Pathway: IL1

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the IL1 pathway:

Specificity Index HSPC as target: 0.200
HSPC as source: 0.655

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the IL1 pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target IL1 Target GRN GRN Secreted Signaling 0.0973 0.0295584781758416 Scatter Plot
Source IL1 Source PTN PTN Secreted Signaling 0.0979 0.0285964670860506 Scatter Plot
Target IL1 Source LIGHT LIGHT Secreted Signaling 0.1024 0.0219933369888874 Scatter Plot
Target IL1 Source THBS THBS ECM-Receptor 0.1032 0.0209893068981735 Scatter Plot
Target IL1 Source PTN PTN Secreted Signaling 0.1045 0.0194220368405402 Scatter Plot
Target IL1 Source IL6 IL6 Secreted Signaling 0.1060 0.0177007976081653 Scatter Plot
Target IL1 Source OSM OSM Secreted Signaling 0.1065 0.0172298348495726 Scatter Plot
Target IL1 Target BMP BMP Secreted Signaling 0.1083 0.0153887619277112 Scatter Plot
Target IL1 Target SPP1 SPP1 Secreted Signaling 0.1087 0.0150442407683911 Scatter Plot
Target IL1 Source CD39 CD39 Cell-Cell Contact 0.1095 0.0142864296789941 Scatter Plot
Target IL1 Target SEMA3 SEMA3 Secreted Signaling 0.1105 0.0134539531303243 Scatter Plot
Target IL1 Source EPHB EPHB Cell-Cell Contact 0.1106 0.0133221319968779 Scatter Plot
Target IL1 Source GAS GAS Secreted Signaling 0.1163 0.009236180598425 Scatter Plot
Target IL1 Source GALECTIN GALECTIN Secreted Signaling 0.1164 0.0091914022596446 Scatter Plot
Target IL1 Target ncWNT ncWNT Secreted Signaling 0.1165 0.0091231797678748 Scatter Plot
Target IL1 Source FLT3 FLT3 Secreted Signaling 0.1169 0.0088681788749737 Scatter Plot
Target IL1 Target PDGF PDGF Secreted Signaling 0.1201 0.007191503892563 Scatter Plot
Target IL1 Source WNT WNT Secreted Signaling 0.1203 0.0070683746347907 Scatter Plot
Target IL1 Source ANGPTL ANGPTL Secreted Signaling 0.1205 0.0069928526137417 Scatter Plot
Target IL1 Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.1261 0.0047536102021641 Scatter Plot
Target IL1 Source CCL CCL Secreted Signaling 0.1271 0.0044049427831115 Scatter Plot
Target IL1 Source VEGF VEGF Secreted Signaling 0.1278 0.004200908130402 Scatter Plot
Target IL1 Target CD52 CD52 Cell-Cell Contact 0.1369 0.0021503932725712 Scatter Plot
Target IL1 Target EPHB EPHB Cell-Cell Contact 0.1401 0.0016848952936977 Scatter Plot
Target IL1 Source LAIR1 LAIR1 Cell-Cell Contact 0.1402 0.0016716703042109 Scatter Plot
Target IL1 Source AGRN AGRN ECM-Receptor 0.1404 0.0016439550752931 Scatter Plot
Target IL1 Source CXCL CXCL Secreted Signaling 0.1442 0.00122638659539 Scatter Plot
Target IL1 Target WNT WNT Secreted Signaling 0.1482 0.0008857593224233 Scatter Plot
Target IL1 Target CD200 CD200 Cell-Cell Contact 0.1490 0.0008345126628869 Scatter Plot
Target IL1 Source TNF TNF Secreted Signaling 0.1536 0.0005668895845494 Scatter Plot
Target IL1 Source COLLAGEN COLLAGEN ECM-Receptor 0.1537 0.0005636423081339 Scatter Plot
Target IL1 Target CXCL CXCL Secreted Signaling 0.1580 0.0003905017117899 Scatter Plot
Target IL1 Source SEMA3 SEMA3 Secreted Signaling 0.1588 0.0003636811997533 Scatter Plot
Target IL1 Target SELE SELE Cell-Cell Contact 0.1624 0.0002648014233347 Scatter Plot
Target IL1 Target KIT KIT Secreted Signaling 0.1656 0.0001997900114135 Scatter Plot
Source IL1 Source GP1BA GP1BA Cell-Cell Contact 0.1669 0.0001774304643026 Scatter Plot
Target IL1 Source THY1 THY1 Cell-Cell Contact 0.1687 0.0001502666190218 Scatter Plot
