Pathway: JAM

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Cell-Cell Contact

Details on the JAM pathway:

Specificity Index HSPC as target: 0.122
HSPC as source: 0.436

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the JAM pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Source JAM Source IL6 IL6 Secreted Signaling 0.1117 0.0124469442322424 Scatter Plot
Target JAM Source AGRN AGRN ECM-Receptor 0.1123 0.0119539682571803 Scatter Plot
Target JAM Source IL6 IL6 Secreted Signaling 0.1126 0.0117158522647328 Scatter Plot
Source JAM Source ICOS ICOS Cell-Cell Contact 0.1203 0.0070942210316629 Scatter Plot
Target JAM Source ANNEXIN ANNEXIN Secreted Signaling 0.1235 0.0056962151817481 Scatter Plot
Target JAM Source THBS THBS ECM-Receptor 0.1322 0.0030635675109873 Scatter Plot
Target JAM Source ICOS ICOS Cell-Cell Contact 0.1325 0.0029919464868258 Scatter Plot
Target JAM Source WNT WNT Secreted Signaling 0.1571 0.0004216332255999 Scatter Plot
Target JAM Source GP1BA GP1BA Cell-Cell Contact 0.1604 0.0003174722895593 Scatter Plot
Target JAM Target CXCL CXCL Secreted Signaling 0.1689 0.0001482607842433 Scatter Plot
Source JAM Source SEMA6 SEMA6 Cell-Cell Contact 0.1727 0.00010435648156 Scatter Plot
Target JAM Source NCAM NCAM Cell-Cell Contact 0.1793 0.00005550114439308633 Scatter Plot
Source JAM Source WNT WNT Secreted Signaling 0.1802 0.00005077523589763048 Scatter Plot
Target JAM Source SEMA6 SEMA6 Cell-Cell Contact 0.1806 0.00004893371195848304 Scatter Plot
Target JAM Source CD1D2 CD1D2 Cell-Cell Contact 0.1836 0.00003613965260444148 Scatter Plot
Target JAM Source PTN PTN Secreted Signaling 0.1857 0.00002923046973137299 Scatter Plot
Target JAM Source GDF GDF Secreted Signaling 0.1936 0.000013077301769966732 Scatter Plot
Target JAM Source ANGPTL ANGPTL Secreted Signaling 0.1949 0.000011315644398361544 Scatter Plot
Target JAM Target GAS GAS Secreted Signaling 0.1961 0.00000995955140933011 Scatter Plot
Target JAM Target SEMA3 SEMA3 Secreted Signaling 0.2011 0.000005838113602186815 Scatter Plot
Target JAM Source APELIN APELIN Secreted Signaling 0.2230 0.0000004692414952803077 Scatter Plot
Target JAM Target RANKL RANKL Secreted Signaling 0.2346 0.00000011186917760411729 Scatter Plot
Target JAM Target VEGF VEGF Secreted Signaling 0.2365 0.00000008731825300998087 Scatter Plot
Target JAM Target EPHA EPHA Cell-Cell Contact 0.2473 0.00000002109957472129909 Scatter Plot
Target JAM Source THY1 THY1 Cell-Cell Contact 0.2476 0.000000020299180520570657 Scatter Plot
Source JAM Source APELIN APELIN Secreted Signaling 0.2484 0.00000001822877515301753 Scatter Plot
Target JAM Target GDF GDF Secreted Signaling 0.2551 0.0000000071552964422798865 Scatter Plot
Target JAM Source APP APP Cell-Cell Contact 0.2587 0.000000004334274560404797 Scatter Plot
Target JAM Source ncWNT ncWNT Secreted Signaling 0.2690 0.000000000975269733570254 Scatter Plot
Source JAM Source ncWNT ncWNT Secreted Signaling 0.2700 0.0000000008461301791789834 Scatter Plot
Target JAM Source SEMA3 SEMA3 Secreted Signaling 0.2759 0.00000000034403921233935996 Scatter Plot
Target JAM Source GRN GRN Secreted Signaling 0.2784 0.0000000002357262512253664 Scatter Plot
Source JAM Source VEGF VEGF Secreted Signaling 0.2814 0.0000000001482125921013439 Scatter Plot
Source JAM Source SEMA3 SEMA3 Secreted Signaling 0.2816 0.00000000014407600560184038 Scatter Plot
Target JAM Source CXCL CXCL Secreted Signaling 0.2928 0.000000000024251051688627824 Scatter Plot
Target JAM Source CCL CCL Secreted Signaling 0.2962 0.000000000013882540641354907 Scatter Plot
Target JAM Source IL2 IL2 Secreted Signaling 0.3223 0.00000000000015051819221877046 Scatter Plot
Target JAM Source VEGF VEGF Secreted Signaling 0.3283 0.000000000000049985094189886623 Scatter Plot
Target JAM Source BAFF BAFF Secreted Signaling 0.3325 0.000000000000022761445941360628 Scatter Plot
Target JAM Source CADM CADM Cell-Cell Contact 0.3431 0.000000000000002937134516511857 Scatter Plot
Target JAM Source CD39 CD39 Cell-Cell Contact 0.3431 0.0000000000000029080808396864443 Scatter Plot
Target JAM Source CD86 CD86 Cell-Cell Contact 0.3449 0.000000000000002068284047836275 Scatter Plot
