Pathway: FLT3

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the FLT3 pathway:

Specificity Index HSPC as target: 0.422
HSPC as source: 0.187

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the FLT3 pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Source FLT3 Source AGRN AGRN ECM-Receptor 0.1041 0.0199546772848817 Scatter Plot
Source FLT3 Source WNT WNT Secreted Signaling 0.1043 0.0196143624713777 Scatter Plot
Source FLT3 Source ncWNT ncWNT Secreted Signaling 0.1277 0.0042377945840159 Scatter Plot
Source FLT3 Source SEMA6 SEMA6 Cell-Cell Contact 0.1281 0.0041104663017644 Scatter Plot
Source FLT3 Source THBS THBS ECM-Receptor 0.1388 0.001865870890202 Scatter Plot
Source FLT3 Source PTN PTN Secreted Signaling 0.1521 0.0006417099091365 Scatter Plot
Source FLT3 Source SEMA3 SEMA3 Secreted Signaling 0.2048 0.000003876925196452229 Scatter Plot
Source FLT3 Source IL16 IL16 Secreted Signaling 0.2135 0.0000014462000469777117 Scatter Plot
Source FLT3 Source GDF GDF Secreted Signaling 0.2187 0.0000007889765698509838 Scatter Plot
Source FLT3 Source CADM CADM Cell-Cell Contact 0.2401 0.000000054658891690383576 Scatter Plot
Source FLT3 Source CD39 CD39 Cell-Cell Contact 0.2408 0.000000049835927684999763 Scatter Plot
Source FLT3 Source VEGF VEGF Secreted Signaling 0.2472 0.000000021235567323707273 Scatter Plot
Source FLT3 Source CCL CCL Secreted Signaling 0.2662 0.0000000014691344609913876 Scatter Plot
Source FLT3 Source CXCL CXCL Secreted Signaling 0.2706 0.0000000007740622829909138 Scatter Plot
Source FLT3 Source CD46 CD46 Cell-Cell Contact 0.2722 0.0000000006056034676992 Scatter Plot
Source FLT3 Source PSAP PSAP Secreted Signaling 0.2918 0.000000000028278310034553918 Scatter Plot
Source FLT3 Source LAMININ LAMININ ECM-Receptor 0.3130 0.0000000000007901112491295081 Scatter Plot
Source FLT3 Source LIGHT LIGHT Secreted Signaling 0.3179 0.0000000000003328928685809169 Scatter Plot
Source FLT3 Source RANKL RANKL Secreted Signaling 0.3204 0.00000000000021029455863628534 Scatter Plot
Source FLT3 Source IGF IGF Secreted Signaling 0.3347 0.00000000000001500541742331191 Scatter Plot
Source FLT3 Source NOTCH NOTCH Cell-Cell Contact 0.3703 0.000000000000000010617823565493148 Scatter Plot
Source FLT3 Source MK MK Secreted Signaling 0.3790 0.0000000000000000015789333620744513 Scatter Plot
Source FLT3 Source PROS PROS Secreted Signaling 0.3800 0.0000000000000000012667722888313537 Scatter Plot
Source FLT3 Source NT NT Secreted Signaling 0.3883 0.00000000000000000019235787203226542 Scatter Plot
Source FLT3 Source EPHB EPHB Cell-Cell Contact 0.4289 0.000000000000000000000008506085219764805 Scatter Plot
Source FLT3 Source LIFR LIFR Secreted Signaling 0.4413 0.0000000000000000000000003007435773665852 Scatter Plot
Source FLT3 Source GAS GAS Secreted Signaling 0.4439 0.00000000000000000000000014652771287531863 Scatter Plot
Source FLT3 Source CDH CDH Cell-Cell Contact 0.4453 0.00000000000000000000000010005800801094888 Scatter Plot
Source FLT3 Source COLLAGEN COLLAGEN ECM-Receptor 0.4477 0.00000000000000000000000005121338485545981 Scatter Plot
Source FLT3 Source TWEAK TWEAK Secreted Signaling 0.4896 0.00000000000000000000000000000016456441928510986 Scatter Plot
