Pathway: IL2

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the IL2 pathway:

Specificity Index HSPC as target: 0.439
HSPC as source: 0.574

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the IL2 pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Source IL2 Source PARs PARs Secreted Signaling 0.0969 0.0302210173253905 Scatter Plot
Source IL2 Source AGRN AGRN ECM-Receptor 0.1076 0.0160984831069976 Scatter Plot
Source IL2 Source ICOS ICOS Cell-Cell Contact 0.1170 0.0088128130475074 Scatter Plot
Source IL2 Source THBS THBS ECM-Receptor 0.1192 0.0076071426785042 Scatter Plot
Source IL2 Source IL6 IL6 Secreted Signaling 0.1246 0.0052515800954018 Scatter Plot
Source IL2 Source ncWNT ncWNT Secreted Signaling 0.1310 0.003344025574206 Scatter Plot
Source IL2 Source SEMA6 SEMA6 Cell-Cell Contact 0.1314 0.00323588951936 Scatter Plot
Source IL2 Source APELIN APELIN Secreted Signaling 0.1408 0.0015927173634699 Scatter Plot
Source IL2 Source WNT WNT Secreted Signaling 0.1589 0.0003615002671244 Scatter Plot
Source IL2 Source PTN PTN Secreted Signaling 0.1635 0.0002405947997009 Scatter Plot
Source IL2 Source CADM CADM Cell-Cell Contact 0.1852 0.00003074556336632607 Scatter Plot
Source IL2 Source GP1BA GP1BA Cell-Cell Contact 0.1863 0.000027701544258486967 Scatter Plot
Source IL2 Source CD46 CD46 Cell-Cell Contact 0.1902 0.00001864472130573301 Scatter Plot
Source IL2 Source NT NT Secreted Signaling 0.1915 0.000016192105950510135 Scatter Plot
Source IL2 Source SEMA3 SEMA3 Secreted Signaling 0.2026 0.000004978076235745618 Scatter Plot
Source IL2 Source GDF GDF Secreted Signaling 0.2026 0.000004941290587271551 Scatter Plot
Source IL2 Source ANGPTL ANGPTL Secreted Signaling 0.2033 0.000004588611298999767 Scatter Plot
Source IL2 Source CD1D2 CD1D2 Cell-Cell Contact 0.2058 0.0000034933786341758263 Scatter Plot
Source IL2 Source CD39 CD39 Cell-Cell Contact 0.2096 0.000002271147983566371 Scatter Plot
Source IL2 Source VCAM VCAM Cell-Cell Contact 0.2113 0.0000018639049589562227 Scatter Plot
Source IL2 Source LAIR1 LAIR1 Cell-Cell Contact 0.2295 0.0000002118667177757865 Scatter Plot
Source IL2 Source NOTCH NOTCH Cell-Cell Contact 0.2320 0.0000001558864017019092 Scatter Plot
Source IL2 Source VEGF VEGF Secreted Signaling 0.2359 0.00000009416701173664205 Scatter Plot
Source IL2 Source LIGHT LIGHT Secreted Signaling 0.2374 0.00000007802076964327704 Scatter Plot
Source IL2 Source CX3C CX3C Secreted Signaling 0.2387 0.00000006584498930787087 Scatter Plot
Source IL2 Source LIFR LIFR Secreted Signaling 0.2426 0.000000039269171759560726 Scatter Plot
Source IL2 Source MK MK Secreted Signaling 0.2451 0.00000002828452222528661 Scatter Plot
Source IL2 Source LAMININ LAMININ ECM-Receptor 0.2502 0.000000014132958678725743 Scatter Plot
Source IL2 Source PDGF PDGF Secreted Signaling 0.2557 0.000000006649063042297935 Scatter Plot
Source IL2 Source PROS PROS Secreted Signaling 0.2597 0.000000003755447044562606 Scatter Plot
Source IL2 Source CXCL CXCL Secreted Signaling 0.2612 0.000000003042345612391274 Scatter Plot
Source IL2 Source RANKL RANKL Secreted Signaling 0.2622 0.0000000026323377695728715 Scatter Plot
