Pathway: SEMA5

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Cell-Cell Contact

Details on the SEMA5 pathway:

Specificity Index HSPC as target: 0.208
HSPC as source: 0.227

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the SEMA5 pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target SEMA5 Source IL16 IL16 Secreted Signaling 0.1007 0.0243182065966578 Scatter Plot
Target SEMA5 Source ncWNT ncWNT Secreted Signaling 0.1131 0.0113895835677955 Scatter Plot
Target SEMA5 Source AGRN AGRN ECM-Receptor 0.1183 0.0080783957314456 Scatter Plot
Target SEMA5 Source WNT WNT Secreted Signaling 0.1191 0.0076906913232253 Scatter Plot
Target SEMA5 Source GDF GDF Secreted Signaling 0.1216 0.0064843347059122 Scatter Plot
Target SEMA5 Target RANKL RANKL Secreted Signaling 0.1293 0.0037659807816999 Scatter Plot
Target SEMA5 Source CD1D2 CD1D2 Cell-Cell Contact 0.1294 0.0037541867097457 Scatter Plot
Target SEMA5 Source ANGPTL ANGPTL Secreted Signaling 0.1381 0.0019711621161384 Scatter Plot
Target SEMA5 Source PTN PTN Secreted Signaling 0.1424 0.0014073344365079 Scatter Plot
Target SEMA5 Target NCAM NCAM Cell-Cell Contact 0.1461 0.001053602855622 Scatter Plot
Target SEMA5 Source SEMA3 SEMA3 Secreted Signaling 0.1510 0.0007034615224148 Scatter Plot
Target SEMA5 Source CD39 CD39 Cell-Cell Contact 0.1518 0.0006613359965433 Scatter Plot
Target SEMA5 Source CD45 CD45 Cell-Cell Contact 0.1656 0.0001998114345612 Scatter Plot
Target SEMA5 Target CSPG4 CSPG4 Cell-Cell Contact 0.1805 0.00004900310925102406 Scatter Plot
Target SEMA5 Source CCL CCL Secreted Signaling 0.1816 0.000044027404982249054 Scatter Plot
Target SEMA5 Source CSF CSF Secreted Signaling 0.1829 0.00003871162904840766 Scatter Plot
Target SEMA5 Target COMPLEMENT COMPLEMENT Secreted Signaling 0.1832 0.00003750155471920639 Scatter Plot
Target SEMA5 Source VCAM VCAM Cell-Cell Contact 0.1870 0.000025645769294502195 Scatter Plot
Target SEMA5 Source APELIN APELIN Secreted Signaling 0.1921 0.000015189441242500604 Scatter Plot
Target SEMA5 Target SPP1 SPP1 Secreted Signaling 0.1926 0.000014523491742773286 Scatter Plot
Target SEMA5 Target ANGPTL ANGPTL Secreted Signaling 0.1978 0.000008369387197631412 Scatter Plot
Target SEMA5 Source THY1 THY1 Cell-Cell Contact 0.2034 0.000004527652438768331 Scatter Plot
Target SEMA5 Source LIGHT LIGHT Secreted Signaling 0.2081 0.0000026893370795341345 Scatter Plot
Target SEMA5 Target VEGF VEGF Secreted Signaling 0.2094 0.000002320266327247056 Scatter Plot
Target SEMA5 Source NOTCH NOTCH Cell-Cell Contact 0.2132 0.0000015020323292077092 Scatter Plot
Target SEMA5 Target THBS THBS ECM-Receptor 0.2155 0.0000011448228087467211 Scatter Plot
Target SEMA5 Source MK MK Secreted Signaling 0.2237 0.0000004314230101306273 Scatter Plot
Target SEMA5 Source IL2 IL2 Secreted Signaling 0.2243 0.0000004043438746707429 Scatter Plot
Target SEMA5 Source NT NT Secreted Signaling 0.2260 0.0000003263914640762964 Scatter Plot
Target SEMA5 Source PROS PROS Secreted Signaling 0.2271 0.00000028504666865914665 Scatter Plot
Target SEMA5 Source GP1BA GP1BA Cell-Cell Contact 0.2283 0.00000024650471654628093 Scatter Plot
Target SEMA5 Source VEGF VEGF Secreted Signaling 0.2305 0.0000001860795243389725 Scatter Plot
Target SEMA5 Source PSAP PSAP Secreted Signaling 0.2308 0.0000001795500522045653 Scatter Plot
Target SEMA5 Source CXCL CXCL Secreted Signaling 0.2326 0.00000014356630658823974 Scatter Plot
Target SEMA5 Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.2354 0.00000010082555694871349 Scatter Plot
