Pathway: PERIOSTIN

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Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the PERIOSTIN pathway:

Specificity Index HSPC as target: 0.266
HSPC as source: 0.239

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the PERIOSTIN pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Target PERIOSTIN Source THBS THBS ECM-Receptor 0.1255 0.004934255752254 Scatter Plot
Target PERIOSTIN Source GDF GDF Secreted Signaling 0.1297 0.0036668533867061 Scatter Plot
Target PERIOSTIN Source IL6 IL6 Secreted Signaling 0.1303 0.0035068480376074 Scatter Plot
Target PERIOSTIN Source ANGPTL ANGPTL Secreted Signaling 0.1332 0.0028333718353126 Scatter Plot
Target PERIOSTIN Target GAS GAS Secreted Signaling 0.1402 0.0016693407394004 Scatter Plot
Target PERIOSTIN Source GP1BA GP1BA Cell-Cell Contact 0.1433 0.0013167051082664 Scatter Plot
Target PERIOSTIN Source SEMA6 SEMA6 Cell-Cell Contact 0.1453 0.0011183823287864 Scatter Plot
Target PERIOSTIN Target RANKL RANKL Secreted Signaling 0.1462 0.0010394728389635 Scatter Plot
Target PERIOSTIN Source WNT WNT Secreted Signaling 0.1546 0.0005219781935724 Scatter Plot
Target PERIOSTIN Source PTN PTN Secreted Signaling 0.1696 0.0001382265395531 Scatter Plot
Target PERIOSTIN Source VCAM VCAM Cell-Cell Contact 0.1805 0.00004913791320255051 Scatter Plot
Target PERIOSTIN Source CD1D2 CD1D2 Cell-Cell Contact 0.1853 0.00003059408464796176 Scatter Plot
Target PERIOSTIN Target NCAM NCAM Cell-Cell Contact 0.1935 0.000013229579984501892 Scatter Plot
Target PERIOSTIN Target GDF GDF Secreted Signaling 0.2058 0.000003469917486652657 Scatter Plot
Target PERIOSTIN Target SEMA3 SEMA3 Secreted Signaling 0.2093 0.000002339960346556656 Scatter Plot
Target PERIOSTIN Target EPHA EPHA Cell-Cell Contact 0.2231 0.0000004630333146615286 Scatter Plot
Target PERIOSTIN Source CD39 CD39 Cell-Cell Contact 0.2294 0.00000021434390461290137 Scatter Plot
Target PERIOSTIN Source CCL CCL Secreted Signaling 0.2352 0.00000010351610559962 Scatter Plot
Target PERIOSTIN Target MK MK Secreted Signaling 0.2407 0.00000005075241459867367 Scatter Plot
Target PERIOSTIN Source IL2 IL2 Secreted Signaling 0.2434 0.00000003555426411210244 Scatter Plot
Target PERIOSTIN Source THY1 THY1 Cell-Cell Contact 0.2453 0.000000027333218081775592 Scatter Plot
Target PERIOSTIN Source SEMA3 SEMA3 Secreted Signaling 0.2499 0.000000014763071472968784 Scatter Plot
Target PERIOSTIN Source EPHB EPHB Cell-Cell Contact 0.2545 0.000000007824722738941557 Scatter Plot
Target PERIOSTIN Source ncWNT ncWNT Secreted Signaling 0.2644 0.000000001909604481157829 Scatter Plot
Target PERIOSTIN Source RANKL RANKL Secreted Signaling 0.2667 0.000000001362857019120914 Scatter Plot
Target PERIOSTIN Target KIT KIT Secreted Signaling 0.2769 0.00000000029572401601161763 Scatter Plot
Target PERIOSTIN Target CSPG4 CSPG4 Cell-Cell Contact 0.2815 0.00000000014695204747429928 Scatter Plot
Target PERIOSTIN Source CADM CADM Cell-Cell Contact 0.2849 0.00000000008571792149077427 Scatter Plot
Target PERIOSTIN Source CD46 CD46 Cell-Cell Contact 0.2917 0.000000000028796095159620947 Scatter Plot
Target PERIOSTIN Source IL16 IL16 Secreted Signaling 0.2921 0.00000000002709341225304326 Scatter Plot
Target PERIOSTIN Source NOTCH NOTCH Cell-Cell Contact 0.2925 0.00000000002548811700066765 Scatter Plot
Target PERIOSTIN Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2984 0.000000000009591863165466743 Scatter Plot
