Pathway: CD86

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Cell-Cell Contact

Details on the CD86 pathway:

Specificity Index HSPC as target: 0.350
HSPC as source: 0.454

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the CD86 pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target CD86 Source CLEC CLEC Cell-Cell Contact 0.0962 0.0315789639158008 Scatter Plot
Target CD86 Source LAMININ LAMININ ECM-Receptor 0.0988 0.0271566219546136 Scatter Plot
Target CD86 Source PROS PROS Secreted Signaling 0.0989 0.0270684179887097 Scatter Plot
Target CD86 Target GRN GRN Secreted Signaling 0.1007 0.0243818994630157 Scatter Plot
Target CD86 Source VISTA VISTA Cell-Cell Contact 0.1012 0.023568131850183 Scatter Plot
Target CD86 Target CD52 CD52 Cell-Cell Contact 0.1042 0.0198343311846046 Scatter Plot
Target CD86 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1052 0.0186214815411334 Scatter Plot
Target CD86 Target BSP BSP ECM-Receptor 0.1068 0.0168762405905028 Scatter Plot
Target CD86 Source SELPLG SELPLG Cell-Cell Contact 0.1069 0.016792165632798 Scatter Plot
Source CD86 Source THBS THBS ECM-Receptor 0.1075 0.0161957655564615 Scatter Plot
Target CD86 Source CD46 CD46 Cell-Cell Contact 0.1081 0.0155508611103616 Scatter Plot
Target CD86 Source WNT WNT Secreted Signaling 0.1097 0.0140939062428995 Scatter Plot
Target CD86 Target ANGPTL ANGPTL Secreted Signaling 0.1160 0.0094231513610278 Scatter Plot
Target CD86 Target PERIOSTIN PERIOSTIN Secreted Signaling 0.1166 0.0090479066573569 Scatter Plot
Target CD86 Source GRN GRN Secreted Signaling 0.1177 0.008441482162284 Scatter Plot
Target CD86 Source NT NT Secreted Signaling 0.1178 0.0083666102492542 Scatter Plot
Target CD86 Target SEMA3 SEMA3 Secreted Signaling 0.1178 0.008359056433286 Scatter Plot
Target CD86 Source CCL CCL Secreted Signaling 0.1178 0.0083552289277519 Scatter Plot
Target CD86 Target CCL CCL Secreted Signaling 0.1189 0.0077743409199894 Scatter Plot
Target CD86 Source RANKL RANKL Secreted Signaling 0.1204 0.0070543518369421 Scatter Plot
Target CD86 Source SEMA4 SEMA4 Cell-Cell Contact 0.1217 0.0064332807261242 Scatter Plot
Target CD86 Source PARs PARs Secreted Signaling 0.1234 0.0057093290509204 Scatter Plot
Target CD86 Target ICAM ICAM Cell-Cell Contact 0.1256 0.0049092078274598 Scatter Plot
Target CD86 Source SELL SELL Cell-Cell Contact 0.1268 0.004529725773817 Scatter Plot
Source CD86 Source WNT WNT Secreted Signaling 0.1310 0.003348334494615 Scatter Plot
Target CD86 Source SEMA6 SEMA6 Cell-Cell Contact 0.1372 0.002101490656398 Scatter Plot
Target CD86 Target SEMA4 SEMA4 Cell-Cell Contact 0.1382 0.0019541060543429 Scatter Plot
Target CD86 Target CLEC CLEC Cell-Cell Contact 0.1393 0.0017986594032308 Scatter Plot
Target CD86 Target CADM CADM Cell-Cell Contact 0.1394 0.0017748205716474 Scatter Plot
Target CD86 Source CADM CADM Cell-Cell Contact 0.1394 0.0017748205716474 Scatter Plot
Source CD86 Source NT NT Secreted Signaling 0.1431 0.0013376353744471 Scatter Plot