Source IL2 Source COLLAGEN COLLAGEN ECM-Receptor 0.2647 0.0000000018334395271645998 Scatter Plot
Source IL2 Source IL16 IL16 Secreted Signaling 0.2736 0.0000000004893139847894364 Scatter Plot
Source IL2 Source ANGPT ANGPT Secreted Signaling 0.2755 0.00000000036687913919327176 Scatter Plot
Source IL2 Source EPHB EPHB Cell-Cell Contact 0.2760 0.00000000033985430916583063 Scatter Plot
Source IL2 Source IGF IGF Secreted Signaling 0.2852 0.00000000008219749977274752 Scatter Plot
Source IL2 Source FLT3 FLT3 Secreted Signaling 0.2905 0.000000000034891748235174786 Scatter Plot
Source IL2 Source ICAM ICAM Cell-Cell Contact 0.2919 0.000000000027894092522848497 Scatter Plot
Source IL2 Source GAS GAS Secreted Signaling 0.3120 0.0000000000009506739167144966 Scatter Plot
Source IL2 Source CSF CSF Secreted Signaling 0.3138 0.0000000000006889150441653009 Scatter Plot
Source IL2 Source ESAM ESAM Cell-Cell Contact 0.3145 0.0000000000006102680446036258 Scatter Plot
Source IL2 Source CDH CDH Cell-Cell Contact 0.3158 0.0000000000004846415398995882 Scatter Plot
Source IL2 Source JAM JAM Cell-Cell Contact 0.3350 0.000000000000014088100004838782 Scatter Plot
Source IL2 Source BST2 BST2 Cell-Cell Contact 0.3574 0.00000000000000016435559443850875 Scatter Plot
Source IL2 Source BMP BMP Secreted Signaling 0.3732 0.000000000000000005649682104391816 Scatter Plot
Source IL2 Source PSAP PSAP Secreted Signaling 0.3794 0.000000000000000001435750190556551 Scatter Plot
Source IL2 Source TWEAK TWEAK Secreted Signaling 0.3858 0.00000000000000000033816897273792413 Scatter Plot
Source IL2 Source SEMA7 SEMA7 Cell-Cell Contact 0.4158 0.0000000000000000000002492752378527362 Scatter Plot
Source IL2 Source MHC-II MHC-II Cell-Cell Contact 0.4721 0.00000000000000000000000000003978974920420589 Scatter Plot
Source IL2 Source CD52 CD52 Cell-Cell Contact -0.2904 0.000000000035575329942190784 Scatter Plot
Source IL2 Source TGFb TGFb Secreted Signaling -0.2899 0.00000000003853746965893834 Scatter Plot
Source IL2 Source SELL SELL Cell-Cell Contact -0.2644 0.000000001914871390608458 Scatter Plot
Source IL2 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.2598 0.0000000036942501073682124 Scatter Plot
Source IL2 Source COMPLEMENT COMPLEMENT Secreted Signaling -0.2524 0.000000010500681119015061 Scatter Plot
Source IL2 Source PARs PARs Secreted Signaling -0.2047 0.000003934024040271716 Scatter Plot
Source IL2 Source CLEC CLEC Cell-Cell Contact -0.1893 0.00002026134679362892 Scatter Plot
Source IL2 Source MIF MIF Secreted Signaling -0.1838 0.000035620566959834937 Scatter Plot
Source IL2 Source VISTA VISTA Cell-Cell Contact -0.1755 0.00008006092086262997 Scatter Plot
Source IL2 Source SEMA4 SEMA4 Cell-Cell Contact -0.1722 0.0001086830725082 Scatter Plot
Source IL2 Source ANGPTL ANGPTL Secreted Signaling -0.1623 0.0002685600832916 Scatter Plot
Source IL2 Source TNF TNF Secreted Signaling -0.1511 0.0007021687941666 Scatter Plot
Source IL2 Source NCAM NCAM Cell-Cell Contact -0.1494 0.000803173801061 Scatter Plot
Source IL2 Source VEGF VEGF Secreted Signaling -0.1352 0.002454394417187 Scatter Plot
