Pathway: NOTCH

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Cell-Cell Contact

Details on the NOTCH pathway:

Specificity Index HSPC as target: 0.249
HSPC as source: 0.113

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the NOTCH pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target NOTCH Source IL16 IL16 Secreted Signaling 0.0984 0.0277562791766111 Scatter Plot
Target NOTCH Source CD34 CD34 Cell-Cell Contact 0.1008 0.0241796320041286 Scatter Plot
Target NOTCH Target PTN PTN Secreted Signaling 0.1014 0.0234223488852006 Scatter Plot
Target NOTCH Source GDF GDF Secreted Signaling 0.1025 0.0218462212216976 Scatter Plot
Target NOTCH Target ANGPTL ANGPTL Secreted Signaling 0.1033 0.0208238624567891 Scatter Plot
Target NOTCH Source PDGF PDGF Secreted Signaling 0.1040 0.0200531919772072 Scatter Plot
Target NOTCH Source OSM OSM Secreted Signaling 0.1041 0.0199499735413938 Scatter Plot
Target NOTCH Source CADM CADM Cell-Cell Contact 0.1053 0.0184681921286179 Scatter Plot
Target NOTCH Target CADM CADM Cell-Cell Contact 0.1053 0.0184681921286179 Scatter Plot
Target NOTCH Target FN1 FN1 ECM-Receptor 0.1060 0.0177556558343525 Scatter Plot
Target NOTCH Target MK MK Secreted Signaling 0.1064 0.0173656666752086 Scatter Plot
Target NOTCH Target NCAM NCAM Cell-Cell Contact 0.1101 0.0137811234579708 Scatter Plot
Target NOTCH Source VEGF VEGF Secreted Signaling 0.1145 0.0104043846146946 Scatter Plot
Target NOTCH Source FLT3 FLT3 Secreted Signaling 0.1200 0.0072391710486149 Scatter Plot
Target NOTCH Source IL2 IL2 Secreted Signaling 0.1210 0.0067319890039583 Scatter Plot
Target NOTCH Target SEMA6 SEMA6 Cell-Cell Contact 0.1255 0.0049608465268759 Scatter Plot
Target NOTCH Target SEMA3 SEMA3 Secreted Signaling 0.1272 0.0043774602013766 Scatter Plot
Source NOTCH Source APELIN APELIN Secreted Signaling 0.1320 0.0031108269063458 Scatter Plot
Target NOTCH Source APELIN APELIN Secreted Signaling 0.1328 0.0029226773096259 Scatter Plot
Target NOTCH Source LIFR LIFR Secreted Signaling 0.1333 0.0028116163753579 Scatter Plot
Source NOTCH Source AGRN AGRN ECM-Receptor 0.1353 0.0024269964640189 Scatter Plot
Target NOTCH Source LCK LCK Cell-Cell Contact 0.1362 0.0022757397512789 Scatter Plot
Target NOTCH Target PARs PARs Secreted Signaling 0.1369 0.0021484515404204 Scatter Plot
Target NOTCH Source IL7 IL7 Secreted Signaling 0.1370 0.0021409923959621 Scatter Plot
Source NOTCH Source SEMA6 SEMA6 Cell-Cell Contact 0.1377 0.002022578825322 Scatter Plot
Source NOTCH Source IL6 IL6 Secreted Signaling 0.1427 0.0013817289039069 Scatter Plot
Target NOTCH Source BMP BMP Secreted Signaling 0.1428 0.0013626648370082 Scatter Plot
Target NOTCH Source PROS PROS Secreted Signaling 0.1431 0.0013321698805362 Scatter Plot
Target NOTCH Source CDH CDH Cell-Cell Contact 0.1469 0.000987632853654 Scatter Plot
Target NOTCH Source ESAM ESAM Cell-Cell Contact 0.1491 0.0008233440627916 Scatter Plot
Target NOTCH Target JAM JAM Cell-Cell Contact 0.1504 0.0007433447866864 Scatter Plot
