Pathway: MHC-I

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Cell-Cell Contact

Details on the MHC-I pathway:

Specificity Index HSPC as target: 0.489
HSPC as source: 0.900

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the MHC-I pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Source MHC-I Source OSM OSM Secreted Signaling 0.0980 0.02850382152193 Scatter Plot
Source MHC-I Source CD34 CD34 Cell-Cell Contact 0.1081 0.0155752248603404 Scatter Plot
Source MHC-I Source IL6 IL6 Secreted Signaling 0.1120 0.012194312728076 Scatter Plot
Source MHC-I Source PECAM1 PECAM1 Cell-Cell Contact 0.1155 0.0097201867450138 Scatter Plot
Source MHC-I Source APELIN APELIN Secreted Signaling 0.1300 0.003580966868992 Scatter Plot
Source MHC-I Source FGF FGF Secreted Signaling 0.1586 0.0003695709209042 Scatter Plot
Source MHC-I Source WNT WNT Secreted Signaling 0.1853 0.000030676126865999526 Scatter Plot
Source MHC-I Source ncWNT ncWNT Secreted Signaling 0.2077 0.00000280023539531896 Scatter Plot
Source MHC-I Source PTN PTN Secreted Signaling 0.2217 0.0000005536701302813025 Scatter Plot
Source MHC-I Source GP1BA GP1BA Cell-Cell Contact 0.2316 0.00000016250629857194688 Scatter Plot
Source MHC-I Source ANGPTL ANGPTL Secreted Signaling 0.2533 0.000000009202337710120247 Scatter Plot
Source MHC-I Source CD1D2 CD1D2 Cell-Cell Contact 0.2691 0.000000000965646670911073 Scatter Plot
Source MHC-I Source GDF GDF Secreted Signaling 0.2817 0.00000000014146655671194622 Scatter Plot
Source MHC-I Source SEMA3 SEMA3 Secreted Signaling 0.2878 0.000000000054483787769827286 Scatter Plot
Source MHC-I Source VEGF VEGF Secreted Signaling 0.3092 0.0000000000015451587244672837 Scatter Plot
Source MHC-I Source IL2 IL2 Secreted Signaling 0.3125 0.0000000000008609506651172094 Scatter Plot
Source MHC-I Source CADM CADM Cell-Cell Contact 0.3262 0.0000000000000735825957913848 Scatter Plot
Source MHC-I Source CD39 CD39 Cell-Cell Contact 0.3601 0.00000000000000009247085326131823 Scatter Plot
Source MHC-I Source NT NT Secreted Signaling 0.3656 0.000000000000000029295385840191106 Scatter Plot
Source MHC-I Source CCL CCL Secreted Signaling 0.3666 0.00000000000000002348778114034585 Scatter Plot
Source MHC-I Source LIGHT LIGHT Secreted Signaling 0.3817 0.0000000000000000008550550685428967 Scatter Plot
Source MHC-I Source CD46 CD46 Cell-Cell Contact 0.3854 0.00000000000000000037005442278274716 Scatter Plot
Source MHC-I Source NOTCH NOTCH Cell-Cell Contact 0.4018 0.00000000000000000000805800174240921 Scatter Plot
Source MHC-I Source CXCL CXCL Secreted Signaling 0.4239 0.00000000000000000000003177755673542964 Scatter Plot
Source MHC-I Source RANKL RANKL Secreted Signaling 0.4259 0.000000000000000000000018598567541330842 Scatter Plot
Source MHC-I Source IL16 IL16 Secreted Signaling 0.4465 0.00000000000000000000000006994217203526714 Scatter Plot
Source MHC-I Source CSF CSF Secreted Signaling 0.4474 0.00000000000000000000000005555045593118165 Scatter Plot
Source MHC-I Source IGF IGF Secreted Signaling 0.4618 0.0000000000000000000000000008693853388066594 Scatter Plot
Source MHC-I Source VCAM VCAM Cell-Cell Contact 0.4689 0.00000000000000000000000000010426113391040896 Scatter Plot
