Cell Contact -0.2047 0.000003949784702291129 Scatter Plot
Target APP Target IL17 IL17 Secreted Signaling -0.2018 0.000005397352602163725 Scatter Plot
Source APP Source ANGPTL ANGPTL Secreted Signaling -0.2002 0.000006412398275949566 Scatter Plot
Target APP Source VISTA VISTA Cell-Cell Contact -0.1950 0.000011240709004355435 Scatter Plot
Source APP Source LIFR LIFR Secreted Signaling -0.1791 0.00005662940161135336 Scatter Plot
Target APP Source SPP1 SPP1 Secreted Signaling -0.1753 0.00008116432382142017 Scatter Plot
Source APP Source CD34 CD34 Cell-Cell Contact -0.1629 0.0002537874051882 Scatter Plot
Source APP Source CCL CCL Secreted Signaling -0.1622 0.0002699292207123 Scatter Plot
Target APP Target COLLAGEN COLLAGEN ECM-Receptor -0.1371 0.0021297573593174 Scatter Plot
Target APP Source NKG2D NKG2D Cell-Cell Contact -0.1349 0.0025036360139228 Scatter Plot
Target APP Source GALECTIN GALECTIN Secreted Signaling -0.1333 0.0028246976358246 Scatter Plot
Source APP Source OSM OSM Secreted Signaling -0.1256 0.0049193880510141 Scatter Plot
Source APP Source ESAM ESAM Cell-Cell Contact -0.1234 0.0057312020199931 Scatter Plot
Source APP Source TWEAK TWEAK Secreted Signaling -0.1211 0.0067037431827263 Scatter Plot
Source APP Source PECAM1 PECAM1 Cell-Cell Contact -0.1209 0.0068036305746686 Scatter Plot
Target APP Source TNF TNF Secreted Signaling -0.1178 0.0083805939568447 Scatter Plot
Source APP Source FLT3 FLT3 Secreted Signaling -0.1161 0.0093397353078342 Scatter Plot
Target APP Source IL1 IL1 Secreted Signaling -0.1099 0.0139423506386847 Scatter Plot
Target APP Target ANNEXIN ANNEXIN Secreted Signaling -0.1028 0.021553918094595 Scatter Plot
Target APP Source VISFATIN VISFATIN Secreted Signaling -0.0990 0.026820243660792 Scatter Plot
Target APP Source CCL CCL Secreted Signaling -0.0974 0.0293494558964786 Scatter Plot
Source APP Source PTN PTN Secreted Signaling -0.0962 0.0314373572324977 Scatter Plot
Target APP Target SELL SELL Cell-Cell Contact 0.0980 0.0284045828972195 Scatter Plot
Target APP Target TWEAK TWEAK Secreted Signaling 0.1112 0.0128553177437736 Scatter Plot
Source APP Target CD22 CD22 Cell-Cell Contact 0.1121 0.0121100560597297 Scatter Plot
Source APP Source ICOS ICOS Cell-Cell Contact 0.1244 0.0053552131376493 Scatter Plot
Source APP Target IL6 IL6 Secreted Signaling 0.1252 0.0050404036597641 Scatter Plot
Source APP Target GRN GRN Secreted Signaling 0.1296 0.0036892635745457 Scatter Plot
Source APP Source FN1 FN1 ECM-Receptor 0.1304 0.0034900131657611 Scatter Plot
Source APP Source CLEC CLEC Cell-Cell Contact 0.1366 0.0022005103325643 Scatter Plot
Source APP Source IL16 IL16 Secreted Signaling 0.1591 0.0003557393650371 Scatter Plot
Target APP Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1781 0.00006234745982317717 Scatter Plot
Source APP Target ANGPTL ANGPTL Secreted Signaling 0.1790 0.0000569544162614741 Scatter Plot
Target APP Target THY1 THY1 Cell-Cell Contact 0.1805 0.00004930193091801035 Scatter Plot
Source APP Target VEGF VEGF Secreted Signaling 0.1844 0.00003342578002836901 Scatter Plot
Target APP Target AGT AGT Secreted Signaling 0.1869 0.000026065500570347023 Scatter Plot
Source APP Target SELE SELE Cell-Cell Contact 0.1881 0.00002292131985460077 Scatter Plot
Source APP Target IL17 IL17 Secreted Signaling 0.1900 0.00001889432920180492 Scatter Plot
Source APP Target COLLAGEN COLLAGEN ECM-Receptor 0.2140 0.00000136165083776189 Scatter Plot
Source APP Target ANNEXIN ANNEXIN Secreted Signaling 0.2219 0.0000005360050585022454 Scatter Plot
Source APP Target SEMA3 SEMA3 Secreted Signaling 0.2278 0.00000026338593819594775 Scatter Plot
Source APP Source CCL CCL Secreted Signaling 0.2312 0.00000017112497451122012 Scatter Plot
Source APP Target CXCL CXCL Secreted Signaling 0.2355 0.00000009941132085127633 Scatter Plot
Source APP Target IL1 IL1 Secreted Signaling 0.2495 0.000000015533390140037277 Scatter Plot
Source APP Target JAM JAM Cell-Cell Contact 0.2587 0.000000004334274560404797 Scatter Plot