Source CD86 Source CD46 CD46 Cell-Cell Contact 0.1450 0.0011472509046501 Scatter Plot
Source CD86 Source OSM OSM Secreted Signaling 0.1463 0.001037105888448 Scatter Plot
Target CD86 Source ICOS ICOS Cell-Cell Contact 0.1493 0.0008139995426725 Scatter Plot
Source CD86 Source SEMA3 SEMA3 Secreted Signaling 0.1579 0.00039249581633 Scatter Plot
Target CD86 Target SELPLG SELPLG Cell-Cell Contact 0.1599 0.0003318111246545 Scatter Plot
Source CD86 Source ncWNT ncWNT Secreted Signaling 0.1599 0.0003316553072032 Scatter Plot
Target CD86 Source ncWNT ncWNT Secreted Signaling 0.1628 0.0002571125134673 Scatter Plot
Source CD86 Source CADM CADM Cell-Cell Contact 0.1672 0.0001721806251976 Scatter Plot
Source CD86 Source CX3C CX3C Secreted Signaling 0.1739 0.00009281733997263268 Scatter Plot
Source CD86 Source RANKL RANKL Secreted Signaling 0.1929 0.000014036232836045248 Scatter Plot
Source CD86 Source NOTCH NOTCH Cell-Cell Contact 0.1948 0.000011502957517049605 Scatter Plot
Source CD86 Source LIFR LIFR Secreted Signaling 0.1960 0.000010126252193277035 Scatter Plot
Target CD86 Source PSAP PSAP Secreted Signaling 0.2086 0.0000025331432370321237 Scatter Plot
Target CD86 Target CSF CSF Secreted Signaling 0.2240 0.0000004193707704745852 Scatter Plot
Source CD86 Source CD34 CD34 Cell-Cell Contact 0.2313 0.0000001684165508016776 Scatter Plot
Source CD86 Source ANGPTL ANGPTL Secreted Signaling 0.2328 0.00000014016138046045178 Scatter Plot
Source CD86 Source PROS PROS Secreted Signaling 0.2356 0.0000000976362685411238 Scatter Plot
Source CD86 Source GDF GDF Secreted Signaling 0.2408 0.00000004986660634534382 Scatter Plot
Source CD86 Source PDGF PDGF Secreted Signaling 0.2475 0.00000002042772525517753 Scatter Plot
Source CD86 Source CD39 CD39 Cell-Cell Contact 0.2502 0.000000014236208829859132 Scatter Plot
Source CD86 Source LIGHT LIGHT Secreted Signaling 0.2753 0.00000000038062515931238224 Scatter Plot
Source CD86 Source CD1D2 CD1D2 Cell-Cell Contact 0.2808 0.00000000016236122966323915 Scatter Plot
Source CD86 Source IGF IGF Secreted Signaling 0.2850 0.00000000008404399720288205 Scatter Plot
Source CD86 Source FLT3 FLT3 Secreted Signaling 0.2852 0.00000000008141581767393192 Scatter Plot
Source CD86 Source CCL CCL Secreted Signaling 0.2936 0.00000000002130918576185015 Scatter Plot
Source CD86 Source CSF CSF Secreted Signaling 0.2979 0.000000000010411549744324592 Scatter Plot
Source CD86 Source LAMININ LAMININ ECM-Receptor 0.3027 0.000000000004659900036225005 Scatter Plot
Source CD86 Source CXCL CXCL Secreted Signaling 0.3051 0.000000000003112899788300759 Scatter Plot
Source CD86 Source CDH CDH Cell-Cell Contact 0.3215 0.00000000000017306948324675926 Scatter Plot
Source CD86 Source EPHB EPHB Cell-Cell Contact 0.3287 0.000000000000046207436028833277 Scatter Plot
Source CD86 Source ICAM ICAM Cell-Cell Contact 0.3323 0.000000000000023523059878014442 Scatter Plot
Source CD86 Source VCAM VCAM Cell-Cell Contact 0.3345 0.000000000000015572344447252775 Scatter Plot
