Pathway: AGT

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the AGT pathway:

Specificity Index HSPC as target: 0.533
HSPC as source: 0.354

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the AGT pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target AGT Source GDF GDF Secreted Signaling 0.0970 0.0300358879217313 Scatter Plot
Target AGT Source ncWNT ncWNT Secreted Signaling 0.0981 0.028198594432663 Scatter Plot
Target AGT Source CCL CCL Secreted Signaling 0.0984 0.0277603778133455 Scatter Plot
Target AGT Target COLLAGEN COLLAGEN ECM-Receptor 0.1013 0.0234929945098312 Scatter Plot
Target AGT Source ICAM ICAM Cell-Cell Contact 0.1073 0.0164062868306455 Scatter Plot
Target AGT Source WNT WNT Secreted Signaling 0.1075 0.0162312686929996 Scatter Plot
Target AGT Source APELIN APELIN Secreted Signaling 0.1109 0.013069241466433 Scatter Plot
Target AGT Source THBS THBS ECM-Receptor 0.1126 0.0117601863231775 Scatter Plot
Target AGT Source CD1D2 CD1D2 Cell-Cell Contact 0.1245 0.0053199545758463 Scatter Plot
Target AGT Source PTN PTN Secreted Signaling 0.1256 0.0049246871181509 Scatter Plot
Target AGT Source CD39 CD39 Cell-Cell Contact 0.1297 0.0036706415294392 Scatter Plot
Target AGT Target GDF GDF Secreted Signaling 0.1323 0.0030416486729432 Scatter Plot
Target AGT Source PSAP PSAP Secreted Signaling 0.1348 0.002530060554197 Scatter Plot
Target AGT Source AGRN AGRN ECM-Receptor 0.1386 0.0018900823724282 Scatter Plot
Target AGT Source LIGHT LIGHT Secreted Signaling 0.1401 0.0016930573996175 Scatter Plot
Target AGT Target KIT KIT Secreted Signaling 0.1421 0.0014486384817013 Scatter Plot
Target AGT Target COMPLEMENT COMPLEMENT Secreted Signaling 0.1453 0.0011225763853822 Scatter Plot
Target AGT Source MHC-II MHC-II Cell-Cell Contact 0.1483 0.0008792293824564 Scatter Plot
Target AGT Target MIF MIF Secreted Signaling 0.1486 0.0008621451354839 Scatter Plot
Target AGT Source MK MK Secreted Signaling 0.1532 0.0005868936717536 Scatter Plot
Target AGT Target NCAM NCAM Cell-Cell Contact 0.1554 0.0004876336419354 Scatter Plot
Target AGT Target ANGPTL ANGPTL Secreted Signaling 0.1556 0.000479628725457 Scatter Plot
Target AGT Source VEGF VEGF Secreted Signaling 0.1599 0.0003324932240339 Scatter Plot
Target AGT Target CSPG4 CSPG4 Cell-Cell Contact 0.1600 0.0003291405048883 Scatter Plot
Target AGT Target ACTIVIN ACTIVIN Secreted Signaling 0.1629 0.0002536683770942 Scatter Plot
Target AGT Target THBS THBS ECM-Receptor 0.1740 0.00009205657911534204 Scatter Plot
Target AGT Target GAS GAS Secreted Signaling 0.1773 0.00006683338178930319 Scatter Plot
Target AGT Target VEGF VEGF Secreted Signaling 0.1812 0.000045696898415731625 Scatter Plot
Target AGT Source GP1BA GP1BA Cell-Cell Contact 0.1829 0.00003869750459766465 Scatter Plot
Target AGT Target PERIOSTIN PERIOSTIN Secreted Signaling 0.1829 0.00003865368949660863 Scatter Plot
Target AGT Source LAMININ LAMININ ECM-Receptor 0.1843 0.0000336246937140407 Scatter Plot
Target AGT Target MK MK Secreted Signaling 0.1852 0.000031006601193748404 Scatter Plot
Target AGT Source COLLAGEN COLLAGEN ECM-Receptor 0.1866 0.000026870479547889014 Scatter Plot
Target AGT Target APP APP Cell-Cell Contact 0.1869 0.000026065500570347023 Scatter Plot
Target AGT Target CD39 CD39 Cell-Cell Contact 0.1890 0.000020905966167187583 Scatter Plot
Target AGT Target BSP BSP ECM-Receptor 0.1893 0.000020305189609543665 Scatter Plot