Target NOTCH Source NT NT Secreted Signaling 0.1511 0.0006974068714108 Scatter Plot
Target NOTCH Source CCL CCL Secreted Signaling 0.1582 0.0003837543297806 Scatter Plot
Target NOTCH Source LAMININ LAMININ ECM-Receptor 0.1590 0.000356986959363 Scatter Plot
Target NOTCH Source EPHB EPHB Cell-Cell Contact 0.1644 0.0002219136743756 Scatter Plot
Target NOTCH Source ICAM ICAM Cell-Cell Contact 0.1647 0.0002171609917385 Scatter Plot
Target NOTCH Source BST2 BST2 Cell-Cell Contact 0.1669 0.0001780861173814 Scatter Plot
Source NOTCH Source WNT WNT Secreted Signaling 0.1707 0.0001250555500808 Scatter Plot
Target NOTCH Source GAS GAS Secreted Signaling 0.1710 0.0001223039628862 Scatter Plot
Target NOTCH Target SEMA5 SEMA5 Cell-Cell Contact 0.1761 0.0000755142890996575 Scatter Plot
Target NOTCH Target NPR2 NPR2 Secreted Signaling 0.1771 0.00006831786409523592 Scatter Plot
Target NOTCH Source LIGHT LIGHT Secreted Signaling 0.1780 0.00006257778173734204 Scatter Plot
Target NOTCH Target SEMA7 SEMA7 Cell-Cell Contact 0.1789 0.00005759348111429045 Scatter Plot
Target NOTCH Source TWEAK TWEAK Secreted Signaling 0.1814 0.00004524741066414396 Scatter Plot
Target NOTCH Source CD86 CD86 Cell-Cell Contact 0.1814 0.00004498538139480129 Scatter Plot
Target NOTCH Source VCAM VCAM Cell-Cell Contact 0.1815 0.000044734632375303166 Scatter Plot
Target NOTCH Target WNT WNT Secreted Signaling 0.1826 0.00003990019778539784 Scatter Plot
Target NOTCH Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.1884 0.000022226711501898855 Scatter Plot
Target NOTCH Source PSAP PSAP Secreted Signaling 0.1969 0.000009229130226985263 Scatter Plot
Source NOTCH Source ncWNT ncWNT Secreted Signaling 0.2054 0.000003648238534769375 Scatter Plot
Target NOTCH Source SEMA7 SEMA7 Cell-Cell Contact 0.2064 0.0000032489525577780835 Scatter Plot
Source NOTCH Source CCL CCL Secreted Signaling 0.2106 0.0000020171806907274946 Scatter Plot
Target NOTCH Source JAM JAM Cell-Cell Contact 0.2107 0.000001991172371962494 Scatter Plot
Target NOTCH Source COLLAGEN COLLAGEN ECM-Receptor 0.2147 0.0000012647103452389333 Scatter Plot
Target NOTCH Target FGF FGF Secreted Signaling 0.2173 0.000000925840850365271 Scatter Plot
Target NOTCH Target THBS THBS ECM-Receptor 0.2182 0.0000008365386302508357 Scatter Plot
Target NOTCH Source MHC-I MHC-I Cell-Cell Contact 0.2215 0.0000005681413770956471 Scatter Plot
Source NOTCH Source EPHB EPHB Cell-Cell Contact 0.2269 0.0000002914883351872114 Scatter Plot
Source NOTCH Source CD46 CD46 Cell-Cell Contact 0.2271 0.0000002866874009982812 Scatter Plot
Target NOTCH Target KIT KIT Secreted Signaling 0.2334 0.0000001302469492792849 Scatter Plot
Source NOTCH Source SEMA3 SEMA3 Secreted Signaling 0.2340 0.0000001205733486351031 Scatter Plot
Target NOTCH Source CD45 CD45 Cell-Cell Contact 0.2364 0.00000008897167910074603 Scatter Plot
Target NOTCH Source ANGPT ANGPT Secreted Signaling 0.2387 0.00000006537399682307373 Scatter Plot
