Pathway: SLURP

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the SLURP pathway:

Specificity Index HSPC as target: 0.423
HSPC as source: 0.731

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the SLURP pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target SLURP Source THBS THBS ECM-Receptor 0.0973 0.0296008117067605 Scatter Plot
Target SLURP Source IL6 IL6 Secreted Signaling 0.1005 0.0246809458320119 Scatter Plot
Target SLURP Source PECAM1 PECAM1 Cell-Cell Contact 0.1024 0.0219704082108189 Scatter Plot
Target SLURP Target GAS GAS Secreted Signaling 0.1094 0.0143417295055597 Scatter Plot
Target SLURP Source SEMA6 SEMA6 Cell-Cell Contact 0.1099 0.0139783445550259 Scatter Plot
Target SLURP Target SEMA3 SEMA3 Secreted Signaling 0.1123 0.0119962850453478 Scatter Plot
Target SLURP Source ANGPTL ANGPTL Secreted Signaling 0.1279 0.0041658607976156 Scatter Plot
Target SLURP Source ncWNT ncWNT Secreted Signaling 0.1294 0.0037522266899404 Scatter Plot
Target SLURP Target NOTCH NOTCH Cell-Cell Contact 0.1594 0.0003451888953151 Scatter Plot
Target SLURP Source PTN PTN Secreted Signaling 0.1726 0.0001044125228738 Scatter Plot
Target SLURP Source APELIN APELIN Secreted Signaling 0.1928 0.00001412800882870401 Scatter Plot
Target SLURP Source WNT WNT Secreted Signaling 0.1948 0.000011478278401210076 Scatter Plot
Target SLURP Target NCAM NCAM Cell-Cell Contact 0.2249 0.00000037583053551060986 Scatter Plot
Target SLURP Source CD46 CD46 Cell-Cell Contact 0.2495 0.00000001569887415426114 Scatter Plot
Target SLURP Target CSPG4 CSPG4 Cell-Cell Contact 0.2581 0.000000004703470546882679 Scatter Plot
Target SLURP Source GDF GDF Secreted Signaling 0.2597 0.000000003780011194478627 Scatter Plot
Target SLURP Source CD1D2 CD1D2 Cell-Cell Contact 0.2644 0.000000001910939966891885 Scatter Plot
Target SLURP Source THY1 THY1 Cell-Cell Contact 0.2659 0.0000000015469296465188071 Scatter Plot
Target SLURP Source VCAM VCAM Cell-Cell Contact 0.2820 0.00000000013632968413418222 Scatter Plot
Target SLURP Target EPHA EPHA Cell-Cell Contact 0.2899 0.000000000038434593311114434 Scatter Plot
Target SLURP Target SPP1 SPP1 Secreted Signaling 0.2946 0.000000000018149610308013856 Scatter Plot
Target SLURP Target GDF GDF Secreted Signaling 0.2975 0.000000000011154411729436809 Scatter Plot
Target SLURP Source CXCL CXCL Secreted Signaling 0.3071 0.000000000002204209100535403 Scatter Plot
Target SLURP Source RANKL RANKL Secreted Signaling 0.3095 0.000000000001465191187908219 Scatter Plot
Target SLURP Source VEGF VEGF Secreted Signaling 0.3107 0.0000000000011844889921427117 Scatter Plot
Target SLURP Target ANGPTL ANGPTL Secreted Signaling 0.3112 0.0000000000010834981105977486 Scatter Plot
Target SLURP Source CADM CADM Cell-Cell Contact 0.3114 0.000000000001044407715617468 Scatter Plot
Target SLURP Source LIGHT LIGHT Secreted Signaling 0.3191 0.0000000000002678570846198028 Scatter Plot
Target SLURP Source CCL CCL Secreted Signaling 0.3252 0.00000000000008858185081997419 Scatter Plot
Target SLURP Source SEMA3 SEMA3 Secreted Signaling 0.3410 0.0000000000000043978515847349774 Scatter Plot
Target SLURP Source CD39 CD39 Cell-Cell Contact 0.3425 0.0000000000000032870047429331958 Scatter Plot
Target SLURP Source IGF IGF Secreted Signaling 0.3466 0.00000000000000145948750770778 Scatter Plot