Source IL2 Source IL1 IL1 Secreted Signaling -0.1234 0.0057226708888173 Scatter Plot
Source IL2 Source SPP1 SPP1 Secreted Signaling -0.1084 0.0153313800189933 Scatter Plot
Source IL2 Source NKG2D NKG2D Cell-Cell Contact -0.1070 0.0166601515928742 Scatter Plot
Source IL2 Source ANNEXIN ANNEXIN Secreted Signaling -0.0962 0.0314214929496404 Scatter Plot
Source IL2 Source APP APP Cell-Cell Contact 0.1147 0.0102418997704765 Scatter Plot
Source IL2 Target SEMA3 SEMA3 Secreted Signaling 0.1198 0.0073014590400429 Scatter Plot
Source IL2 Target NOTCH NOTCH Cell-Cell Contact 0.1210 0.0067319890039583 Scatter Plot
Source IL2 Target VCAM VCAM Cell-Cell Contact 0.1229 0.0059388509375043 Scatter Plot
Source IL2 Target IL17 IL17 Secreted Signaling 0.1372 0.0021068601303267 Scatter Plot
Source IL2 Target IFN-II IFN-II Secreted Signaling 0.1422 0.001435819059282 Scatter Plot
Source IL2 Target GAS GAS Secreted Signaling 0.1477 0.0009246178232853 Scatter Plot
Source IL2 Target OSM OSM Secreted Signaling 0.1485 0.0008665465330034 Scatter Plot
Source IL2 Target RANKL RANKL Secreted Signaling 0.1541 0.0005442791303708 Scatter Plot
Source IL2 Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1615 0.0002876724530312 Scatter Plot
Source IL2 Target THY1 THY1 Cell-Cell Contact 0.1654 0.0002034180789924 Scatter Plot
Source IL2 Target GALECTIN GALECTIN Secreted Signaling 0.1668 0.0001786559930034 Scatter Plot
Source IL2 Target SPP1 SPP1 Secreted Signaling 0.1723 0.0001074589935186 Scatter Plot
Source IL2 Target MK MK Secreted Signaling 0.1726 0.0001047512096269 Scatter Plot
Source IL2 Source ICAM ICAM Cell-Cell Contact 0.1752 0.00008167996600101376 Scatter Plot
Source IL2 Target IL6 IL6 Secreted Signaling 0.1794 0.00005480679623337011 Scatter Plot
Source IL2 Target NCAM NCAM Cell-Cell Contact 0.1835 0.00003657015917351766 Scatter Plot
Source IL2 Target CD23 CD23 Cell-Cell Contact 0.1838 0.00003560497097146348 Scatter Plot
Source IL2 Target CADM CADM Cell-Cell Contact 0.1852 0.00003074556336632607 Scatter Plot
Source IL2 Target GDF GDF Secreted Signaling 0.1870 0.000025674146949679125 Scatter Plot
Source IL2 Target CD52 CD52 Cell-Cell Contact 0.1898 0.000019316465474075723 Scatter Plot
Source IL2 Target FN1 FN1 ECM-Receptor 0.1961 0.000009959500771338338 Scatter Plot
Source IL2 Target NODAL NODAL Secreted Signaling 0.2002 0.000006442156274167031 Scatter Plot
Source IL2 Target SEMA7 SEMA7 Cell-Cell Contact 0.2006 0.000006153265419692908 Scatter Plot
Source IL2 Target VEGF VEGF Secreted Signaling 0.2032 0.000004619642039764528 Scatter Plot
Source IL2 Target EPHA EPHA Cell-Cell Contact 0.2061 0.0000033497698314445327 Scatter Plot
Source IL2 Target AGT AGT Secreted Signaling 0.2064 0.0000032654781746411067 Scatter Plot
Source IL2 Source THY1 THY1 Cell-Cell Contact 0.2066 0.000003190172412689764 Scatter Plot
Source IL2 Target ANGPT ANGPT Secreted Signaling 0.2100 0.0000021566777687554296 Scatter Plot
Source IL2 Source ANNEXIN ANNEXIN Secreted Signaling 0.2103 0.0000020952287156994023 Scatter Plot
Source IL2 Target PTN PTN Secreted Signaling 0.2110 0.000001938611370499935 Scatter Plot
