Pathway: LCK

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Cell-Cell Contact

Details on the LCK pathway:

Specificity Index HSPC as target: 0.182
HSPC as source: 0.377

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the LCK pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Source LCK Source ICOS ICOS Cell-Cell Contact 0.1037 0.0203314277428728 Scatter Plot
Source LCK Source IL6 IL6 Secreted Signaling 0.1062 0.0175160913636204 Scatter Plot
Source LCK Source WNT WNT Secreted Signaling 0.1075 0.016225867896977 Scatter Plot
Source LCK Source PECAM1 PECAM1 Cell-Cell Contact 0.1141 0.0106866411476272 Scatter Plot
Source LCK Source OSM OSM Secreted Signaling 0.1270 0.0044515966083984 Scatter Plot
Source LCK Source GP1BA GP1BA Cell-Cell Contact 0.1308 0.0033977340140083 Scatter Plot
Source LCK Source AGRN AGRN ECM-Receptor 0.1316 0.0031982674737839 Scatter Plot
Source LCK Source GALECTIN GALECTIN Secreted Signaling 0.1416 0.0014967883303676 Scatter Plot
Source LCK Source APELIN APELIN Secreted Signaling 0.1593 0.0003475760843322 Scatter Plot
Source LCK Source PTN PTN Secreted Signaling 0.1871 0.00002560508826561113 Scatter Plot
Source LCK Source RANKL RANKL Secreted Signaling 0.1889 0.00002113241172375796 Scatter Plot
Source LCK Source CD39 CD39 Cell-Cell Contact 0.1999 0.000006693687863673188 Scatter Plot
Source LCK Source NT NT Secreted Signaling 0.2049 0.000003856935320897531 Scatter Plot
Source LCK Source PROS PROS Secreted Signaling 0.2120 0.0000017178768117713156 Scatter Plot
Source LCK Source IL2 IL2 Secreted Signaling 0.2163 0.0000010445612900021183 Scatter Plot
Source LCK Source CCL CCL Secreted Signaling 0.2261 0.0000003231896811451798 Scatter Plot
Source LCK Source CD46 CD46 Cell-Cell Contact 0.2342 0.00000011705823960913788 Scatter Plot
Source LCK Source GDF GDF Secreted Signaling 0.2358 0.00000009538038143398404 Scatter Plot
Source LCK Source CD34 CD34 Cell-Cell Contact 0.2375 0.00000007710722771141555 Scatter Plot
Source LCK Source CD1D2 CD1D2 Cell-Cell Contact 0.2473 0.000000021158314823603633 Scatter Plot
Source LCK Source VEGF VEGF Secreted Signaling 0.2485 0.000000017759830003918348 Scatter Plot
Source LCK Source IGF IGF Secreted Signaling 0.2495 0.00000001569021620587507 Scatter Plot
Source LCK Source FGF FGF Secreted Signaling 0.2558 0.000000006539646345735182 Scatter Plot
Source LCK Source CADM CADM Cell-Cell Contact 0.2596 0.0000000038463133247535775 Scatter Plot
Source LCK Source CSF CSF Secreted Signaling 0.2690 0.0000000009794985868761494 Scatter Plot
Source LCK Source IL16 IL16 Secreted Signaling 0.2710 0.0000000007208597789651107 Scatter Plot
Source LCK Source EPHB EPHB Cell-Cell Contact 0.2743 0.00000000044482185504813324 Scatter Plot
Source LCK Source NOTCH NOTCH Cell-Cell Contact 0.2791 0.00000000021389673692084068 Scatter Plot
Source LCK Source SEMA3 SEMA3 Secreted Signaling 0.2816 0.0000000001437452175941932 Scatter Plot
Source LCK Source ANGPTL ANGPTL Secreted Signaling 0.2832 0.00000000011223279657704491 Scatter Plot
Source LCK Source VCAM VCAM Cell-Cell Contact 0.2880 0.00000000005246267334360346 Scatter Plot