Source NOTCH Source CADM CADM Cell-Cell Contact 0.2389 0.00000006382441857566373 Scatter Plot
Target NOTCH Source MHC-II MHC-II Cell-Cell Contact 0.2446 0.000000030077730072266693 Scatter Plot
Source NOTCH Source LIGHT LIGHT Secreted Signaling 0.2491 0.00000001641185713125178 Scatter Plot
Source NOTCH Source CD39 CD39 Cell-Cell Contact 0.2575 0.000000005132924122629 Scatter Plot
Source NOTCH Source PSAP PSAP Secreted Signaling 0.2694 0.0000000009239167031056207 Scatter Plot
Source NOTCH Source RANKL RANKL Secreted Signaling 0.2926 0.00000000002485872407956954 Scatter Plot
Source NOTCH Source MK MK Secreted Signaling 0.3093 0.000000000001510625342751272 Scatter Plot
Source NOTCH Source LIFR LIFR Secreted Signaling 0.3187 0.00000000000028706480949197743 Scatter Plot
Source NOTCH Source IGF IGF Secreted Signaling 0.3302 0.000000000000035073958366783613 Scatter Plot
Source NOTCH Source ANGPT ANGPT Secreted Signaling 0.3491 0.0000000000000008887353129223626 Scatter Plot
Source NOTCH Source CDH CDH Cell-Cell Contact 0.3695 0.000000000000000012569185159623589 Scatter Plot
Source NOTCH Source NT NT Secreted Signaling 0.3747 0.000000000000000004049952398483281 Scatter Plot
Source NOTCH Source LAMININ LAMININ ECM-Receptor 0.3871 0.000000000000000000250653355233948 Scatter Plot
Source NOTCH Source BMP BMP Secreted Signaling 0.4027 0.000000000000000000006361773466189124 Scatter Plot
Source NOTCH Source TWEAK TWEAK Secreted Signaling 0.4049 0.00000000000000000000377488730605242 Scatter Plot
Source NOTCH Source GAS GAS Secreted Signaling 0.4179 0.00000000000000000000014901479458714724 Scatter Plot
Source NOTCH Source SEMA7 SEMA7 Cell-Cell Contact 0.4363 0.0000000000000000000000011655164284992991 Scatter Plot
Source NOTCH Source PDGF PDGF Secreted Signaling 0.4446 0.00000000000000000000000011967670595464542 Scatter Plot
Source NOTCH Source TGFb TGFb Secreted Signaling -0.3338 0.000000000000017623404743097277 Scatter Plot
Target NOTCH Source COMPLEMENT COMPLEMENT Secreted Signaling -0.2163 0.0000010430349813017616 Scatter Plot
Source NOTCH Source ANGPTL ANGPTL Secreted Signaling -0.2149 0.000001238385137683876 Scatter Plot
Target NOTCH Source MIF MIF Secreted Signaling -0.1832 0.0000378634105100972 Scatter Plot
Source NOTCH Source CLEC CLEC Cell-Cell Contact -0.1830 0.00003826275778144974 Scatter Plot
Target NOTCH Source SEMA4 SEMA4 Cell-Cell Contact -0.1604 0.0003157912751871 Scatter Plot
Target NOTCH Source VISTA VISTA Cell-Cell Contact -0.1521 0.0006446013337483 Scatter Plot
Target NOTCH Source SELL SELL Cell-Cell Contact -0.1383 0.0019403551229052 Scatter Plot
Target NOTCH Target ICAM ICAM Cell-Cell Contact -0.1373 0.002094081921066 Scatter Plot
Target NOTCH Source CD52 CD52 Cell-Cell Contact -0.1367 0.0021858116155343 Scatter Plot
Source NOTCH Source SEMA4 SEMA4 Cell-Cell Contact -0.1314 0.0032548481587782 Scatter Plot
Target NOTCH Source TGFb TGFb Secreted Signaling -0.1298 0.0036400076182783 Scatter Plot