Target AGT Source PROS PROS Secreted Signaling 0.1927 0.000014255615809401256 Scatter Plot
Target AGT Target CADM CADM Cell-Cell Contact 0.1969 0.000009153921242575252 Scatter Plot
Target AGT Source CADM CADM Cell-Cell Contact 0.1969 0.000009153921242575252 Scatter Plot
Target AGT Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.1992 0.000007158654058178344 Scatter Plot
Target AGT Target EPHA EPHA Cell-Cell Contact 0.2006 0.0000061662675923181565 Scatter Plot
Target AGT Target DMP1 DMP1 ECM-Receptor 0.2046 0.000003983516192424805 Scatter Plot
Target AGT Target VWF VWF ECM-Receptor 0.2047 0.000003929026929544014 Scatter Plot
Target AGT Target ANGPT ANGPT Secreted Signaling 0.2062 0.000003346736526698817 Scatter Plot
Target AGT Source IL2 IL2 Secreted Signaling 0.2064 0.0000032654781746411067 Scatter Plot
Target AGT Source RANKL RANKL Secreted Signaling 0.2124 0.0000016571373998858122 Scatter Plot
Target AGT Source EPHB EPHB Cell-Cell Contact 0.2151 0.0000011999369241868096 Scatter Plot
Target AGT Source ANGPT ANGPT Secreted Signaling 0.2158 0.0000011136891863453493 Scatter Plot
Target AGT Target PTN PTN Secreted Signaling 0.2186 0.0000007966618597957299 Scatter Plot
Target AGT Source LCK LCK Cell-Cell Contact 0.2187 0.000000787476276694395 Scatter Plot
Target AGT Source CX3C CX3C Secreted Signaling 0.2221 0.0000005263878746798331 Scatter Plot
Target AGT Source MHC-I MHC-I Cell-Cell Contact 0.2295 0.0000002125059767376337 Scatter Plot
Target AGT Target SEMA7 SEMA7 Cell-Cell Contact 0.2319 0.00000015719246904122356 Scatter Plot
Target AGT Source BMP BMP Secreted Signaling 0.2357 0.00000009680981189268256 Scatter Plot
Target AGT Target TENASCIN TENASCIN ECM-Receptor 0.2370 0.0000000815884011703494 Scatter Plot
Target AGT Target EPHB EPHB Cell-Cell Contact 0.2445 0.00000003055981607640706 Scatter Plot
Target AGT Source CSF CSF Secreted Signaling 0.2471 0.000000021595954367215063 Scatter Plot
Target AGT Source IL7 IL7 Secreted Signaling 0.2498 0.000000014957630264077876 Scatter Plot
Target AGT Source GAS GAS Secreted Signaling 0.2507 0.000000013180154788008281 Scatter Plot
Target AGT Source IGF IGF Secreted Signaling 0.2542 0.000000008129275089888969 Scatter Plot
Target AGT Source LIFR LIFR Secreted Signaling 0.2557 0.000000006653706997269644 Scatter Plot
Target AGT Source TWEAK TWEAK Secreted Signaling 0.2582 0.000000004643633954406742 Scatter Plot
Target AGT Source CD46 CD46 Cell-Cell Contact 0.2674 0.0000000012305390282541203 Scatter Plot
Target AGT Source BST2 BST2 Cell-Cell Contact 0.2681 0.0000000011163670908644941 Scatter Plot
Target AGT Source CXCL CXCL Secreted Signaling 0.2822 0.0000000001314682189772941 Scatter Plot
Target AGT Target SEMA6 SEMA6 Cell-Cell Contact 0.2981 0.000000000010196358078484443 Scatter Plot
Target AGT Source SEMA7 SEMA7 Cell-Cell Contact 0.2981 0.000000000010156535035192332 Scatter Plot
Target AGT Target SLURP SLURP Secreted Signaling 0.3048 0.0000000000032849379116988287 Scatter Plot
Target AGT Source NOTCH NOTCH Cell-Cell Contact 0.3049 0.000000000003225309499801583 Scatter Plot
Target AGT Target BMP BMP Secreted Signaling 0.3059 0.0000000000027152764187341146 Scatter Plot
Target AGT Source CDH CDH Cell-Cell Contact 0.3213 0.0000000000001787991287115562 Scatter Plot
Target AGT Source ESAM ESAM Cell-Cell Contact 0.3284 0.00000000000004848082414834706 Scatter Plot