Source CD86 Source VEGF VEGF Secreted Signaling 0.3352 0.00000000000001363321110570428 Scatter Plot
Source CD86 Source BST2 BST2 Cell-Cell Contact 0.3440 0.000000000000002454405543103817 Scatter Plot
Source CD86 Source CD45 CD45 Cell-Cell Contact 0.3630 0.00000000000000005091721527634807 Scatter Plot
Source CD86 Source IL2 IL2 Secreted Signaling 0.3795 0.0000000000000000014209165634122706 Scatter Plot
Source CD86 Source BMP BMP Secreted Signaling 0.3825 0.0000000000000000007190278983498605 Scatter Plot
Source CD86 Source IL16 IL16 Secreted Signaling 0.3865 0.0000000000000000002904493700412741 Scatter Plot
Source CD86 Source TWEAK TWEAK Secreted Signaling 0.3908 0.00000000000000000010633555734410845 Scatter Plot
Source CD86 Source MK MK Secreted Signaling 0.4008 0.000000000000000000010072360871227996 Scatter Plot
Source CD86 Source JAM JAM Cell-Cell Contact 0.4022 0.000000000000000000007303568708767694 Scatter Plot
Source CD86 Source ESAM ESAM Cell-Cell Contact 0.4067 0.0000000000000000000024014537248858 Scatter Plot
Source CD86 Source SEMA7 SEMA7 Cell-Cell Contact 0.4206 0.00000000000000000000007376312023776967 Scatter Plot
Source CD86 Source IL7 IL7 Secreted Signaling 0.4390 0.0000000000000000000000005644740975118691 Scatter Plot
Source CD86 Source PSAP PSAP Secreted Signaling 0.4441 0.0000000000000000000000001386641612528699 Scatter Plot
Source CD86 Source GAS GAS Secreted Signaling 0.4581 0.0000000000000000000000000025576264751195725 Scatter Plot
Source CD86 Source ANGPT ANGPT Secreted Signaling 0.4936 0.00000000000000000000000000000004534665616460218 Scatter Plot
Source CD86 Source COLLAGEN COLLAGEN ECM-Receptor 0.5335 0.00000000000000000000000000000000000003973301230335731 Scatter Plot
Source CD86 Source MHC-I MHC-I Cell-Cell Contact 0.5382 0.000000000000000000000000000000000000006789100758384945 Scatter Plot
Source CD86 Source MHC-II MHC-II Cell-Cell Contact 0.6154 0.000000000000000000000000000000000000000000000000000018837810051978882 Scatter Plot
Source CD86 Source COMPLEMENT COMPLEMENT Secreted Signaling -0.2670 0.00000000131632424456587 Scatter Plot
Source CD86 Source MIF MIF Secreted Signaling -0.2631 0.000000002329131482891329 Scatter Plot
Source CD86 Source TGFb TGFb Secreted Signaling -0.2576 0.0000000050585577393293276 Scatter Plot
Source CD86 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.2398 0.00000005677010099607709 Scatter Plot
Source CD86 Source NCAM NCAM Cell-Cell Contact -0.2147 0.0000012605772579925249 Scatter Plot
Source CD86 Source CD52 CD52 Cell-Cell Contact -0.2054 0.000003648310177530732 Scatter Plot
Source CD86 Source CLEC CLEC Cell-Cell Contact -0.1965 0.000009587807186382376 Scatter Plot
Source CD86 Source PARs PARs Secreted Signaling -0.1871 0.000025584083743814866 Scatter Plot
Source CD86 Source VISTA VISTA Cell-Cell Contact -0.1810 0.00004673504650396455 Scatter Plot
Source CD86 Source SEMA4 SEMA4 Cell-Cell Contact -0.1587 0.0003681032678983 Scatter Plot
Source CD86 Source SPP1 SPP1 Secreted Signaling -0.1453 0.0011181716077076 Scatter Plot
