Pathway: CEACAM

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Cell-Cell Contact

Details on the CEACAM pathway:

Specificity Index HSPC as target: 0.388
HSPC as source: 0.221

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the CEACAM pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target CEACAM Source CCL CCL Secreted Signaling 0.1166 0.0090705737648119 Scatter Plot
Target CEACAM Target CSF CSF Secreted Signaling 0.1710 0.0001220458874047 Scatter Plot
Target CEACAM Target VEGF VEGF Secreted Signaling 0.1716 0.0001149996363368 Scatter Plot
Target CEACAM Target SELE SELE Cell-Cell Contact 0.1727 0.0001042073316142 Scatter Plot
Target CEACAM Target COLLAGEN COLLAGEN ECM-Receptor 0.1952 0.000010972046605362067 Scatter Plot
Target CEACAM Source CLEC CLEC Cell-Cell Contact 0.1969 0.000009185224686414896 Scatter Plot
Target CEACAM Source SPP1 SPP1 Secreted Signaling 0.2287 0.0000002331839730818865 Scatter Plot
Target CEACAM Target CXCL CXCL Secreted Signaling 0.2331 0.00000013510855265242918 Scatter Plot
Target CEACAM Source TNF TNF Secreted Signaling 0.2517 0.00000001148328973276606 Scatter Plot
Target CEACAM Target NCAM NCAM Cell-Cell Contact 0.2622 0.000000002638967438239863 Scatter Plot
Target CEACAM Source PARs PARs Secreted Signaling 0.2688 0.0000000010062463813429163 Scatter Plot
Target CEACAM Target CD23 CD23 Cell-Cell Contact 0.2749 0.00000000040626336909259814 Scatter Plot
Target CEACAM Source LAIR1 LAIR1 Cell-Cell Contact 0.2926 0.000000000024849888127556424 Scatter Plot
Target CEACAM Target CLEC CLEC Cell-Cell Contact 0.3071 0.0000000000021960543455926377 Scatter Plot
Target CEACAM Source BAFF BAFF Secreted Signaling 0.3105 0.0000000000012224315338378484 Scatter Plot
Target CEACAM Source GRN GRN Secreted Signaling 0.3277 0.000000000000055902357440931643 Scatter Plot
Target CEACAM Source SELL SELL Cell-Cell Contact 0.3334 0.000000000000019154652744420023 Scatter Plot
Target CEACAM Target CD52 CD52 Cell-Cell Contact 0.3558 0.0000000000000002269508651573365 Scatter Plot
Target CEACAM Target CCL CCL Secreted Signaling 0.3802 0.0000000000000000012023003605324217 Scatter Plot
Target CEACAM Source APP APP Cell-Cell Contact 0.3853 0.00000000000000000038453606818369383 Scatter Plot
Target CEACAM Target COMPLEMENT COMPLEMENT Secreted Signaling 0.3944 0.00000000000000000004638318716810145 Scatter Plot
Target CEACAM Source NCAM NCAM Cell-Cell Contact 0.3955 0.00000000000000000003601725944146841 Scatter Plot
Target CEACAM Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.4084 0.0000000000000000000015949261705774756 Scatter Plot
Target CEACAM Source SEMA4 SEMA4 Cell-Cell Contact 0.4268 0.00000000000000000000001488723981094948 Scatter Plot
Target CEACAM Source CD52 CD52 Cell-Cell Contact 0.4448 0.00000000000000000000000011265447175525323 Scatter Plot
Target CEACAM Source VISTA VISTA Cell-Cell Contact 0.4515 0.000000000000000000000000017497422394575132 Scatter Plot
Target CEACAM Source ANNEXIN ANNEXIN Secreted Signaling 0.4554 0.000000000000000000000000005602192209494325 Scatter Plot
Target CEACAM Target ICAM ICAM Cell-Cell Contact 0.4766 0.000000000000000000000000000010183219028833417 Scatter Plot
Target CEACAM Source COMPLEMENT COMPLEMENT Secreted Signaling 0.5132 0.00000000000000000000000000000000006011883179421193 Scatter Plot
Target CEACAM Target MK MK Secreted Signaling -0.4180 0.0000000000000000000001435114945989773 Scatter Plot
Target CEACAM Source GALECTIN GALECTIN Secreted Signaling -0.3882 0.00000000000000000019405349800513485 Scatter Plot
Target CEACAM Target PTN PTN Secreted Signaling -0.3843 0.0000000000000000004833679408881077 Scatter Plot
