Pathway: LIGHT

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the LIGHT pathway:

Specificity Index HSPC as target: 0.291
HSPC as source: 0.589

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the LIGHT pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Source LIGHT Source CD34 CD34 Cell-Cell Contact 0.1729 0.0001015563326739 Scatter Plot
Source LIGHT Source LIFR LIFR Secreted Signaling 0.2890 0.00000000004471512074162743 Scatter Plot
Source LIGHT Source LAMININ LAMININ ECM-Receptor 0.3290 0.00000000000004343086534325414 Scatter Plot
Source LIGHT Source TWEAK TWEAK Secreted Signaling 0.3655 0.000000000000000029955055958825776 Scatter Plot
Source LIGHT Source TGFb TGFb Secreted Signaling -0.1930 0.000013848576759333686 Scatter Plot
Source LIGHT Source SEMA4 SEMA4 Cell-Cell Contact -0.1842 0.00003410685468524584 Scatter Plot
Source LIGHT Target SEMA3 SEMA3 Secreted Signaling 0.0988 0.0271491070531923 Scatter Plot
Source LIGHT Target CD45 CD45 Cell-Cell Contact 0.0989 0.0269762721584228 Scatter Plot
Source LIGHT Target IL1 IL1 Secreted Signaling 0.1024 0.0219933369888874 Scatter Plot
Source LIGHT Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1067 0.0170481531825035 Scatter Plot
Source LIGHT Target PTN PTN Secreted Signaling 0.1177 0.0084137940529237 Scatter Plot
Source LIGHT Source GP1BA GP1BA Cell-Cell Contact 0.1196 0.0074337269876395 Scatter Plot
Source LIGHT Source ANGPTL ANGPTL Secreted Signaling 0.1204 0.0070481488530921 Scatter Plot
Source LIGHT Target COLLAGEN COLLAGEN ECM-Receptor 0.1228 0.00598524477435 Scatter Plot
Source LIGHT Target RANKL RANKL Secreted Signaling 0.1269 0.0044681200795716 Scatter Plot
Source LIGHT Source APELIN APELIN Secreted Signaling 0.1320 0.0030939325383163 Scatter Plot
Source LIGHT Target IL6 IL6 Secreted Signaling 0.1333 0.0028124979250088 Scatter Plot
Source LIGHT Source WNT WNT Secreted Signaling 0.1345 0.0025897834757798 Scatter Plot
Source LIGHT Target SELPLG SELPLG Cell-Cell Contact 0.1359 0.0023300551088359 Scatter Plot
Source LIGHT Target SEMA7 SEMA7 Cell-Cell Contact 0.1361 0.0022909071803557 Scatter Plot
Source LIGHT Target SPP1 SPP1 Secreted Signaling 0.1380 0.0019866488552197 Scatter Plot
Source LIGHT Target AGT AGT Secreted Signaling 0.1401 0.0016930573996175 Scatter Plot
Source LIGHT Source CD1D2 CD1D2 Cell-Cell Contact 0.1409 0.0015796416445895 Scatter Plot
Source LIGHT Source ICOS ICOS Cell-Cell Contact 0.1432 0.0013234930552319 Scatter Plot
Source LIGHT Target FN1 FN1 ECM-Receptor 0.1484 0.0008721267559254 Scatter Plot
Source LIGHT Target COMPLEMENT COMPLEMENT Secreted Signaling 0.1493 0.0008111123092066 Scatter Plot
Source LIGHT Target VEGF VEGF Secreted Signaling 0.1500 0.0007629524628906 Scatter Plot
Source LIGHT Source FGF FGF Secreted Signaling 0.1528 0.0006076076944856 Scatter Plot
Source LIGHT Target OSM OSM Secreted Signaling 0.1543 0.0005349096669428 Scatter Plot
Source LIGHT Source SEMA3 SEMA3 Secreted Signaling 0.1617 0.000281826956075 Scatter Plot
Source LIGHT Source NT NT Secreted Signaling 0.1625 0.0002638077245549 Scatter Plot
Source LIGHT Target CSPG4 CSPG4 Cell-Cell Contact 0.1631 0.0002497907359861 Scatter Plot
Source LIGHT Source RANKL RANKL Secreted Signaling 0.1768 0.00007027355760262958 Scatter Plot
Source LIGHT Target NOTCH NOTCH Cell-Cell Contact 0.1780 0.00006257778173734204 Scatter Plot
Source LIGHT Target GALECTIN GALECTIN Secreted Signaling 0.1881 0.000023067137699614655 Scatter Plot
Source LIGHT Target SELL SELL Cell-Cell Contact 0.1894 0.00002007250966709396 Scatter Plot