Source FLT3 Source PDGF PDGF Secreted Signaling 0.4980 0.00000000000000000000000000000001056156479395209 Scatter Plot
Source FLT3 Source BMP BMP Secreted Signaling 0.5205 0.0000000000000000000000000000000000045882120946579896 Scatter Plot
Source FLT3 Source ANGPT ANGPT Secreted Signaling 0.5266 0.0000000000000000000000000000000000004995818438169359 Scatter Plot
Source FLT3 Source ESAM ESAM Cell-Cell Contact 0.5613 0.0000000000000000000000000000000000000000007225866229354405 Scatter Plot
Source FLT3 Source SELL SELL Cell-Cell Contact -0.4497 0.000000000000000000000000028713654836554573 Scatter Plot
Source FLT3 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.4235 0.000000000000000000000035013349282992854 Scatter Plot
Source FLT3 Source SEMA4 SEMA4 Cell-Cell Contact -0.3776 0.0000000000000000021693322812598003 Scatter Plot
Source FLT3 Source VISTA VISTA Cell-Cell Contact -0.3239 0.00000000000011104604718135809 Scatter Plot
Source FLT3 Source TGFb TGFb Secreted Signaling -0.2712 0.0000000007008069249006036 Scatter Plot
Source FLT3 Source NCAM NCAM Cell-Cell Contact -0.2631 0.0000000023069832017042394 Scatter Plot
Source FLT3 Source ANGPTL ANGPTL Secreted Signaling -0.2611 0.0000000030811952609706572 Scatter Plot
Source FLT3 Source SPP1 SPP1 Secreted Signaling -0.2471 0.000000021691905575808524 Scatter Plot
Source FLT3 Source TNF TNF Secreted Signaling -0.2043 0.000004104307761592196 Scatter Plot
Source FLT3 Source VISFATIN VISFATIN Secreted Signaling -0.1518 0.0006621479456422 Scatter Plot
Source FLT3 Source ANGPTL ANGPTL Secreted Signaling 0.1038 0.0202577976697701 Scatter Plot
Source FLT3 Target IL6 IL6 Secreted Signaling 0.1155 0.0097148375652049 Scatter Plot
Source FLT3 Target IL1 IL1 Secreted Signaling 0.1169 0.0088681788749737 Scatter Plot
Source FLT3 Target NOTCH NOTCH Cell-Cell Contact 0.1200 0.0072391710486149 Scatter Plot
Source FLT3 Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1215 0.0065309383288787 Scatter Plot
Source FLT3 Source GALECTIN GALECTIN Secreted Signaling 0.1296 0.0037074466851577 Scatter Plot
Source FLT3 Target CXCL CXCL Secreted Signaling 0.1354 0.0024107130601603 Scatter Plot
Source FLT3 Target RANKL RANKL Secreted Signaling 0.1364 0.0022306369723765 Scatter Plot
Source FLT3 Target THY1 THY1 Cell-Cell Contact 0.1367 0.0021891909916767 Scatter Plot
Source FLT3 Target COLLAGEN COLLAGEN ECM-Receptor 0.1423 0.0014244883629584 Scatter Plot
Source FLT3 Target CD23 CD23 Cell-Cell Contact 0.1520 0.0006504907959536 Scatter Plot
Source FLT3 Target GDF GDF Secreted Signaling 0.1606 0.000310816000518 Scatter Plot
Source FLT3 Target NCAM NCAM Cell-Cell Contact 0.1630 0.0002518808999719 Scatter Plot
Source FLT3 Target EPHA EPHA Cell-Cell Contact 0.1646 0.0002176864217479 Scatter Plot
Source FLT3 Source CD1D2 CD1D2 Cell-Cell Contact 0.1703 0.0001303669068601 Scatter Plot
Source FLT3 Source THY1 THY1 Cell-Cell Contact 0.1822 0.00004160694079339028 Scatter Plot
Source FLT3 Source VCAM VCAM Cell-Cell Contact 0.1854 0.00003026561620129737 Scatter Plot
Source FLT3 Target NODAL NODAL Secreted Signaling 0.1993 0.000007105352694576632 Scatter Plot