Target CEACAM Target KIT KIT Secreted Signaling -0.3722 0.00000000000000000702824359215002 Scatter Plot
Target CEACAM Source ANGPT ANGPT Secreted Signaling -0.3587 0.0000000000000001237455853514267 Scatter Plot
Target CEACAM Source MHC-I MHC-I Cell-Cell Contact -0.3524 0.000000000000000452932645686634 Scatter Plot
Target CEACAM Source BST2 BST2 Cell-Cell Contact -0.3496 0.0000000000000008057424429956973 Scatter Plot
Target CEACAM Target CD34 CD34 Cell-Cell Contact -0.3455 0.0000000000000018060280275336795 Scatter Plot
Target CEACAM Source VCAM VCAM Cell-Cell Contact -0.3421 0.000000000000003534408879142559 Scatter Plot
Target CEACAM Source MHC-II MHC-II Cell-Cell Contact -0.3190 0.0000000000002710023768560123 Scatter Plot
Target CEACAM Target SPP1 SPP1 Secreted Signaling -0.2962 0.00000000001393862940296715 Scatter Plot
Target CEACAM Target ncWNT ncWNT Secreted Signaling -0.2913 0.000000000030895362966757857 Scatter Plot
Target CEACAM Source ESAM ESAM Cell-Cell Contact -0.2871 0.00000000006071013978634802 Scatter Plot
Target CEACAM Target ESAM ESAM Cell-Cell Contact -0.2871 0.00000000006071013978634802 Scatter Plot
Target CEACAM Source JAM JAM Cell-Cell Contact -0.2838 0.00000000010254693495155157 Scatter Plot
Target CEACAM Target TENASCIN TENASCIN ECM-Receptor -0.2758 0.00000000035377848966159926 Scatter Plot
Target CEACAM Target VWF VWF ECM-Receptor -0.2729 0.0000000005437722650761073 Scatter Plot
Target CEACAM Source COLLAGEN COLLAGEN ECM-Receptor -0.2698 0.0000000008618290535706241 Scatter Plot
Target CEACAM Target SEMA7 SEMA7 Cell-Cell Contact -0.2681 0.000000001122325795577267 Scatter Plot
Target CEACAM Target CD39 CD39 Cell-Cell Contact -0.2619 0.0000000027611257345173807 Scatter Plot
Target CEACAM Source LIFR LIFR Secreted Signaling -0.2592 0.000000004030352947998685 Scatter Plot
Target CEACAM Source LCK LCK Cell-Cell Contact -0.2508 0.000000013038672524120109 Scatter Plot
Target CEACAM Source SEMA7 SEMA7 Cell-Cell Contact -0.2431 0.000000036838043505966375 Scatter Plot
Target CEACAM Source EPHB EPHB Cell-Cell Contact -0.2421 0.0000000423032397786264 Scatter Plot
Target CEACAM Source BMP BMP Secreted Signaling -0.2414 0.000000046129252970572216 Scatter Plot
Target CEACAM Target VTN VTN ECM-Receptor -0.2408 0.0000000500829717247027 Scatter Plot
Target CEACAM Target FN1 FN1 ECM-Receptor -0.2349 0.0000001070555633587078 Scatter Plot
Target CEACAM Source TWEAK TWEAK Secreted Signaling -0.2328 0.00000014028979064188694 Scatter Plot
Target CEACAM Source ICAM ICAM Cell-Cell Contact -0.2311 0.00000017437288352298614 Scatter Plot
Target CEACAM Target IGF IGF Secreted Signaling -0.2307 0.00000018217040051612417 Scatter Plot
Target CEACAM Target JAM JAM Cell-Cell Contact -0.2246 0.0000003873234291470072 Scatter Plot
Target CEACAM Source PDGF PDGF Secreted Signaling -0.2231 0.0000004652052082523131 Scatter Plot
Target CEACAM Source GAS GAS Secreted Signaling -0.2207 0.0000006179682378960423 Scatter Plot
Target CEACAM Target EPHB EPHB Cell-Cell Contact -0.2142 0.0000013403777544800425 Scatter Plot
Target CEACAM Source VEGF VEGF Secreted Signaling -0.2129 0.0000015616619247139484 Scatter Plot
Target CEACAM Target SLURP SLURP Secreted Signaling -0.2113 0.0000018623032419662011 Scatter Plot
Target CEACAM Source THY1 THY1 Cell-Cell Contact -0.2110 0.0000019369236238784717 Scatter Plot
Target CEACAM Source FLT3 FLT3 Secreted Signaling -0.2104 0.0000020638985209787444 Scatter Plot
Target CEACAM Source MK MK Secreted Signaling -0.2037 0.000004402448088371797 Scatter Plot
Target CEACAM Source CD34 CD34 Cell-Cell Contact -0.2012 0.000005787012036640239 Scatter Plot