Source IL1 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1694 0.0001407667980476 Scatter Plot
Target IL1 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1732 0.00009885881786213202 Scatter Plot
Target IL1 Target GDF GDF Secreted Signaling 0.1734 0.00009708751782900191 Scatter Plot
Target IL1 Source SEMA4 SEMA4 Cell-Cell Contact 0.1750 0.00008363630853661722 Scatter Plot
Target IL1 Source SELL SELL Cell-Cell Contact 0.1760 0.00007613892686160805 Scatter Plot
Target IL1 Source CD1D2 CD1D2 Cell-Cell Contact 0.1776 0.00006527813832772924 Scatter Plot
Target IL1 Source CD45 CD45 Cell-Cell Contact 0.1791 0.00005626354317025534 Scatter Plot
Target IL1 Source CD86 CD86 Cell-Cell Contact 0.1796 0.00005349475763625992 Scatter Plot
Source IL1 Source SEMA4 SEMA4 Cell-Cell Contact 0.1828 0.00003927815368075759 Scatter Plot
Target IL1 Source VCAM VCAM Cell-Cell Contact 0.1850 0.00003158137613228444 Scatter Plot
Source IL1 Source GALECTIN GALECTIN Secreted Signaling 0.1850 0.00003149062701363015 Scatter Plot
Target IL1 Target COLLAGEN COLLAGEN ECM-Receptor 0.1881 0.000023122836631344725 Scatter Plot
Target IL1 Source VISTA VISTA Cell-Cell Contact 0.2124 0.0000016530444713409216 Scatter Plot
Target IL1 Source IL16 IL16 Secreted Signaling 0.2130 0.0000015320951159570035 Scatter Plot
Target IL1 Target CCL CCL Secreted Signaling 0.2318 0.00000015889536422500913 Scatter Plot
Target IL1 Target NCAM NCAM Cell-Cell Contact 0.2344 0.00000011380349161754525 Scatter Plot
Target IL1 Target VCAM VCAM Cell-Cell Contact 0.2350 0.0000001053467112414644 Scatter Plot
Target IL1 Source GRN GRN Secreted Signaling 0.2384 0.0000000684935231100679 Scatter Plot
Target IL1 Target ANGPTL ANGPTL Secreted Signaling 0.2398 0.00000005710656873005415 Scatter Plot
Target IL1 Target ICAM ICAM Cell-Cell Contact 0.2418 0.00000004369993497799541 Scatter Plot
Target IL1 Source BAFF BAFF Secreted Signaling 0.2474 0.000000020709628491810757 Scatter Plot
Target IL1 Source APP APP Cell-Cell Contact 0.2495 0.000000015533390140037277 Scatter Plot
Source IL1 Source FGF FGF Secreted Signaling 0.2539 0.000000008544338745260803 Scatter Plot
Target IL1 Source COMPLEMENT COMPLEMENT Secreted Signaling 0.2541 0.000000008280332477964458 Scatter Plot
Target IL1 Source NCAM NCAM Cell-Cell Contact 0.2585 0.000000004495604697429413 Scatter Plot
Target IL1 Source CD52 CD52 Cell-Cell Contact 0.2596 0.000000003812763214765611 Scatter Plot
Source IL1 Source CCL CCL Secreted Signaling 0.2637 0.000000002132753625806116 Scatter Plot
Target IL1 Target JAM JAM Cell-Cell Contact 0.2711 0.000000000713408779799756 Scatter Plot
Source IL1 Source CXCL CXCL Secreted Signaling 0.2713 0.0000000006944501892300903 Scatter Plot
Target IL1 Target CEACAM CEACAM Cell-Cell Contact 0.2794 0.0000000002019917557305932 Scatter Plot
Target IL1 Target NODAL NODAL Secreted Signaling 0.3005 0.000000000006758862770874193 Scatter Plot
Source IL1 Source TGFb TGFb Secreted Signaling 0.3150 0.000000000000553108984361281 Scatter Plot
Target IL1 Source ANNEXIN ANNEXIN Secreted Signaling 0.3152 0.0000000000005418201186317794 Scatter Plot
Target IL1 Target THY1 THY1 Cell-Cell Contact 0.3634 0.00000000000000004696919404976469 Scatter Plot
Target IL1 Target CD23 CD23 Cell-Cell Contact 0.3704 0.00000000000000001044064351133166 Scatter Plot
Target IL1 Source GALECTIN GALECTIN Secreted Signaling -0.2740 0.00000000046344646726457987 Scatter Plot
