Pathway: PECAM1

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Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Cell-Cell Contact

Details on the PECAM1 pathway:

Specificity Index HSPC as target: 0.566
HSPC as source: 0.566

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the PECAM1 pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target PECAM1 Source ICAM ICAM Cell-Cell Contact 0.0965 0.030889648801161 Scatter Plot
Target PECAM1 Target FN1 FN1 ECM-Receptor 0.0969 0.0302324833012306 Scatter Plot
Target PECAM1 Target PDGF PDGF Secreted Signaling 0.0980 0.0284467569187032 Scatter Plot
Target PECAM1 Source LAMININ LAMININ ECM-Receptor 0.0996 0.0258910419888657 Scatter Plot
Source PECAM1 Source LAMININ LAMININ ECM-Receptor 0.0996 0.0258910419888657 Scatter Plot
Target PECAM1 Target ESAM ESAM Cell-Cell Contact 0.1004 0.0248148170067968 Scatter Plot
Target PECAM1 Source ESAM ESAM Cell-Cell Contact 0.1004 0.0248148170067968 Scatter Plot
Source PECAM1 Source ESAM ESAM Cell-Cell Contact 0.1004 0.0248148170067968 Scatter Plot
Target PECAM1 Source SEMA7 SEMA7 Cell-Cell Contact 0.1015 0.0232249118455703 Scatter Plot
Target PECAM1 Target SLURP SLURP Secreted Signaling 0.1024 0.0219704082108189 Scatter Plot
Target PECAM1 Source IL16 IL16 Secreted Signaling 0.1042 0.0197367640437956 Scatter Plot
Target PECAM1 Source TGFb TGFb Secreted Signaling 0.1068 0.0169157453337329 Scatter Plot
Target PECAM1 Source CXCL CXCL Secreted Signaling 0.1131 0.0113630168529294 Scatter Plot
Target PECAM1 Source LCK LCK Cell-Cell Contact 0.1141 0.0106866411476272 Scatter Plot
Target PECAM1 Source MHC-I MHC-I Cell-Cell Contact 0.1155 0.0097201867450138 Scatter Plot
Target PECAM1 Source VCAM VCAM Cell-Cell Contact 0.1165 0.0091084151780113 Scatter Plot
Source PECAM1 Source VCAM VCAM Cell-Cell Contact 0.1165 0.0091084151780113 Scatter Plot
Target PECAM1 Target THBS THBS ECM-Receptor 0.1180 0.008286583951015 Scatter Plot
Target PECAM1 Source CD45 CD45 Cell-Cell Contact 0.1187 0.0078742566287711 Scatter Plot
Target PECAM1 Source NT NT Secreted Signaling 0.1190 0.0077174867533087 Scatter Plot
Target PECAM1 Target EPHB EPHB Cell-Cell Contact 0.1225 0.0061065425875509 Scatter Plot
Target PECAM1 Source ANGPTL ANGPTL Secreted Signaling 0.1248 0.0051836809800162 Scatter Plot
Source PECAM1 Source CCL CCL Secreted Signaling 0.1266 0.0045809735422758 Scatter Plot
Target PECAM1 Source CCL CCL Secreted Signaling 0.1266 0.0045809735422758 Scatter Plot
Target PECAM1 Source PSAP PSAP Secreted Signaling 0.1389 0.0018498855800692 Scatter Plot
Target PECAM1 Source SELPLG SELPLG Cell-Cell Contact 0.1479 0.0009118964365963 Scatter Plot
Target PECAM1 Source CD34 CD34 Cell-Cell Contact 0.1540 0.0005469311194608 Scatter Plot
Target PECAM1 Source COMPLEMENT COMPLEMENT Secreted Signaling -0.1445 0.0011979969589296 Scatter Plot
Target PECAM1 Source APELIN APELIN Secreted Signaling -0.1444 0.0012009527545189 Scatter Plot
Target PECAM1 Source APP APP Cell-Cell Contact -0.1209 0.0068036305746686 Scatter Plot
Target PECAM1 Target ICAM ICAM Cell-Cell Contact -0.1137 0.010921657386826 Scatter Plot
Source PECAM1 Source IL6 IL6 Secreted Signaling -0.1076 0.0160924579322644 Scatter Plot
Target PECAM1 Source IL6 IL6 Secreted Signaling -0.1076 0.0160924579322644 Scatter Plot
Target PECAM1 Target NCAM NCAM Cell-Cell Contact -0.1022 0.0222474149495366 Scatter Plot
Source PECAM1 Source ANGPTL ANGPTL Secreted Signaling -0.1015 0.0231558627854368 Scatter Plot
Target PECAM1 Source ANGPTL ANGPTL Secreted Signaling -0.1015 0.0231558627854368 Scatter Plot