Target SEMA5 Source ICAM ICAM Cell-Cell Contact 0.2372 0.00000007957593615787085 Scatter Plot
Target SEMA5 Source RANKL RANKL Secreted Signaling 0.2374 0.00000007739152122873543 Scatter Plot
Target SEMA5 Source CD86 CD86 Cell-Cell Contact 0.2438 0.00000003352924558527991 Scatter Plot
Target SEMA5 Source CX3C CX3C Secreted Signaling 0.2668 0.000000001342779689402868 Scatter Plot
Target SEMA5 Target MK MK Secreted Signaling 0.2671 0.0000000013001536154785999 Scatter Plot
Target SEMA5 Source CD46 CD46 Cell-Cell Contact 0.2730 0.0000000005342652951921605 Scatter Plot
Target SEMA5 Source IGF IGF Secreted Signaling 0.2731 0.0000000005293743756361124 Scatter Plot
Target SEMA5 Source LAMININ LAMININ ECM-Receptor 0.2761 0.00000000033534943434694437 Scatter Plot
Target SEMA5 Source EPHB EPHB Cell-Cell Contact 0.2868 0.00000000006374345006071972 Scatter Plot
Target SEMA5 Source FLT3 FLT3 Secreted Signaling 0.2871 0.00000000006022336538657152 Scatter Plot
Target SEMA5 Target AGT AGT Secreted Signaling 0.2896 0.000000000040401164335634567 Scatter Plot
Target SEMA5 Target PERIOSTIN PERIOSTIN Secreted Signaling 0.3020 0.000000000005299514705504043 Scatter Plot
Target SEMA5 Target CD200 CD200 Cell-Cell Contact 0.3054 0.000000000002963852886659008 Scatter Plot
Target SEMA5 Target BSP BSP ECM-Receptor 0.3102 0.0000000000012916795419477226 Scatter Plot
Target SEMA5 Target GDF GDF Secreted Signaling 0.3134 0.000000000000738154268343705 Scatter Plot
Target SEMA5 Target DMP1 DMP1 ECM-Receptor 0.3160 0.0000000000004698362236390807 Scatter Plot
Target SEMA5 Source IL7 IL7 Secreted Signaling 0.3160 0.0000000000004652900692931756 Scatter Plot
Target SEMA5 Source LCK LCK Cell-Cell Contact 0.3202 0.00000000000021912054332211358 Scatter Plot
Target SEMA5 Source SEMA7 SEMA7 Cell-Cell Contact 0.3250 0.00000000000009072992731867287 Scatter Plot
Target SEMA5 Source LIFR LIFR Secreted Signaling 0.3283 0.000000000000049407555056214354 Scatter Plot
Target SEMA5 Target ACTIVIN ACTIVIN Secreted Signaling 0.3309 0.00000000000003067685390007909 Scatter Plot
Target SEMA5 Source PDGF PDGF Secreted Signaling 0.3311 0.000000000000029474706153727664 Scatter Plot
Target SEMA5 Source BST2 BST2 Cell-Cell Contact 0.3353 0.000000000000013175970950374182 Scatter Plot
Target SEMA5 Target SLURP SLURP Secreted Signaling 0.3356 0.000000000000012578077066151024 Scatter Plot
Target SEMA5 Target IGF IGF Secreted Signaling 0.3370 0.000000000000009604952231051221 Scatter Plot
Target SEMA5 Target CDH CDH Cell-Cell Contact 0.3385 0.000000000000007112035967628069 Scatter Plot
Target SEMA5 Source CDH CDH Cell-Cell Contact 0.3385 0.000000000000007112035967628069 Scatter Plot
Target SEMA5 Target SEMA7 SEMA7 Cell-Cell Contact 0.3424 0.0000000000000033724064892309625 Scatter Plot
Target SEMA5 Target VWF VWF ECM-Receptor 0.3432 0.0000000000000028408748018430614 Scatter Plot
Target SEMA5 Source CADM CADM Cell-Cell Contact 0.3452 0.0000000000000019208774449635198 Scatter Plot
Target SEMA5 Target CADM CADM Cell-Cell Contact 0.3452 0.0000000000000019208774449635198 Scatter Plot
Target SEMA5 Target CD39 CD39 Cell-Cell Contact 0.3539 0.00000000000000033576239462373763 Scatter Plot
Target SEMA5 Target KIT KIT Secreted Signaling 0.3576 0.00000000000000015534183312992495 Scatter Plot
Target SEMA5 Target BMP BMP Secreted Signaling 0.3594 0.00000000000000010745869552715975 Scatter Plot
Target SEMA5 Source BMP BMP Secreted Signaling 0.3645 0.0000000000000000371916735582876 Scatter Plot