Target CEACAM Target ANGPTL ANGPTL Secreted Signaling -0.1972 0.000008924930655166653 Scatter Plot
Target CEACAM Target SEMA5 SEMA5 Cell-Cell Contact -0.1963 0.000009790910142629703 Scatter Plot
Target CEACAM Target SEMA6 SEMA6 Cell-Cell Contact -0.1942 0.0000122546588011305 Scatter Plot
Target CEACAM Target LAMININ LAMININ ECM-Receptor -0.1877 0.000024000980051439702 Scatter Plot
Target CEACAM Source FGF FGF Secreted Signaling -0.1873 0.00002500444754912902 Scatter Plot
Target CEACAM Target APP APP Cell-Cell Contact -0.1870 0.00002561032136322387 Scatter Plot
Target CEACAM Source GP1BA GP1BA Cell-Cell Contact -0.1870 0.00002566327698913742 Scatter Plot
Target CEACAM Target VISFATIN VISFATIN Secreted Signaling -0.1849 0.00003182412987458108 Scatter Plot
Target CEACAM Target MIF MIF Secreted Signaling -0.1841 0.00003430078460769932 Scatter Plot
Target CEACAM Target DMP1 DMP1 ECM-Receptor -0.1829 0.00003881140985799657 Scatter Plot
Target CEACAM Target CDH CDH Cell-Cell Contact -0.1820 0.00004264952983349823 Scatter Plot
Target CEACAM Source CDH CDH Cell-Cell Contact -0.1820 0.00004264952983349846 Scatter Plot
Target CEACAM Target NPR2 NPR2 Secreted Signaling -0.1808 0.00004780491928021766 Scatter Plot
Target CEACAM Target BSP BSP ECM-Receptor -0.1755 0.00007957469970376029 Scatter Plot
Target CEACAM Source IL2 IL2 Secreted Signaling -0.1718 0.0001132358085532 Scatter Plot
Target CEACAM Source IL7 IL7 Secreted Signaling -0.1718 0.0001132358085532 Scatter Plot
Target CEACAM Source CXCL CXCL Secreted Signaling -0.1703 0.0001299891469124 Scatter Plot
Target CEACAM Source SEMA4 SEMA4 Cell-Cell Contact -0.1610 0.0003010335047333 Scatter Plot
Target CEACAM Target PERIOSTIN PERIOSTIN Secreted Signaling -0.1596 0.0003393032960184 Scatter Plot
Target CEACAM Target VEGF VEGF Secreted Signaling -0.1563 0.000449934213269 Scatter Plot
Target CEACAM Target THBS THBS ECM-Receptor -0.1553 0.0004918386584621 Scatter Plot
Target CEACAM Source PSAP PSAP Secreted Signaling -0.1540 0.0005485345450972 Scatter Plot
Target CEACAM Target TWEAK TWEAK Secreted Signaling -0.1524 0.0006266495584979 Scatter Plot
Target CEACAM Source CD86 CD86 Cell-Cell Contact -0.1496 0.0007937906870597 Scatter Plot
Target CEACAM Source CCL CCL Secreted Signaling -0.1491 0.0008274557054547 Scatter Plot
Target CEACAM Source PROS PROS Secreted Signaling -0.1475 0.0009430368274945 Scatter Plot
Target CEACAM Target BMP BMP Secreted Signaling -0.1404 0.0016468672369336 Scatter Plot
Target CEACAM Source NT NT Secreted Signaling -0.1382 0.0019479899815279 Scatter Plot
Target CEACAM Source ANGPTL ANGPTL Secreted Signaling -0.1376 0.002047655214927 Scatter Plot
Target CEACAM Target CD200 CD200 Cell-Cell Contact -0.1374 0.0020673194064628 Scatter Plot
Target CEACAM Target PDGF PDGF Secreted Signaling -0.1329 0.0028962315671006 Scatter Plot
Target CEACAM Source MIF MIF Secreted Signaling -0.1300 0.0035790474129829 Scatter Plot
Target CEACAM Target COLLAGEN COLLAGEN ECM-Receptor -0.1298 0.0036436096931104 Scatter Plot
Target CEACAM Source CD46 CD46 Cell-Cell Contact -0.1275 0.0043054010667939 Scatter Plot
Target CEACAM Source IGF IGF Secreted Signaling -0.1238 0.0055593099505304 Scatter Plot
Target CEACAM Target ACTIVIN ACTIVIN Secreted Signaling -0.1234 0.0057158704134106 Scatter Plot
Target CEACAM Source PTN PTN Secreted Signaling -0.1229 0.0059480911926799 Scatter Plot
Target CEACAM Source CSF CSF Secreted Signaling -0.1227 0.0059984288617785 Scatter Plot
Target CEACAM Source RANKL RANKL Secreted Signaling -0.1189 0.0077636655679534 Scatter Plot
Target CEACAM Target CSPG4 CSPG4 Cell-Cell Contact -0.1153 0.0098786459469339 Scatter Plot