Source APP Target GALECTIN GALECTIN Secreted Signaling 0.2664 0.0000000014227239876933314 Scatter Plot
Source APP Source BAFF BAFF Secreted Signaling 0.2731 0.000000000532223190977114 Scatter Plot
Target APP Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2967 0.000000000012754862081407815 Scatter Plot
Source APP Target ICAM ICAM Cell-Cell Contact 0.2992 0.000000000008449748827063128 Scatter Plot
Source APP Source SPP1 SPP1 Secreted Signaling 0.3053 0.0000000000030047842905327007 Scatter Plot
Source APP Target CSF CSF Secreted Signaling 0.3179 0.0000000000003315694261342662 Scatter Plot
Target APP Target VISFATIN VISFATIN Secreted Signaling 0.3249 0.00000000000009398906650356089 Scatter Plot
Target APP Target IL6 IL6 Secreted Signaling 0.3257 0.00000000000008046555482096377 Scatter Plot
Source APP Source LAIR1 LAIR1 Cell-Cell Contact 0.3430 0.0000000000000030013646636285616 Scatter Plot
Source APP Target VCAM VCAM Cell-Cell Contact 0.3460 0.0000000000000016383457301780602 Scatter Plot
Source APP Target NCAM NCAM Cell-Cell Contact 0.3496 0.0000000000000007986027124109308 Scatter Plot
Source APP Target COMPLEMENT COMPLEMENT Secreted Signaling 0.3516 0.0000000000000005407941436378599 Scatter Plot
Source APP Target CD23 CD23 Cell-Cell Contact 0.3541 0.00000000000000032046534746450847 Scatter Plot
Target APP Target LAMININ LAMININ ECM-Receptor 0.3643 0.0000000000000000384909975751158 Scatter Plot
Source APP Target CCL CCL Secreted Signaling 0.3734 0.000000000000000005460812196360894 Scatter Plot
Target APP Target ANGPTL ANGPTL Secreted Signaling 0.3764 0.0000000000000000027830662423848373 Scatter Plot
Source APP Target THY1 THY1 Cell-Cell Contact 0.3770 0.000000000000000002476203685946251 Scatter Plot
Source APP Target CEACAM CEACAM Cell-Cell Contact 0.3853 0.00000000000000000038453606818369383 Scatter Plot
Source APP Target CLEC CLEC Cell-Cell Contact 0.3926 0.00000000000000000007079953497176022 Scatter Plot
Source APP Source PARs PARs Secreted Signaling 0.3997 0.000000000000000000013043554935149992 Scatter Plot
Source APP Target SELPLG SELPLG Cell-Cell Contact 0.4018 0.000000000000000000008008550403968594 Scatter Plot
Source APP Target CD52 CD52 Cell-Cell Contact 0.4053 0.0000000000000000000034336912484275726 Scatter Plot
Source APP Target IFN-II IFN-II Secreted Signaling 0.4065 0.0000000000000000000025637444995643326 Scatter Plot
Target APP Target NRG NRG Secreted Signaling 0.4219 0.00000000000000000000005313142747165744 Scatter Plot
Target APP Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.4268 0.000000000000000000000014842990507906746 Scatter Plot
Target APP Target ANGPT ANGPT Secreted Signaling 0.4417 0.000000000000000000000000266836725601053 Scatter Plot
Target APP Target ACTIVIN ACTIVIN Secreted Signaling 0.4437 0.00000000000000000000000015372798114422803 Scatter Plot
Target APP Target SEMA4 SEMA4 Cell-Cell Contact 0.4591 0.0000000000000000000000000019430898809954808 Scatter Plot
Target APP Target BAFF BAFF Secreted Signaling 0.4703 0.000000000000000000000000000069855773431141 Scatter Plot
Target APP Target CD22 CD22 Cell-Cell Contact 0.4802 0.0000000000000000000000000000033116232623584455 Scatter Plot
Target APP Target TGFb TGFb Secreted Signaling 0.5018 0.0000000000000000000000000000000029657662893922925 Scatter Plot
Source APP Source COMPLEMENT COMPLEMENT Secreted Signaling 0.5123 0.0000000000000000000000000000000000826328678934186 Scatter Plot
Target APP Target CD34 CD34 Cell-Cell Contact 0.5419 0.0000000000000000000000000000000000000016182510364020916 Scatter Plot
Source APP Source ANNEXIN ANNEXIN Secreted Signaling 0.5560 0.000000000000000000000000000000000000000006248909746658489 Scatter Plot
Source APP Target MK MK Secreted Signaling -0.4550 0.000000000000000000000000006362798710356688 Scatter Plot
Source APP Target PARs PARs Secreted Signaling -0.4092 0.000000000000000000001321907156298672 Scatter Plot
Source APP Target KIT KIT Secreted Signaling -0.3883 0.0000000000000000001921528570875225 Scatter Plot
Source APP Target PTN PTN Secreted Signaling -0.3266 0.00000000000006753803530527492 Scatter Plot