Target SEMA5 Source COLLAGEN COLLAGEN ECM-Receptor 0.3659 0.00000000000000002754610947557657 Scatter Plot
Target SEMA5 Source MHC-I MHC-I Cell-Cell Contact 0.3808 0.0000000000000000010512594931216025 Scatter Plot
Target SEMA5 Source MHC-II MHC-II Cell-Cell Contact 0.3893 0.00000000000000000015244398789062202 Scatter Plot
Target SEMA5 Source ANGPT ANGPT Secreted Signaling 0.3951 0.00000000000000000003931665049383178 Scatter Plot
Target SEMA5 Source ESAM ESAM Cell-Cell Contact 0.3967 0.000000000000000000026862615292687602 Scatter Plot
Target SEMA5 Source TWEAK TWEAK Secreted Signaling 0.3974 0.000000000000000000023080251806353735 Scatter Plot
Target SEMA5 Target FGF FGF Secreted Signaling 0.3990 0.00000000000000000001560669838788995 Scatter Plot
Target SEMA5 Source GAS GAS Secreted Signaling 0.4208 0.00000000000000000000007015692320317359 Scatter Plot
Target SEMA5 Source JAM JAM Cell-Cell Contact 0.4630 0.0000000000000000000000000006141800621106428 Scatter Plot
Target SEMA5 Target WNT WNT Secreted Signaling 0.4726 0.0000000000000000000000000000338274739839178 Scatter Plot
Target SEMA5 Source CD52 CD52 Cell-Cell Contact -0.3855 0.00000000000000000036417667863925703 Scatter Plot
Target SEMA5 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.3738 0.0000000000000000050197774435906554 Scatter Plot
Target SEMA5 Source SELL SELL Cell-Cell Contact -0.3141 0.0000000000006560075791451591 Scatter Plot
Target SEMA5 Source SEMA4 SEMA4 Cell-Cell Contact -0.2911 0.000000000031827634763865746 Scatter Plot
Target SEMA5 Source COMPLEMENT COMPLEMENT Secreted Signaling -0.2777 0.00000000026138401274284727 Scatter Plot
Target SEMA5 Source PARs PARs Secreted Signaling -0.2701 0.000000000832534298574 Scatter Plot
Target SEMA5 Target CXCL CXCL Secreted Signaling -0.2643 0.000000001947615046863415 Scatter Plot
Target SEMA5 Source ANNEXIN ANNEXIN Secreted Signaling -0.2295 0.00000021072208610351938 Scatter Plot
Target SEMA5 Target CSF CSF Secreted Signaling -0.2222 0.0000005195209561852148 Scatter Plot
Target SEMA5 Source VISTA VISTA Cell-Cell Contact -0.2209 0.0000006064577631878319 Scatter Plot
Target SEMA5 Source CLEC CLEC Cell-Cell Contact -0.2200 0.0000006797249856882054 Scatter Plot
Target SEMA5 Source CCL CCL Secreted Signaling -0.2136 0.000001427649919231677 Scatter Plot
Target SEMA5 Source SPP1 SPP1 Secreted Signaling -0.2079 0.000002761225419790169 Scatter Plot
Target SEMA5 Source TGFb TGFb Secreted Signaling -0.1996 0.000006879831257715968 Scatter Plot
Target SEMA5 Source SELPLG SELPLG Cell-Cell Contact -0.1785 0.000059681283569587753 Scatter Plot
Target SEMA5 Target IL17 IL17 Secreted Signaling -0.1754 0.0000804956642607264 Scatter Plot
Target SEMA5 Source MIF MIF Secreted Signaling -0.1337 0.0027299200522728 Scatter Plot
Target SEMA5 Source LAIR1 LAIR1 Cell-Cell Contact -0.1095 0.0142783016121055 Scatter Plot
Target SEMA5 Target NODAL NODAL Secreted Signaling 0.1164 0.0091545395753022 Scatter Plot
Target SEMA5 Target COLLAGEN COLLAGEN ECM-Receptor 0.1214 0.0065603369025641 Scatter Plot
Target SEMA5 Target IL6 IL6 Secreted Signaling 0.1219 0.0063494079729763 Scatter Plot
Target SEMA5 Target EPHA EPHA Cell-Cell Contact 0.1329 0.0029148014987569 Scatter Plot
Target SEMA5 Target OSM OSM Secreted Signaling 0.1569 0.0004298396535199 Scatter Plot
Target SEMA5 Target CD22 CD22 Cell-Cell Contact 0.1656 0.0001998114345612 Scatter Plot
Target SEMA5 Target NOTCH NOTCH Cell-Cell Contact 0.1761 0.0000755142890996575 Scatter Plot