Target CEACAM Source GDF GDF Secreted Signaling -0.1142 0.0105752951910626 Scatter Plot
Target CEACAM Source OSM OSM Secreted Signaling -0.1080 0.0156727334414839 Scatter Plot
Target CEACAM Source LAMININ LAMININ ECM-Receptor -0.1040 0.0200714296829757 Scatter Plot
Target CEACAM Target GRN GRN Secreted Signaling 0.1201 0.0071739221677573 Scatter Plot
Target CEACAM Target CSF CSF Secreted Signaling 0.1710 0.0001220458874047 Scatter Plot
Target CEACAM Target GALECTIN GALECTIN Secreted Signaling 0.1748 0.00008511601166723248 Scatter Plot
Target CEACAM Target ANGPTL ANGPTL Secreted Signaling 0.1786 0.0000593786526342825 Scatter Plot
Target CEACAM Target COLLAGEN COLLAGEN ECM-Receptor 0.1803 0.00005029408263958589 Scatter Plot
Target CEACAM Target SEMA3 SEMA3 Secreted Signaling 0.1950 0.000011275562547468878 Scatter Plot
Target CEACAM Target CXCL CXCL Secreted Signaling 0.2341 0.00000011868591817528196 Scatter Plot
Target CEACAM Target CD23 CD23 Cell-Cell Contact 0.2749 0.00000000040626336909259814 Scatter Plot
Target CEACAM Target THY1 THY1 Cell-Cell Contact 0.2766 0.000000000313671763039361 Scatter Plot
Target CEACAM Target IL1 IL1 Secreted Signaling 0.2794 0.0000000002019917557305932 Scatter Plot
Target CEACAM Target ANNEXIN ANNEXIN Secreted Signaling 0.2905 0.000000000035200187743507206 Scatter Plot
Target CEACAM Target CLEC CLEC Cell-Cell Contact 0.3071 0.0000000000021960543455926377 Scatter Plot
Target CEACAM Target IFN-II IFN-II Secreted Signaling 0.3492 0.0000000000000008686744672609157 Scatter Plot
Target CEACAM Target CCL CCL Secreted Signaling 0.3513 0.0000000000000005661511020723555 Scatter Plot
Target CEACAM Target CD52 CD52 Cell-Cell Contact 0.3558 0.0000000000000002269508651573365 Scatter Plot
Target CEACAM Target COMPLEMENT COMPLEMENT Secreted Signaling 0.4255 0.00000000000000000000002060620178007971 Scatter Plot
Target CEACAM Target VCAM VCAM Cell-Cell Contact 0.4396 0.00000000000000000000000048119263689628775 Scatter Plot
Target CEACAM Target PARs PARs Secreted Signaling -0.3778 0.0000000000000000020733825338938735 Scatter Plot
Target CEACAM Target CD34 CD34 Cell-Cell Contact -0.3455 0.0000000000000018060280275336795 Scatter Plot
Target CEACAM Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.2815 0.00000000014611913760949363 Scatter Plot
Target CEACAM Target WNT WNT Secreted Signaling -0.2719 0.0000000006298300046154317 Scatter Plot
Target CEACAM Target SEMA4 SEMA4 Cell-Cell Contact -0.2668 0.0000000013539623889197011 Scatter Plot
Target CEACAM Target CD39 CD39 Cell-Cell Contact -0.2619 0.0000000027611257345173807 Scatter Plot
Target CEACAM Target FGF FGF Secreted Signaling -0.2183 0.0000008289049016318097 Scatter Plot
Target CEACAM Target SELL SELL Cell-Cell Contact -0.2164 0.0000010296861602797829 Scatter Plot
Target CEACAM Target TGFb TGFb Secreted Signaling -0.2108 0.000001983596445894082 Scatter Plot
Target CEACAM Target NRG NRG Secreted Signaling -0.2027 0.000004879700490761422 Scatter Plot
Target CEACAM Target CDH CDH Cell-Cell Contact -0.1820 0.00004264952983349846 Scatter Plot
Target CEACAM Target ANGPT ANGPT Secreted Signaling -0.1649 0.0002127680093539 Scatter Plot
Target CEACAM Target BAFF BAFF Secreted Signaling -0.1540 0.0005492944430579 Scatter Plot
Target CEACAM Target CD200 CD200 Cell-Cell Contact -0.1375 0.0020584905092191 Scatter Plot
Target CEACAM Target COLLAGEN COLLAGEN ECM-Receptor -0.1283 0.0040627347805045 Scatter Plot
Target CEACAM Target CSPG4 CSPG4 Cell-Cell Contact -0.1153 0.0098786459469339 Scatter Plot

Cells that are targets of CEACAM from HSCs*

    No cell populations

Cells that are source of CEACAM to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.