Target NOTCH Target IL17 IL17 Secreted Signaling -0.1063 0.0174225103051476 Scatter Plot
Target NOTCH Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.1046 0.0192579100646094 Scatter Plot
Target NOTCH Source CLEC CLEC Cell-Cell Contact -0.1032 0.0210074372837383 Scatter Plot
Target NOTCH Source PARs PARs Secreted Signaling -0.1008 0.0242023903100317 Scatter Plot
Target NOTCH Source APP APP Cell-Cell Contact -0.0995 0.0261135477642974 Scatter Plot
Target NOTCH Source BAFF BAFF Secreted Signaling -0.0961 0.0316500430414761 Scatter Plot
Source NOTCH Target GALECTIN GALECTIN Secreted Signaling 0.0961 0.0316421190442126 Scatter Plot
Target NOTCH Target RANKL RANKL Secreted Signaling 0.0984 0.0277999960687981 Scatter Plot
Source NOTCH Source ICOS ICOS Cell-Cell Contact 0.1025 0.0219254474094919 Scatter Plot
Target NOTCH Target SPP1 SPP1 Secreted Signaling 0.1049 0.0189451140093339 Scatter Plot
Source NOTCH Source FN1 FN1 ECM-Receptor 0.1057 0.0180318348996326 Scatter Plot
Target NOTCH Target SELL SELL Cell-Cell Contact 0.1061 0.0176357595658132 Scatter Plot
Source NOTCH Source GDF GDF Secreted Signaling 0.1080 0.0156951771891833 Scatter Plot
Source NOTCH Target SEMA3 SEMA3 Secreted Signaling 0.1086 0.015121520356405 Scatter Plot
Source NOTCH Target MK MK Secreted Signaling 0.1088 0.0149368663070491 Scatter Plot
Target NOTCH Target NCAM NCAM Cell-Cell Contact 0.1102 0.0136952964266626 Scatter Plot
Target NOTCH Target ACTIVIN ACTIVIN Secreted Signaling 0.1142 0.0106222043563779 Scatter Plot
Source NOTCH Source PTN PTN Secreted Signaling 0.1160 0.0094380546587214 Scatter Plot
Source NOTCH Target SELPLG SELPLG Cell-Cell Contact 0.1213 0.0066251503443333 Scatter Plot
Source NOTCH Target SPP1 SPP1 Secreted Signaling 0.1310 0.003328096893791 Scatter Plot
Source NOTCH Source CD1D2 CD1D2 Cell-Cell Contact 0.1366 0.0022011395519469 Scatter Plot
Target NOTCH Target CD200 CD200 Cell-Cell Contact 0.1414 0.0015271431722326 Scatter Plot
Source NOTCH Source ANGPTL ANGPTL Secreted Signaling 0.1430 0.0013472326896414 Scatter Plot
Target NOTCH Target TENASCIN TENASCIN ECM-Receptor 0.1455 0.001107094071001 Scatter Plot
Target NOTCH Target CDH CDH Cell-Cell Contact 0.1469 0.000987632853654 Scatter Plot
Target NOTCH Target TGFb TGFb Secreted Signaling 0.1475 0.000937502347661 Scatter Plot
Target NOTCH Target ESAM ESAM Cell-Cell Contact 0.1491 0.0008233440627916 Scatter Plot
Target NOTCH Target IL6 IL6 Secreted Signaling 0.1505 0.000734707516724 Scatter Plot
Target NOTCH Target BAFF BAFF Secreted Signaling 0.1513 0.0006885870114878 Scatter Plot
Target NOTCH Target OSM OSM Secreted Signaling 0.1520 0.0006471598576586 Scatter Plot
Target NOTCH Target ANGPT ANGPT Secreted Signaling 0.1523 0.0006328485696785 Scatter Plot
Source NOTCH Source GRN GRN Secreted Signaling 0.1563 0.0004534084847722 Scatter Plot
Source NOTCH Source CXCL CXCL Secreted Signaling 0.1568 0.0004329718024743 Scatter Plot
Target NOTCH Target NODAL NODAL Secreted Signaling 0.1576 0.0004024532942791 Scatter Plot
