Pathway: EPHA

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Cell-Cell Contact

Details on the EPHA pathway:

Specificity Index HSPC as target: 0.338
HSPC as source: 0.529

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the EPHA pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target EPHA Target IL17 IL17 Secreted Signaling 0.1054 0.0183586752211738 Scatter Plot
Target EPHA Source PTN PTN Secreted Signaling 0.1064 0.0172764882455096 Scatter Plot
Target EPHA Source ICOS ICOS Cell-Cell Contact 0.1073 0.0163401859948693 Scatter Plot
Target EPHA Target VWF VWF ECM-Receptor 0.1093 0.014448060301446 Scatter Plot
Target EPHA Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.1123 0.0119913466601873 Scatter Plot
Target EPHA Source VCAM VCAM Cell-Cell Contact 0.1138 0.0108459189928078 Scatter Plot
Target EPHA Target SEMA3 SEMA3 Secreted Signaling 0.1160 0.0094136178229142 Scatter Plot
Target EPHA Target FN1 FN1 ECM-Receptor 0.1174 0.008604666592602 Scatter Plot
Target EPHA Target VEGF VEGF Secreted Signaling 0.1202 0.0071087230229577 Scatter Plot
Target EPHA Source THY1 THY1 Cell-Cell Contact 0.1214 0.0065718568861367 Scatter Plot
Target EPHA Target SPP1 SPP1 Secreted Signaling 0.1273 0.0043504653486059 Scatter Plot
Target EPHA Target SEMA5 SEMA5 Cell-Cell Contact 0.1329 0.0029148014987569 Scatter Plot
Target EPHA Target PTN PTN Secreted Signaling 0.1331 0.0028594287509009 Scatter Plot
Target EPHA Target GDF GDF Secreted Signaling 0.1415 0.0015108822612969 Scatter Plot
Target EPHA Source CADM CADM Cell-Cell Contact 0.1445 0.0011931661768265 Scatter Plot
Target EPHA Source CD86 CD86 Cell-Cell Contact 0.1457 0.0010827863964826 Scatter Plot
Target EPHA Source LCK LCK Cell-Cell Contact 0.1462 0.0010413811748637 Scatter Plot
Target EPHA Source LIFR LIFR Secreted Signaling 0.1532 0.0005859417960367 Scatter Plot
Target EPHA Target NCAM NCAM Cell-Cell Contact 0.1592 0.0003503792806548 Scatter Plot
Target EPHA Source RANKL RANKL Secreted Signaling 0.1600 0.0003268609064364 Scatter Plot
Target EPHA Source SEMA3 SEMA3 Secreted Signaling 0.1646 0.0002183985262025 Scatter Plot
Target EPHA Source FLT3 FLT3 Secreted Signaling 0.1646 0.0002176864217479 Scatter Plot
Target EPHA Source ncWNT ncWNT Secreted Signaling 0.1653 0.0002050840932449 Scatter Plot
Target EPHA Source SEMA6 SEMA6 Cell-Cell Contact 0.1657 0.0001976589531695 Scatter Plot
Target EPHA Source MK MK Secreted Signaling 0.1665 0.0001833043760093 Scatter Plot
Target EPHA Target SEMA4 SEMA4 Cell-Cell Contact 0.1714 0.0001168210745872 Scatter Plot
Target EPHA Source VEGF VEGF Secreted Signaling 0.1761 0.00007509216034845263 Scatter Plot
Target EPHA Source CD45 CD45 Cell-Cell Contact 0.1772 0.00006771309512291598 Scatter Plot
Target EPHA Target ANGPTL ANGPTL Secreted Signaling 0.1796 0.00005363185362677853 Scatter Plot
Target EPHA Source PSAP PSAP Secreted Signaling 0.1816 0.00004406794049107572 Scatter Plot
Target EPHA Target KIT KIT Secreted Signaling 0.1823 0.00004111760424564777 Scatter Plot
Target EPHA Target IGF IGF Secreted Signaling 0.1832 0.00003776361989308681 Scatter Plot
Target EPHA Source EPHB EPHB Cell-Cell Contact 0.1850 0.00003137886032148592 Scatter Plot
Target EPHA Source ICAM ICAM Cell-Cell Contact 0.1859 0.00002880789262461138 Scatter Plot
Target EPHA Source LAMININ LAMININ ECM-Receptor 0.1867 0.00002641239628839893 Scatter Plot
Target EPHA Target THBS THBS ECM-Receptor 0.1945 0.00001189592451103477 Scatter Plot
Target EPHA Source LIGHT LIGHT Secreted Signaling 0.1949 0.00001139030313390584 Scatter Plot
Target EPHA Target CSPG4 CSPG4 Cell-Cell Contact 0.1989 0.000007424861481168582 Scatter Plot
