Pathway: SELE

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Cell-Cell Contact

Details on the SELE pathway:

Specificity Index HSPC as target: 0.386
HSPC as source: 0.547

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the SELE pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target SELE Source SPP1 SPP1 Secreted Signaling 0.0991 0.0266802509152319 Scatter Plot
Target SELE Source PARs PARs Secreted Signaling 0.1005 0.0245838786238203 Scatter Plot
Target SELE Source CLEC CLEC Cell-Cell Contact 0.1053 0.0185529652624288 Scatter Plot
Target SELE Source OSM OSM Secreted Signaling 0.1082 0.0155338674268362 Scatter Plot
Target SELE Target GDF GDF Secreted Signaling 0.1160 0.0094424955756812 Scatter Plot
Target SELE Source NCAM NCAM Cell-Cell Contact 0.1193 0.0075970181130997 Scatter Plot
Target SELE Source ANGPTL ANGPTL Secreted Signaling 0.1241 0.005470373695304 Scatter Plot
Target SELE Source SELPLG SELPLG Cell-Cell Contact 0.1254 0.0049801867867975 Scatter Plot
Target SELE Source BAFF BAFF Secreted Signaling 0.1419 0.0014675899264193 Scatter Plot
Target SELE Source TNF TNF Secreted Signaling 0.1538 0.0005586278345573 Scatter Plot
Target SELE Source IL16 IL16 Secreted Signaling 0.1569 0.0004281724744096 Scatter Plot
Target SELE Source SEMA4 SEMA4 Cell-Cell Contact 0.1576 0.0004048348683439 Scatter Plot
Target SELE Source GRN GRN Secreted Signaling 0.1611 0.0002972891454431 Scatter Plot
Target SELE Source PSAP PSAP Secreted Signaling 0.1613 0.000292855801709 Scatter Plot
Target SELE Source CD45 CD45 Cell-Cell Contact 0.1681 0.0001586296907708 Scatter Plot
Target SELE Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1728 0.0001029119574009 Scatter Plot
Target SELE Source VISTA VISTA Cell-Cell Contact 0.1756 0.00007927061581019324 Scatter Plot
Target SELE Source SELL SELL Cell-Cell Contact 0.1881 0.000023129787896154862 Scatter Plot
Target SELE Source APP APP Cell-Cell Contact 0.1881 0.00002292131985460077 Scatter Plot
Target SELE Source COMPLEMENT COMPLEMENT Secreted Signaling 0.1975 0.000008616566914766887 Scatter Plot
Target SELE Source CD52 CD52 Cell-Cell Contact 0.2034 0.00000453437457593318 Scatter Plot
Target SELE Source ANNEXIN ANNEXIN Secreted Signaling 0.2038 0.00000435310887504757 Scatter Plot
Target SELE Source GALECTIN GALECTIN Secreted Signaling -0.1971 0.000008986193479695662 Scatter Plot
Target SELE Source LIFR LIFR Secreted Signaling -0.1599 0.0003308904016253 Scatter Plot
Target SELE Source ICAM ICAM Cell-Cell Contact -0.1480 0.0009044111209284 Scatter Plot
Target SELE Source TGFb TGFb Secreted Signaling -0.1423 0.0014229430258704 Scatter Plot
Target SELE Source MIF MIF Secreted Signaling -0.1395 0.0017687901235618 Scatter Plot
Target SELE Source FGF FGF Secreted Signaling -0.1384 0.0019206497727321 Scatter Plot
Target SELE Source PDGF PDGF Secreted Signaling -0.1312 0.003288806340624 Scatter Plot
Target SELE Target VWF VWF ECM-Receptor -0.1266 0.0045719270012158 Scatter Plot
Target SELE Source THBS THBS ECM-Receptor -0.1186 0.0079486565011639 Scatter Plot
Target SELE Source EPHB EPHB Cell-Cell Contact -0.1030 0.0212481063619599 Scatter Plot
Target SELE Source JAM JAM Cell-Cell Contact -0.1003 0.0249740970202421 Scatter Plot
Target SELE Source THY1 THY1 Cell-Cell Contact -0.0997 0.0258203006333339 Scatter Plot
Target SELE Source BST2 BST2 Cell-Cell Contact -0.0967 0.0305435598489021 Scatter Plot
Target SELE Target CD45 CD45 Cell-Cell Contact 0.0988 0.0272257566494254 Scatter Plot
Target SELE Target CD52 CD52 Cell-Cell Contact 0.1003 0.0248599948364312 Scatter Plot
Target SELE Target LAIR1 LAIR1 Cell-Cell Contact 0.1043 0.0196753565956737 Scatter Plot
Target SELE Target BST2 BST2 Cell-Cell Contact 0.1043 0.0196753565956737 Scatter Plot
Target SELE Target THY1 THY1 Cell-Cell Contact 0.1063 0.0174402592262155 Scatter Plot
Target SELE Target CD23 CD23 Cell-Cell Contact 0.1066 0.0171009279611469 Scatter Plot
Target SELE Target CXCL CXCL Secreted Signaling 0.1119 0.0122881003602278 Scatter Plot
Target SELE Target VCAM VCAM Cell-Cell Contact 0.1126 0.0117763819212701 Scatter Plot
Target SELE Target CSF CSF Secreted Signaling 0.1295 0.003719096886249 Scatter Plot
Target SELE Target GRN GRN Secreted Signaling 0.1390 0.0018356943563347 Scatter Plot
Target SELE Target COMPLEMENT COMPLEMENT Secreted Signaling 0.1557 0.000473827633691 Scatter Plot
Target SELE Target ANGPTL ANGPTL Secreted Signaling 0.1561 0.0004581395553262 Scatter Plot
Target SELE Target IL1 IL1 Secreted Signaling 0.1624 0.0002648014233347 Scatter Plot
Target SELE Target CD22 CD22 Cell-Cell Contact 0.1681 0.0001586296907708 Scatter Plot
Target SELE Target NODAL NODAL Secreted Signaling 0.1695 0.000139634632137 Scatter Plot
Target SELE Target CEACAM CEACAM Cell-Cell Contact 0.1727 0.0001042073316142 Scatter Plot
Target SELE Target ICAM ICAM Cell-Cell Contact 0.1788 0.00005808641476652036 Scatter Plot
Target SELE Target IFN-II IFN-II Secreted Signaling 0.1927 0.000014310494684569768 Scatter Plot
Target SELE Target ANNEXIN ANNEXIN Secreted Signaling 0.1965 0.000009567645554671615 Scatter Plot
Target SELE Target CLEC CLEC Cell-Cell Contact 0.2010 0.000005901941262952053 Scatter Plot
Target SELE Target CCL CCL Secreted Signaling 0.2087 0.0000025166163799992867 Scatter Plot
Target SELE Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.1625 0.0002623186795386 Scatter Plot
Target SELE Target PARs PARs Secreted Signaling -0.1340 0.0026743557933327 Scatter Plot
Target SELE Target PTN PTN Secreted Signaling -0.1316 0.0031967094387108 Scatter Plot
Target SELE Target CD34 CD34 Cell-Cell Contact -0.1270 0.0044429173900634 Scatter Plot
Target SELE Target MK MK Secreted Signaling -0.1096 0.0141964212081632 Scatter Plot
Target SELE Target TENASCIN TENASCIN ECM-Receptor -0.1060 0.0176954302268591 Scatter Plot

Cells that are targets of SELE from HSCs*

    No cell populations

Cells that are source of SELE to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.