Source MHC-I Source LAMININ LAMININ ECM-Receptor 0.4803 0.000000000000000000000000000003144069918235913 Scatter Plot
Source MHC-I Source PROS PROS Secreted Signaling 0.5002 0.0000000000000000000000000000000050859885622288274 Scatter Plot
Source MHC-I Source CX3C CX3C Secreted Signaling 0.5092 0.00000000000000000000000000000000023864969551936033 Scatter Plot
Source MHC-I Source CD45 CD45 Cell-Cell Contact 0.5306 0.00000000000000000000000000000000000011292548436877857 Scatter Plot
Source MHC-I Source CDH CDH Cell-Cell Contact 0.5524 0.000000000000000000000000000000000000000027267004021115144 Scatter Plot
Source MHC-I Source MK MK Secreted Signaling 0.5565 0.0000000000000000000000000000000000000000052133462436956726 Scatter Plot
Source MHC-I Source PSAP PSAP Secreted Signaling 0.5694 0.000000000000000000000000000000000000000000025281160754214164 Scatter Plot
Source MHC-I Source EPHB EPHB Cell-Cell Contact 0.5702 0.000000000000000000000000000000000000000000018277579963484116 Scatter Plot
Source MHC-I Source LIFR LIFR Secreted Signaling 0.5799 0.00000000000000000000000000000000000000000000027724264648059697 Scatter Plot
Source MHC-I Source FLT3 FLT3 Secreted Signaling 0.5822 0.0000000000000000000000000000000000000000000000995963290802474 Scatter Plot
Source MHC-I Source PDGF PDGF Secreted Signaling 0.5919 0.0000000000000000000000000000000000000000000000013103166745119744 Scatter Plot
Source MHC-I Source IL7 IL7 Secreted Signaling 0.6393 0.00000000000000000000000000000000000000000000000000000000007967772061016057 Scatter Plot
Source MHC-I Source SEMA7 SEMA7 Cell-Cell Contact 0.6495 0.00000000000000000000000000000000000000000000000000000000000028698953528272357 Scatter Plot
Source MHC-I Source BST2 BST2 Cell-Cell Contact 0.6805 0.000000000000000000000000000000000000000000000000000000000000000000002758700956781457 Scatter Plot
Source MHC-I Source BMP BMP Secreted Signaling 0.6975 0.00000000000000000000000000000000000000000000000000000000000000000000000003881858173501952 Scatter Plot
Source MHC-I Source TWEAK TWEAK Secreted Signaling 0.6979 0.00000000000000000000000000000000000000000000000000000000000000000000000002994727889065674 Scatter Plot
Source MHC-I Source COLLAGEN COLLAGEN ECM-Receptor 0.7119 0.0000000000000000000000000000000000000000000000000000000000000000000000000000016538694156158763 Scatter Plot
Source MHC-I Source GAS GAS Secreted Signaling 0.7307 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000011738051755497723 Scatter Plot
Source MHC-I Source ESAM ESAM Cell-Cell Contact 0.7706 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014450168389945563 Scatter Plot
Source MHC-I Source ANGPT ANGPT Secreted Signaling 0.7922 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000005576301133088149 Scatter Plot
Source MHC-I Source JAM JAM Cell-Cell Contact 0.8006 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006423006429088673 Scatter Plot
Source MHC-I Source MHC-II MHC-II Cell-Cell Contact 0.8842 0.00000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000006218987578633271 Scatter Plot
Source MHC-I Source CD52 CD52 Cell-Cell Contact -0.6532 0.00000000000000000000000000000000000000000000000000000000000003516127331233152 Scatter Plot