Target PERIOSTIN Source VEGF VEGF Secreted Signaling 0.3040 0.000000000003752571173130903 Scatter Plot
Target PERIOSTIN Source NT NT Secreted Signaling 0.3104 0.000000000001250584506654126 Scatter Plot
Target PERIOSTIN Target SEMA6 SEMA6 Cell-Cell Contact 0.3169 0.00000000000040018740783623893 Scatter Plot
Target PERIOSTIN Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.3234 0.00000000000012213871900627333 Scatter Plot
Target PERIOSTIN Target EPHB EPHB Cell-Cell Contact 0.3239 0.00000000000011246170373305469 Scatter Plot
Target PERIOSTIN Source CSF CSF Secreted Signaling 0.3312 0.000000000000029110949977246835 Scatter Plot
Target PERIOSTIN Target PARs PARs Secreted Signaling 0.3331 0.000000000000020241939515366965 Scatter Plot
Target PERIOSTIN Source CXCL CXCL Secreted Signaling 0.3376 0.000000000000008569227354624038 Scatter Plot
Target PERIOSTIN Source CD86 CD86 Cell-Cell Contact 0.3388 0.000000000000006728848202757639 Scatter Plot
Target PERIOSTIN Source LIGHT LIGHT Secreted Signaling 0.3398 0.000000000000005521396132093557 Scatter Plot
Target PERIOSTIN Target ACTIVIN ACTIVIN Secreted Signaling 0.3462 0.0000000000000015716171322291468 Scatter Plot
Target PERIOSTIN Source IGF IGF Secreted Signaling 0.3644 0.00000000000000003806539148016858 Scatter Plot
Target PERIOSTIN Source LCK LCK Cell-Cell Contact 0.3645 0.00000000000000003718307228019157 Scatter Plot
Target PERIOSTIN Source FLT3 FLT3 Secreted Signaling 0.3649 0.000000000000000034294994232773536 Scatter Plot
Target PERIOSTIN Source CX3C CX3C Secreted Signaling 0.3668 0.000000000000000022754749518411318 Scatter Plot
Target PERIOSTIN Target TGFb TGFb Secreted Signaling 0.3670 0.00000000000000002166236614855204 Scatter Plot
Target PERIOSTIN Source CD45 CD45 Cell-Cell Contact 0.3721 0.000000000000000007150541564410576 Scatter Plot
Target PERIOSTIN Source PROS PROS Secreted Signaling 0.3819 0.0000000000000000008217385705867659 Scatter Plot
Target PERIOSTIN Source ICAM ICAM Cell-Cell Contact 0.3827 0.0000000000000000006858874071499632 Scatter Plot
Target PERIOSTIN Target CD200 CD200 Cell-Cell Contact 0.3838 0.0000000000000000005313935362179086 Scatter Plot
Target PERIOSTIN Source BST2 BST2 Cell-Cell Contact 0.3906 0.00000000000000000011271173201569957 Scatter Plot
Target PERIOSTIN Source LAMININ LAMININ ECM-Receptor 0.3928 0.00000000000000000006730062426426964 Scatter Plot
Target PERIOSTIN Source MK MK Secreted Signaling 0.4228 0.00000000000000000000004238859293043258 Scatter Plot
Target PERIOSTIN Target SLURP SLURP Secreted Signaling 0.4347 0.0000000000000000000000018230417618364996 Scatter Plot
Target PERIOSTIN Source LIFR LIFR Secreted Signaling 0.4367 0.000000000000000000000001053424258936697 Scatter Plot
Target PERIOSTIN Source PDGF PDGF Secreted Signaling 0.4372 0.0000000000000000000000009115571803125784 Scatter Plot
Target PERIOSTIN Source PSAP PSAP Secreted Signaling 0.4396 0.0000000000000000000000004770444280211688 Scatter Plot
Target PERIOSTIN Source COLLAGEN COLLAGEN ECM-Receptor 0.4434 0.00000000000000000000000016578681114187656 Scatter Plot
Target PERIOSTIN Target CDH CDH Cell-Cell Contact 0.4491 0.000000000000000000000000034274452983993644 Scatter Plot
Target PERIOSTIN Source CDH CDH Cell-Cell Contact 0.4491 0.000000000000000000000000034274452983993644 Scatter Plot
Target PERIOSTIN Source IL7 IL7 Secreted Signaling 0.4610 0.0000000000000000000000000010981941178193346 Scatter Plot