Target JAM Target SEMA6 SEMA6 Cell-Cell Contact 0.3486 0.0000000000000009872213664344332 Scatter Plot
Target JAM Target KIT KIT Secreted Signaling 0.3526 0.0000000000000004379513697597989 Scatter Plot
Target JAM Source CD46 CD46 Cell-Cell Contact 0.3604 0.00000000000000008723295388713542 Scatter Plot
Source JAM Source CADM CADM Cell-Cell Contact 0.3609 0.00000000000000007929429715822815 Scatter Plot
Target JAM Target AGT AGT Secreted Signaling 0.3630 0.000000000000000051001630229297625 Scatter Plot
Target JAM Target ACTIVIN ACTIVIN Secreted Signaling 0.3741 0.000000000000000004702157244499524 Scatter Plot
Target JAM Target SEMA5 SEMA5 Cell-Cell Contact 0.3862 0.000000000000000000310045830479628 Scatter Plot
Source JAM Source CD46 CD46 Cell-Cell Contact 0.3896 0.00000000000000000014291506175873512 Scatter Plot
Target JAM Source IL16 IL16 Secreted Signaling 0.3930 0.00000000000000000006424335206302921 Scatter Plot
Target JAM Source EPHB EPHB Cell-Cell Contact 0.3932 0.00000000000000000006088452625049321 Scatter Plot
Target JAM Source ICAM ICAM Cell-Cell Contact 0.3967 0.00000000000000000002720562121230053 Scatter Plot
Target JAM Source LCK LCK Cell-Cell Contact 0.4102 0.0000000000000000000010147820549147992 Scatter Plot
Target JAM Target TGFb TGFb Secreted Signaling 0.4162 0.00000000000000000000022864015244277593 Scatter Plot
Target JAM Target EPHB EPHB Cell-Cell Contact 0.4222 0.000000000000000000000048655378700695893 Scatter Plot
Source JAM Source LIGHT LIGHT Secreted Signaling 0.4292 0.00000000000000000000000788796926719162 Scatter Plot
Target JAM Source RANKL RANKL Secreted Signaling 0.4327 0.000000000000000000000003124209496516344 Scatter Plot
Target JAM Source NT NT Secreted Signaling 0.4374 0.0000000000000000000000008616925237194607 Scatter Plot
Target JAM Source LIGHT LIGHT Secreted Signaling 0.4390 0.0000000000000000000000005592600267097555 Scatter Plot
Target JAM Source CX3C CX3C Secreted Signaling 0.4427 0.0000000000000000000000002026411219891016 Scatter Plot
Target JAM Source IGF IGF Secreted Signaling 0.4467 0.00000000000000000000000006775408816143887 Scatter Plot
Source JAM Source NT NT Secreted Signaling 0.4559 0.0000000000000000000000000048894321669366465 Scatter Plot
Target JAM Source CSF CSF Secreted Signaling 0.4604 0.0000000000000000000000000013321041842595904 Scatter Plot
Source JAM Source RANKL RANKL Secreted Signaling 0.4610 0.0000000000000000000000000011218367987856654 Scatter Plot
Target JAM Source NOTCH NOTCH Cell-Cell Contact 0.4685 0.0000000000000000000000000001199840984475954 Scatter Plot
Target JAM Target PARs PARs Secreted Signaling 0.4750 0.00000000000000000000000000001631524775956254 Scatter Plot
Target JAM Source LAMININ LAMININ ECM-Receptor 0.4758 0.000000000000000000000000000012982711499120117 Scatter Plot
Source JAM Source IGF IGF Secreted Signaling 0.4760 0.000000000000000000000000000012075788275156944 Scatter Plot
Target JAM Target BMP BMP Secreted Signaling 0.4792 0.000000000000000000000000000004509302534180664 Scatter Plot
Target JAM Source MK MK Secreted Signaling 0.4949 0.00000000000000000000000000000002918033328768296 Scatter Plot
Source JAM Source NOTCH NOTCH Cell-Cell Contact 0.4960 0.00000000000000000000000000000002068518722680856 Scatter Plot
Source JAM Source EPHB EPHB Cell-Cell Contact 0.4963 0.000000000000000000000000000000018597024344187806 Scatter Plot
Target JAM Source PROS PROS Secreted Signaling 0.4999 0.000000000000000000000000000000005656398245362253 Scatter Plot
Source JAM Source LAMININ LAMININ ECM-Receptor 0.5068 0.0000000000000000000000000000000005437556458490503 Scatter Plot
Target JAM Source PSAP PSAP Secreted Signaling 0.5099 0.00000000000000000000000000000000018871840605972043 Scatter Plot
Target JAM Target CD200 CD200 Cell-Cell Contact 0.5103 0.00000000000000000000000000000000016603958663223694 Scatter Plot
Target JAM Target NCAM NCAM Cell-Cell Contact 0.5134 0.00000000000000000000000000000000005539854522855001 Scatter Plot
Target JAM Source FLT3 FLT3 Secreted Signaling 0.5144 0.000000000000000000000000000000000039599935028212966 Scatter Plot