Target NOTCH Target SLURP SLURP Secreted Signaling 0.1594 0.0003451888953151 Scatter Plot
Target NOTCH Target GALECTIN GALECTIN Secreted Signaling 0.1601 0.0003256131511318 Scatter Plot
Source NOTCH Target FN1 FN1 ECM-Receptor 0.1603 0.0003202747524012 Scatter Plot
Source NOTCH Target RANKL RANKL Secreted Signaling 0.1640 0.0002297236650448 Scatter Plot
Source NOTCH Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1644 0.0002225403473063 Scatter Plot
Source NOTCH Target COLLAGEN COLLAGEN ECM-Receptor 0.1744 0.00008821269085688779 Scatter Plot
Source NOTCH Target NODAL NODAL Secreted Signaling 0.1755 0.0000795848749524938 Scatter Plot
Target NOTCH Target PDGF PDGF Secreted Signaling 0.1764 0.00007282192072783367 Scatter Plot
Target NOTCH Target NPR2 NPR2 Secreted Signaling 0.1772 0.00006748058697605588 Scatter Plot
Target NOTCH Target SEMA4 SEMA4 Cell-Cell Contact 0.1791 0.000056639910620598455 Scatter Plot
Source NOTCH Target PTN PTN Secreted Signaling 0.1879 0.00002345075896133448 Scatter Plot
Source NOTCH Source VEGF VEGF Secreted Signaling 0.1890 0.00002109846534985275 Scatter Plot
Source NOTCH Target SEMA7 SEMA7 Cell-Cell Contact 0.1918 0.000015771701236102007 Scatter Plot
Source NOTCH Source CD86 CD86 Cell-Cell Contact 0.1948 0.000011502957517049605 Scatter Plot
Source NOTCH Target SEMA6 SEMA6 Cell-Cell Contact 0.1948 0.00001143579239579758 Scatter Plot
Source NOTCH Target THY1 THY1 Cell-Cell Contact 0.1960 0.000010101378167235769 Scatter Plot
Target NOTCH Target APP APP Cell-Cell Contact 0.1974 0.000008738498216346881 Scatter Plot
Target NOTCH Target IGF IGF Secreted Signaling 0.1991 0.000007227375142953247 Scatter Plot
Source NOTCH Source IL16 IL16 Secreted Signaling 0.2008 0.000006039111431131975 Scatter Plot
Source NOTCH Target LAMININ LAMININ ECM-Receptor 0.2032 0.000004663363864611223 Scatter Plot
Target NOTCH Target MIF MIF Secreted Signaling 0.2042 0.000004176044057208868 Scatter Plot
Target NOTCH Target ncWNT ncWNT Secreted Signaling 0.2055 0.000003587919373075912 Scatter Plot
Target NOTCH Target COLLAGEN COLLAGEN ECM-Receptor 0.2071 0.0000029980604053225264 Scatter Plot
Source NOTCH Target SEMA5 SEMA5 Cell-Cell Contact 0.2132 0.0000015020323292077092 Scatter Plot
Source NOTCH Target IL6 IL6 Secreted Signaling 0.2134 0.0000014647382962150222 Scatter Plot
Source NOTCH Target ANGPTL ANGPTL Secreted Signaling 0.2144 0.0000013138874567614736 Scatter Plot
Target NOTCH Target EPHB EPHB Cell-Cell Contact 0.2144 0.0000013035956415753178 Scatter Plot
Source NOTCH Target CD23 CD23 Cell-Cell Contact 0.2146 0.000001283720710429317 Scatter Plot
Source NOTCH Target OSM OSM Secreted Signaling 0.2159 0.0000011031263624373218 Scatter Plot
Source NOTCH Target GDF GDF Secreted Signaling 0.2166 0.000001011915684490045 Scatter Plot
Target NOTCH Target CD39 CD39 Cell-Cell Contact 0.2174 0.0000009228177988483058 Scatter Plot
Target NOTCH Target CD34 CD34 Cell-Cell Contact 0.2185 0.0000008067148416680493 Scatter Plot