Target PERIOSTIN Target FGF FGF Secreted Signaling 0.4685 0.00000000000000000000000000011733447581827203 Scatter Plot
Target PERIOSTIN Source SEMA7 SEMA7 Cell-Cell Contact 0.4798 0.0000000000000000000000000000037598485945830654 Scatter Plot
Target PERIOSTIN Source ANGPT ANGPT Secreted Signaling 0.4798 0.000000000000000000000000000003744693640015613 Scatter Plot
Target PERIOSTIN Source BMP BMP Secreted Signaling 0.4911 0.00000000000000000000000000000010305884737455446 Scatter Plot
Target PERIOSTIN Target CD39 CD39 Cell-Cell Contact 0.4917 0.00000000000000000000000000000008308832802986431 Scatter Plot
Target PERIOSTIN Source TWEAK TWEAK Secreted Signaling 0.5022 0.0000000000000000000000000000000025994745890308338 Scatter Plot
Target PERIOSTIN Source GAS GAS Secreted Signaling 0.5034 0.000000000000000000000000000000001704648853931493 Scatter Plot
Target PERIOSTIN Target MIF MIF Secreted Signaling 0.5050 0.0000000000000000000000000000000010203730897943163 Scatter Plot
Target PERIOSTIN Target WNT WNT Secreted Signaling 0.5124 0.00000000000000000000000000000000007867622224947142 Scatter Plot
Target PERIOSTIN Source ESAM ESAM Cell-Cell Contact 0.5170 0.000000000000000000000000000000000015490813206391668 Scatter Plot
Target PERIOSTIN Source MHC-II MHC-II Cell-Cell Contact 0.5190 0.000000000000000000000000000000000007844710356333185 Scatter Plot
Target PERIOSTIN Source MHC-I MHC-I Cell-Cell Contact 0.5233 0.000000000000000000000000000000000001679377222974128 Scatter Plot
Target PERIOSTIN Source JAM JAM Cell-Cell Contact 0.5743 0.000000000000000000000000000000000000000000003156424800259416 Scatter Plot
Target PERIOSTIN Source CD52 CD52 Cell-Cell Contact -0.3518 0.0000000000000005099168346506342 Scatter Plot
Target PERIOSTIN Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.3200 0.00000000000022692709091059187 Scatter Plot
Target PERIOSTIN Source SELL SELL Cell-Cell Contact -0.2813 0.00000000015013590906103455 Scatter Plot
Target PERIOSTIN Source TGFb TGFb Secreted Signaling -0.2679 0.0000000011433165670098043 Scatter Plot
Target PERIOSTIN Source COMPLEMENT COMPLEMENT Secreted Signaling -0.2658 0.000000001552059844467094 Scatter Plot
Target PERIOSTIN Source PARs PARs Secreted Signaling -0.2508 0.000000012969122816113045 Scatter Plot
Target PERIOSTIN Source ANGPTL ANGPTL Secreted Signaling -0.2421 0.00000004228330496065926 Scatter Plot
Target PERIOSTIN Source CLEC CLEC Cell-Cell Contact -0.2320 0.0000001548728461244469 Scatter Plot
Target PERIOSTIN Source MIF MIF Secreted Signaling -0.2254 0.0000003506986243652237 Scatter Plot
Target PERIOSTIN Target VEGF VEGF Secreted Signaling -0.1604 0.0003167437386804 Scatter Plot
Target PERIOSTIN Source NCAM NCAM Cell-Cell Contact -0.1574 0.0004115901614485 Scatter Plot
Target PERIOSTIN Source CCL CCL Secreted Signaling -0.1531 0.0005915638230893 Scatter Plot
Target PERIOSTIN Source SEMA4 SEMA4 Cell-Cell Contact -0.1504 0.0007381680349629 Scatter Plot
Target PERIOSTIN Target CXCL CXCL Secreted Signaling -0.1483 0.000878567801823 Scatter Plot
Target PERIOSTIN Source VISTA VISTA Cell-Cell Contact -0.1390 0.00183420480571 Scatter Plot
Target PERIOSTIN Source SPP1 SPP1 Secreted Signaling -0.1319 0.0031228500261305 Scatter Plot
Target PERIOSTIN Target IL17 IL17 Secreted Signaling -0.1082 0.0155032919788871 Scatter Plot
Target PERIOSTIN Target CSF CSF Secreted Signaling -0.1045 0.0194075430914638 Scatter Plot
Target PERIOSTIN Source NKG2D NKG2D Cell-Cell Contact -0.1037 0.0204140351863579 Scatter Plot