Target SLURP Source NT NT Secreted Signaling 0.3572 0.00000000000000016876701134109263 Scatter Plot
Target SLURP Source IL2 IL2 Secreted Signaling 0.3699 0.000000000000000011730518150016992 Scatter Plot
Target SLURP Target THBS THBS ECM-Receptor 0.3733 0.00000000000000000559827014454768 Scatter Plot
Target SLURP Source PROS PROS Secreted Signaling 0.3765 0.000000000000000002779041048556823 Scatter Plot
Target SLURP Target VWF VWF ECM-Receptor 0.3855 0.0000000000000000003642964766771596 Scatter Plot
Target SLURP Target SEMA6 SEMA6 Cell-Cell Contact 0.3876 0.0000000000000000002246513641521105 Scatter Plot
Target SLURP Source LAMININ LAMININ ECM-Receptor 0.3892 0.00000000000000000015619756127531434 Scatter Plot
Target SLURP Source CSF CSF Secreted Signaling 0.3950 0.00000000000000000004052009274593082 Scatter Plot
Target SLURP Source NOTCH NOTCH Cell-Cell Contact 0.4174 0.00000000000000000000016686274944344971 Scatter Plot
Target SLURP Target BMP BMP Secreted Signaling 0.4181 0.00000000000000000000013958558258788713 Scatter Plot
Target SLURP Target ACTIVIN ACTIVIN Secreted Signaling 0.4192 0.00000000000000000000010504391933268028 Scatter Plot
Target SLURP Source LIFR LIFR Secreted Signaling 0.4200 0.00000000000000000000008532241409198785 Scatter Plot
Target SLURP Source EPHB EPHB Cell-Cell Contact 0.4202 0.00000000000000000000008215713334953438 Scatter Plot
Target SLURP Source ICAM ICAM Cell-Cell Contact 0.4270 0.0000000000000000000000140452822048616 Scatter Plot
Target SLURP Source CX3C CX3C Secreted Signaling 0.4276 0.000000000000000000000011869221276321586 Scatter Plot
Target SLURP Source CD45 CD45 Cell-Cell Contact 0.4291 0.000000000000000000000008048350572191757 Scatter Plot
Target SLURP Source LCK LCK Cell-Cell Contact 0.4296 0.000000000000000000000007005241224310058 Scatter Plot
Target SLURP Source IL16 IL16 Secreted Signaling 0.4356 0.0000000000000000000000014296272153114592 Scatter Plot
Target SLURP Source CD86 CD86 Cell-Cell Contact 0.4399 0.0000000000000000000000004393909876702961 Scatter Plot
Target SLURP Source CDH CDH Cell-Cell Contact 0.4669 0.0000000000000000000000000001914709426407789 Scatter Plot
Target SLURP Source MK MK Secreted Signaling 0.4836 0.0000000000000000000000000000011067938537412774 Scatter Plot
Target SLURP Source PSAP PSAP Secreted Signaling 0.4972 0.000000000000000000000000000000013885744313861948 Scatter Plot
Target SLURP Source FLT3 FLT3 Secreted Signaling 0.5021 0.000000000000000000000000000000002718260627214246 Scatter Plot
Target SLURP Source PDGF PDGF Secreted Signaling 0.5229 0.000000000000000000000000000000000001878705443944396 Scatter Plot
Target SLURP Target CD39 CD39 Cell-Cell Contact 0.5465 0.0000000000000000000000000000000000000002776284067163324 Scatter Plot
Target SLURP Source TWEAK TWEAK Secreted Signaling 0.5474 0.00000000000000000000000000000000000000019148212428920724 Scatter Plot
Target SLURP Source BMP BMP Secreted Signaling 0.5476 0.0000000000000000000000000000000000000001797471010190228 Scatter Plot
Target SLURP Source SEMA7 SEMA7 Cell-Cell Contact 0.5504 0.00000000000000000000000000000000000000005932053152027468 Scatter Plot
Target SLURP Source IL7 IL7 Secreted Signaling 0.5674 0.00000000000000000000000000000000000000000005767935962590099 Scatter Plot
Target SLURP Target CD200 CD200 Cell-Cell Contact 0.5722 0.000000000000000000000000000000000000000000007705683189020203 Scatter Plot