Source MHC-I Source COMPLEMENT COMPLEMENT Secreted Signaling -0.6288 0.000000000000000000000000000000000000000000000000000000020664362192152455 Scatter Plot
Source MHC-I Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.5630 0.0000000000000000000000000000000000000000003592209720912312 Scatter Plot
Source MHC-I Source SELL SELL Cell-Cell Contact -0.5383 0.000000000000000000000000000000000000006507940242930827 Scatter Plot
Source MHC-I Source PARs PARs Secreted Signaling -0.4698 0.000000000000000000000000000079562441639205 Scatter Plot
Source MHC-I Source MIF MIF Secreted Signaling -0.4356 0.0000000000000000000000014315648470441796 Scatter Plot
Source MHC-I Source VISTA VISTA Cell-Cell Contact -0.4221 0.000000000000000000000050538792271143713 Scatter Plot
Source MHC-I Source TGFb TGFb Secreted Signaling -0.3599 0.00000000000000009761125314193399 Scatter Plot
Source MHC-I Source CLEC CLEC Cell-Cell Contact -0.3237 0.0000000000001169814723726788 Scatter Plot
Source MHC-I Source NCAM NCAM Cell-Cell Contact -0.3149 0.0000000000005685041970166237 Scatter Plot
Source MHC-I Source ANGPTL ANGPTL Secreted Signaling -0.3080 0.0000000000018953413204031213 Scatter Plot
Source MHC-I Source SPP1 SPP1 Secreted Signaling -0.2854 0.00000000007994809974388907 Scatter Plot
Source MHC-I Source SEMA4 SEMA4 Cell-Cell Contact -0.2592 0.000000004061060028795464 Scatter Plot
Source MHC-I Source ANNEXIN ANNEXIN Secreted Signaling -0.2542 0.000000008163315393815668 Scatter Plot
Source MHC-I Source APP APP Cell-Cell Contact -0.2390 0.00000006303992435123562 Scatter Plot
Source MHC-I Source TNF TNF Secreted Signaling -0.2360 0.00000009348420706950905 Scatter Plot
Source MHC-I Source LAIR1 LAIR1 Cell-Cell Contact -0.1678 0.0001631700660843 Scatter Plot
Source MHC-I Source BAFF BAFF Secreted Signaling -0.1481 0.0008913619444216 Scatter Plot
Source MHC-I Source VISFATIN VISFATIN Secreted Signaling -0.1393 0.0017972370090174 Scatter Plot
Source MHC-I Source GRN GRN Secreted Signaling -0.0988 0.0272107796913709 Scatter Plot
Source MHC-I Target PDGF PDGF Secreted Signaling 0.0998 0.0256108840225882 Scatter Plot
Source MHC-I Target THY1 THY1 Cell-Cell Contact 0.1107 0.013265135423114 Scatter Plot
Source MHC-I Target TWEAK TWEAK Secreted Signaling 0.1121 0.0121439396020433 Scatter Plot
Source MHC-I Target PECAM1 PECAM1 Cell-Cell Contact 0.1155 0.0097201867450138 Scatter Plot
Source MHC-I Target SELL SELL Cell-Cell Contact 0.1160 0.0094284220125646 Scatter Plot
Source MHC-I Source THBS THBS ECM-Receptor 0.1317 0.0031813174381561 Scatter Plot
Source MHC-I Source GALECTIN GALECTIN Secreted Signaling 0.1319 0.0031187082956635 Scatter Plot
Source MHC-I Target SEMA3 SEMA3 Secreted Signaling 0.1330 0.0028949705060261 Scatter Plot
Source MHC-I Target CD23 CD23 Cell-Cell Contact 0.1400 0.0017009427079996 Scatter Plot
Source MHC-I Target GAS GAS Secreted Signaling 0.1430 0.0013414598516044 Scatter Plot
Source MHC-I Target NCAM NCAM Cell-Cell Contact 0.1987 0.000007618295063441031 Scatter Plot
Source MHC-I Target GALECTIN GALECTIN Secreted Signaling 0.2109 0.0000019671533533025306 Scatter Plot
Source MHC-I Target NOTCH NOTCH Cell-Cell Contact 0.2215 0.0000005681413770956471 Scatter Plot