Source FLT3 Target OSM OSM Secreted Signaling 0.2379 0.0000000730296316223562 Scatter Plot
Source FLT3 Target CADM CADM Cell-Cell Contact 0.2401 0.000000054658891690383576 Scatter Plot
Source FLT3 Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2480 0.000000019240377423272783 Scatter Plot
Source FLT3 Target SPP1 SPP1 Secreted Signaling 0.2500 0.000000014574509259895346 Scatter Plot
Source FLT3 Source GP1BA GP1BA Cell-Cell Contact 0.2507 0.000000013222365935000348 Scatter Plot
Source FLT3 Target CSPG4 CSPG4 Cell-Cell Contact 0.2574 0.000000005226286979938991 Scatter Plot
Source FLT3 Target SEMA6 SEMA6 Cell-Cell Contact 0.2635 0.0000000021854024937247083 Scatter Plot
Source FLT3 Source ICAM ICAM Cell-Cell Contact 0.2706 0.0000000007689842409033944 Scatter Plot
Source FLT3 Target BAFF BAFF Secreted Signaling 0.2718 0.0000000006419874925204132 Scatter Plot
Source FLT3 Target ANGPTL ANGPTL Secreted Signaling 0.2779 0.00000000025402470295917047 Scatter Plot
Source FLT3 Target PTN PTN Secreted Signaling 0.2802 0.00000000017979894135155509 Scatter Plot
Source FLT3 Source CD86 CD86 Cell-Cell Contact 0.2852 0.00000000008141581767393192 Scatter Plot
Source FLT3 Target SEMA5 SEMA5 Cell-Cell Contact 0.2871 0.00000000006022336538657152 Scatter Plot
Source FLT3 Source IL2 IL2 Secreted Signaling 0.2905 0.000000000034891748235174786 Scatter Plot
Source FLT3 Target MK MK Secreted Signaling 0.2937 0.000000000020821574811294583 Scatter Plot
Source FLT3 Target FN1 FN1 ECM-Receptor 0.2961 0.000000000013991466222103809 Scatter Plot
Source FLT3 Target ACTIVIN ACTIVIN Secreted Signaling 0.2962 0.000000000013767846463753284 Scatter Plot
Source FLT3 Target VEGF VEGF Secreted Signaling 0.2999 0.00000000000755248364014642 Scatter Plot
Source FLT3 Target TGFb TGFb Secreted Signaling 0.3018 0.0000000000054795528618260886 Scatter Plot
Source FLT3 Target CD22 CD22 Cell-Cell Contact 0.3045 0.000000000003451278853583564 Scatter Plot
Source FLT3 Source CD45 CD45 Cell-Cell Contact 0.3045 0.000000000003451278853583564 Scatter Plot
Source FLT3 Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.3167 0.00000000000041445019421176134 Scatter Plot
Source FLT3 Target THBS THBS ECM-Receptor 0.3226 0.0000000000001410764605508337 Scatter Plot
Source FLT3 Target LAMININ LAMININ ECM-Receptor 0.3460 0.000000000000001654467612000174 Scatter Plot
Source FLT3 Target BMP BMP Secreted Signaling 0.3513 0.0000000000000005701734062036405 Scatter Plot
Source FLT3 Target AGT AGT Secreted Signaling 0.3559 0.0000000000000002240637123331433 Scatter Plot
Source FLT3 Source CSF CSF Secreted Signaling 0.3570 0.00000000000000017908724443759007 Scatter Plot
Source FLT3 Source CX3C CX3C Secreted Signaling 0.3576 0.00000000000000015757961984054738 Scatter Plot
Source FLT3 Source LCK LCK Cell-Cell Contact 0.3593 0.00000000000000010937114305502163 Scatter Plot
Source FLT3 Target VISFATIN VISFATIN Secreted Signaling 0.3602 0.00000000000000009228098509752427 Scatter Plot
Source FLT3 Target KIT KIT Secreted Signaling 0.3630 0.00000000000000005066040982587429 Scatter Plot
Source FLT3 Target PERIOSTIN PERIOSTIN Secreted Signaling 0.3649 0.000000000000000034294994232773536 Scatter Plot