Target IL1 Source TGFb TGFb Secreted Signaling -0.2318 0.00000015943782818834337 Scatter Plot
Target IL1 Target MK MK Secreted Signaling -0.2289 0.00000022827004078858826 Scatter Plot
Target IL1 Target PTN PTN Secreted Signaling -0.2281 0.0000002525223404903604 Scatter Plot
Source IL1 Source BST2 BST2 Cell-Cell Contact -0.2255 0.000000347201371154272 Scatter Plot
Target IL1 Source MIF MIF Secreted Signaling -0.2231 0.0000004675994655694678 Scatter Plot
Target IL1 Source PARs PARs Secreted Signaling -0.2151 0.000001200254109419039 Scatter Plot
Source IL1 Source LAMININ LAMININ ECM-Receptor -0.2143 0.0000013300680646534291 Scatter Plot
Source IL1 Source LAIR1 LAIR1 Cell-Cell Contact -0.2104 0.000002074142115803648 Scatter Plot
Target IL1 Source ANGPTL ANGPTL Secreted Signaling -0.2040 0.000004252779985938502 Scatter Plot
Target IL1 Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.1991 0.000007289342106632674 Scatter Plot
Target IL1 Target PARs PARs Secreted Signaling -0.1880 0.000023181460154000645 Scatter Plot
Source IL1 Source GAS GAS Secreted Signaling -0.1878 0.00002377809938224095 Scatter Plot
Source IL1 Source ANNEXIN ANNEXIN Secreted Signaling -0.1814 0.00004503102117565362 Scatter Plot
Target IL1 Source ICAM ICAM Cell-Cell Contact -0.1784 0.00006017948600103616 Scatter Plot
Source IL1 Source IL16 IL16 Secreted Signaling -0.1774 0.0000665111791098952 Scatter Plot
Target IL1 Target CCL CCL Secreted Signaling -0.1760 0.00007637661014784048 Scatter Plot
Source IL1 Source NOTCH NOTCH Cell-Cell Contact -0.1586 0.0003701007282662 Scatter Plot
Source IL1 Source JAM JAM Cell-Cell Contact -0.1583 0.0003796475172733 Scatter Plot
Source IL1 Source APP APP Cell-Cell Contact -0.1574 0.0004094437941731 Scatter Plot
Target IL1 Source VEGF VEGF Secreted Signaling -0.1546 0.0005227955402836 Scatter Plot
Source IL1 Source CDH CDH Cell-Cell Contact -0.1495 0.0007976170074555 Scatter Plot
Source IL1 Source COLLAGEN COLLAGEN ECM-Receptor -0.1480 0.0009053898204667 Scatter Plot
Target IL1 Target TWEAK TWEAK Secreted Signaling -0.1441 0.0012336121259491 Scatter Plot
Source IL1 Source PSAP PSAP Secreted Signaling -0.1428 0.0013656814214648 Scatter Plot
Target IL1 Source SEMA4 SEMA4 Cell-Cell Contact -0.1426 0.0013924045790263 Scatter Plot
Target IL1 Target SEMA7 SEMA7 Cell-Cell Contact -0.1403 0.0016590252011641 Scatter Plot
Target IL1 Source BST2 BST2 Cell-Cell Contact -0.1394 0.0017769815067446 Scatter Plot
Source IL1 Source SEMA7 SEMA7 Cell-Cell Contact -0.1391 0.0018232000638347 Scatter Plot
Target IL1 Target FN1 FN1 ECM-Receptor -0.1384 0.0019188445233555 Scatter Plot
Source IL1 Source CD45 CD45 Cell-Cell Contact -0.1348 0.0025172175295835 Scatter Plot
Source IL1 Source CCL CCL Secreted Signaling -0.1299 0.0036214745928024 Scatter Plot
Source IL1 Source ICAM ICAM Cell-Cell Contact -0.1274 0.0043336799487627 Scatter Plot
Target IL1 Source VCAM VCAM Cell-Cell Contact -0.1253 0.0050255693164179 Scatter Plot
Target IL1 Source CCL CCL Secreted Signaling -0.1242 0.0054196455400055 Scatter Plot
Target IL1 Source GRN GRN Secreted Signaling -0.1202 0.007123466076886 Scatter Plot
Target IL1 Source LIFR LIFR Secreted Signaling -0.1197 0.0073599826465802 Scatter Plot
Source IL1 Source MK MK Secreted Signaling -0.1183 0.0081018504848414 Scatter Plot
Source IL1 Source CSF CSF Secreted Signaling -0.1169 0.0089108194538233 Scatter Plot