Target SLURP Target WNT WNT Secreted Signaling 0.5820 0.00000000000000000000000000000000000000000000010936392708560163 Scatter Plot
Target SLURP Source ANGPT ANGPT Secreted Signaling 0.5862 0.000000000000000000000000000000000000000000000016987807153468268 Scatter Plot
Target SLURP Source GAS GAS Secreted Signaling 0.6147 0.000000000000000000000000000000000000000000000000000025859496677230423 Scatter Plot
Target SLURP Source COLLAGEN COLLAGEN ECM-Receptor 0.6156 0.00000000000000000000000000000000000000000000000000001705741815264428 Scatter Plot
Target SLURP Source ESAM ESAM Cell-Cell Contact 0.6268 0.00000000000000000000000000000000000000000000000000000005880707400581914 Scatter Plot
Target SLURP Source BST2 BST2 Cell-Cell Contact 0.6380 0.0000000000000000000000000000000000000000000000000000000001623648448870488 Scatter Plot
Target SLURP Source JAM JAM Cell-Cell Contact 0.6613 0.00000000000000000000000000000000000000000000000000000000000000032128971047644274 Scatter Plot
Target SLURP Source MHC-II MHC-II Cell-Cell Contact 0.7138 0.0000000000000000000000000000000000000000000000000000000000000000000000000000004229157349860617 Scatter Plot
Target SLURP Source MHC-I MHC-I Cell-Cell Contact 0.7210 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002044701724429951 Scatter Plot
Target SLURP Source CD52 CD52 Cell-Cell Contact -0.4665 0.0000000000000000000000000002155501991795329 Scatter Plot
Target SLURP Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.4341 0.000000000000000000000002138800824053965 Scatter Plot
Target SLURP Source COMPLEMENT COMPLEMENT Secreted Signaling -0.4008 0.000000000000000000010170126760930424 Scatter Plot
Target SLURP Source TGFb TGFb Secreted Signaling -0.3802 0.0000000000000000012068889694408413 Scatter Plot
Target SLURP Source SELL SELL Cell-Cell Contact -0.3641 0.00000000000000004052684080634124 Scatter Plot
Target SLURP Source PARs PARs Secreted Signaling -0.3433 0.000000000000002787246972701897 Scatter Plot
Target SLURP Source MIF MIF Secreted Signaling -0.2900 0.000000000038258358923991454 Scatter Plot
Target SLURP Source CLEC CLEC Cell-Cell Contact -0.2728 0.0000000005531151895287756 Scatter Plot
Target SLURP Source ANGPTL ANGPTL Secreted Signaling -0.2443 0.000000031453003529015296 Scatter Plot
Target SLURP Target CXCL CXCL Secreted Signaling -0.2335 0.00000012739231552922408 Scatter Plot
Target SLURP Source VISTA VISTA Cell-Cell Contact -0.2237 0.00000043169322020455486 Scatter Plot
Target SLURP Target IL17 IL17 Secreted Signaling -0.2052 0.0000037246166947798608 Scatter Plot
Target SLURP Source NCAM NCAM Cell-Cell Contact -0.1998 0.000006725267504912829 Scatter Plot
Target SLURP Source SPP1 SPP1 Secreted Signaling -0.1970 0.000009111237094506784 Scatter Plot
Target SLURP Source SEMA4 SEMA4 Cell-Cell Contact -0.1889 0.000021295266187828373 Scatter Plot
Target SLURP Target COLLAGEN COLLAGEN ECM-Receptor -0.1507 0.0007225218112054 Scatter Plot
Target SLURP Source TNF TNF Secreted Signaling -0.1502 0.0007543439482221 Scatter Plot
Target SLURP Source IL1 IL1 Secreted Signaling -0.1469 0.0009868799313393 Scatter Plot
Target SLURP Source CCL CCL Secreted Signaling -0.1399 0.001718703843107 Scatter Plot
Target SLURP Source ANNEXIN ANNEXIN Secreted Signaling -0.1036 0.0204641772615511 Scatter Plot