Source NOTCH Target KIT KIT Secreted Signaling 0.2209 0.0000006046045943665482 Scatter Plot
Source NOTCH Target PARs PARs Secreted Signaling 0.2263 0.0000003150669258810338 Scatter Plot
Source NOTCH Source IL2 IL2 Secreted Signaling 0.2320 0.0000001558864017019092 Scatter Plot
Source NOTCH Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.2323 0.00000014944278559524098 Scatter Plot
Source NOTCH Target VTN VTN ECM-Receptor 0.2350 0.00000010638424272068345 Scatter Plot
Target NOTCH Target CD22 CD22 Cell-Cell Contact 0.2364 0.00000008897167910074603 Scatter Plot
Source NOTCH Target CADM CADM Cell-Cell Contact 0.2389 0.00000006382441857566373 Scatter Plot
Source NOTCH Target EPHA EPHA Cell-Cell Contact 0.2391 0.0000000627270062906996 Scatter Plot
Source NOTCH Target VEGF VEGF Secreted Signaling 0.2403 0.000000053557368964560945 Scatter Plot
Source NOTCH Target VISFATIN VISFATIN Secreted Signaling 0.2420 0.000000042745885915856185 Scatter Plot
Source NOTCH Target THBS THBS ECM-Receptor 0.2445 0.00000003054769570558409 Scatter Plot
Source NOTCH Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2526 0.000000010213866588768472 Scatter Plot
Source NOTCH Source ICAM ICAM Cell-Cell Contact 0.2529 0.000000009741652858439709 Scatter Plot
Source NOTCH Target BAFF BAFF Secreted Signaling 0.2555 0.000000006812702965692838 Scatter Plot
Source NOTCH Target TGFb TGFb Secreted Signaling 0.2563 0.0000000060996385289393445 Scatter Plot
Source NOTCH Target ACTIVIN ACTIVIN Secreted Signaling 0.2601 0.000000003548262195265718 Scatter Plot
Source NOTCH Target VWF VWF ECM-Receptor 0.2609 0.000000003174656994710916 Scatter Plot
Source NOTCH Target CSPG4 CSPG4 Cell-Cell Contact 0.2700 0.0000000008460273567317523 Scatter Plot
Source NOTCH Source CD45 CD45 Cell-Cell Contact 0.2721 0.0000000006132698491033568 Scatter Plot
Source NOTCH Target CD22 CD22 Cell-Cell Contact 0.2721 0.000000000613269849103357 Scatter Plot
Source NOTCH Target EPHB EPHB Cell-Cell Contact 0.2742 0.0000000004514523000790579 Scatter Plot
Source NOTCH Source LCK LCK Cell-Cell Contact 0.2791 0.00000000021389673692084068 Scatter Plot
Source NOTCH Target SEMA4 SEMA4 Cell-Cell Contact 0.2858 0.00000000007404367124127278 Scatter Plot
Source NOTCH Source CX3C CX3C Secreted Signaling 0.2897 0.000000000039818109437200935 Scatter Plot
Source NOTCH Target PERIOSTIN PERIOSTIN Secreted Signaling 0.2925 0.00000000002548811700066765 Scatter Plot
Source NOTCH Target NRG NRG Secreted Signaling 0.2947 0.000000000017847189545084705 Scatter Plot
Source NOTCH Target CD200 CD200 Cell-Cell Contact 0.3010 0.000000000006258415166626563 Scatter Plot
Source NOTCH Target AGT AGT Secreted Signaling 0.3049 0.000000000003225309499801583 Scatter Plot
Source NOTCH Target BSP BSP ECM-Receptor 0.3060 0.0000000000026542618686430398 Scatter Plot
Source NOTCH Target BMP BMP Secreted Signaling 0.3139 0.0000000000006820504493277435 Scatter Plot