Source MHC-I Target AGT AGT Secreted Signaling 0.2295 0.0000002125059767376337 Scatter Plot
Source MHC-I Target RANKL RANKL Secreted Signaling 0.2419 0.000000043240244243669945 Scatter Plot
Source MHC-I Target IL6 IL6 Secreted Signaling 0.2513 0.000000012117308041307248 Scatter Plot
Source MHC-I Target EPHA EPHA Cell-Cell Contact 0.2521 0.000000010866750519237058 Scatter Plot
Source MHC-I Target GDF GDF Secreted Signaling 0.2628 0.0000000024064945277921807 Scatter Plot
Source MHC-I Target COLLAGEN COLLAGEN ECM-Receptor 0.2636 0.000000002166334922174054 Scatter Plot
Source MHC-I Target OSM OSM Secreted Signaling 0.2828 0.000000000119772173848898 Scatter Plot
Source MHC-I Target NODAL NODAL Secreted Signaling 0.3007 0.000000000006583744318390237 Scatter Plot
Source MHC-I Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.3078 0.0000000000019630744723077656 Scatter Plot
Source MHC-I Target PTN PTN Secreted Signaling 0.3200 0.00000000000022599646768543542 Scatter Plot
Source MHC-I Target VEGF VEGF Secreted Signaling 0.3217 0.00000000000016707972813564112 Scatter Plot
Source MHC-I Target CADM CADM Cell-Cell Contact 0.3262 0.0000000000000735825957913848 Scatter Plot
Source MHC-I Target CSPG4 CSPG4 Cell-Cell Contact 0.3391 0.0000000000000063859979107595086 Scatter Plot
Source MHC-I Source THY1 THY1 Cell-Cell Contact 0.3414 0.000000000000004068092182681013 Scatter Plot
Source MHC-I Target SEMA6 SEMA6 Cell-Cell Contact 0.3616 0.0000000000000000678376757139582 Scatter Plot
Source MHC-I Target COMPLEMENT COMPLEMENT Secreted Signaling 0.3701 0.000000000000000011242798059592108 Scatter Plot
Source MHC-I Target SEMA5 SEMA5 Cell-Cell Contact 0.3808 0.0000000000000000010512594931216025 Scatter Plot
Source MHC-I Target ANGPTL ANGPTL Secreted Signaling 0.3971 0.00000000000000000002433391043556613 Scatter Plot
Source MHC-I Target MK MK Secreted Signaling 0.4043 0.00000000000000000000435448059064357 Scatter Plot
Source MHC-I Target SPP1 SPP1 Secreted Signaling 0.4268 0.000000000000000000000014963227866687194 Scatter Plot
Source MHC-I Target ACTIVIN ACTIVIN Secreted Signaling 0.4270 0.000000000000000000000013955327150385805 Scatter Plot
Source MHC-I Target VISFATIN VISFATIN Secreted Signaling 0.4318 0.0000000000000000000000039442522998939845 Scatter Plot
Source MHC-I Target FN1 FN1 ECM-Receptor 0.4390 0.0000000000000000000000005564980119673584 Scatter Plot
Source MHC-I Target THBS THBS ECM-Receptor 0.4645 0.00000000000000000000000000039757876127928635 Scatter Plot
Source MHC-I Target BMP BMP Secreted Signaling 0.4770 0.000000000000000000000000000008969834050984942 Scatter Plot
Source MHC-I Target EPHB EPHB Cell-Cell Contact 0.4842 0.0000000000000000000000000000009216852387290182 Scatter Plot
Source MHC-I Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.4883 0.0000000000000000000000000000002519151586416003 Scatter Plot
Source MHC-I Target LAMININ LAMININ ECM-Receptor 0.4966 0.00000000000000000000000000000001679304524130053 Scatter Plot
Source MHC-I Source ICAM ICAM Cell-Cell Contact 0.5059 0.0000000000000000000000000000000007387697812736614 Scatter Plot
Source MHC-I Target SEMA7 SEMA7 Cell-Cell Contact 0.5150 0.000000000000000000000000000000000032070551504638804 Scatter Plot