Source IL2 Source LCK LCK Cell-Cell Contact 0.2163 0.0000010445612900021183 Scatter Plot
Source IL2 Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2207 0.0000006226421293592003 Scatter Plot
Source IL2 Target KIT KIT Secreted Signaling 0.2228 0.0000004825396928881699 Scatter Plot
Source IL2 Target SEMA6 SEMA6 Cell-Cell Contact 0.2229 0.0000004772112651744248 Scatter Plot
Source IL2 Target SEMA5 SEMA5 Cell-Cell Contact 0.2243 0.0000004043438746707429 Scatter Plot
Source IL2 Target ANGPTL ANGPTL Secreted Signaling 0.2325 0.00000014476727006251208 Scatter Plot
Source IL2 Target VTN VTN ECM-Receptor 0.2382 0.00000006995132534621228 Scatter Plot
Source IL2 Target VWF VWF ECM-Receptor 0.2418 0.00000004375354656197798 Scatter Plot
Source IL2 Target IGF IGF Secreted Signaling 0.2425 0.000000039826285908414146 Scatter Plot
Source IL2 Target PERIOSTIN PERIOSTIN Secreted Signaling 0.2434 0.00000003555426411210244 Scatter Plot
Source IL2 Target COLLAGEN COLLAGEN ECM-Receptor 0.2442 0.000000031838549009411 Scatter Plot
Source IL2 Target CD22 CD22 Cell-Cell Contact 0.2459 0.00000002524978481442073 Scatter Plot
Source IL2 Source CD45 CD45 Cell-Cell Contact 0.2459 0.00000002524978481442073 Scatter Plot
Source IL2 Target VISFATIN VISFATIN Secreted Signaling 0.2466 0.000000023223557662264583 Scatter Plot
Source IL2 Target BSP BSP ECM-Receptor 0.2493 0.00000001608781725428023 Scatter Plot
Source IL2 Source CCL CCL Secreted Signaling 0.2496 0.000000015342323872180528 Scatter Plot
Source IL2 Target DMP1 DMP1 ECM-Receptor 0.2544 0.000000007921829164908877 Scatter Plot
Source IL2 Target THBS THBS ECM-Receptor 0.2549 0.000000007453261927170671 Scatter Plot
Source IL2 Target NRG NRG Secreted Signaling 0.2554 0.0000000068751388678179915 Scatter Plot
Source IL2 Target SEMA4 SEMA4 Cell-Cell Contact 0.2559 0.00000000647755303393701 Scatter Plot
Source IL2 Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.2606 0.000000003334238983431244 Scatter Plot
Source IL2 Target EPHB EPHB Cell-Cell Contact 0.2629 0.000000002369714221423275 Scatter Plot
Source IL2 Target CD200 CD200 Cell-Cell Contact 0.2635 0.000000002167652292340384 Scatter Plot
Source IL2 Target FGF FGF Secreted Signaling 0.2695 0.0000000009107392327718793 Scatter Plot
Source IL2 Target PARs PARs Secreted Signaling 0.2757 0.00000000035752669649021123 Scatter Plot
Source IL2 Target CD39 CD39 Cell-Cell Contact 0.2791 0.00000000021272183615053872 Scatter Plot
Source IL2 Target TGFb TGFb Secreted Signaling 0.2826 0.00000000012303634740666279 Scatter Plot
Source IL2 Target LAMININ LAMININ ECM-Receptor 0.2862 0.00000000007012359200103808 Scatter Plot
Source IL2 Target WNT WNT Secreted Signaling 0.2862 0.00000000006978369278094989 Scatter Plot
Source IL2 Target BMP BMP Secreted Signaling 0.2881 0.00000000005187958016174559 Scatter Plot
Source IL2 Target ACTIVIN ACTIVIN Secreted Signaling 0.2961 0.00000000001406131054449232 Scatter Plot
Source IL2 Target BAFF BAFF Secreted Signaling 0.2995 0.000000000008032097904707635 Scatter Plot
Source IL2 Target NPR2 NPR2 Secreted Signaling 0.3103 0.0000000000012626617288486222 Scatter Plot