Source LCK Source PSAP PSAP Secreted Signaling 0.3062 0.0000000000026029793484417298 Scatter Plot
Source LCK Source MK MK Secreted Signaling 0.3151 0.0000000000005445459069830627 Scatter Plot
Source LCK Source CXCL CXCL Secreted Signaling 0.3229 0.00000000000013488575265018085 Scatter Plot
Source LCK Source THY1 THY1 Cell-Cell Contact 0.3311 0.000000000000029617472200249184 Scatter Plot
Source LCK Source CX3C CX3C Secreted Signaling 0.3478 0.000000000000001149649962542244 Scatter Plot
Source LCK Source CD86 CD86 Cell-Cell Contact 0.3527 0.0000000000000004295965453925567 Scatter Plot
Source LCK Source LIGHT LIGHT Secreted Signaling 0.3542 0.00000000000000031470717755849715 Scatter Plot
Source LCK Source FLT3 FLT3 Secreted Signaling 0.3593 0.00000000000000010937114305502163 Scatter Plot
Source LCK Source TWEAK TWEAK Secreted Signaling 0.3633 0.00000000000000004757774798562597 Scatter Plot
Source LCK Source PDGF PDGF Secreted Signaling 0.3713 0.000000000000000008555047503330876 Scatter Plot
Source LCK Source SEMA7 SEMA7 Cell-Cell Contact 0.3716 0.000000000000000008101513769849873 Scatter Plot
Source LCK Source LIFR LIFR Secreted Signaling 0.3752 0.000000000000000003661438538469272 Scatter Plot
Source LCK Source CDH CDH Cell-Cell Contact 0.3755 0.0000000000000000034090861869223847 Scatter Plot
Source LCK Source ICAM ICAM Cell-Cell Contact 0.3800 0.0000000000000000012607621823666665 Scatter Plot
Source LCK Source CD45 CD45 Cell-Cell Contact 0.3811 0.0000000000000000009754940231930185 Scatter Plot
Source LCK Source BMP BMP Secreted Signaling 0.4022 0.000000000000000000007222406185805562 Scatter Plot
Source LCK Source BST2 BST2 Cell-Cell Contact 0.4181 0.00000000000000000000013919943647374808 Scatter Plot
Source LCK Source GAS GAS Secreted Signaling 0.4433 0.00000000000000000000000017116767429969442 Scatter Plot
Source LCK Source LAMININ LAMININ ECM-Receptor 0.4588 0.000000000000000000000000002106446997301817 Scatter Plot
Source LCK Source ESAM ESAM Cell-Cell Contact 0.4952 0.000000000000000000000000000000026203437896957784 Scatter Plot
Source LCK Source JAM JAM Cell-Cell Contact 0.5027 0.0000000000000000000000000000000022239740459503765 Scatter Plot
Source LCK Source ANGPT ANGPT Secreted Signaling 0.5146 0.00000000000000000000000000000000003630378159859376 Scatter Plot
Source LCK Source COLLAGEN COLLAGEN ECM-Receptor 0.5172 0.000000000000000000000000000000000014405089523977125 Scatter Plot
Source LCK Source MHC-I MHC-I Cell-Cell Contact 0.5246 0.0000000000000000000000000000000000010275368161712567 Scatter Plot
Source LCK Source MHC-II MHC-II Cell-Cell Contact 0.5521 0.000000000000000000000000000000000000000030408797353806875 Scatter Plot
Source LCK Source COMPLEMENT COMPLEMENT Secreted Signaling -0.4407 0.0000000000000000000000003545029292609591 Scatter Plot
Source LCK Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.4215 0.00000000000000000000005924369904631393 Scatter Plot
Source LCK Source SEMA4 SEMA4 Cell-Cell Contact -0.3630 0.00000000000000005051962818196504 Scatter Plot
Source LCK Source CD52 CD52 Cell-Cell Contact -0.3442 0.0000000000000023615055461019977 Scatter Plot