Target PECAM1 Source GRN GRN Secreted Signaling -0.0973 0.0296271071568478 Scatter Plot
Target PECAM1 Target ANNEXIN ANNEXIN Secreted Signaling -0.0972 0.0296866920753763 Scatter Plot
Target PECAM1 Source MIF MIF Secreted Signaling -0.0965 0.031040630428615 Scatter Plot
Target PECAM1 Target PARs PARs Secreted Signaling 0.0964 0.0310944277949151 Scatter Plot
Source PECAM1 Target PARs PARs Secreted Signaling 0.0964 0.0310944277949151 Scatter Plot
Source PECAM1 Source ICAM ICAM Cell-Cell Contact 0.0965 0.0308896488011611 Scatter Plot
Source PECAM1 Target FN1 FN1 ECM-Receptor 0.0969 0.0302324833012306 Scatter Plot
Target PECAM1 Target CD45 CD45 Cell-Cell Contact 0.0983 0.0280237853616738 Scatter Plot
Source PECAM1 Target CD45 CD45 Cell-Cell Contact 0.0983 0.0280237853616738 Scatter Plot
Source PECAM1 Target PDGF PDGF Secreted Signaling 0.0991 0.0267434901091835 Scatter Plot
Target PECAM1 Target PDGF PDGF Secreted Signaling 0.0993 0.0263317098496724 Scatter Plot
Source PECAM1 Target ESAM ESAM Cell-Cell Contact 0.1004 0.0248148170067969 Scatter Plot
Source PECAM1 Target CSF CSF Secreted Signaling 0.1013 0.0234599601065879 Scatter Plot
Target PECAM1 Target CSF CSF Secreted Signaling 0.1013 0.0234599601065879 Scatter Plot
Source PECAM1 Source SEMA7 SEMA7 Cell-Cell Contact 0.1015 0.0232249118455703 Scatter Plot
Source PECAM1 Target SLURP SLURP Secreted Signaling 0.1024 0.0219704082108189 Scatter Plot
Source PECAM1 Target GALECTIN GALECTIN Secreted Signaling 0.1037 0.0203327932068642 Scatter Plot
Target PECAM1 Target GALECTIN GALECTIN Secreted Signaling 0.1037 0.0203327932068642 Scatter Plot
Source PECAM1 Source IL16 IL16 Secreted Signaling 0.1042 0.0197367640437956 Scatter Plot
Source PECAM1 Target MIF MIF Secreted Signaling 0.1060 0.0177084939526505 Scatter Plot
Target PECAM1 Target MIF MIF Secreted Signaling 0.1060 0.0177084939526505 Scatter Plot
Source PECAM1 Source TGFb TGFb Secreted Signaling 0.1068 0.016915745333733 Scatter Plot
Target PECAM1 Target GAS GAS Secreted Signaling 0.1092 0.014610602224564 Scatter Plot
Source PECAM1 Target GAS GAS Secreted Signaling 0.1092 0.014610602224564 Scatter Plot
Target PECAM1 Target CD34 CD34 Cell-Cell Contact 0.1127 0.0117090525674555 Scatter Plot
Source PECAM1 Target CD34 CD34 Cell-Cell Contact 0.1127 0.0117090525674555 Scatter Plot
Source PECAM1 Source CXCL CXCL Secreted Signaling 0.1131 0.0113630168529294 Scatter Plot
Source PECAM1 Source LCK LCK Cell-Cell Contact 0.1141 0.0106866411476272 Scatter Plot
Source PECAM1 Source MHC-I MHC-I Cell-Cell Contact 0.1155 0.0097201867450138 Scatter Plot
Source PECAM1 Target CCL CCL Secreted Signaling 0.1177 0.0084295335707187 Scatter Plot
Target PECAM1 Target CCL CCL Secreted Signaling 0.1177 0.0084295335707187 Scatter Plot
Source PECAM1 Target THBS THBS ECM-Receptor 0.1180 0.008286583951015 Scatter Plot
Target PECAM1 Target CD22 CD22 Cell-Cell Contact 0.1187 0.0078742566287711 Scatter Plot
Source PECAM1 Source CD45 CD45 Cell-Cell Contact 0.1187 0.0078742566287711 Scatter Plot
Source PECAM1 Target CD22 CD22 Cell-Cell Contact 0.1187 0.0078742566287711 Scatter Plot
Source PECAM1 Source NT NT Secreted Signaling 0.1190 0.0077174867533087 Scatter Plot
Source PECAM1 Target EPHB EPHB Cell-Cell Contact 0.1225 0.0061065425875509 Scatter Plot
Target PECAM1 Target CD39 CD39 Cell-Cell Contact 0.1232 0.0058242816430508 Scatter Plot
Source PECAM1 Target CD39 CD39 Cell-Cell Contact 0.1232 0.0058242816430508 Scatter Plot
Source PECAM1 Target BST2 BST2 Cell-Cell Contact 0.1247 0.0052286967682577 Scatter Plot
Source PECAM1 Target LAIR1 LAIR1 Cell-Cell Contact 0.1247 0.0052286967682577 Scatter Plot