Source NOTCH Target DMP1 DMP1 ECM-Receptor 0.3159 0.0000000000004723693691899284 Scatter Plot
Source NOTCH Source PROS PROS Secreted Signaling 0.3192 0.0000000000002622725791815752 Scatter Plot
Source NOTCH Target ANGPT ANGPT Secreted Signaling 0.3273 0.00000000000005967296438271812 Scatter Plot
Source NOTCH Target NCAM NCAM Cell-Cell Contact 0.3295 0.000000000000039894334188079103 Scatter Plot
Source NOTCH Target TENASCIN TENASCIN ECM-Receptor 0.3376 0.000000000000008511680012410848 Scatter Plot
Source NOTCH Target IGF IGF Secreted Signaling 0.3471 0.0000000000000013155249094551938 Scatter Plot
Source NOTCH Target CD39 CD39 Cell-Cell Contact 0.3647 0.0000000000000000356234558741597 Scatter Plot
Source NOTCH Source IL7 IL7 Secreted Signaling 0.3671 0.00000000000000002104594753433572 Scatter Plot
Source NOTCH Target CDH CDH Cell-Cell Contact 0.3695 0.000000000000000012569185159623589 Scatter Plot
Source NOTCH Source FLT3 FLT3 Secreted Signaling 0.3703 0.000000000000000010617823565493148 Scatter Plot
Source NOTCH Source NT NT Secreted Signaling 0.3747 0.000000000000000004044712963312997 Scatter Plot
Source NOTCH Target APP APP Cell-Cell Contact 0.3792 0.0000000000000000015250958438275521 Scatter Plot
Source NOTCH Source COLLAGEN COLLAGEN ECM-Receptor 0.3845 0.0000000000000000004567601471149404 Scatter Plot
Source NOTCH Target MIF MIF Secreted Signaling 0.3903 0.00000000000000000012073257258578023 Scatter Plot
Source NOTCH Source BST2 BST2 Cell-Cell Contact 0.3925 0.00000000000000000007175352460839182 Scatter Plot
Source NOTCH Target NPR2 NPR2 Secreted Signaling 0.3981 0.000000000000000000019360455197588422 Scatter Plot
Source NOTCH Source MHC-I MHC-I Cell-Cell Contact 0.4018 0.00000000000000000000805800174240921 Scatter Plot
Source NOTCH Source MHC-II MHC-II Cell-Cell Contact 0.4019 0.000000000000000000007805396680153493 Scatter Plot
Source NOTCH Source CSF CSF Secreted Signaling 0.4045 0.000000000000000000004169425533176949 Scatter Plot
Source NOTCH Source ESAM ESAM Cell-Cell Contact 0.4115 0.0000000000000000000007416476051732817 Scatter Plot
Source NOTCH Target ESAM ESAM Cell-Cell Contact 0.4115 0.0000000000000000000007416476051732817 Scatter Plot
Source NOTCH Target FGF FGF Secreted Signaling 0.4119 0.0000000000000000000006704900515772481 Scatter Plot
Source NOTCH Target SLURP SLURP Secreted Signaling 0.4174 0.00000000000000000000016686274944344971 Scatter Plot
Source NOTCH Target ncWNT ncWNT Secreted Signaling 0.4321 0.0000000000000000000000036760629762151375 Scatter Plot
Source NOTCH Target WNT WNT Secreted Signaling 0.4517 0.000000000000000000000000016287228416175523 Scatter Plot
Source NOTCH Target CD34 CD34 Cell-Cell Contact 0.4589 0.000000000000000000000000002066072946931307 Scatter Plot
Source NOTCH Target JAM JAM Cell-Cell Contact 0.4685 0.0000000000000000000000000001199840984475954 Scatter Plot
Source NOTCH Source JAM JAM Cell-Cell Contact 0.4960 0.00000000000000000000000000000002068518722680856 Scatter Plot