Target CD86 Source GALECTIN GALECTIN Secreted Signaling -0.1299 0.0036079767149249 Scatter Plot
Source CD86 Source SELL SELL Cell-Cell Contact -0.1275 0.0042946614253996 Scatter Plot
Target CD86 Target KIT KIT Secreted Signaling -0.1268 0.0044993274835365 Scatter Plot
Source CD86 Source ANGPTL ANGPTL Secreted Signaling -0.1125 0.0117969639741076 Scatter Plot
Target CD86 Target PDGF PDGF Secreted Signaling -0.1102 0.0136559429758999 Scatter Plot
Target CD86 Source ANGPTL ANGPTL Secreted Signaling -0.1040 0.0200519021355575 Scatter Plot
Target CD86 Source FGF FGF Secreted Signaling -0.0974 0.0293733357191467 Scatter Plot
Target CD86 Source BAFF BAFF Secreted Signaling -0.0973 0.0296730548743008 Scatter Plot
Target CD86 Target CD52 CD52 Cell-Cell Contact 0.1042 0.0198343311846045 Scatter Plot
Target CD86 Target CCL CCL Secreted Signaling 0.1145 0.0103908100170055 Scatter Plot
Source CD86 Source PTN PTN Secreted Signaling 0.1150 0.0100774435848096 Scatter Plot
Source CD86 Target OSM OSM Secreted Signaling 0.1353 0.0024311194464404 Scatter Plot
Source CD86 Target EPHA EPHA Cell-Cell Contact 0.1457 0.0010827863964826 Scatter Plot
Source CD86 Source ICOS ICOS Cell-Cell Contact 0.1462 0.0010425336109118 Scatter Plot
Target CD86 Target BAFF BAFF Secreted Signaling 0.1494 0.0008067392738552 Scatter Plot
Source CD86 Target LAIR1 LAIR1 Cell-Cell Contact 0.1503 0.0007489920042012 Scatter Plot
Source CD86 Target BST2 BST2 Cell-Cell Contact 0.1503 0.0007489920042012 Scatter Plot
Source CD86 Target SEMA3 SEMA3 Secreted Signaling 0.1514 0.0006832923094728 Scatter Plot
Source CD86 Target THY1 THY1 Cell-Cell Contact 0.1591 0.0003545945561593 Scatter Plot
Source CD86 Target COLLAGEN COLLAGEN ECM-Receptor 0.1636 0.0002378303470139 Scatter Plot
Source CD86 Target RANKL RANKL Secreted Signaling 0.1655 0.0002009809096047 Scatter Plot
Source CD86 Target CADM CADM Cell-Cell Contact 0.1672 0.0001721806251976 Scatter Plot
Source CD86 Target VISFATIN VISFATIN Secreted Signaling 0.1714 0.0001168933856791 Scatter Plot
Source CD86 Target PTN PTN Secreted Signaling 0.1717 0.000113725268054 Scatter Plot
Source CD86 Target MK MK Secreted Signaling 0.1765 0.00007245022508677551 Scatter Plot
Source CD86 Target IL1 IL1 Secreted Signaling 0.1796 0.00005349475763625992 Scatter Plot
Source CD86 Target NOTCH NOTCH Cell-Cell Contact 0.1814 0.00004498538139480129 Scatter Plot
Source CD86 Target CD23 CD23 Cell-Cell Contact 0.1843 0.00003389830745884066 Scatter Plot
Source CD86 Target CSPG4 CSPG4 Cell-Cell Contact 0.1995 0.000006932264384495567 Scatter Plot
Source CD86 Target SEMA6 SEMA6 Cell-Cell Contact 0.2128 0.0000015817525775780882 Scatter Plot
Source CD86 Target SEMA7 SEMA7 Cell-Cell Contact 0.2141 0.000001361426988147861 Scatter Plot
Source CD86 Target SPP1 SPP1 Secreted Signaling 0.2165 0.0000010194583571522622 Scatter Plot
Source CD86 Target THBS THBS ECM-Receptor 0.2254 0.00000035163363575008106 Scatter Plot
Source CD86 Target SELL SELL Cell-Cell Contact 0.2281 0.0000002510600519046336 Scatter Plot