Target JAM Source LIFR LIFR Secreted Signaling 0.5157 0.000000000000000000000000000000000025125864730571146 Scatter Plot
Target JAM Source CD45 CD45 Cell-Cell Contact 0.5226 0.0000000000000000000000000000000000021291965694186348 Scatter Plot
Target JAM Source COLLAGEN COLLAGEN ECM-Receptor 0.5534 0.000000000000000000000000000000000000000017859217658943758 Scatter Plot
Source JAM Source PROS PROS Secreted Signaling 0.5537 0.000000000000000000000000000000000000000015861224669896216 Scatter Plot
Target JAM Source BST2 BST2 Cell-Cell Contact 0.5585 0.000000000000000000000000000000000000000002331831751066284 Scatter Plot
Target JAM Source IL7 IL7 Secreted Signaling 0.5646 0.0000000000000000000000000000000000000000001894323037607818 Scatter Plot
Source JAM Source FLT3 FLT3 Secreted Signaling 0.5766 0.000000000000000000000000000000000000000000001157949376759639 Scatter Plot
Target JAM Source CDH CDH Cell-Cell Contact 0.5804 0.00000000000000000000000000000000000000000000021997868905490907 Scatter Plot
Target JAM Target CDH CDH Cell-Cell Contact 0.5804 0.00000000000000000000000000000000000000000000021997868905490907 Scatter Plot
Target JAM Target SLURP SLURP Secreted Signaling 0.5944 0.0000000000000000000000000000000000000000000000004200452097320036 Scatter Plot
Source JAM Source LIFR LIFR Secreted Signaling 0.5998 0.00000000000000000000000000000000000000000000000003451907765783879 Scatter Plot
Target JAM Target WNT WNT Secreted Signaling 0.6006 0.00000000000000000000000000000000000000000000000002326689419569619 Scatter Plot
Target JAM Target CD39 CD39 Cell-Cell Contact 0.6039 0.000000000000000000000000000000000000000000000000004862989423510684 Scatter Plot
Target JAM Source ANGPT ANGPT Secreted Signaling 0.6047 0.0000000000000000000000000000000000000000000000000033051797202493864 Scatter Plot
Target JAM Target ncWNT ncWNT Secreted Signaling 0.6048 0.000000000000000000000000000000000000000000000000003214674830567575 Scatter Plot
Target JAM Target MIF MIF Secreted Signaling 0.6093 0.0000000000000000000000000000000000000000000000000003641011508573958 Scatter Plot
Target JAM Target FGF FGF Secreted Signaling 0.6122 0.00000000000000000000000000000000000000000000000000009086549446870824 Scatter Plot
Target JAM Source PDGF PDGF Secreted Signaling 0.6231 0.00000000000000000000000000000000000000000000000000000038119678732878625 Scatter Plot
Target JAM Source MHC-II MHC-II Cell-Cell Contact 0.6316 0.0000000000000000000000000000000000000000000000000000000048555166543483454 Scatter Plot
Target JAM Source GAS GAS Secreted Signaling 0.6320 0.000000000000000000000000000000000000000000000000000000003933088275590737 Scatter Plot
Target JAM Source SEMA7 SEMA7 Cell-Cell Contact 0.6449 0.0000000000000000000000000000000000000000000000000000000000037804978094421606 Scatter Plot
Target JAM Source TWEAK TWEAK Secreted Signaling 0.6489 0.00000000000000000000000000000000000000000000000000000000000039759052462224636 Scatter Plot
Target JAM Source BMP BMP Secreted Signaling 0.6586 0.0000000000000000000000000000000000000000000000000000000000000015667636238187456 Scatter Plot
Source JAM Source PDGF PDGF Secreted Signaling 0.6888 0.000000000000000000000000000000000000000000000000000000000000000000000012895720195308124 Scatter Plot
Target JAM Source MHC-I MHC-I Cell-Cell Contact 0.6994 0.000000000000000000000000000000000000000000000000000000000000000000000000010909619005508394 Scatter Plot
Target JAM Source ESAM ESAM Cell-Cell Contact 0.7021 0.0000000000000000000000000000000000000000000000000000000000000000000000000017190907084014706 Scatter Plot
Source JAM Source ANGPT ANGPT Secreted Signaling 0.7231 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000041589325623328746 Scatter Plot
Source JAM Source ESAM ESAM Cell-Cell Contact 0.7920 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000689219865212399 Scatter Plot
Target JAM Source TGFb TGFb Secreted Signaling -0.5264 0.0000000000000000000000000000000000005380382997922188 Scatter Plot
Target JAM Source MIF MIF Secreted Signaling -0.5101 0.0000000000000000000000000000000001733618405159629 Scatter Plot
Target JAM Source CD52 CD52 Cell-Cell Contact -0.4929 0.00000000000000000000000000000005702436561688383 Scatter Plot