Source LIGHT Source CD39 CD39 Cell-Cell Contact 0.1897 0.00001955366153713316 Scatter Plot
Source LIGHT Target EPHA EPHA Cell-Cell Contact 0.1949 0.00001139030313390584 Scatter Plot
Source LIGHT Source PTN PTN Secreted Signaling 0.1989 0.000007444882124739472 Scatter Plot
Source LIGHT Source SEMA6 SEMA6 Cell-Cell Contact 0.1989 0.000007392455831307951 Scatter Plot
Source LIGHT Source PROS PROS Secreted Signaling 0.2004 0.000006339633314807896 Scatter Plot
Source LIGHT Source GDF GDF Secreted Signaling 0.2010 0.000005935804366345299 Scatter Plot
Source LIGHT Source IGF IGF Secreted Signaling 0.2063 0.000003290396862684505 Scatter Plot
Source LIGHT Target SEMA5 SEMA5 Cell-Cell Contact 0.2081 0.0000026893370795341345 Scatter Plot
Source LIGHT Target SEMA6 SEMA6 Cell-Cell Contact 0.2081 0.000002687598876516456 Scatter Plot
Source LIGHT Target VISFATIN VISFATIN Secreted Signaling 0.2095 0.0000023066951261210725 Scatter Plot
Source LIGHT Source CADM CADM Cell-Cell Contact 0.2118 0.0000017641257815032352 Scatter Plot
Source LIGHT Target CADM CADM Cell-Cell Contact 0.2118 0.0000017641257815032352 Scatter Plot
Source LIGHT Source CD46 CD46 Cell-Cell Contact 0.2123 0.0000016647836875205485 Scatter Plot
Source LIGHT Source CX3C CX3C Secreted Signaling 0.2236 0.00000044081205604469 Scatter Plot
Source LIGHT Target GDF GDF Secreted Signaling 0.2239 0.0000004222540706157306 Scatter Plot
Source LIGHT Source EPHB EPHB Cell-Cell Contact 0.2288 0.00000023200570301157566 Scatter Plot
Source LIGHT Target LAMININ LAMININ ECM-Receptor 0.2304 0.00000018910435341168346 Scatter Plot
Source LIGHT Target NCAM NCAM Cell-Cell Contact 0.2333 0.0000001306501646714584 Scatter Plot
Source LIGHT Source IL2 IL2 Secreted Signaling 0.2374 0.00000007802076964327704 Scatter Plot
Source LIGHT Source CXCL CXCL Secreted Signaling 0.2451 0.000000028380384349337385 Scatter Plot
Source LIGHT Target NODAL NODAL Secreted Signaling 0.2464 0.00000002369260179986784 Scatter Plot
Source LIGHT Source MK MK Secreted Signaling 0.2476 0.000000020179278178925123 Scatter Plot
Source LIGHT Source NOTCH NOTCH Cell-Cell Contact 0.2491 0.00000001641185713125178 Scatter Plot
Source LIGHT Target ANGPTL ANGPTL Secreted Signaling 0.2564 0.000000005972532210654859 Scatter Plot
Source LIGHT Source CCL CCL Secreted Signaling 0.2619 0.0000000027618699866839862 Scatter Plot
Source LIGHT Target PARs PARs Secreted Signaling 0.2649 0.000000001785309164899987 Scatter Plot
Source LIGHT Target BMP BMP Secreted Signaling 0.2677 0.0000000011745861827100134 Scatter Plot
Source LIGHT Source ICAM ICAM Cell-Cell Contact 0.2714 0.0000000006818714573269321 Scatter Plot
Source LIGHT Target THBS THBS ECM-Receptor 0.2729 0.0000000005491558103706055 Scatter Plot
Source LIGHT Source PDGF PDGF Secreted Signaling 0.2740 0.00000000046471472720102287 Scatter Plot
Source LIGHT Source CD86 CD86 Cell-Cell Contact 0.2753 0.00000000038062515931238224 Scatter Plot
Source LIGHT Target CD23 CD23 Cell-Cell Contact 0.2799 0.00000000018661473581644046 Scatter Plot
Source LIGHT Target APP APP Cell-Cell Contact 0.2844 0.00000000009226103505889682 Scatter Plot
Source LIGHT Target ANGPT ANGPT Secreted Signaling 0.2853 0.00000000008027316644188954 Scatter Plot
Source LIGHT Target THY1 THY1 Cell-Cell Contact 0.2856 0.00000000007699790430039003 Scatter Plot
Source LIGHT Source IL16 IL16 Secreted Signaling 0.2856 0.0000000000766305788133719 Scatter Plot
Source LIGHT Target NPR2 NPR2 Secreted Signaling 0.2883 0.000000000050416205306740006 Scatter Plot