Target EPHA Target TENASCIN TENASCIN ECM-Receptor 0.2026 0.00000493580312455516 Scatter Plot
Target EPHA Source CCL CCL Secreted Signaling 0.2058 0.000003463198812030743 Scatter Plot
Target EPHA Source IL2 IL2 Secreted Signaling 0.2061 0.0000033497698314445327 Scatter Plot
Target EPHA Source NT NT Secreted Signaling 0.2064 0.0000032622533049161086 Scatter Plot
Target EPHA Target BSP BSP ECM-Receptor 0.2105 0.0000020601251762598712 Scatter Plot
Target EPHA Source WNT WNT Secreted Signaling 0.2120 0.0000017220388118386514 Scatter Plot
Target EPHA Source PROS PROS Secreted Signaling 0.2164 0.0000010374158554448624 Scatter Plot
Target EPHA Source CXCL CXCL Secreted Signaling 0.2177 0.0000008837753208137203 Scatter Plot
Target EPHA Source CX3C CX3C Secreted Signaling 0.2209 0.0000006035850468284138 Scatter Plot
Target EPHA Source COLLAGEN COLLAGEN ECM-Receptor 0.2227 0.0000004875910387737025 Scatter Plot
Target EPHA Source CD39 CD39 Cell-Cell Contact 0.2238 0.00000042610354184347537 Scatter Plot
Target EPHA Source ANGPT ANGPT Secreted Signaling 0.2257 0.0000003371654989646379 Scatter Plot
Target EPHA Source ESAM ESAM Cell-Cell Contact 0.2305 0.00000018737471655275898 Scatter Plot
Target EPHA Source CSF CSF Secreted Signaling 0.2387 0.00000006578952554618928 Scatter Plot
Target EPHA Source NOTCH NOTCH Cell-Cell Contact 0.2391 0.0000000627270062906996 Scatter Plot
Target EPHA Source SEMA7 SEMA7 Cell-Cell Contact 0.2391 0.00000006259730963851494 Scatter Plot
Target EPHA Source MHC-II MHC-II Cell-Cell Contact 0.2414 0.000000045977752251735323 Scatter Plot
Target EPHA Source TWEAK TWEAK Secreted Signaling 0.2451 0.00000002834795459460905 Scatter Plot
Target EPHA Source BMP BMP Secreted Signaling 0.2510 0.000000012772327541490816 Scatter Plot
Target EPHA Source MHC-I MHC-I Cell-Cell Contact 0.2521 0.000000010866750519237058 Scatter Plot
Target EPHA Target ESAM ESAM Cell-Cell Contact 0.2539 0.000000008486969293999659 Scatter Plot
Target EPHA Source GAS GAS Secreted Signaling 0.2574 0.000000005243036094145233 Scatter Plot
Target EPHA Source PDGF PDGF Secreted Signaling 0.2665 0.0000000014078738017234715 Scatter Plot
Target EPHA Source IL7 IL7 Secreted Signaling 0.2689 0.0000000009841381680644795 Scatter Plot
Target EPHA Source BST2 BST2 Cell-Cell Contact 0.2774 0.00000000027613431075076187 Scatter Plot
Target EPHA Source IGF IGF Secreted Signaling 0.2797 0.00000000019262756274674768 Scatter Plot
Target EPHA Source JAM JAM Cell-Cell Contact 0.2894 0.000000000041818561290787945 Scatter Plot
Target EPHA Source CDH CDH Cell-Cell Contact 0.2906 0.000000000034427109751367974 Scatter Plot
Target EPHA Source CD52 CD52 Cell-Cell Contact -0.2115 0.000001817085422234378 Scatter Plot
Target EPHA Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.1720 0.0001106514767107 Scatter Plot
Target EPHA Source TGFb TGFb Secreted Signaling -0.1676 0.0001668668047946 Scatter Plot
Target EPHA Source SEMA4 SEMA4 Cell-Cell Contact -0.1454 0.0011106862277202 Scatter Plot
Target EPHA Source SPP1 SPP1 Secreted Signaling -0.1311 0.0033206042591708 Scatter Plot
Target EPHA Source IL1 IL1 Secreted Signaling -0.1217 0.0064497095387638 Scatter Plot
Target EPHA Source COMPLEMENT COMPLEMENT Secreted Signaling -0.1139 0.0108005725652406 Scatter Plot
Target EPHA Target VISFATIN VISFATIN Secreted Signaling 0.0961 0.0317053354671843 Scatter Plot
Target EPHA Target TWEAK TWEAK Secreted Signaling 0.0964 0.0311619019078578 Scatter Plot
Target EPHA Target PARs PARs Secreted Signaling 0.1012 0.02356567659811 Scatter Plot
Target EPHA Target MK MK Secreted Signaling 0.1087 0.0150291098520986 Scatter Plot