Target JAM Source ANGPTL ANGPTL Secreted Signaling -0.4704 0.00000000000000000000000000006665909829315361 Scatter Plot
Source JAM Source PARs PARs Secreted Signaling -0.4361 0.0000000000000000000000012531824348079254 Scatter Plot
Source JAM Source TGFb TGFb Secreted Signaling -0.4248 0.00000000000000000000002505763209781187 Scatter Plot
Target JAM Source COMPLEMENT COMPLEMENT Secreted Signaling -0.4120 0.0000000000000000000006440312231569975 Scatter Plot
Target JAM Source SELL SELL Cell-Cell Contact -0.4056 0.000000000000000000003170138198684138 Scatter Plot
Target JAM Source PARs PARs Secreted Signaling -0.3897 0.00000000000000000013968164990555022 Scatter Plot
Source JAM Source MIF MIF Secreted Signaling -0.3563 0.00000000000000020422935632438634 Scatter Plot
Source JAM Source ANGPTL ANGPTL Secreted Signaling -0.3500 0.0000000000000007366553849159751 Scatter Plot
Target JAM Target CSF CSF Secreted Signaling -0.3122 0.0000000000009092771321854012 Scatter Plot
Target JAM Source CLEC CLEC Cell-Cell Contact -0.3035 0.00000000000409996140318877 Scatter Plot
Source JAM Source VISTA VISTA Cell-Cell Contact -0.3021 0.000000000005172406692079339 Scatter Plot
Target JAM Source SEMA4 SEMA4 Cell-Cell Contact -0.2830 0.00000000011602970477850461 Scatter Plot
Target JAM Target IL17 IL17 Secreted Signaling -0.2729 0.0000000005464637261333096 Scatter Plot
Target JAM Source CD34 CD34 Cell-Cell Contact -0.2687 0.000000001019519870509899 Scatter Plot
Target JAM Source CCL CCL Secreted Signaling -0.2665 0.0000000014070800722294002 Scatter Plot
Target JAM Source SELPLG SELPLG Cell-Cell Contact -0.2567 0.000000005767387879851012 Scatter Plot
Source JAM Source SEMA4 SEMA4 Cell-Cell Contact -0.2550 0.000000007285778798624198 Scatter Plot
Target JAM Target CXCL CXCL Secreted Signaling -0.2367 0.00000008466192594675841 Scatter Plot
Source JAM Source SPP1 SPP1 Secreted Signaling -0.2291 0.00000022260011087509337 Scatter Plot
Target JAM Source GALECTIN GALECTIN Secreted Signaling -0.2235 0.0000004440495224799314 Scatter Plot
Target JAM Source VISTA VISTA Cell-Cell Contact -0.2231 0.00000046601377478882046 Scatter Plot
Source JAM Source SELPLG SELPLG Cell-Cell Contact -0.2081 0.000002677707872570566 Scatter Plot
Target JAM Source SPP1 SPP1 Secreted Signaling -0.1897 0.00001957365438453704 Scatter Plot
Target JAM Source TNF TNF Secreted Signaling -0.1785 0.0000595584885735856 Scatter Plot
Source JAM Source NCAM NCAM Cell-Cell Contact -0.1747 0.00008639216807361977 Scatter Plot
Target JAM Source ANNEXIN ANNEXIN Secreted Signaling -0.1685 0.0001540105105781 Scatter Plot
Target JAM Source NKG2D NKG2D Cell-Cell Contact -0.1620 0.0002751552820116 Scatter Plot
Source JAM Source VISFATIN VISFATIN Secreted Signaling -0.1591 0.0003559127078815 Scatter Plot
Target JAM Source VISFATIN VISFATIN Secreted Signaling -0.1512 0.0006958121806341 Scatter Plot
Target JAM Source FGF FGF Secreted Signaling -0.1307 0.0034026303776132 Scatter Plot
Target JAM Source NCAM NCAM Cell-Cell Contact -0.1303 0.0035045213974578 Scatter Plot
Target JAM Source IL1 IL1 Secreted Signaling -0.1057 0.0180552693267977 Scatter Plot
Target JAM Target TWEAK TWEAK Secreted Signaling -0.1041 0.0198603583552682 Scatter Plot
Source JAM Source APP APP Cell-Cell Contact -0.1036 0.0204987579491411 Scatter Plot
Target JAM Source LAIR1 LAIR1 Cell-Cell Contact -0.0966 0.0307690649332855 Scatter Plot
Source JAM Target TWEAK TWEAK Secreted Signaling 0.0969 0.0303609137009723 Scatter Plot
Source JAM Target CXCL CXCL Secreted Signaling 0.1050 0.0188981437086998 Scatter Plot
Source JAM Source AGRN AGRN ECM-Receptor 0.1173 0.0086305218426864 Scatter Plot
Target JAM Target SELPLG SELPLG Cell-Cell Contact 0.1198 0.0073396195816908 Scatter Plot
Source JAM Target SELPLG SELPLG Cell-Cell Contact 0.1226 0.0060644766977643 Scatter Plot
Source JAM Source THBS THBS ECM-Receptor 0.1306 0.003433954575693 Scatter Plot
Source JAM Target GALECTIN GALECTIN Secreted Signaling 0.1468 0.0009974456368498 Scatter Plot
Target JAM Target NOTCH NOTCH Cell-Cell Contact 0.1504 0.0007433447866864 Scatter Plot
Target JAM Target CCL CCL Secreted Signaling 0.1668 0.0001799387296355 Scatter Plot