Target SLURP Target SELL SELL Cell-Cell Contact 0.0986 0.0274639025774032 Scatter Plot
Target SLURP Target PECAM1 PECAM1 Cell-Cell Contact 0.1024 0.0219704082108189 Scatter Plot
Target SLURP Target SEMA3 SEMA3 Secreted Signaling 0.1054 0.0184081276438861 Scatter Plot
Target SLURP Target THY1 THY1 Cell-Cell Contact 0.1608 0.0003057733411806 Scatter Plot
Target SLURP Target RANKL RANKL Secreted Signaling 0.1859 0.00002882028685791688 Scatter Plot
Target SLURP Target GALECTIN GALECTIN Secreted Signaling 0.1883 0.000022449318278452105 Scatter Plot
Target SLURP Target CD23 CD23 Cell-Cell Contact 0.1918 0.000015739488414547382 Scatter Plot
Target SLURP Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.2099 0.000002183728020914347 Scatter Plot
Target SLURP Target OSM OSM Secreted Signaling 0.2137 0.000001421044079858492 Scatter Plot
Target SLURP Target VEGF VEGF Secreted Signaling 0.2249 0.0000003757584695939536 Scatter Plot
Target SLURP Target COLLAGEN COLLAGEN ECM-Receptor 0.2264 0.00000031084563044765864 Scatter Plot
Target SLURP Target FN1 FN1 ECM-Receptor 0.2566 0.000000005863031832801755 Scatter Plot
Target SLURP Target SPP1 SPP1 Secreted Signaling 0.2568 0.000000005672934799519079 Scatter Plot
Target SLURP Target MK MK Secreted Signaling 0.2615 0.00000000291032014740878 Scatter Plot
Target SLURP Target SEMA6 SEMA6 Cell-Cell Contact 0.2649 0.0000000017859255812361691 Scatter Plot
Target SLURP Target PTN PTN Secreted Signaling 0.2690 0.000000000976128727938569 Scatter Plot
Target SLURP Target NODAL NODAL Secreted Signaling 0.2695 0.0000000009109384632075279 Scatter Plot
Target SLURP Target IL6 IL6 Secreted Signaling 0.2746 0.00000000041937235704950966 Scatter Plot
Target SLURP Target VISFATIN VISFATIN Secreted Signaling 0.3034 0.000000000004190957949762912 Scatter Plot
Target SLURP Target AGT AGT Secreted Signaling 0.3048 0.0000000000032849379116988287 Scatter Plot
Target SLURP Target CADM CADM Cell-Cell Contact 0.3114 0.000000000001044407715617468 Scatter Plot
Target SLURP Target SEMA7 SEMA7 Cell-Cell Contact 0.3334 0.00000000000001894033894346364 Scatter Plot
Target SLURP Target SEMA5 SEMA5 Cell-Cell Contact 0.3356 0.000000000000012578077066151024 Scatter Plot
Target SLURP Target COMPLEMENT COMPLEMENT Secreted Signaling 0.3452 0.0000000000000019307892468925946 Scatter Plot
Target SLURP Target LAMININ LAMININ ECM-Receptor 0.3535 0.0000000000000003653103027504983 Scatter Plot
Target SLURP Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.3723 0.000000000000000006955947445571308 Scatter Plot
Target SLURP Target VTN VTN ECM-Receptor 0.3929 0.00000000000000000006577083070682574 Scatter Plot
Target SLURP Target PARs PARs Secreted Signaling 0.3939 0.00000000000000000005168546594665407 Scatter Plot
Target SLURP Target EPHB EPHB Cell-Cell Contact 0.4056 0.0000000000000000000031487597303105093 Scatter Plot
Target SLURP Target TGFb TGFb Secreted Signaling 0.4269 0.000000000000000000000014570062658549238 Scatter Plot
Target SLURP Target KIT KIT Secreted Signaling 0.4286 0.00000000000000000000000912009518055073 Scatter Plot
Target SLURP Target CD22 CD22 Cell-Cell Contact 0.4291 0.000000000000000000000008048350572191757 Scatter Plot
Target SLURP Target PERIOSTIN PERIOSTIN Secreted Signaling 0.4347 0.0000000000000000000000018230417618364996 Scatter Plot