Source MHC-I Target PERIOSTIN PERIOSTIN Secreted Signaling 0.5233 0.000000000000000000000000000000000001679377222974128 Scatter Plot
Source MHC-I Source LCK LCK Cell-Cell Contact 0.5246 0.0000000000000000000000000000000000010275368161712567 Scatter Plot
Source MHC-I Target BAFF BAFF Secreted Signaling 0.5305 0.00000000000000000000000000000000000012022504154304055 Scatter Plot
Source MHC-I Target CD22 CD22 Cell-Cell Contact 0.5306 0.00000000000000000000000000000000000011292548436878502 Scatter Plot
Source MHC-I Target VTN VTN ECM-Receptor 0.5309 0.00000000000000000000000000000000000010431231824900822 Scatter Plot
Source MHC-I Source CD86 CD86 Cell-Cell Contact 0.5382 0.000000000000000000000000000000000000006789100758384945 Scatter Plot
Source MHC-I Target NPR2 NPR2 Secreted Signaling 0.5415 0.000000000000000000000000000000000000001903974242951669 Scatter Plot
Source MHC-I Target TGFb TGFb Secreted Signaling 0.5425 0.0000000000000000000000000000000000000012751288690210189 Scatter Plot
Source MHC-I Target BSP BSP ECM-Receptor 0.5428 0.0000000000000000000000000000000000000011367282546310646 Scatter Plot
Source MHC-I Target NRG NRG Secreted Signaling 0.5457 0.0000000000000000000000000000000000000003674049492813373 Scatter Plot
Source MHC-I Target DMP1 DMP1 ECM-Receptor 0.5523 0.00000000000000000000000000000000000000002747223018597613 Scatter Plot
Source MHC-I Target CDH CDH Cell-Cell Contact 0.5524 0.000000000000000000000000000000000000000027267004021115144 Scatter Plot
Source MHC-I Source MK MK Secreted Signaling 0.5533 0.000000000000000000000000000000000000000018541823291617743 Scatter Plot
Source MHC-I Target VWF VWF ECM-Receptor 0.5572 0.000000000000000000000000000000000000000003923326496386596 Scatter Plot
Source MHC-I Target SEMA4 SEMA4 Cell-Cell Contact 0.5784 0.0000000000000000000000000000000000000000000005435796189376732 Scatter Plot
Source MHC-I Target ANGPT ANGPT Secreted Signaling 0.5884 0.000000000000000000000000000000000000000000000006536279771730693 Scatter Plot
Source MHC-I Target KIT KIT Secreted Signaling 0.6143 0.00000000000000000000000000000000000000000000000000003275200950022846 Scatter Plot
Source MHC-I Target CD200 CD200 Cell-Cell Contact 0.6534 0.00000000000000000000000000000000000000000000000000000000000003103332408282933 Scatter Plot
Source MHC-I Target FGF FGF Secreted Signaling 0.6663 0.000000000000000000000000000000000000000000000000000000000000000016650931418231065 Scatter Plot
Source MHC-I Target IGF IGF Secreted Signaling 0.6726 0.0000000000000000000000000000000000000000000000000000000000000000003658188374916215 Scatter Plot
Source MHC-I Target PARs PARs Secreted Signaling 0.6760 0.00000000000000000000000000000000000000000000000000000000000000000004433131422486694 Scatter Plot
Source MHC-I Target TENASCIN TENASCIN ECM-Receptor 0.6778 0.00000000000000000000000000000000000000000000000000000000000000000001506187487524203 Scatter Plot
Source MHC-I Target CD34 CD34 Cell-Cell Contact 0.6828 0.0000000000000000000000000000000000000000000000000000000000000000000006311594421471116 Scatter Plot
Source MHC-I Target WNT WNT Secreted Signaling 0.6934 0.0000000000000000000000000000000000000000000000000000000000000000000000006086279947725589 Scatter Plot