Source JAM Source GP1BA GP1BA Cell-Cell Contact 0.2013 0.000005698729228984623 Scatter Plot
Source JAM Target GAS GAS Secreted Signaling 0.2084 0.000002613508585595131 Scatter Plot
Source JAM Target THY1 THY1 Cell-Cell Contact 0.2104 0.0000020837859356837125 Scatter Plot
Source JAM Target NOTCH NOTCH Cell-Cell Contact 0.2107 0.000001991172371962494 Scatter Plot
Source JAM Target SEMA3 SEMA3 Secreted Signaling 0.2185 0.0000008117327941832123 Scatter Plot
Source JAM Source ANGPTL ANGPTL Secreted Signaling 0.2193 0.0000007325787082419296 Scatter Plot
Target JAM Target IL6 IL6 Secreted Signaling 0.2206 0.0000006253896543588584 Scatter Plot
Source JAM Source PTN PTN Secreted Signaling 0.2246 0.00000038852181866208586 Scatter Plot
Source JAM Source CD1D2 CD1D2 Cell-Cell Contact 0.2251 0.0000003652850924780845 Scatter Plot
Target JAM Target NODAL NODAL Secreted Signaling 0.2296 0.0000002082124901699706 Scatter Plot
Source JAM Target CD23 CD23 Cell-Cell Contact 0.2333 0.00000013218889606388554 Scatter Plot
Source JAM Source VCAM VCAM Cell-Cell Contact 0.2369 0.00000008314316570131397 Scatter Plot
Source JAM Source GDF GDF Secreted Signaling 0.2434 0.000000035274577693897785 Scatter Plot
Source JAM Target RANKL RANKL Secreted Signaling 0.2460 0.000000024913160569045222 Scatter Plot
Target JAM Target GALECTIN GALECTIN Secreted Signaling 0.2503 0.00000001391030536409417 Scatter Plot
Target JAM Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.2535 0.000000008993344220436955 Scatter Plot
Source JAM Target VEGF VEGF Secreted Signaling 0.2558 0.000000006540894938716106 Scatter Plot
Source JAM Target COLLAGEN COLLAGEN ECM-Receptor 0.2605 0.0000000033643262383396213 Scatter Plot
Source JAM Target NODAL NODAL Secreted Signaling 0.2631 0.000000002308518510319936 Scatter Plot
Source JAM Target IL6 IL6 Secreted Signaling 0.2676 0.0000000011968619934704436 Scatter Plot
Target JAM Target IL1 IL1 Secreted Signaling 0.2711 0.000000000713408779799756 Scatter Plot
Target JAM Target ANNEXIN ANNEXIN Secreted Signaling 0.2800 0.0000000001854277193167733 Scatter Plot
Source JAM Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.2815 0.00000000014638916130830963 Scatter Plot
Source JAM Target GDF GDF Secreted Signaling 0.2848 0.00000000008669926732425019 Scatter Plot
Source JAM Target EPHA EPHA Cell-Cell Contact 0.2894 0.000000000041818561290787945 Scatter Plot
Source JAM Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2977 0.00000000001090491569625356 Scatter Plot
Source JAM Target PTN PTN Secreted Signaling 0.3098 0.0000000000013809806629972036 Scatter Plot
Source JAM Source THY1 THY1 Cell-Cell Contact 0.3121 0.000000000000920963911058183 Scatter Plot
Source JAM Source IL16 IL16 Secreted Signaling 0.3123 0.0000000000008933691988628277 Scatter Plot
Target JAM Target OSM OSM Secreted Signaling 0.3170 0.000000000000391098870968006 Scatter Plot
Source JAM Target MK MK Secreted Signaling 0.3211 0.0000000000001872539230226589 Scatter Plot
Source JAM Target SPP1 SPP1 Secreted Signaling 0.3230 0.0000000000001324190990854572 Scatter Plot
Source JAM Target OSM OSM Secreted Signaling 0.3296 0.00000000000003862948694575893 Scatter Plot
Source JAM Source IL2 IL2 Secreted Signaling 0.3350 0.000000000000014088100004838782 Scatter Plot
Target JAM Target CADM CADM Cell-Cell Contact 0.3431 0.000000000000002937134516511857 Scatter Plot
Source JAM Target FN1 FN1 ECM-Receptor 0.3453 0.0000000000000018824281696914517 Scatter Plot
Source JAM Source CCL CCL Secreted Signaling 0.3473 0.0000000000000012645068128251845 Scatter Plot
Source JAM Source CXCL CXCL Secreted Signaling 0.3511 0.0000000000000005959426362426732 Scatter Plot
Source JAM Source CD39 CD39 Cell-Cell Contact 0.3527 0.00000000000000042605108951408815 Scatter Plot
Source JAM Target CADM CADM Cell-Cell Contact 0.3609 0.00000000000000007929429715822815 Scatter Plot
Source JAM Target NCAM NCAM Cell-Cell Contact 0.3648 0.000000000000000034659513244809816 Scatter Plot
Source JAM Target CSPG4 CSPG4 Cell-Cell Contact 0.3764 0.000000000000000002800768996462286 Scatter Plot
Source JAM Target AGT AGT Secreted Signaling 0.3992 0.000000000000000000014774264616503592 Scatter Plot