Target EPHA Target PDGF PDGF Secreted Signaling 0.1096 0.0142257922798432 Scatter Plot
Target EPHA Target OSM OSM Secreted Signaling 0.1221 0.0062482783632393 Scatter Plot
Target EPHA Target CADM CADM Cell-Cell Contact 0.1445 0.0011931661768265 Scatter Plot
Target EPHA Target COLLAGEN COLLAGEN ECM-Receptor 0.1529 0.0006022883817775 Scatter Plot
Target EPHA Target RANKL RANKL Secreted Signaling 0.1549 0.0005104892500231 Scatter Plot
Target EPHA Target ANGPT ANGPT Secreted Signaling 0.1559 0.0004661860538586 Scatter Plot
Target EPHA Target ACTIVIN ACTIVIN Secreted Signaling 0.1578 0.0003964417482182 Scatter Plot
Target EPHA Target VTN VTN ECM-Receptor 0.1618 0.0002792012301072 Scatter Plot
Target EPHA Target BMP BMP Secreted Signaling 0.1661 0.0001912604875974 Scatter Plot
Target EPHA Target SEMA6 SEMA6 Cell-Cell Contact 0.1665 0.0001833360308737 Scatter Plot
Target EPHA Target CD22 CD22 Cell-Cell Contact 0.1772 0.00006771309512291598 Scatter Plot
Target EPHA Target COMPLEMENT COMPLEMENT Secreted Signaling 0.1834 0.000036954502440606175 Scatter Plot
Target EPHA Target LAMININ LAMININ ECM-Receptor 0.1836 0.00003610577894011991 Scatter Plot
Target EPHA Target CD200 CD200 Cell-Cell Contact 0.1879 0.000023443532137665745 Scatter Plot
Target EPHA Target IL6 IL6 Secreted Signaling 0.1951 0.000011141921240907302 Scatter Plot
Target EPHA Target AGT AGT Secreted Signaling 0.2006 0.0000061662675923181565 Scatter Plot
Target EPHA Target CD34 CD34 Cell-Cell Contact 0.2051 0.000003754786632580519 Scatter Plot
Target EPHA Target NRG NRG Secreted Signaling 0.2081 0.000002704642460181055 Scatter Plot
Target EPHA Target ESAM ESAM Cell-Cell Contact 0.2086 0.00000253735686830538 Scatter Plot
Target EPHA Target DMP1 DMP1 ECM-Receptor 0.2093 0.000002358488072068803 Scatter Plot
Target EPHA Target CD39 CD39 Cell-Cell Contact 0.2195 0.0000007196472904318163 Scatter Plot
Target EPHA Target NPR2 NPR2 Secreted Signaling 0.2198 0.0000006958466886961199 Scatter Plot
Target EPHA Target PERIOSTIN PERIOSTIN Secreted Signaling 0.2231 0.0000004630333146615286 Scatter Plot
Target EPHA Target APP APP Cell-Cell Contact 0.2458 0.000000025892938806831082 Scatter Plot
Target EPHA Target JAM JAM Cell-Cell Contact 0.2473 0.00000002109957472129909 Scatter Plot
Target EPHA Target BAFF BAFF Secreted Signaling 0.2610 0.0000000031237747776083434 Scatter Plot
Target EPHA Target TGFb TGFb Secreted Signaling 0.2641 0.0000000019880470413754806 Scatter Plot
Target EPHA Target MIF MIF Secreted Signaling 0.2762 0.00000000033361889001628315 Scatter Plot
Target EPHA Target FGF FGF Secreted Signaling 0.2793 0.00000000020698002392321167 Scatter Plot
Target EPHA Target SLURP SLURP Secreted Signaling 0.2899 0.000000000038434593311114434 Scatter Plot
Target EPHA Target CDH CDH Cell-Cell Contact 0.2906 0.000000000034427109751367974 Scatter Plot
Target EPHA Target WNT WNT Secreted Signaling 0.2962 0.000000000013803313061345396 Scatter Plot
Target EPHA Target ncWNT ncWNT Secreted Signaling 0.3001 0.000000000007267633788085439 Scatter Plot
Target EPHA Target ANNEXIN ANNEXIN Secreted Signaling -0.1787 0.0000587102768496425 Scatter Plot
Target EPHA Target ICAM ICAM Cell-Cell Contact -0.1493 0.0008112588212028 Scatter Plot
Target EPHA Target CCL CCL Secreted Signaling -0.1445 0.0011921701148167 Scatter Plot
Target EPHA Target GRN GRN Secreted Signaling -0.1294 0.0037445760807218 Scatter Plot
Target EPHA Target CXCL CXCL Secreted Signaling -0.1052 0.0185862441585676 Scatter Plot

Cells that are targets of EPHA from HSCs*

    No cell populations

Cells that are source of EPHA to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.