Source CD86 Target PARs PARs Secreted Signaling 0.2295 0.0000002107396667483865 Scatter Plot
Source CD86 Target IL6 IL6 Secreted Signaling 0.2311 0.00000017440921979608165 Scatter Plot
Source CD86 Target FN1 FN1 ECM-Receptor 0.2372 0.00000008007591108052438 Scatter Plot
Source CD86 Target SEMA5 SEMA5 Cell-Cell Contact 0.2438 0.00000003352924558527991 Scatter Plot
Source CD86 Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.2448 0.000000029553366659805295 Scatter Plot
Source CD86 Target GALECTIN GALECTIN Secreted Signaling 0.2489 0.000000016900923305452097 Scatter Plot
Source CD86 Target VWF VWF ECM-Receptor 0.2532 0.00000000933270655798103 Scatter Plot
Source CD86 Target GDF GDF Secreted Signaling 0.2639 0.000000002060944625628677 Scatter Plot
Source CD86 Target ANGPTL ANGPTL Secreted Signaling 0.2654 0.000000001645859882858529 Scatter Plot
Source CD86 Target BMP BMP Secreted Signaling 0.2694 0.0000000009196393802498473 Scatter Plot
Source CD86 Target VTN VTN ECM-Receptor 0.2809 0.000000000161229522914139 Scatter Plot
Source CD86 Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2942 0.00000000001915049068925563 Scatter Plot
Source CD86 Target ANGPT ANGPT Secreted Signaling 0.2967 0.000000000012703940540412334 Scatter Plot
Source CD86 Target LAMININ LAMININ ECM-Receptor 0.2974 0.000000000011339117177511606 Scatter Plot
Source CD86 Target EPHB EPHB Cell-Cell Contact 0.3010 0.0000000000062440723239483895 Scatter Plot
Source CD86 Target IGF IGF Secreted Signaling 0.3086 0.0000000000017157428576909157 Scatter Plot
Source CD86 Target CD34 CD34 Cell-Cell Contact 0.3094 0.000000000001479657751822873 Scatter Plot
Source CD86 Source THY1 THY1 Cell-Cell Contact 0.3109 0.0000000000011456889216325038 Scatter Plot
Source CD86 Target CDH CDH Cell-Cell Contact 0.3215 0.00000000000017306948324675926 Scatter Plot
Source CD86 Target PERIOSTIN PERIOSTIN Secreted Signaling 0.3388 0.000000000000006728848202757639 Scatter Plot
Source CD86 Target NODAL NODAL Secreted Signaling 0.3392 0.0000000000000062782676076008766 Scatter Plot
Source CD86 Target BSP BSP ECM-Receptor 0.3403 0.00000000000000501366530828949 Scatter Plot
Source CD86 Target TENASCIN TENASCIN ECM-Receptor 0.3407 0.000000000000004645809694798041 Scatter Plot
Source CD86 Target NRG NRG Secreted Signaling 0.3415 0.000000000000003971219799399412 Scatter Plot
Source CD86 Target JAM JAM Cell-Cell Contact 0.3449 0.000000000000002068284047836275 Scatter Plot
Source CD86 Source CXCL CXCL Secreted Signaling 0.3462 0.0000000000000015983437785950773 Scatter Plot
Source CD86 Target DMP1 DMP1 ECM-Receptor 0.3471 0.000000000000001332732243948786 Scatter Plot
Source CD86 Source LCK LCK Cell-Cell Contact 0.3527 0.0000000000000004295965453925567 Scatter Plot
Source CD86 Target NPR2 NPR2 Secreted Signaling 0.3534 0.0000000000000003721959745279592 Scatter Plot
Source CD86 Target ACTIVIN ACTIVIN Secreted Signaling 0.3547 0.0000000000000002826607604208818 Scatter Plot