Target PECAM1 Target BST2 BST2 Cell-Cell Contact 0.1247 0.0052286967682577 Scatter Plot
Target PECAM1 Target LAIR1 LAIR1 Cell-Cell Contact 0.1247 0.0052286967682577 Scatter Plot
Source PECAM1 Source ANGPTL ANGPTL Secreted Signaling 0.1248 0.0051836809800162 Scatter Plot
Target PECAM1 Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.1304 0.0034905171948748 Scatter Plot
Source PECAM1 Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.1304 0.0034905171948748 Scatter Plot
Source PECAM1 Target BAFF BAFF Secreted Signaling 0.1324 0.0030040474181224 Scatter Plot
Target PECAM1 Target BAFF BAFF Secreted Signaling 0.1324 0.0030040474181224 Scatter Plot
Target PECAM1 Target IL6 IL6 Secreted Signaling 0.1347 0.0025405485743487 Scatter Plot
Source PECAM1 Target IL6 IL6 Secreted Signaling 0.1347 0.0025405485743487 Scatter Plot
Source PECAM1 Source PSAP PSAP Secreted Signaling 0.1389 0.0018498855800692 Scatter Plot
Source PECAM1 Source SELPLG SELPLG Cell-Cell Contact 0.1479 0.0009118964365963 Scatter Plot
Source PECAM1 Target SELPLG SELPLG Cell-Cell Contact 0.1514 0.00068292812403 Scatter Plot
Target PECAM1 Target SELPLG SELPLG Cell-Cell Contact 0.1514 0.00068292812403 Scatter Plot
Source PECAM1 Source CD34 CD34 Cell-Cell Contact 0.1540 0.0005469311194608 Scatter Plot
Target PECAM1 Target SELL SELL Cell-Cell Contact 0.1578 0.000396526598688 Scatter Plot
Source PECAM1 Target SELL SELL Cell-Cell Contact 0.1578 0.000396526598688 Scatter Plot
Source PECAM1 Target OSM OSM Secreted Signaling 0.1785 0.00005965879599844908 Scatter Plot
Target PECAM1 Target OSM OSM Secreted Signaling 0.1785 0.00005965879599844908 Scatter Plot
Target PECAM1 Target VCAM VCAM Cell-Cell Contact -0.1646 0.0002190018370772 Scatter Plot
Source PECAM1 Target VCAM VCAM Cell-Cell Contact -0.1646 0.0002190018370772 Scatter Plot
Source PECAM1 Source COMPLEMENT COMPLEMENT Secreted Signaling -0.1445 0.0011979969589296 Scatter Plot
Source PECAM1 Source APELIN APELIN Secreted Signaling -0.1444 0.0012009527545189 Scatter Plot
Source PECAM1 Source APP APP Cell-Cell Contact -0.1209 0.0068036305746686 Scatter Plot
Target PECAM1 Target CD23 CD23 Cell-Cell Contact -0.1206 0.0069360474259251 Scatter Plot
Source PECAM1 Target CD23 CD23 Cell-Cell Contact -0.1206 0.0069360474259251 Scatter Plot
Target PECAM1 Target THY1 THY1 Cell-Cell Contact -0.1196 0.0074274854104555 Scatter Plot
Source PECAM1 Target THY1 THY1 Cell-Cell Contact -0.1196 0.0074274854104555 Scatter Plot
Source PECAM1 Target ICAM ICAM Cell-Cell Contact -0.1137 0.010921657386826 Scatter Plot
Target PECAM1 Target VEGF VEGF Secreted Signaling -0.1073 0.0163904066477357 Scatter Plot
Source PECAM1 Target VEGF VEGF Secreted Signaling -0.1073 0.0163904066477357 Scatter Plot
Source PECAM1 Target IL1 IL1 Secreted Signaling -0.1065 0.0172435139861156 Scatter Plot
Target PECAM1 Target IL1 IL1 Secreted Signaling -0.1065 0.0172435139861156 Scatter Plot
Target PECAM1 Target COMPLEMENT COMPLEMENT Secreted Signaling -0.1047 0.0192438655679846 Scatter Plot
Source PECAM1 Target COMPLEMENT COMPLEMENT Secreted Signaling -0.1047 0.0192438655679846 Scatter Plot
Source PECAM1 Target NCAM NCAM Cell-Cell Contact -0.1022 0.0222474149495366 Scatter Plot
Source PECAM1 Source GRN GRN Secreted Signaling -0.0973 0.0296271071568478 Scatter Plot
Source PECAM1 Target ANNEXIN ANNEXIN Secreted Signaling -0.0972 0.0296866920753763 Scatter Plot
Source PECAM1 Source MIF MIF Secreted Signaling -0.0965 0.031040630428615 Scatter Plot

Cells that are targets of PECAM1 from HSCs*

Cells that are source of PECAM1 to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.