Source LIGHT Source THY1 THY1 Cell-Cell Contact 0.2887 0.0000000000470709581240488 Scatter Plot
Source LIGHT Source BST2 BST2 Cell-Cell Contact 0.2892 0.000000000043041529679796845 Scatter Plot
Source LIGHT Target EPHB EPHB Cell-Cell Contact 0.2948 0.000000000017336444672151777 Scatter Plot
Source LIGHT Source PSAP PSAP Secreted Signaling 0.3009 0.000000000006322779839853173 Scatter Plot
Source LIGHT Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.3020 0.0000000000052512317997208426 Scatter Plot
Source LIGHT Source VEGF VEGF Secreted Signaling 0.3023 0.000000000004981787474670993 Scatter Plot
Source LIGHT Source LIFR LIFR Secreted Signaling 0.3066 0.0000000000024089893474717235 Scatter Plot
Source LIGHT Source FLT3 FLT3 Secreted Signaling 0.3179 0.0000000000003328928685809169 Scatter Plot
Source LIGHT Target SLURP SLURP Secreted Signaling 0.3191 0.0000000000002678570846198028 Scatter Plot
Source LIGHT Target KIT KIT Secreted Signaling 0.3204 0.00000000000021095392409700371 Scatter Plot
Source LIGHT Target NRG NRG Secreted Signaling 0.3238 0.00000000000011416627055848682 Scatter Plot
Source LIGHT Target VTN VTN ECM-Receptor 0.3340 0.00000000000001705057232455436 Scatter Plot
Source LIGHT Source CSF CSF Secreted Signaling 0.3387 0.0000000000000069263842651154375 Scatter Plot
Source LIGHT Target VWF VWF ECM-Receptor 0.3390 0.000000000000006471269167119674 Scatter Plot
Source LIGHT Target PERIOSTIN PERIOSTIN Secreted Signaling 0.3398 0.000000000000005521396132093557 Scatter Plot
Source LIGHT Source LAMININ LAMININ ECM-Receptor 0.3408 0.000000000000004574609167649214 Scatter Plot
Source LIGHT Target ncWNT ncWNT Secreted Signaling 0.3427 0.0000000000000031436802400531304 Scatter Plot
Source LIGHT Target TGFb TGFb Secreted Signaling 0.3429 0.0000000000000030574627696904546 Scatter Plot
Source LIGHT Source IL7 IL7 Secreted Signaling 0.3430 0.000000000000003005374709591811 Scatter Plot
Source LIGHT Target IGF IGF Secreted Signaling 0.3449 0.0000000000000020690943017572708 Scatter Plot
Source LIGHT Target FGF FGF Secreted Signaling 0.3475 0.0000000000000012199565327717802 Scatter Plot
Source LIGHT Target BSP BSP ECM-Receptor 0.3479 0.0000000000000011298093920472808 Scatter Plot
Source LIGHT Target ACTIVIN ACTIVIN Secreted Signaling 0.3500 0.0000000000000007376695813317359 Scatter Plot
Source LIGHT Source LCK LCK Cell-Cell Contact 0.3542 0.00000000000000031470717755849715 Scatter Plot
Source LIGHT Source SEMA7 SEMA7 Cell-Cell Contact 0.3557 0.0000000000000002312026003395996 Scatter Plot
Source LIGHT Target DMP1 DMP1 ECM-Receptor 0.3561 0.00000000000000021283444334305687 Scatter Plot
Source LIGHT Target WNT WNT Secreted Signaling 0.3573 0.00000000000000016531368214820075 Scatter Plot
Source LIGHT Source COLLAGEN COLLAGEN ECM-Receptor 0.3584 0.00000000000000013221518962772104 Scatter Plot
Source LIGHT Target BAFF BAFF Secreted Signaling 0.3590 0.00000000000000011849103801207618 Scatter Plot
Source LIGHT Target MIF MIF Secreted Signaling 0.3643 0.00000000000000003857451959335121 Scatter Plot
Source LIGHT Target CD200 CD200 Cell-Cell Contact 0.3658 0.000000000000000028193428547610056 Scatter Plot
Source LIGHT Target TENASCIN TENASCIN ECM-Receptor 0.3763 0.000000000000000002890879207822919 Scatter Plot
Source LIGHT Target SEMA4 SEMA4 Cell-Cell Contact 0.3780 0.000000000000000001991481501067531 Scatter Plot
Source LIGHT Source GAS GAS Secreted Signaling 0.3781 0.000000000000000001948264387241492 Scatter Plot