Target AGT Source PDGF PDGF Secreted Signaling 0.3344 0.000000000000015591537956738124 Scatter Plot
Target AGT Target WNT WNT Secreted Signaling 0.3352 0.000000000000013525434009250352 Scatter Plot
Target AGT Target ncWNT ncWNT Secreted Signaling 0.3530 0.0000000000000004005902862351432 Scatter Plot
Target AGT Source NT NT Secreted Signaling 0.3546 0.0000000000000002939617795483924 Scatter Plot
Target AGT Source FLT3 FLT3 Secreted Signaling 0.3559 0.0000000000000002240637123331433 Scatter Plot
Target AGT Source JAM JAM Cell-Cell Contact 0.3992 0.000000000000000000014774264616503592 Scatter Plot
Target AGT Source SEMA3 SEMA3 Secreted Signaling 0.4025 0.000000000000000000006700381362258886 Scatter Plot
Target AGT Source CD52 CD52 Cell-Cell Contact -0.4302 0.0000000000000000000000059693706073393486 Scatter Plot
Target AGT Source SELPLG SELPLG Cell-Cell Contact -0.3133 0.0000000000007568258767739694 Scatter Plot
Target AGT Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.3094 0.000000000001483428920294126 Scatter Plot
Target AGT Source SELL SELL Cell-Cell Contact -0.2898 0.00000000003948994021360876 Scatter Plot
Target AGT Target ICAM ICAM Cell-Cell Contact -0.2807 0.00000000016571746043149495 Scatter Plot
Target AGT Source CCL CCL Secreted Signaling -0.2669 0.0000000013341427654693228 Scatter Plot
Target AGT Source PARs PARs Secreted Signaling -0.2588 0.000000004298485420638405 Scatter Plot
Target AGT Source ANNEXIN ANNEXIN Secreted Signaling -0.2499 0.000000014817171346322678 Scatter Plot
Target AGT Target CXCL CXCL Secreted Signaling -0.2383 0.0000000687984580529543 Scatter Plot
Target AGT Source TGFb TGFb Secreted Signaling -0.2337 0.00000012535811806951476 Scatter Plot
Target AGT Source CLEC CLEC Cell-Cell Contact -0.2019 0.00000534131720924043 Scatter Plot
Target AGT Source COMPLEMENT COMPLEMENT Secreted Signaling -0.2017 0.000005500881964109729 Scatter Plot
Target AGT Source LAIR1 LAIR1 Cell-Cell Contact -0.2012 0.000005792909744655195 Scatter Plot
Target AGT Source ANGPTL ANGPTL Secreted Signaling -0.2005 0.0000062376914758443945 Scatter Plot
Target AGT Source CD34 CD34 Cell-Cell Contact -0.1929 0.00001403870282961233 Scatter Plot
Target AGT Source SEMA4 SEMA4 Cell-Cell Contact -0.1851 0.000031071317501314825 Scatter Plot
Target AGT Source VISTA VISTA Cell-Cell Contact -0.1663 0.000187659150198 Scatter Plot
Target AGT Source SPP1 SPP1 Secreted Signaling -0.1590 0.0003575225601028 Scatter Plot
Target AGT Target IL17 IL17 Secreted Signaling -0.1518 0.0006596887082957 Scatter Plot
Target AGT Source NKG2D NKG2D Cell-Cell Contact -0.1418 0.0014739060617328 Scatter Plot
Target AGT Target ANNEXIN ANNEXIN Secreted Signaling -0.1373 0.0020833802345545 Scatter Plot
Target AGT Target COLLAGEN COLLAGEN ECM-Receptor -0.1274 0.0043385357696838 Scatter Plot
Target AGT Source IL1 IL1 Secreted Signaling -0.1159 0.0094660814209624 Scatter Plot
Target AGT Source TNF TNF Secreted Signaling -0.1048 0.0191155104947647 Scatter Plot
Target AGT Source MIF MIF Secreted Signaling -0.0970 0.0301005365899168 Scatter Plot
Target AGT Target CD45 CD45 Cell-Cell Contact 0.0979 0.0285701589730828 Scatter Plot
Target AGT Target CCL CCL Secreted Signaling 0.1009 0.0240313738077315 Scatter Plot
Target AGT Target SELPLG SELPLG Cell-Cell Contact 0.1052 0.0186600326991083 Scatter Plot
Target AGT Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1171 0.0087601349002574 Scatter Plot