Source CD86 Target CD22 CD22 Cell-Cell Contact 0.3630 0.00000000000000005091721527634807 Scatter Plot
Source CD86 Source COLLAGEN COLLAGEN ECM-Receptor 0.3790 0.0000000000000000015674817367448185 Scatter Plot
Source CD86 Target SEMA4 SEMA4 Cell-Cell Contact 0.3795 0.000000000000000001405433809173717 Scatter Plot
Source CD86 Target TGFb TGFb Secreted Signaling 0.3883 0.0000000000000000001896706552056048 Scatter Plot
Source CD86 Target ESAM ESAM Cell-Cell Contact 0.4067 0.000000000000000000002401453724885868 Scatter Plot
Source CD86 Target KIT KIT Secreted Signaling 0.4104 0.0000000000000000000009620270794917046 Scatter Plot
Source CD86 Target FGF FGF Secreted Signaling 0.4128 0.0000000000000000000005296135706745366 Scatter Plot
Source CD86 Target BAFF BAFF Secreted Signaling 0.4159 0.0000000000000000000002462060281143756 Scatter Plot
Source CD86 Target SLURP SLURP Secreted Signaling 0.4399 0.0000000000000000000000004393909876702961 Scatter Plot
Source CD86 Target WNT WNT Secreted Signaling 0.4610 0.0000000000000000000000000011160606697586046 Scatter Plot
Source CD86 Target ncWNT ncWNT Secreted Signaling 0.4617 0.0000000000000000000000000009102680972826195 Scatter Plot
Source CD86 Target CD39 CD39 Cell-Cell Contact 0.4672 0.00000000000000000000000000017579035590639463 Scatter Plot
Source CD86 Target CD200 CD200 Cell-Cell Contact 0.4776 0.00000000000000000000000000000739479524492582 Scatter Plot
Source CD86 Target APP APP Cell-Cell Contact 0.4941 0.000000000000000000000000000000038698916945504416 Scatter Plot
Source CD86 Target MIF MIF Secreted Signaling 0.5597 0.0000000000000000000000000000000000000000014178064909519255 Scatter Plot
Source CD86 Source COMPLEMENT COMPLEMENT Secreted Signaling -0.2670 0.00000000131632424456587 Scatter Plot
Source CD86 Source CD52 CD52 Cell-Cell Contact -0.2054 0.000003648310177530697 Scatter Plot
Source CD86 Target ICAM ICAM Cell-Cell Contact -0.2018 0.000005427753844675948 Scatter Plot
Source CD86 Target CSF CSF Secreted Signaling -0.2012 0.000005759805873994815 Scatter Plot
Source CD86 Target CD52 CD52 Cell-Cell Contact -0.1704 0.0001287077175684 Scatter Plot
Source CD86 Target VCAM VCAM Cell-Cell Contact -0.1646 0.0002184841432486 Scatter Plot
Source CD86 Target CEACAM CEACAM Cell-Cell Contact -0.1496 0.0007937906870597 Scatter Plot
Source CD86 Target VEGF VEGF Secreted Signaling -0.1426 0.0013912059337817 Scatter Plot
Source CD86 Target IL17 IL17 Secreted Signaling -0.1330 0.0028830377555786 Scatter Plot
Source CD86 Target CXCL CXCL Secreted Signaling -0.1322 0.0030500890434881 Scatter Plot
Source CD86 Target CLEC CLEC Cell-Cell Contact -0.1215 0.0065404609198458 Scatter Plot
Source CD86 Target GRN GRN Secreted Signaling -0.1133 0.0112063681907525 Scatter Plot
Source CD86 Target CCL CCL Secreted Signaling -0.1126 0.0117138982838728 Scatter Plot
Source CD86 Source IL1 IL1 Secreted Signaling -0.1118 0.0123779676517016 Scatter Plot

Cells that are targets of CD86 from HSCs*

Cells that are source of CD86 to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.