Source LIGHT Target ESAM ESAM Cell-Cell Contact 0.3815 0.0000000000000000009113702970180597 Scatter Plot
Source LIGHT Source ESAM ESAM Cell-Cell Contact 0.3815 0.0000000000000000009113702970180597 Scatter Plot
Source LIGHT Source MHC-I MHC-I Cell-Cell Contact 0.3817 0.0000000000000000008550550685428967 Scatter Plot
Source LIGHT Source CDH CDH Cell-Cell Contact 0.3834 0.0000000000000000005910020445689641 Scatter Plot
Source LIGHT Target CDH CDH Cell-Cell Contact 0.3834 0.0000000000000000005910020445689641 Scatter Plot
Source LIGHT Source BMP BMP Secreted Signaling 0.3854 0.0000000000000000003695534866847205 Scatter Plot
Source LIGHT Target CD22 CD22 Cell-Cell Contact 0.4115 0.000000000000000000000743914603460769 Scatter Plot
Source LIGHT Source CD45 CD45 Cell-Cell Contact 0.4115 0.000000000000000000000743914603460769 Scatter Plot
Source LIGHT Target CD34 CD34 Cell-Cell Contact 0.4138 0.00000000000000000000042061537013223793 Scatter Plot
Source LIGHT Target CD39 CD39 Cell-Cell Contact 0.4155 0.0000000000000000000002736298856480668 Scatter Plot
Source LIGHT Source MHC-II MHC-II Cell-Cell Contact 0.4182 0.0000000000000000000001366662131207199 Scatter Plot
Source LIGHT Source JAM JAM Cell-Cell Contact 0.4292 0.00000000000000000000000788796926719162 Scatter Plot
Source LIGHT Target JAM JAM Cell-Cell Contact 0.4390 0.0000000000000000000000005592600267097555 Scatter Plot
Source LIGHT Source ANGPT ANGPT Secreted Signaling 0.4700 0.00000000000000000000000000007619717589320665 Scatter Plot
Source LIGHT Source ANGPTL ANGPTL Secreted Signaling -0.2589 0.0000000042262079096058096 Scatter Plot
Source LIGHT Source MIF MIF Secreted Signaling -0.2419 0.00000004301382081593364 Scatter Plot
Source LIGHT Target IFN-II IFN-II Secreted Signaling -0.2303 0.0000001918070035695867 Scatter Plot
Source LIGHT Target VEGF VEGF Secreted Signaling -0.2273 0.0000002795069281596484 Scatter Plot
Source LIGHT Source PARs PARs Secreted Signaling -0.2233 0.0000004525127462704489 Scatter Plot
Source LIGHT Source COMPLEMENT COMPLEMENT Secreted Signaling -0.2129 0.0000015642208500979177 Scatter Plot
Source LIGHT Target CSF CSF Secreted Signaling -0.2075 0.00000286333041866961 Scatter Plot
Source LIGHT Source CD52 CD52 Cell-Cell Contact -0.1986 0.000007694355356382112 Scatter Plot
Source LIGHT Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.1704 0.0001286638712758 Scatter Plot
Source LIGHT Target VCAM VCAM Cell-Cell Contact -0.1492 0.0008181166753564 Scatter Plot
Source LIGHT Target CXCL CXCL Secreted Signaling -0.1490 0.0008299579461432 Scatter Plot
Source LIGHT Source VISFATIN VISFATIN Secreted Signaling -0.1466 0.001006329809256 Scatter Plot
Source LIGHT Target IL17 IL17 Secreted Signaling -0.1424 0.0014070097758679 Scatter Plot
Source LIGHT Target CD52 CD52 Cell-Cell Contact -0.1200 0.0072035354867072 Scatter Plot
Source LIGHT Source SELL SELL Cell-Cell Contact -0.1147 0.0102780627928026 Scatter Plot
Source LIGHT Target COLLAGEN COLLAGEN ECM-Receptor -0.1137 0.0109399804857537 Scatter Plot
Source LIGHT Target CCL CCL Secreted Signaling -0.1135 0.011069600759965 Scatter Plot
Source LIGHT Target GRN GRN Secreted Signaling -0.1067 0.0169759918929123 Scatter Plot
Source LIGHT Source CLEC CLEC Cell-Cell Contact -0.1043 0.0196546183461049 Scatter Plot
Source LIGHT Target ICAM ICAM Cell-Cell Contact -0.1027 0.021630007492383 Scatter Plot

Cells that are targets of LIGHT from HSCs*

Cells that are source of LIGHT to HSCs*

    No cell populations

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.