Source FLT3 Target SEMA4 SEMA4 Cell-Cell Contact 0.3698 0.000000000000000011890718671899153 Scatter Plot
Source FLT3 Target EPHB EPHB Cell-Cell Contact 0.3752 0.000000000000000003674233473349622 Scatter Plot
Source FLT3 Target NRG NRG Secreted Signaling 0.3813 0.0000000000000000009377305953861777 Scatter Plot
Source FLT3 Target BSP BSP ECM-Receptor 0.3854 0.00000000000000000037264940463319953 Scatter Plot
Source FLT3 Target CD200 CD200 Cell-Cell Contact 0.3878 0.0000000000000000002144672388712567 Scatter Plot
Source FLT3 Target DMP1 DMP1 ECM-Receptor 0.4043 0.000000000000000000004344640295988855 Scatter Plot
Source FLT3 Target SEMA7 SEMA7 Cell-Cell Contact 0.4069 0.0000000000000000000022898449929827026 Scatter Plot
Source FLT3 Target APP APP Cell-Cell Contact 0.4106 0.0000000000000000000009318224019746696 Scatter Plot
Source FLT3 Target NPR2 NPR2 Secreted Signaling 0.4155 0.00000000000000000000026845017017879597 Scatter Plot
Source FLT3 Target ANGPT ANGPT Secreted Signaling 0.4170 0.000000000000000000000185854174487593 Scatter Plot
Source FLT3 Target VTN VTN ECM-Receptor 0.4170 0.00000000000000000000018512101598771608 Scatter Plot
Source FLT3 Target MIF MIF Secreted Signaling 0.4288 0.000000000000000000000008732472397838665 Scatter Plot
Source FLT3 Source SEMA7 SEMA7 Cell-Cell Contact 0.4432 0.00000000000000000000000017548415446498611 Scatter Plot
Source FLT3 Target CDH CDH Cell-Cell Contact 0.4453 0.00000000000000000000000010005800801094888 Scatter Plot
Source FLT3 Source IL7 IL7 Secreted Signaling 0.4585 0.0000000000000000000000000022715262399560617 Scatter Plot
Source FLT3 Source BST2 BST2 Cell-Cell Contact 0.4592 0.000000000000000000000000001882221489826393 Scatter Plot
Source FLT3 Target IGF IGF Secreted Signaling 0.4668 0.00000000000000000000000000019829523981987806 Scatter Plot
Source FLT3 Target FGF FGF Secreted Signaling 0.4695 0.00000000000000000000000000008742770867593528 Scatter Plot
Source FLT3 Target CD39 CD39 Cell-Cell Contact 0.4754 0.000000000000000000000000000014659064397472856 Scatter Plot
Source FLT3 Target VWF VWF ECM-Receptor 0.4760 0.000000000000000000000000000011949458478369827 Scatter Plot
Source FLT3 Target PARs PARs Secreted Signaling 0.4956 0.00000000000000000000000000000002330586728660534 Scatter Plot
Source FLT3 Target WNT WNT Secreted Signaling 0.4994 0.000000000000000000000000000000006609581213275022 Scatter Plot
Source FLT3 Target SLURP SLURP Secreted Signaling 0.5021 0.000000000000000000000000000000002718260627214246 Scatter Plot
Source FLT3 Target ncWNT ncWNT Secreted Signaling 0.5058 0.0000000000000000000000000000000007572703361196893 Scatter Plot
Source FLT3 Target TENASCIN TENASCIN ECM-Receptor 0.5063 0.0000000000000000000000000000000006442504488808366 Scatter Plot
Source FLT3 Target JAM JAM Cell-Cell Contact 0.5144 0.000000000000000000000000000000000039599935028212966 Scatter Plot
Source FLT3 Source MHC-II MHC-II Cell-Cell Contact 0.5286 0.0000000000000000000000000000000000002372961119135036 Scatter Plot
Source FLT3 Target CD34 CD34 Cell-Cell Contact 0.5474 0.0000000000000000000000000000000000000001959478914976553 Scatter Plot