Source LCK Source VISTA VISTA Cell-Cell Contact -0.3282 0.000000000000050712895131383997 Scatter Plot
Source LCK Source PARs PARs Secreted Signaling -0.2964 0.000000000013356103215997011 Scatter Plot
Source LCK Source SELL SELL Cell-Cell Contact -0.2483 0.000000018447847874583777 Scatter Plot
Source LCK Source CLEC CLEC Cell-Cell Contact -0.2395 0.000000059356480641219075 Scatter Plot
Source LCK Source CCL CCL Secreted Signaling -0.1766 0.00007210924005614685 Scatter Plot
Source LCK Source TGFb TGFb Secreted Signaling -0.1761 0.00007499637999797288 Scatter Plot
Source LCK Source SPP1 SPP1 Secreted Signaling -0.1738 0.00009387132945366684 Scatter Plot
Source LCK Source NCAM NCAM Cell-Cell Contact -0.1681 0.0001595997656511 Scatter Plot
Source LCK Source TNF TNF Secreted Signaling -0.1534 0.0005758564043938 Scatter Plot
Source LCK Source ANNEXIN ANNEXIN Secreted Signaling -0.1452 0.0011313677633434 Scatter Plot
Source LCK Source APP APP Cell-Cell Contact -0.1444 0.0012055242598393 Scatter Plot
Source LCK Source IL1 IL1 Secreted Signaling -0.1389 0.0018553956558788 Scatter Plot
Source LCK Source ANGPTL ANGPTL Secreted Signaling -0.1354 0.0024205270883026 Scatter Plot
Source LCK Source VISFATIN VISFATIN Secreted Signaling -0.1271 0.0044235693168328 Scatter Plot
Source LCK Source MIF MIF Secreted Signaling -0.1258 0.0048291733049447 Scatter Plot
Source LCK Source NKG2D NKG2D Cell-Cell Contact -0.0984 0.027721080739941 Scatter Plot
Source LCK Source BAFF BAFF Secreted Signaling -0.0969 0.030333678017242 Scatter Plot
Source LCK Target PECAM1 PECAM1 Cell-Cell Contact 0.1141 0.0106866411476272 Scatter Plot
Source LCK Target PDGF PDGF Secreted Signaling 0.1182 0.0081356459858242 Scatter Plot
Source LCK Target NOTCH NOTCH Cell-Cell Contact 0.1362 0.0022757397512789 Scatter Plot
Source LCK Target EPHA EPHA Cell-Cell Contact 0.1462 0.0010413811748637 Scatter Plot
Source LCK Target COLLAGEN COLLAGEN ECM-Receptor 0.1551 0.0004997388495454 Scatter Plot
Source LCK Target GALECTIN GALECTIN Secreted Signaling 0.1592 0.0003504153547633 Scatter Plot
Source LCK Target OSM OSM Secreted Signaling 0.1617 0.0002825237926442 Scatter Plot
Source LCK Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2108 0.000001981060976517393 Scatter Plot
Source LCK Target AGT AGT Secreted Signaling 0.2187 0.000000787476276694395 Scatter Plot
Source LCK Target VEGF VEGF Secreted Signaling 0.2264 0.0000003113687008820998 Scatter Plot
Source LCK Target GDF GDF Secreted Signaling 0.2338 0.0000001226214600396727 Scatter Plot
Source LCK Target VISFATIN VISFATIN Secreted Signaling 0.2472 0.00000002118049023643136 Scatter Plot
Source LCK Target SELL SELL Cell-Cell Contact 0.2503 0.000000013889742949504189 Scatter Plot
Source LCK Target PTN PTN Secreted Signaling 0.2540 0.000000008377147471799473 Scatter Plot
Source LCK Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.2568 0.000000005714206480951303 Scatter Plot
Source LCK Target SEMA7 SEMA7 Cell-Cell Contact 0.2576 0.000000005074691255695061 Scatter Plot
Source LCK Target CADM CADM Cell-Cell Contact 0.2596 0.0000000038463133247535775 Scatter Plot