Target SEMA5 Target FN1 FN1 ECM-Receptor 0.1776 0.00006514471483824842 Scatter Plot
Target SEMA5 Target SPP1 SPP1 Secreted Signaling 0.1936 0.000013012867849918907 Scatter Plot
Target SEMA5 Target BAFF BAFF Secreted Signaling 0.2084 0.000002612873892524656 Scatter Plot
Target SEMA5 Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.2084 0.000002605547033457592 Scatter Plot
Target SEMA5 Target LAMININ LAMININ ECM-Receptor 0.2284 0.0000002417582479803491 Scatter Plot
Target SEMA5 Target EPHB EPHB Cell-Cell Contact 0.2656 0.0000000015996301180989507 Scatter Plot
Target SEMA5 Target PTN PTN Secreted Signaling 0.2745 0.00000000042994514572129165 Scatter Plot
Target SEMA5 Target VTN VTN ECM-Receptor 0.2984 0.000000000009579942486084602 Scatter Plot
Target SEMA5 Target ANGPT ANGPT Secreted Signaling 0.2989 0.000000000008868262496943488 Scatter Plot
Target SEMA5 Target VISFATIN VISFATIN Secreted Signaling 0.3085 0.0000000000017424917710082202 Scatter Plot
Target SEMA5 Target TGFb TGFb Secreted Signaling 0.3146 0.0000000000005987984944101251 Scatter Plot
Target SEMA5 Target NRG NRG Secreted Signaling 0.3160 0.0000000000004694805108554141 Scatter Plot
Target SEMA5 Target PARs PARs Secreted Signaling 0.3182 0.0000000000003133554994588142 Scatter Plot
Target SEMA5 Target APP APP Cell-Cell Contact 0.3227 0.00000000000013881229818386484 Scatter Plot
Target SEMA5 Target SEMA7 SEMA7 Cell-Cell Contact 0.3425 0.0000000000000033177917375045288 Scatter Plot
Target SEMA5 Target TENASCIN TENASCIN ECM-Receptor 0.3443 0.0000000000000022976077252363028 Scatter Plot
Target SEMA5 Target MIF MIF Secreted Signaling 0.3472 0.0000000000000012989342491344985 Scatter Plot
Target SEMA5 Target NPR2 NPR2 Secreted Signaling 0.3601 0.00000000000000009266330838046146 Scatter Plot
Target SEMA5 Target JAM JAM Cell-Cell Contact 0.3862 0.000000000000000000310045830479628 Scatter Plot
Target SEMA5 Target ESAM ESAM Cell-Cell Contact 0.3967 0.000000000000000000026862615292687602 Scatter Plot
Target SEMA5 Target CD34 CD34 Cell-Cell Contact 0.4224 0.00000000000000000000004606910006796244 Scatter Plot
Target SEMA5 Target ncWNT ncWNT Secreted Signaling 0.4577 0.0000000000000000000000000028734987262099943 Scatter Plot
Target SEMA5 Target ICAM ICAM Cell-Cell Contact -0.3576 0.00000000000000015629624696982082 Scatter Plot
Target SEMA5 Target IFN-II IFN-II Secreted Signaling -0.2725 0.0000000005786916443477256 Scatter Plot
Target SEMA5 Target CD52 CD52 Cell-Cell Contact -0.2623 0.000000002604707540213092 Scatter Plot
Target SEMA5 Target CCL CCL Secreted Signaling -0.2372 0.00000008021260195951225 Scatter Plot
Target SEMA5 Target CLEC CLEC Cell-Cell Contact -0.2205 0.0000006361808196947716 Scatter Plot
Target SEMA5 Target VCAM VCAM Cell-Cell Contact -0.2182 0.0000008332326916198376 Scatter Plot
Target SEMA5 Target CEACAM CEACAM Cell-Cell Contact -0.1963 0.000009790910142629703 Scatter Plot
Target SEMA5 Target ANNEXIN ANNEXIN Secreted Signaling -0.1442 0.0012190576504879 Scatter Plot
Target SEMA5 Target GRN GRN Secreted Signaling -0.1306 0.0034400250861296 Scatter Plot
Target SEMA5 Target COLLAGEN COLLAGEN ECM-Receptor -0.1207 0.0068693307630022 Scatter Plot
Target SEMA5 Target COMPLEMENT COMPLEMENT Secreted Signaling -0.1168 0.0089683422513049 Scatter Plot
Target SEMA5 Target VEGF VEGF Secreted Signaling -0.1056 0.0181849868862114 Scatter Plot

Cells that are targets of SEMA5 from HSCs*

    No cell populations

Cells that are source of SEMA5 to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.