Source IL2 Source MHC-I MHC-I Cell-Cell Contact 0.3125 0.0000000000008609506651172094 Scatter Plot
Source IL2 Target ESAM ESAM Cell-Cell Contact 0.3145 0.0000000000006102680446036258 Scatter Plot
Source IL2 Target CDH CDH Cell-Cell Contact 0.3158 0.0000000000004846415398995882 Scatter Plot
Source IL2 Target JAM JAM Cell-Cell Contact 0.3223 0.00000000000015051819221877046 Scatter Plot
Source IL2 Target APP APP Cell-Cell Contact 0.3319 0.00000000000002520247477199284 Scatter Plot
Source IL2 Target CSPG4 CSPG4 Cell-Cell Contact 0.3400 0.0000000000000053161639854311015 Scatter Plot
Source IL2 Target ncWNT ncWNT Secreted Signaling 0.3675 0.00000000000000001963705094058107 Scatter Plot
Source IL2 Target SLURP SLURP Secreted Signaling 0.3699 0.000000000000000011730518150016992 Scatter Plot
Source IL2 Target TENASCIN TENASCIN ECM-Receptor 0.3754 0.0000000000000000035189417019882296 Scatter Plot
Source IL2 Source CD86 CD86 Cell-Cell Contact 0.3795 0.0000000000000000014209165634122706 Scatter Plot
Source IL2 Target CD34 CD34 Cell-Cell Contact 0.3936 0.00000000000000000005594095351606531 Scatter Plot
Source IL2 Target MIF MIF Secreted Signaling 0.5155 0.000000000000000000000000000000000027015395682099094 Scatter Plot
Source IL2 Target CD52 CD52 Cell-Cell Contact -0.2992 0.000000000008412346962307387 Scatter Plot
Source IL2 Target ICAM ICAM Cell-Cell Contact -0.2556 0.000000006685424289968062 Scatter Plot
Source IL2 Target CSF CSF Secreted Signaling -0.2125 0.0000016296749561103225 Scatter Plot
Source IL2 Target ANNEXIN ANNEXIN Secreted Signaling -0.2031 0.000004671666726886014 Scatter Plot
Source IL2 Target IL17 IL17 Secreted Signaling -0.1962 0.000009885969814524362 Scatter Plot
Source IL2 Target CXCL CXCL Secreted Signaling -0.1835 0.000036535498920673725 Scatter Plot
Source IL2 Target VCAM VCAM Cell-Cell Contact -0.1824 0.00004064279912425612 Scatter Plot
Source IL2 Target CEACAM CEACAM Cell-Cell Contact -0.1718 0.0001132358085532 Scatter Plot
Source IL2 Target CLEC CLEC Cell-Cell Contact -0.1692 0.0001433742600128 Scatter Plot
Source IL2 Target IFN-II IFN-II Secreted Signaling -0.1676 0.0001658286615247 Scatter Plot
Source IL2 Target VEGF VEGF Secreted Signaling -0.1589 0.0003622187141588 Scatter Plot
Source IL2 Target CCL CCL Secreted Signaling -0.1522 0.0006403522999562 Scatter Plot
Source IL2 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.1248 0.0052044571369278 Scatter Plot
Source IL2 Source BAFF BAFF Secreted Signaling -0.1172 0.0087094335506336 Scatter Plot
Source IL2 Target PTN PTN Secreted Signaling -0.1119 0.0122518973962887 Scatter Plot
Source IL2 Target COLLAGEN COLLAGEN ECM-Receptor -0.1071 0.0165606387720658 Scatter Plot
Source IL2 Target GRN GRN Secreted Signaling -0.1039 0.0200962430613445 Scatter Plot
Source IL2 Target ANGPTL ANGPTL Secreted Signaling -0.1020 0.022510771734454 Scatter Plot
Source IL2 Source CCL CCL Secreted Signaling -0.1017 0.0229387481720955 Scatter Plot

Cells that are targets of IL2 from HSCs*

Cells that are source of IL2 to HSCs*

    No cell populations

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.