Target PERIOSTIN Target SELPLG SELPLG Cell-Cell Contact 0.0985 0.0276621209559211 Scatter Plot
Target PERIOSTIN Target CD86 CD86 Cell-Cell Contact 0.1166 0.0090479066573569 Scatter Plot
Target PERIOSTIN Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1492 0.0008185277791051 Scatter Plot
Target PERIOSTIN Target GALECTIN GALECTIN Secreted Signaling 0.1622 0.000270530336781 Scatter Plot
Target PERIOSTIN Target AGT AGT Secreted Signaling 0.1829 0.00003865368949660863 Scatter Plot
Target PERIOSTIN Target VEGF VEGF Secreted Signaling 0.1970 0.00000912890659408374 Scatter Plot
Target PERIOSTIN Target NODAL NODAL Secreted Signaling 0.2305 0.00000018749266624458442 Scatter Plot
Target PERIOSTIN Target SEMA7 SEMA7 Cell-Cell Contact 0.2774 0.00000000027672357041808193 Scatter Plot
Target PERIOSTIN Target CADM CADM Cell-Cell Contact 0.2849 0.00000000008571792149077427 Scatter Plot
Target PERIOSTIN Target OSM OSM Secreted Signaling 0.2954 0.000000000015833985710890856 Scatter Plot
Target PERIOSTIN Target SEMA5 SEMA5 Cell-Cell Contact 0.3020 0.000000000005299514705504043 Scatter Plot
Target PERIOSTIN Target IL6 IL6 Secreted Signaling 0.3248 0.00000000000009440484437375203 Scatter Plot
Target PERIOSTIN Target VISFATIN VISFATIN Secreted Signaling 0.3316 0.000000000000026969000843374492 Scatter Plot
Target PERIOSTIN Target PARs PARs Secreted Signaling 0.3342 0.000000000000016463393877484683 Scatter Plot
Target PERIOSTIN Target CD22 CD22 Cell-Cell Contact 0.3721 0.000000000000000007150541564410576 Scatter Plot
Target PERIOSTIN Target BAFF BAFF Secreted Signaling 0.3753 0.000000000000000003618753430551238 Scatter Plot
Target PERIOSTIN Target BMP BMP Secreted Signaling 0.3814 0.0000000000000000009316560862053757 Scatter Plot
Target PERIOSTIN Target SEMA4 SEMA4 Cell-Cell Contact 0.3958 0.00000000000000000003371673311672075 Scatter Plot
Target PERIOSTIN Target APP APP Cell-Cell Contact 0.4173 0.00000000000000000000017349075666153193 Scatter Plot
Target PERIOSTIN Target ANGPT ANGPT Secreted Signaling 0.4228 0.00000000000000000000004189396376028641 Scatter Plot
Target PERIOSTIN Target NPR2 NPR2 Secreted Signaling 0.4485 0.00000000000000000000000004074825993503907 Scatter Plot
Target PERIOSTIN Target ncWNT ncWNT Secreted Signaling 0.4604 0.0000000000000000000000000013056236836700866 Scatter Plot
Target PERIOSTIN Target ESAM ESAM Cell-Cell Contact 0.5170 0.000000000000000000000000000000000015490813206391668 Scatter Plot
Target PERIOSTIN Target CD34 CD34 Cell-Cell Contact 0.5235 0.0000000000000000000000000000000000015244302736846094 Scatter Plot
Target PERIOSTIN Target ICAM ICAM Cell-Cell Contact -0.2983 0.000000000009756817656209939 Scatter Plot
Target PERIOSTIN Target CD52 CD52 Cell-Cell Contact -0.2457 0.000000026224832202595148 Scatter Plot
Target PERIOSTIN Target VCAM VCAM Cell-Cell Contact -0.2155 0.0000011494172780319776 Scatter Plot
Target PERIOSTIN Target IFN-II IFN-II Secreted Signaling -0.1874 0.00002460923938395602 Scatter Plot
Target PERIOSTIN Target CEACAM CEACAM Cell-Cell Contact -0.1596 0.0003393032960184 Scatter Plot
Target PERIOSTIN Target CCL CCL Secreted Signaling -0.1338 0.0027175471805009 Scatter Plot
Target PERIOSTIN Target GRN GRN Secreted Signaling -0.1042 0.0198025876071974 Scatter Plot

Cells that are targets of PERIOSTIN from HSCs*

    No cell populations

Cells that are source of PERIOSTIN to HSCs*

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.