Source NOTCH Source CD52 CD52 Cell-Cell Contact -0.3435 0.000000000000002705391037624195 Scatter Plot
Source NOTCH Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.2847 0.00000000008802169205933805 Scatter Plot
Source NOTCH Source SELL SELL Cell-Cell Contact -0.2634 0.0000000022093892570212117 Scatter Plot
Source NOTCH Target ICAM ICAM Cell-Cell Contact -0.2422 0.00000004167709826437204 Scatter Plot
Target NOTCH Target VCAM VCAM Cell-Cell Contact -0.2241 0.00000041065691043734393 Scatter Plot
Source NOTCH Source MIF MIF Secreted Signaling -0.2142 0.0000013376911044439135 Scatter Plot
Source NOTCH Source SELPLG SELPLG Cell-Cell Contact -0.2109 0.000001959987631491152 Scatter Plot
Source NOTCH Source COMPLEMENT COMPLEMENT Secreted Signaling -0.1951 0.000011165778914508734 Scatter Plot
Source NOTCH Target CLEC CLEC Cell-Cell Contact -0.1939 0.000012561741140086924 Scatter Plot
Source NOTCH Source PARs PARs Secreted Signaling -0.1833 0.00003735326594584235 Scatter Plot
Source NOTCH Target CXCL CXCL Secreted Signaling -0.1805 0.0000492458806442336 Scatter Plot
Source NOTCH Target CD52 CD52 Cell-Cell Contact -0.1726 0.0001049707160055 Scatter Plot
Target NOTCH Target CXCL CXCL Secreted Signaling -0.1717 0.0001142955047946 Scatter Plot
Source NOTCH Source IL1 IL1 Secreted Signaling -0.1586 0.0003701007282662 Scatter Plot
Source NOTCH Target CCL CCL Secreted Signaling -0.1560 0.0004640846580185 Scatter Plot
Source NOTCH Target CSF CSF Secreted Signaling -0.1541 0.0005434942318885 Scatter Plot
Source NOTCH Source TNF TNF Secreted Signaling -0.1461 0.0010497563642819 Scatter Plot
Source NOTCH Source NKG2D NKG2D Cell-Cell Contact -0.1283 0.0040668109717443 Scatter Plot
Target NOTCH Target VEGF VEGF Secreted Signaling -0.1196 0.0074301850309396 Scatter Plot
Source NOTCH Source GALECTIN GALECTIN Secreted Signaling -0.1158 0.0095319367636798 Scatter Plot
Target NOTCH Target CD52 CD52 Cell-Cell Contact -0.1143 0.0105416367874237 Scatter Plot
Source NOTCH Source CCL CCL Secreted Signaling -0.1140 0.010771160991436 Scatter Plot
Source NOTCH Target ANNEXIN ANNEXIN Secreted Signaling -0.1119 0.0122535339334584 Scatter Plot
Target NOTCH Target COMPLEMENT COMPLEMENT Secreted Signaling -0.1106 0.0133553516066245 Scatter Plot
Target NOTCH Target CLEC CLEC Cell-Cell Contact -0.1097 0.0141306346344987 Scatter Plot
Source NOTCH Target IFN-II IFN-II Secreted Signaling -0.1096 0.0142458058857234 Scatter Plot
Target NOTCH Target CCL CCL Secreted Signaling -0.1089 0.0147997516319341 Scatter Plot
Source NOTCH Target COLLAGEN COLLAGEN ECM-Receptor -0.1076 0.016127408871704 Scatter Plot
Target NOTCH Target GRN GRN Secreted Signaling -0.0993 0.0263946760039753 Scatter Plot
Source NOTCH Source SPP1 SPP1 Secreted Signaling -0.0979 0.0285340950449814 Scatter Plot
Source NOTCH Source CD34 CD34 Cell-Cell Contact -0.0969 0.0303011459039903 Scatter Plot

Cells that are targets of NOTCH from HSCs*

Cells that are source of NOTCH to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.