Target IL1 Target SEMA3 SEMA3 Secreted Signaling -0.1162 0.0092980498868867 Scatter Plot
Source IL1 Source GRN GRN Secreted Signaling -0.1161 0.0093656957617073 Scatter Plot
Target IL1 Target IL17 IL17 Secreted Signaling -0.1120 0.0121969977521367 Scatter Plot
Source IL1 Source CD86 CD86 Cell-Cell Contact -0.1118 0.0123779676517016 Scatter Plot
Target IL1 Target CXCL CXCL Secreted Signaling -0.1113 0.0127406754222741 Scatter Plot
Target IL1 Target SPP1 SPP1 Secreted Signaling -0.1111 0.0129115543426874 Scatter Plot
Target IL1 Target PDGF PDGF Secreted Signaling -0.1076 0.0161302011844248 Scatter Plot
Target IL1 Source PECAM1 PECAM1 Cell-Cell Contact -0.1065 0.0172435139861156 Scatter Plot
Target IL1 Target PECAM1 PECAM1 Cell-Cell Contact -0.1065 0.0172435139861156 Scatter Plot
Source IL1 Source VISTA VISTA Cell-Cell Contact -0.1049 0.0189360433977186 Scatter Plot
Source IL1 Source ESAM ESAM Cell-Cell Contact -0.1046 0.0193087264299381 Scatter Plot
Target IL1 Source PDGF PDGF Secreted Signaling -0.1044 0.0195892248383607 Scatter Plot
Source IL1 Source SEMA3 SEMA3 Secreted Signaling -0.1033 0.0209090310170576 Scatter Plot
Target IL1 Source VISTA VISTA Cell-Cell Contact -0.1033 0.0209157320205075 Scatter Plot
Source IL1 Source CD1D2 CD1D2 Cell-Cell Contact -0.1017 0.022910716850947 Scatter Plot
Source IL1 Source NT NT Secreted Signaling -0.0997 0.0257282558298907 Scatter Plot
Target IL1 Target SELL SELL Cell-Cell Contact -0.0995 0.0260862854178721 Scatter Plot
Target IL1 Source FGF FGF Secreted Signaling -0.0992 0.0266173438085619 Scatter Plot
Source IL1 Source SELL SELL Cell-Cell Contact -0.0990 0.02687494141514 Scatter Plot
Target IL1 Target KIT KIT Secreted Signaling -0.0976 0.0290956437632313 Scatter Plot
Source IL1 Target MK MK Secreted Signaling 0.1078 0.0158652860717227 Scatter Plot
Source IL1 Target THBS THBS ECM-Receptor 0.1085 0.0151842764195803 Scatter Plot
Target IL1 Target IFN-II IFN-II Secreted Signaling 0.1140 0.0107670706521476 Scatter Plot
Target IL1 Target MIF MIF Secreted Signaling 0.1159 0.0094657072672126 Scatter Plot
Source IL1 Target ICAM ICAM Cell-Cell Contact 0.1179 0.0083049556041797 Scatter Plot
Source IL1 Source THBS THBS ECM-Receptor 0.1278 0.0041985685322265 Scatter Plot
Source IL1 Target CXCL CXCL Secreted Signaling 0.1401 0.0016873443755974 Scatter Plot
Source IL1 Target LAMININ LAMININ ECM-Receptor 0.1417 0.0014866553007252 Scatter Plot
Target IL1 Target CLEC CLEC Cell-Cell Contact 0.1437 0.0012717957463803 Scatter Plot
Source IL1 Target CCL CCL Secreted Signaling 0.1475 0.0009429375983507 Scatter Plot
Source IL1 Target ANNEXIN ANNEXIN Secreted Signaling 0.1494 0.0008057033335645 Scatter Plot
Target IL1 Target TGFb TGFb Secreted Signaling 0.1525 0.0006206512137901 Scatter Plot
Source IL1 Target SEMA7 SEMA7 Cell-Cell Contact 0.1594 0.0003454322421947 Scatter Plot
Source IL1 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1694 0.0001406805063114 Scatter Plot
Target IL1 Target CD22 CD22 Cell-Cell Contact 0.1791 0.00005626354317025534 Scatter Plot
Source IL1 Target TENASCIN TENASCIN ECM-Receptor 0.2111 0.000001912049118590158 Scatter Plot
Source IL1 Target VTN VTN ECM-Receptor 0.2140 0.0000013713292761253202 Scatter Plot
Target IL1 Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2166 0.00000101382806958397 Scatter Plot
Target IL1 Target ANNEXIN ANNEXIN Secreted Signaling 0.2335 0.00000012755198133398413 Scatter Plot