Target JAM Target BAFF BAFF Secreted Signaling 0.3992 0.000000000000000000014722161907500494 Scatter Plot
Source JAM Source CD86 CD86 Cell-Cell Contact 0.4022 0.000000000000000000007303568708767694 Scatter Plot
Source JAM Target ANGPTL ANGPTL Secreted Signaling 0.4073 0.0000000000000000000020670086735949453 Scatter Plot
Source JAM Target SEMA6 SEMA6 Cell-Cell Contact 0.4111 0.0000000000000000000008239079570567723 Scatter Plot
Source JAM Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.4235 0.00000000000000000000003503340070784664 Scatter Plot
Source JAM Target ACTIVIN ACTIVIN Secreted Signaling 0.4261 0.000000000000000000000017929731987387778 Scatter Plot
Source JAM Source ICAM ICAM Cell-Cell Contact 0.4557 0.000000000000000000000000005139272327229664 Scatter Plot
Target JAM Target SEMA4 SEMA4 Cell-Cell Contact 0.4621 0.0000000000000000000000000008008965136635057 Scatter Plot
Source JAM Target SEMA5 SEMA5 Cell-Cell Contact 0.4630 0.0000000000000000000000000006141800621106428 Scatter Plot
Source JAM Target THBS THBS ECM-Receptor 0.4673 0.00000000000000000000000000016795858259045402 Scatter Plot
Target JAM Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.4707 0.00000000000000000000000000006041098278139559 Scatter Plot
Source JAM Target TGFb TGFb Secreted Signaling 0.4726 0.000000000000000000000000000034793653715640565 Scatter Plot
Source JAM Target LAMININ LAMININ ECM-Receptor 0.4730 0.00000000000000000000000000003028430282651041 Scatter Plot
Source JAM Target VISFATIN VISFATIN Secreted Signaling 0.4737 0.000000000000000000000000000024422834687818657 Scatter Plot
Source JAM Source CX3C CX3C Secreted Signaling 0.4773 0.000000000000000000000000000008042907712611774 Scatter Plot
Source JAM Target BAFF BAFF Secreted Signaling 0.4782 0.0000000000000000000000000000061107083674109014 Scatter Plot
Source JAM Source CD45 CD45 Cell-Cell Contact 0.4792 0.0000000000000000000000000000044697707947358286 Scatter Plot
Source JAM Target CD22 CD22 Cell-Cell Contact 0.4792 0.0000000000000000000000000000044697707947357 Scatter Plot
Source JAM Target KIT KIT Secreted Signaling 0.4796 0.000000000000000000000000000003968556445589892 Scatter Plot
Source JAM Source CSF CSF Secreted Signaling 0.4871 0.0000000000000000000000000000003675538403222608 Scatter Plot
Source JAM Target EPHB EPHB Cell-Cell Contact 0.4887 0.00000000000000000000000000000022286426045235577 Scatter Plot
Source JAM Target SEMA7 SEMA7 Cell-Cell Contact 0.5007 0.000000000000000000000000000000004265394458257579 Scatter Plot
Target JAM Target NPR2 NPR2 Secreted Signaling 0.5016 0.0000000000000000000000000000000031973720903414816 Scatter Plot
Source JAM Source LCK LCK Cell-Cell Contact 0.5027 0.0000000000000000000000000000000022239740459503765 Scatter Plot
Source JAM Source PSAP PSAP Secreted Signaling 0.5203 0.000000000000000000000000000000000004845457112518291 Scatter Plot
Source JAM Target BMP BMP Secreted Signaling 0.5211 0.000000000000000000000000000000000003593284198425268 Scatter Plot
Target JAM Target CD22 CD22 Cell-Cell Contact 0.5226 0.0000000000000000000000000000000000021291965694186348 Scatter Plot
Source JAM Source MK MK Secreted Signaling 0.5342 0.00000000000000000000000000000000000003034257820538919 Scatter Plot
Source JAM Target NPR2 NPR2 Secreted Signaling 0.5521 0.0000000000000000000000000000000000000000299869763001272 Scatter Plot
Source JAM Target CD200 CD200 Cell-Cell Contact 0.5537 0.00000000000000000000000000000000000000001621535693988799 Scatter Plot
Source JAM Target SEMA4 SEMA4 Cell-Cell Contact 0.5565 0.0000000000000000000000000000000000000000052137074900892973 Scatter Plot
Target JAM Target APP APP Cell-Cell Contact 0.5624 0.00000000000000000000000000000000000000000046713518620319865 Scatter Plot
Source JAM Target PERIOSTIN PERIOSTIN Secreted Signaling 0.5743 0.000000000000000000000000000000000000000000003156424800259416 Scatter Plot
Source JAM Target VTN VTN ECM-Receptor 0.5826 0.00000000000000000000000000000000000000000000008482126373135051 Scatter Plot
Source JAM Target NRG NRG Secreted Signaling 0.5826 0.00000000000000000000000000000000000000000000008406340582658536 Scatter Plot