Source LCK Target FN1 FN1 ECM-Receptor 0.2751 0.000000000390352698705943 Scatter Plot
Source LCK Target CSPG4 CSPG4 Cell-Cell Contact 0.2794 0.00000000020350096262085889 Scatter Plot
Source LCK Target EPHB EPHB Cell-Cell Contact 0.2797 0.00000000019309489559553782 Scatter Plot
Source LCK Target ANGPTL ANGPTL Secreted Signaling 0.2819 0.00000000013730871992371792 Scatter Plot
Source LCK Target SEMA6 SEMA6 Cell-Cell Contact 0.2885 0.00000000004880085476743183 Scatter Plot
Source LCK Target SPP1 SPP1 Secreted Signaling 0.2901 0.00000000003752071601231264 Scatter Plot
Source LCK Target BMP BMP Secreted Signaling 0.2965 0.000000000013238094516407694 Scatter Plot
Source LCK Target NODAL NODAL Secreted Signaling 0.2971 0.000000000011861136156513635 Scatter Plot
Source LCK Target MK MK Secreted Signaling 0.3002 0.000000000007111565168405464 Scatter Plot
Source LCK Target LAMININ LAMININ ECM-Receptor 0.3041 0.00000000000369926393074824 Scatter Plot
Source LCK Target THBS THBS ECM-Receptor 0.3067 0.0000000000023511019725718584 Scatter Plot
Source LCK Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.3090 0.0000000000015873167889001126 Scatter Plot
Source LCK Target SEMA5 SEMA5 Cell-Cell Contact 0.3202 0.00000000000021912054332211358 Scatter Plot
Source LCK Target ANGPT ANGPT Secreted Signaling 0.3483 0.000000000000001038027373558109 Scatter Plot
Source LCK Target PERIOSTIN PERIOSTIN Secreted Signaling 0.3645 0.00000000000000003718307228019157 Scatter Plot
Source LCK Target PARs PARs Secreted Signaling 0.3681 0.000000000000000017008230739787938 Scatter Plot
Source LCK Target VTN VTN ECM-Receptor 0.3702 0.00000000000000001090813983999562 Scatter Plot
Source LCK Target VWF VWF ECM-Receptor 0.3714 0.000000000000000008335170826084887 Scatter Plot
Source LCK Target NRG NRG Secreted Signaling 0.3716 0.000000000000000008049345369660515 Scatter Plot
Source LCK Target BSP BSP ECM-Receptor 0.3747 0.0000000000000000041296783052242885 Scatter Plot
Source LCK Target CDH CDH Cell-Cell Contact 0.3755 0.0000000000000000034090861869223847 Scatter Plot
Source LCK Target BAFF BAFF Secreted Signaling 0.3800 0.0000000000000000012581715225297958 Scatter Plot
Source LCK Target CD22 CD22 Cell-Cell Contact 0.3811 0.0000000000000000009754940231930185 Scatter Plot
Source LCK Target ACTIVIN ACTIVIN Secreted Signaling 0.3841 0.0000000000000000005054257150278531 Scatter Plot
Source LCK Target NPR2 NPR2 Secreted Signaling 0.3847 0.000000000000000000433797314971031 Scatter Plot
Source LCK Target DMP1 DMP1 ECM-Receptor 0.3852 0.00000000000000000038785065632162975 Scatter Plot
Source LCK Target CD200 CD200 Cell-Cell Contact 0.3854 0.0000000000000000003692190582942891 Scatter Plot
Source LCK Source IL7 IL7 Secreted Signaling 0.3863 0.00000000000000000030515238279055044 Scatter Plot
Source LCK Target APP APP Cell-Cell Contact 0.3873 0.0000000000000000002434502617680166 Scatter Plot
Source LCK Target IGF IGF Secreted Signaling 0.3962 0.000000000000000000030591798374943383 Scatter Plot
Source LCK Target TENASCIN TENASCIN ECM-Receptor 0.4094 0.000000000000000000001257909114450109 Scatter Plot