Target IL1 Target GALECTIN GALECTIN Secreted Signaling 0.2349 0.00000010690463497574664 Scatter Plot
Target IL1 Target ICAM ICAM Cell-Cell Contact 0.2423 0.0000000408069717517871 Scatter Plot
Source IL1 Target PARs PARs Secreted Signaling 0.2586 0.000000004398857708574991 Scatter Plot
Source IL1 Target VWF VWF ECM-Receptor 0.2597 0.000000003763442291862099 Scatter Plot
Source IL1 Target FN1 FN1 ECM-Receptor 0.2714 0.0000000006782188645375461 Scatter Plot
Source IL1 Target CD200 CD200 Cell-Cell Contact -0.2044 0.00000405877029711982 Scatter Plot
Target IL1 Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.1984 0.000007858221910334738 Scatter Plot
Source IL1 Target IFN-II IFN-II Secreted Signaling -0.1934 0.000013373240219273071 Scatter Plot
Target IL1 Target SELPLG SELPLG Cell-Cell Contact -0.1682 0.000157088182055 Scatter Plot
Source IL1 Target WNT WNT Secreted Signaling -0.1655 0.0002010110621889 Scatter Plot
Source IL1 Target CDH CDH Cell-Cell Contact -0.1495 0.0007976170074555 Scatter Plot
Target IL1 Target CSF CSF Secreted Signaling -0.1487 0.0008547164123959 Scatter Plot
Source IL1 Target SLURP SLURP Secreted Signaling -0.1469 0.0009868799313393 Scatter Plot
Source IL1 Target ncWNT ncWNT Secreted Signaling -0.1465 0.0010160606023502 Scatter Plot
Source IL1 Target NCAM NCAM Cell-Cell Contact -0.1434 0.0013050274712533 Scatter Plot
Source IL1 Source LCK LCK Cell-Cell Contact -0.1389 0.0018553956558788 Scatter Plot
Source IL1 Target CD22 CD22 Cell-Cell Contact -0.1348 0.0025172175295835 Scatter Plot
Source IL1 Source IL2 IL2 Secreted Signaling -0.1234 0.0057226708888173 Scatter Plot
Source IL1 Target BMP BMP Secreted Signaling -0.1222 0.006203251956822 Scatter Plot
Source IL1 Target EPHA EPHA Cell-Cell Contact -0.1217 0.0064497095387638 Scatter Plot
Source IL1 Source CXCL CXCL Secreted Signaling -0.1199 0.0072643153365907 Scatter Plot
Source IL1 Target KIT KIT Secreted Signaling -0.1197 0.0073968148327148 Scatter Plot
Source IL1 Target CD52 CD52 Cell-Cell Contact -0.1182 0.0081736474930715 Scatter Plot
Source IL1 Target NPR2 NPR2 Secreted Signaling -0.1165 0.0091374875488933 Scatter Plot
Source IL1 Target AGT AGT Secreted Signaling -0.1159 0.0094660814209624 Scatter Plot
Source IL1 Target SEMA4 SEMA4 Cell-Cell Contact -0.1117 0.0124598509024869 Scatter Plot
Source IL1 Target BAFF BAFF Secreted Signaling -0.1116 0.0125587568605844 Scatter Plot
Source IL1 Target APP APP Cell-Cell Contact -0.1099 0.0139423506386847 Scatter Plot
Target IL1 Target CLEC CLEC Cell-Cell Contact -0.1065 0.017235035288689 Scatter Plot
Source IL1 Target JAM JAM Cell-Cell Contact -0.1057 0.0180552693267977 Scatter Plot
Source IL1 Target ESAM ESAM Cell-Cell Contact -0.1046 0.0193087264299381 Scatter Plot
Source IL1 Target FGF FGF Secreted Signaling -0.1034 0.0207013256171051 Scatter Plot
Source IL1 Target CSPG4 CSPG4 Cell-Cell Contact -0.1033 0.0209322479819531 Scatter Plot
Source IL1 Target IL17 IL17 Secreted Signaling -0.1032 0.0210532178843711 Scatter Plot
Source IL1 Target SELPLG SELPLG Cell-Cell Contact -0.1029 0.0213889177528614 Scatter Plot
Source IL1 Target TGFb TGFb Secreted Signaling -0.1024 0.0220089057390147 Scatter Plot
Target IL1 Target GRN GRN Secreted Signaling -0.0981 0.0282773880728319 Scatter Plot

Cells that are targets of IL1 from HSCs*

Cells that are source of IL1 to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.