Source JAM Target ANGPT ANGPT Secreted Signaling 0.5860 0.000000000000000000000000000000000000000000000018447703986301528 Scatter Plot
Source JAM Target PARs PARs Secreted Signaling 0.5941 0.00000000000000000000000000000000000000000000000049177769905688966 Scatter Plot
Source JAM Target BSP BSP ECM-Receptor 0.5976 0.00000000000000000000000000000000000000000000000009333069233044178 Scatter Plot
Source JAM Target DMP1 DMP1 ECM-Receptor 0.6030 0.000000000000000000000000000000000000000000000000007576386016055114 Scatter Plot
Source JAM Target VWF VWF ECM-Receptor 0.6159 0.000000000000000000000000000000000000000000000000000014697170644992643 Scatter Plot
Source JAM Source COLLAGEN COLLAGEN ECM-Receptor 0.6167 0.000000000000000000000000000000000000000000000000000009611331335791344 Scatter Plot
Source JAM Source CDH CDH Cell-Cell Contact 0.6210 0.0000000000000000000000000000000000000000000000000000011083713385290906 Scatter Plot
Source JAM Target CDH CDH Cell-Cell Contact 0.6210 0.0000000000000000000000000000000000000000000000000000011083713385290906 Scatter Plot
Source JAM Source IL7 IL7 Secreted Signaling 0.6246 0.0000000000000000000000000000000000000000000000000000001842144791276345 Scatter Plot
Source JAM Target APP APP Cell-Cell Contact 0.6277 0.00000000000000000000000000000000000000000000000000000003694317393912732 Scatter Plot
Source JAM Target SLURP SLURP Secreted Signaling 0.6613 0.00000000000000000000000000000000000000000000000000000000000000032128971047644274 Scatter Plot
Source JAM Target MIF MIF Secreted Signaling 0.6654 0.000000000000000000000000000000000000000000000000000000000000000028378908175212164 Scatter Plot
Source JAM Target IGF IGF Secreted Signaling 0.6678 0.000000000000000000000000000000000000000000000000000000000000000007048501666229791 Scatter Plot
Source JAM Source BST2 BST2 Cell-Cell Contact 0.6693 0.000000000000000000000000000000000000000000000000000000000000000002836258495248892 Scatter Plot
Source JAM Target FGF FGF Secreted Signaling 0.6790 0.000000000000000000000000000000000000000000000000000000000000000000006957544154751385 Scatter Plot
Source JAM Target ncWNT ncWNT Secreted Signaling 0.6877 0.00000000000000000000000000000000000000000000000000000000000000000000002568622794159564 Scatter Plot
Source JAM Target CD39 CD39 Cell-Cell Contact 0.6900 0.000000000000000000000000000000000000000000000000000000000000000000000006002857616152536 Scatter Plot
Source JAM Source GAS GAS Secreted Signaling 0.6902 0.000000000000000000000000000000000000000000000000000000000000000000000005278811369468445 Scatter Plot
Target JAM Target CD34 CD34 Cell-Cell Contact 0.6923 0.000000000000000000000000000000000000000000000000000000000000000000000001306833891371884 Scatter Plot
Source JAM Target WNT WNT Secreted Signaling 0.6948 0.00000000000000000000000000000000000000000000000000000000000000000000000024172366743023695 Scatter Plot
Source JAM Source SEMA7 SEMA7 Cell-Cell Contact 0.6949 0.0000000000000000000000000000000000000000000000000000000000000000000000002199771197746333 Scatter Plot
Source JAM Source TWEAK TWEAK Secreted Signaling 0.7019 0.0000000000000000000000000000000000000000000000000000000000000000000000000018941292314055022 Scatter Plot
Target JAM Target ESAM ESAM Cell-Cell Contact 0.7021 0.0000000000000000000000000000000000000000000000000000000000000000000000000017190907084014706 Scatter Plot
Source JAM Source BMP BMP Secreted Signaling 0.7118 0.0000000000000000000000000000000000000000000000000000000000000000000000000000018261277979177724 Scatter Plot
Source JAM Target TENASCIN TENASCIN ECM-Receptor 0.7123 0.0000000000000000000000000000000000000000000000000000000000000000000000000000012071294537528632 Scatter Plot
Source JAM Source MHC-II MHC-II Cell-Cell Contact 0.7413 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002399294168826305 Scatter Plot
Source JAM Target CD34 CD34 Cell-Cell Contact 0.7855 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000642341502875225 Scatter Plot
Source JAM Target ESAM ESAM Cell-Cell Contact 0.7920 0.000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000689219865212399 Scatter Plot