Source MHC-I Target JAM JAM Cell-Cell Contact 0.6994 0.000000000000000000000000000000000000000000000000000000000000000000000000010909619005508394 Scatter Plot
Source MHC-I Target ncWNT ncWNT Secreted Signaling 0.7156 0.00000000000000000000000000000000000000000000000000000000000000000000000000000011037245944617332 Scatter Plot
Source MHC-I Target APP APP Cell-Cell Contact 0.7157 0.00000000000000000000000000000000000000000000000000000000000000000000000000000010181466397376622 Scatter Plot
Source MHC-I Target SLURP SLURP Secreted Signaling 0.7210 0.000000000000000000000000000000000000000000000000000000000000000000000000000000002044701724429951 Scatter Plot
Source MHC-I Target CD39 CD39 Cell-Cell Contact 0.7390 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000016774341285397422 Scatter Plot
Source MHC-I Target MIF MIF Secreted Signaling 0.7413 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000002390733784813692 Scatter Plot
Source MHC-I Target ESAM ESAM Cell-Cell Contact 0.7706 0.0000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000000014450168389945563 Scatter Plot
Source MHC-I Target ICAM ICAM Cell-Cell Contact -0.5280 0.000000000000000000000000000000000000297002947272062 Scatter Plot
Source MHC-I Target CD52 CD52 Cell-Cell Contact -0.5055 0.0000000000000000000000000000000008553511827937166 Scatter Plot
Source MHC-I Target CSF CSF Secreted Signaling -0.4195 0.00000000000000000000009900514214403096 Scatter Plot
Source MHC-I Target VCAM VCAM Cell-Cell Contact -0.4167 0.00000000000000000000019771283790053401 Scatter Plot
Source MHC-I Target CLEC CLEC Cell-Cell Contact -0.3814 0.0000000000000000009209056343320833 Scatter Plot
Source MHC-I Target CCL CCL Secreted Signaling -0.3812 0.0000000000000000009711516944398471 Scatter Plot
Source MHC-I Target CEACAM CEACAM Cell-Cell Contact -0.3524 0.000000000000000452932645686634 Scatter Plot
Source MHC-I Target CXCL CXCL Secreted Signaling -0.3378 0.000000000000008162107733718721 Scatter Plot
Source MHC-I Target IFN-II IFN-II Secreted Signaling -0.3278 0.000000000000054734091559348255 Scatter Plot
Source MHC-I Target IL17 IL17 Secreted Signaling -0.2801 0.00000000018083468761896936 Scatter Plot
Source MHC-I Target VEGF VEGF Secreted Signaling -0.2419 0.00000004339783003475556 Scatter Plot
Source MHC-I Source CCL CCL Secreted Signaling -0.2372 0.00000007983761681611223 Scatter Plot
Source MHC-I Target ANNEXIN ANNEXIN Secreted Signaling -0.2172 0.000000947561498285306 Scatter Plot
Source MHC-I Target COMPLEMENT COMPLEMENT Secreted Signaling -0.1913 0.000016500998850280256 Scatter Plot
Source MHC-I Target SEMA3 SEMA3 Secreted Signaling -0.1892 0.00002056465452489284 Scatter Plot
Source MHC-I Target COLLAGEN COLLAGEN ECM-Receptor -0.1832 0.000037808565840192445 Scatter Plot
Source MHC-I Target GRN GRN Secreted Signaling -0.1250 0.0051277005753898 Scatter Plot
Source MHC-I Target SELPLG SELPLG Cell-Cell Contact -0.0981 0.0282208565543573 Scatter Plot
Source MHC-I Source SELPLG SELPLG Cell-Cell Contact -0.0974 0.0294936858108287 Scatter Plot

Cells that are targets of MHC-I from HSCs*

Cells that are source of MHC-I to HSCs*

    No cell populations

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.