Source LCK Target JAM JAM Cell-Cell Contact 0.4102 0.0000000000000000000010147820549147992 Scatter Plot
Source LCK Target TGFb TGFb Secreted Signaling 0.4161 0.0000000000000000000002329311103516617 Scatter Plot
Source LCK Target FGF FGF Secreted Signaling 0.4183 0.00000000000000000000013434983820338271 Scatter Plot
Source LCK Target SLURP SLURP Secreted Signaling 0.4296 0.000000000000000000000007005241224310058 Scatter Plot
Source LCK Target KIT KIT Secreted Signaling 0.4326 0.000000000000000000000003156314585378145 Scatter Plot
Source LCK Source LAMININ LAMININ ECM-Receptor 0.4739 0.000000000000000000000000000023371925881886888 Scatter Plot
Source LCK Target ncWNT ncWNT Secreted Signaling 0.4750 0.000000000000000000000000000016288273096878058 Scatter Plot
Source LCK Target MIF MIF Secreted Signaling 0.4774 0.00000000000000000000000000000779900761331727 Scatter Plot
Source LCK Target SEMA4 SEMA4 Cell-Cell Contact 0.4775 0.000000000000000000000000000007528009715018697 Scatter Plot
Source LCK Target WNT WNT Secreted Signaling 0.4922 0.0000000000000000000000000000000704169680449867 Scatter Plot
Source LCK Target ESAM ESAM Cell-Cell Contact 0.4952 0.000000000000000000000000000000026203437896957784 Scatter Plot
Source LCK Target CD34 CD34 Cell-Cell Contact 0.5099 0.00000000000000000000000000000000018677675587038666 Scatter Plot
Source LCK Target CD39 CD39 Cell-Cell Contact 0.5335 0.00000000000000000000000000000000000003857712067416452 Scatter Plot
Source LCK Target ICAM ICAM Cell-Cell Contact -0.3915 0.0000000000000000000924094452303332 Scatter Plot
Source LCK Target IFN-II IFN-II Secreted Signaling -0.3176 0.000000000000350911303391963 Scatter Plot
Source LCK Target CSF CSF Secreted Signaling -0.3055 0.000000000002926001523369058 Scatter Plot
Source LCK Target CD52 CD52 Cell-Cell Contact -0.2977 0.000000000010745155398365388 Scatter Plot
Source LCK Target VCAM VCAM Cell-Cell Contact -0.2602 0.0000000035005217016151772 Scatter Plot
Source LCK Target CCL CCL Secreted Signaling -0.2578 0.000000004921636879708877 Scatter Plot
Source LCK Target CEACAM CEACAM Cell-Cell Contact -0.2508 0.000000013038672524120109 Scatter Plot
Source LCK Target CLEC CLEC Cell-Cell Contact -0.2359 0.00000009488307966145472 Scatter Plot
Source LCK Target CXCL CXCL Secreted Signaling -0.1983 0.000007945257600137597 Scatter Plot
Source LCK Target ANNEXIN ANNEXIN Secreted Signaling -0.1956 0.00001059909039642295 Scatter Plot
Source LCK Target SEMA3 SEMA3 Secreted Signaling -0.1890 0.00002090670839117687 Scatter Plot
Source LCK Target IL17 IL17 Secreted Signaling -0.1721 0.0001100909418404 Scatter Plot
Source LCK Target COLLAGEN COLLAGEN ECM-Receptor -0.1613 0.0002935495790644 Scatter Plot
Source LCK Target VEGF VEGF Secreted Signaling -0.1558 0.0004716192403438 Scatter Plot
Source LCK Target COMPLEMENT COMPLEMENT Secreted Signaling -0.1503 0.0007493527768587 Scatter Plot
Source LCK Target GRN GRN Secreted Signaling -0.1095 0.0143053878960596 Scatter Plot

Cells that are targets of LCK from HSCs*

Cells that are source of LCK to HSCs*

    No cell populations

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.