Target AGT Target FN1 FN1 ECM-Receptor 0.1250 0.0051182376184056 Scatter Plot
Target AGT Target CXCL CXCL Secreted Signaling 0.1252 0.0050510663557856 Scatter Plot
Target AGT Target TGFb TGFb Secreted Signaling 0.1264 0.0046554735268682 Scatter Plot
Target AGT Target SPP1 SPP1 Secreted Signaling 0.1464 0.0010234984466344 Scatter Plot
Target AGT Target VTN VTN ECM-Receptor 0.1574 0.000412191725619 Scatter Plot
Target AGT Target SEMA4 SEMA4 Cell-Cell Contact 0.1599 0.0003298775326554 Scatter Plot
Target AGT Target LAMININ LAMININ ECM-Receptor 0.1660 0.0001931804239477 Scatter Plot
Target AGT Target APP APP Cell-Cell Contact 0.1701 0.000131893310789 Scatter Plot
Target AGT Target ANGPTL ANGPTL Secreted Signaling 0.1738 0.00009407525931538654 Scatter Plot
Target AGT Target NRG NRG Secreted Signaling 0.1818 0.000043087635032467945 Scatter Plot
Target AGT Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.1961 0.000010056127431480964 Scatter Plot
Target AGT Target ANGPT ANGPT Secreted Signaling 0.2062 0.0000033467365266988117 Scatter Plot
Target AGT Target OSM OSM Secreted Signaling 0.2117 0.0000017911271966633215 Scatter Plot
Target AGT Target VISFATIN VISFATIN Secreted Signaling 0.2261 0.0000003213944017338855 Scatter Plot
Target AGT Target PARs PARs Secreted Signaling 0.2303 0.0000001918613226626425 Scatter Plot
Target AGT Target IGF IGF Secreted Signaling 0.2385 0.00000006772055169529745 Scatter Plot
Target AGT Target FGF FGF Secreted Signaling 0.2595 0.000000003894819249983713 Scatter Plot
Target AGT Target NPR2 NPR2 Secreted Signaling 0.2749 0.00000000040601817767778304 Scatter Plot
Target AGT Target SEMA5 SEMA5 Cell-Cell Contact 0.2896 0.000000000040401164335634567 Scatter Plot
Target AGT Target CDH CDH Cell-Cell Contact 0.3213 0.0000000000001787991287115562 Scatter Plot
Target AGT Target ESAM ESAM Cell-Cell Contact 0.3284 0.00000000000004848082414834706 Scatter Plot
Target AGT Target JAM JAM Cell-Cell Contact 0.3630 0.000000000000000051001630229297625 Scatter Plot
Target AGT Target CD34 CD34 Cell-Cell Contact 0.3803 0.0000000000000000011809847517934197 Scatter Plot
Target AGT Target CD52 CD52 Cell-Cell Contact -0.2739 0.0000000004673384737168891 Scatter Plot
Target AGT Target VCAM VCAM Cell-Cell Contact -0.2136 0.0000014333268933916203 Scatter Plot
Target AGT Target SELL SELL Cell-Cell Contact -0.1784 0.00006058633608442872 Scatter Plot
Target AGT Target IFN-II IFN-II Secreted Signaling -0.1763 0.00007384038691693661 Scatter Plot
Target AGT Target CCL CCL Secreted Signaling -0.1469 0.0009885198569635 Scatter Plot
Target AGT Target ANNEXIN ANNEXIN Secreted Signaling -0.1373 0.0020833802345545 Scatter Plot
Target AGT Target GRN GRN Secreted Signaling -0.1362 0.0022724227760357 Scatter Plot
Target AGT Target VEGF VEGF Secreted Signaling -0.1352 0.0024421240280661 Scatter Plot
Target AGT Target CLEC CLEC Cell-Cell Contact -0.1140 0.0107658008079523 Scatter Plot
Target AGT Target PDGF PDGF Secreted Signaling -0.1004 0.0248348364153926 Scatter Plot
Target AGT Target CSF CSF Secreted Signaling -0.0991 0.0267572917282641 Scatter Plot
Target AGT Target COMPLEMENT COMPLEMENT Secreted Signaling -0.0989 0.0269469103256441 Scatter Plot

Cells that are targets of AGT from HSCs*

    No cell populations

Cells that are source of AGT to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.