Source FLT3 Target ESAM ESAM Cell-Cell Contact 0.5613 0.0000000000000000000000000000000000000000007225866229354405 Scatter Plot
Source FLT3 Source JAM JAM Cell-Cell Contact 0.5766 0.000000000000000000000000000000000000000000001157949376759639 Scatter Plot
Source FLT3 Source MHC-I MHC-I Cell-Cell Contact 0.5822 0.0000000000000000000000000000000000000000000000995963290802474 Scatter Plot
Source FLT3 Source CD52 CD52 Cell-Cell Contact -0.5508 0.00000000000000000000000000000000000000005133350880442858 Scatter Plot
Source FLT3 Target CD52 CD52 Cell-Cell Contact -0.4200 0.00000000000000000000008671885287777111 Scatter Plot
Source FLT3 Source PARs PARs Secreted Signaling -0.4154 0.00000000000000000000027767724111907734 Scatter Plot
Source FLT3 Source COMPLEMENT COMPLEMENT Secreted Signaling -0.4085 0.0000000000000000000015726861539349552 Scatter Plot
Source FLT3 Target ICAM ICAM Cell-Cell Contact -0.4037 0.000000000000000000005078016849035088 Scatter Plot
Source FLT3 Target IFN-II IFN-II Secreted Signaling -0.3484 0.0000000000000010150557170289784 Scatter Plot
Source FLT3 Target CSF CSF Secreted Signaling -0.3320 0.000000000000024727802954099176 Scatter Plot
Source FLT3 Source CCL CCL Secreted Signaling -0.3226 0.0000000000001418464793642002 Scatter Plot
Source FLT3 Target CXCL CXCL Secreted Signaling -0.2912 0.00000000003127823756570361 Scatter Plot
Source FLT3 Source MIF MIF Secreted Signaling -0.2912 0.000000000031565603417698714 Scatter Plot
Source FLT3 Target VCAM VCAM Cell-Cell Contact -0.2883 0.000000000050051988677573245 Scatter Plot
Source FLT3 Target CLEC CLEC Cell-Cell Contact -0.2863 0.000000000068735649287463 Scatter Plot
Source FLT3 Source CLEC CLEC Cell-Cell Contact -0.2653 0.0000000016822414867724014 Scatter Plot
Source FLT3 Source SELPLG SELPLG Cell-Cell Contact -0.2612 0.000000003049980545356908 Scatter Plot
Source FLT3 Target CCL CCL Secreted Signaling -0.2610 0.000000003109236624574097 Scatter Plot
Source FLT3 Source ANNEXIN ANNEXIN Secreted Signaling -0.2526 0.0000000101571526650749 Scatter Plot
Source FLT3 Target IL17 IL17 Secreted Signaling -0.2498 0.000000015072007119494332 Scatter Plot
Source FLT3 Target VEGF VEGF Secreted Signaling -0.2406 0.00000005095620735539621 Scatter Plot
Source FLT3 Target SEMA3 SEMA3 Secreted Signaling -0.2146 0.0000012845083725596129 Scatter Plot
Source FLT3 Target CEACAM CEACAM Cell-Cell Contact -0.2104 0.0000020638985209787444 Scatter Plot
Source FLT3 Target COLLAGEN COLLAGEN ECM-Receptor -0.1556 0.0004775138295888 Scatter Plot
Source FLT3 Source LAIR1 LAIR1 Cell-Cell Contact -0.1431 0.0013361614622566 Scatter Plot
Source FLT3 Source NKG2D NKG2D Cell-Cell Contact -0.1407 0.0016091229570553 Scatter Plot
Source FLT3 Target COMPLEMENT COMPLEMENT Secreted Signaling -0.1367 0.0021800788943155 Scatter Plot
Source FLT3 Target GRN GRN Secreted Signaling -0.1232 0.0057967537179872 Scatter Plot
Source FLT3 Source APP APP Cell-Cell Contact -0.1161 0.0093397353078342 Scatter Plot

Cells that are targets of FLT3 from HSCs*

Cells that are source of FLT3 to HSCs*

    No cell populations

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.