Source JAM Source MHC-I MHC-I Cell-Cell Contact 0.8006 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006423006429088673 Scatter Plot
Source JAM Source CD52 CD52 Cell-Cell Contact -0.6444 0.000000000000000000000000000000000000000000000000000000000004956326095938904 Scatter Plot
Source JAM Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.5399 0.0000000000000000000000000000000000000035154219791766515 Scatter Plot
Source JAM Target ICAM ICAM Cell-Cell Contact -0.5208 0.000000000000000000000000000000000004051600388556471 Scatter Plot
Source JAM Source SELL SELL Cell-Cell Contact -0.5132 0.00000000000000000000000000000000005936155059016734 Scatter Plot
Source JAM Source COMPLEMENT COMPLEMENT Secreted Signaling -0.4861 0.0000000000000000000000000000005075722118188936 Scatter Plot
Source JAM Target CD52 CD52 Cell-Cell Contact -0.4411 0.0000000000000000000000003137792435891664 Scatter Plot
Source JAM Target IFN-II IFN-II Secreted Signaling -0.3762 0.0000000000000000029175940569844622 Scatter Plot
Source JAM Source CLEC CLEC Cell-Cell Contact -0.3640 0.00000000000000004086691192899993 Scatter Plot
Source JAM Target VCAM VCAM Cell-Cell Contact -0.3632 0.00000000000000004867528413575434 Scatter Plot
Target JAM Target CD52 CD52 Cell-Cell Contact -0.3430 0.000000000000002979123552875028 Scatter Plot
Source JAM Target CCL CCL Secreted Signaling -0.3356 0.000000000000012430527842028496 Scatter Plot
Source JAM Target CSF CSF Secreted Signaling -0.3276 0.000000000000056652948024644055 Scatter Plot
Target JAM Target IFN-II IFN-II Secreted Signaling -0.3158 0.0000000000004806136700231456 Scatter Plot
Source JAM Source CCL CCL Secreted Signaling -0.3097 0.0000000000014145352076865217 Scatter Plot
Target JAM Target VCAM VCAM Cell-Cell Contact -0.3064 0.0000000000024740439521368 Scatter Plot
Source JAM Target CXCL CXCL Secreted Signaling -0.3008 0.0000000000064424729405059386 Scatter Plot
Source JAM Target CEACAM CEACAM Cell-Cell Contact -0.2838 0.00000000010254693495155157 Scatter Plot
Source JAM Target CLEC CLEC Cell-Cell Contact -0.2832 0.00000000011228062230480287 Scatter Plot
Source JAM Target IL17 IL17 Secreted Signaling -0.2641 0.0000000019981406395009907 Scatter Plot
Target JAM Target CCL CCL Secreted Signaling -0.2546 0.000000007768220126458407 Scatter Plot
Source JAM Source ANNEXIN ANNEXIN Secreted Signaling -0.2523 0.000000010583038851321649 Scatter Plot
Target JAM Target SELL SELL Cell-Cell Contact -0.2503 0.00000001395215528433139 Scatter Plot
Target JAM Target CEACAM CEACAM Cell-Cell Contact -0.2246 0.0000003873234291470072 Scatter Plot
Target JAM Target CLEC CLEC Cell-Cell Contact -0.2195 0.0000007216270046742752 Scatter Plot
Source JAM Target VEGF VEGF Secreted Signaling -0.2094 0.0000023221188995594308 Scatter Plot
Source JAM Source TNF TNF Secreted Signaling -0.2080 0.0000027305091174781568 Scatter Plot
Target JAM Target VEGF VEGF Secreted Signaling -0.2067 0.0000031574077424797166 Scatter Plot
Source JAM Target COLLAGEN COLLAGEN ECM-Receptor -0.2063 0.0000032979760886446536 Scatter Plot
Target JAM Target PDGF PDGF Secreted Signaling -0.1931 0.00001367317941449892 Scatter Plot
Source JAM Target COMPLEMENT COMPLEMENT Secreted Signaling -0.1641 0.0002286760827901 Scatter Plot
Source JAM Target ANNEXIN ANNEXIN Secreted Signaling -0.1585 0.0003725379111087 Scatter Plot
Source JAM Source IL1 IL1 Secreted Signaling -0.1583 0.0003796475172733 Scatter Plot
Source JAM Target GRN GRN Secreted Signaling -0.1564 0.0004461706599805 Scatter Plot
Source JAM Source NKG2D NKG2D Cell-Cell Contact -0.1531 0.0005907315236059 Scatter Plot
Target JAM Target GRN GRN Secreted Signaling -0.1371 0.0021160342859531 Scatter Plot
Target JAM Target ANNEXIN ANNEXIN Secreted Signaling -0.1292 0.0038083524735694 Scatter Plot
Source JAM Source LAIR1 LAIR1 Cell-Cell Contact -0.1198 0.0073098708303343 Scatter Plot
Source JAM Target PDGF PDGF Secreted Signaling -0.1087 0.0150443062086447 Scatter Plot
Source JAM Target SELE SELE Cell-Cell Contact -0.1003 0.0249740970202421 Scatter Plot

Cells that are targets of JAM from HSCs*

Cells that are source of JAM to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.