Target SLURP Target BSP BSP ECM-Receptor 0.4409 0.0000000000000000000000003321874804373722 Scatter Plot
Target SLURP Target NRG NRG Secreted Signaling 0.4424 0.0000000000000000000000002196673540813277 Scatter Plot
Target SLURP Target DMP1 DMP1 ECM-Receptor 0.4574 0.0000000000000000000000000032028167838651728 Scatter Plot
Target SLURP Target BAFF BAFF Secreted Signaling 0.4602 0.0000000000000000000000000013832567549210388 Scatter Plot
Target SLURP Target NPR2 NPR2 Secreted Signaling 0.4620 0.0000000000000000000000000008313116978157816 Scatter Plot
Target SLURP Target CDH CDH Cell-Cell Contact 0.4669 0.0000000000000000000000000001914709426407789 Scatter Plot
Target SLURP Target ANGPT ANGPT Secreted Signaling 0.4702 0.00000000000000000000000000007127993638171768 Scatter Plot
Target SLURP Target IGF IGF Secreted Signaling 0.4754 0.00000000000000000000000000001468350250122891 Scatter Plot
Target SLURP Target SEMA4 SEMA4 Cell-Cell Contact 0.4867 0.00000000000000000000000000000041899723673380436 Scatter Plot
Target SLURP Target TENASCIN TENASCIN ECM-Receptor 0.5241 0.0000000000000000000000000000000000012564843047601111 Scatter Plot
Target SLURP Target CD34 CD34 Cell-Cell Contact 0.5557 0.000000000000000000000000000000000000000007031465603829892 Scatter Plot
Target SLURP Target FGF FGF Secreted Signaling 0.5761 0.0000000000000000000000000000000000000000000014637397311797947 Scatter Plot
Target SLURP Target ncWNT ncWNT Secreted Signaling 0.5894 0.0000000000000000000000000000000000000000000000040276857992002285 Scatter Plot
Target SLURP Target JAM JAM Cell-Cell Contact 0.5944 0.0000000000000000000000000000000000000000000000004200452097320036 Scatter Plot
Target SLURP Target APP APP Cell-Cell Contact 0.6025 0.000000000000000000000000000000000000000000000000009458257752865696 Scatter Plot
Target SLURP Target ESAM ESAM Cell-Cell Contact 0.6268 0.00000000000000000000000000000000000000000000000000000005880707400581914 Scatter Plot
Target SLURP Target MIF MIF Secreted Signaling 0.6419 0.000000000000000000000000000000000000000000000000000000000019084595143431716 Scatter Plot
Target SLURP Target ICAM ICAM Cell-Cell Contact -0.4011 0.000000000000000000009478635508433038 Scatter Plot
Target SLURP Target CD52 CD52 Cell-Cell Contact -0.3575 0.00000000000000015973750831345558 Scatter Plot
Target SLURP Target VCAM VCAM Cell-Cell Contact -0.2809 0.0000000001614786237200064 Scatter Plot
Target SLURP Target CSF CSF Secreted Signaling -0.2476 0.000000020146473446423605 Scatter Plot
Target SLURP Target CCL CCL Secreted Signaling -0.2332 0.00000013322712657068348 Scatter Plot
Target SLURP Target CLEC CLEC Cell-Cell Contact -0.2222 0.0000005163473742981921 Scatter Plot
Target SLURP Target CEACAM CEACAM Cell-Cell Contact -0.2113 0.0000018623032419662011 Scatter Plot
Target SLURP Target VEGF VEGF Secreted Signaling -0.1539 0.0005531374610471 Scatter Plot
Target SLURP Target ANNEXIN ANNEXIN Secreted Signaling -0.1484 0.0008765278096528 Scatter Plot
Target SLURP Target IFN-II IFN-II Secreted Signaling -0.1355 0.0023864672087495 Scatter Plot
Target SLURP Target GRN GRN Secreted Signaling -0.1288 0.0039096302821265 Scatter Plot

Cells that are targets of SLURP from HSCs*

    No cell populations

Cells that are source of SLURP to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.