Target APP Target ICAM ICAM Cell-Cell Contact -0.3126 0.0000000000008432896490713175 Scatter Plot
Source APP Target SPP1 SPP1 Secreted Signaling -0.3015 0.0000000000057169803740296274 Scatter Plot
Source APP Target FN1 FN1 ECM-Receptor -0.2744 0.00000000043846188641540847 Scatter Plot
Source APP Target SEMA7 SEMA7 Cell-Cell Contact -0.2712 0.0000000006998951067900102 Scatter Plot
Target APP Target CD52 CD52 Cell-Cell Contact -0.2669 0.000000001337040819169303 Scatter Plot
Source APP Target PDGF PDGF Secreted Signaling -0.2513 0.000000012112518273654641 Scatter Plot
Target APP Target VCAM VCAM Cell-Cell Contact -0.2394 0.00000006014212312541002 Scatter Plot
Source APP Source MHC-I MHC-I Cell-Cell Contact -0.2390 0.00000006303992435123562 Scatter Plot
Source APP Source GP1BA GP1BA Cell-Cell Contact -0.2316 0.00000016247093543324698 Scatter Plot
Source APP Source CXCL CXCL Secreted Signaling -0.2294 0.0000002137006253918249 Scatter Plot
Source APP Target SEMA4 SEMA4 Cell-Cell Contact -0.2145 0.0000012994693133196982 Scatter Plot
Source APP Target VWF VWF ECM-Receptor -0.2079 0.000002757683285107017 Scatter Plot
Source APP Source ANGPTL ANGPTL Secreted Signaling -0.2048 0.000003889564550882906 Scatter Plot
Source APP Target TENASCIN TENASCIN ECM-Receptor -0.1995 0.00000695492559019836 Scatter Plot
Target APP Target CCL CCL Secreted Signaling -0.1960 0.000010142565352566855 Scatter Plot
Target APP Target CEACAM CEACAM Cell-Cell Contact -0.1870 0.00002561032136322387 Scatter Plot
Source APP Source MHC-II MHC-II Cell-Cell Contact -0.1810 0.000046833189039113766 Scatter Plot
Target APP Target CLEC CLEC Cell-Cell Contact -0.1716 0.0001146641497783 Scatter Plot
Source APP Source COLLAGEN COLLAGEN ECM-Receptor -0.1671 0.0001744578982251 Scatter Plot
Source APP Target CD39 CD39 Cell-Cell Contact -0.1664 0.0001857136238645 Scatter Plot
Source APP Target SELL SELL Cell-Cell Contact -0.1617 0.0002821839153635 Scatter Plot
Target APP Target IFN-II IFN-II Secreted Signaling -0.1597 0.0003377282349007 Scatter Plot
Source APP Target THBS THBS ECM-Receptor -0.1577 0.0004015143413655 Scatter Plot
Source APP Source IL1 IL1 Secreted Signaling -0.1574 0.0004094437941731 Scatter Plot
Source APP Source THY1 THY1 Cell-Cell Contact -0.1527 0.0006117592522861 Scatter Plot
Target APP Target VEGF VEGF Secreted Signaling -0.1515 0.0006773654430616 Scatter Plot
Source APP Target ANGPT ANGPT Secreted Signaling -0.1468 0.0009947255470428 Scatter Plot
Source APP Source LCK LCK Cell-Cell Contact -0.1444 0.0012055242598393 Scatter Plot
Source APP Target TGFb TGFb Secreted Signaling -0.1423 0.0014175489390426 Scatter Plot
Source APP Target IGF IGF Secreted Signaling -0.1384 0.001923426177722 Scatter Plot
Source APP Target ncWNT ncWNT Secreted Signaling -0.1306 0.0034298844696619 Scatter Plot
Source APP Target ESAM ESAM Cell-Cell Contact -0.1234 0.0057312020199931 Scatter Plot
Source APP Target PECAM1 PECAM1 Cell-Cell Contact -0.1209 0.0068036305746686 Scatter Plot
Target APP Target GRN GRN Secreted Signaling -0.1153 0.009851236351109 Scatter Plot
Source APP Target WNT WNT Secreted Signaling -0.1148 0.0102271235425556 Scatter Plot
Source APP Target EPHB EPHB Cell-Cell Contact -0.1147 0.0102917706568619 Scatter Plot
Source APP Target VTN VTN ECM-Receptor -0.1138 0.0108700442457604 Scatter Plot
Source APP Target LAMININ LAMININ ECM-Receptor -0.1093 0.0144388486707007 Scatter Plot
Source APP Target VISFATIN VISFATIN Secreted Signaling -0.1086 0.0151208444362576 Scatter Plot
Source APP Source JAM JAM Cell-Cell Contact -0.1036 0.0204987579491411 Scatter Plot
Target APP Target ANNEXIN ANNEXIN Secreted Signaling -0.1018 0.0228376577819042 Scatter Plot
Source APP Target NOTCH NOTCH Cell-Cell Contact -0.0995 0.0261135477642974 Scatter Plot
Source APP Target FGF FGF Secreted Signaling -0.0974 0.0293555680017767 Scatter Plot

Cells that are targets of APP from HSCs*

Cells that are source of APP to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.