Pathway: IL7

colormap

Average Signaling Potential

  • Edge Color:
  • — HSCs as target
  • — HSCs as source

Pathway Category: Secreted Signaling

Details on the IL7 pathway:

Specificity Index HSPC as target: 0.198
HSPC as source: 0.504

Graph Terms:

  • Average Signaling Potential: Score given to cell-type pathway pair that describes the intensity of the potential interaction. This score is based on ligand/receptor gene expression levels.
  • HSC Percent: Proportion of HSCs that interact with the given cell type in the IL7 pathway.
  • Node Size: Node size refelcts percent of HSCs interacting
  • Node Color: Node color reflects Average Signaling Potential

Correlation Name Pathway Name Pathway Category Correlation Score -log10(adj. p-value) Plot
Source IL7 Source AGRN AGRN ECM-Receptor 0.1079 0.015768414272868 Scatter Plot
Source IL7 Source ICOS ICOS Cell-Cell Contact 0.1170 0.0088128130475074 Scatter Plot
Source IL7 Source IL6 IL6 Secreted Signaling 0.1246 0.0052515800954018 Scatter Plot
Source IL7 Source ncWNT ncWNT Secreted Signaling 0.1350 0.0024863107234185 Scatter Plot
Source IL7 Source SEMA6 SEMA6 Cell-Cell Contact 0.1391 0.0018226159922788 Scatter Plot
Source IL7 Source APELIN APELIN Secreted Signaling 0.1794 0.000054967672586923606 Scatter Plot
Source IL7 Source PTN PTN Secreted Signaling 0.1988 0.000007509389205605952 Scatter Plot
Source IL7 Source WNT WNT Secreted Signaling 0.2091 0.000002400643518501313 Scatter Plot
Source IL7 Source ANGPTL ANGPTL Secreted Signaling 0.2401 0.000000054784283827908026 Scatter Plot
Source IL7 Source GDF GDF Secreted Signaling 0.2421 0.00000004219486427842293 Scatter Plot
Source IL7 Source CADM CADM Cell-Cell Contact 0.2603 0.000000003443643134857921 Scatter Plot
Source IL7 Source NT NT Secreted Signaling 0.2615 0.0000000029150492860897193 Scatter Plot
Source IL7 Source VEGF VEGF Secreted Signaling 0.2840 0.00000000009825448608014108 Scatter Plot
Source IL7 Source SEMA3 SEMA3 Secreted Signaling 0.2876 0.000000000056390825704033385 Scatter Plot
Source IL7 Source CD46 CD46 Cell-Cell Contact 0.2947 0.000000000017848811110970722 Scatter Plot
Source IL7 Source CXCL CXCL Secreted Signaling 0.2992 0.000000000008434151703186146 Scatter Plot
Source IL7 Source CCL CCL Secreted Signaling 0.3190 0.00000000000027367288555289563 Scatter Plot
Source IL7 Source LAMININ LAMININ ECM-Receptor 0.3404 0.000000000000004954622555489847 Scatter Plot
Source IL7 Source LIGHT LIGHT Secreted Signaling 0.3430 0.000000000000003005374709591811 Scatter Plot
Source IL7 Source CD39 CD39 Cell-Cell Contact 0.3430 0.000000000000002968044479051052 Scatter Plot
Source IL7 Source IL16 IL16 Secreted Signaling 0.3533 0.00000000000000037888205080558212 Scatter Plot
Source IL7 Source RANKL RANKL Secreted Signaling 0.3649 0.000000000000000034328462280926215 Scatter Plot
Source IL7 Source NOTCH NOTCH Cell-Cell Contact 0.3671 0.00000000000000002104594753433572 Scatter Plot
Source IL7 Source IGF IGF Secreted Signaling 0.3843 0.0000000000000000004805075581740639 Scatter Plot
Source IL7 Source LCK LCK Cell-Cell Contact 0.3863 0.00000000000000000030515238279055044 Scatter Plot
Source IL7 Source LIFR LIFR Secreted Signaling 0.3874 0.00000000000000000023562130412592103 Scatter Plot
Source IL7 Source PROS PROS Secreted Signaling 0.3957 0.000000000000000000034503455148525416 Scatter Plot
Source IL7 Source EPHB EPHB Cell-Cell Contact 0.4121 0.00000000000000000000062807835459812235 Scatter Plot
Source IL7 Source ICAM ICAM Cell-Cell Contact 0.4186 0.00000000000000000000012201700103817353 Scatter Plot
Source IL7 Source CDH CDH Cell-Cell Contact 0.4575 0.000000000000000000000000003103364436058146 Scatter Plot
Source IL7 Source FLT3 FLT3 Secreted Signaling 0.4585 0.0000000000000000000000000022715262399560617 Scatter Plot
Source IL7 Source PDGF PDGF Secreted Signaling 0.4666 0.00000000000000000000000000021078273548610063 Scatter Plot
Source IL7 Source PSAP PSAP Secreted Signaling 0.4823 0.000000000000000000000000000001719064768611683 Scatter Plot
Source IL7 Source BMP BMP Secreted Signaling 0.5396 0.0000000000000000000000000000000000000039578090165933516 Scatter Plot
Source IL7 Source COLLAGEN COLLAGEN ECM-Receptor 0.5447 0.0000000000000000000000000000000000000005472346552760533 Scatter Plot
Source IL7 Source TWEAK TWEAK Secreted Signaling 0.5455 0.00000000000000000000000000000000000000039783911658844675 Scatter Plot
Source IL7 Source ANGPT ANGPT Secreted Signaling 0.5456 0.0000000000000000000000000000000000000003861796318220704 Scatter Plot
Source IL7 Source GAS GAS Secreted Signaling 0.5786 0.00000000000000000000000000000000000000000000049867101929001824 Scatter Plot
Source IL7 Source JAM JAM Cell-Cell Contact 0.6246 0.0000000000000000000000000000000000000000000000000000001842144791276345 Scatter Plot
Source IL7 Source MHC-II MHC-II Cell-Cell Contact 0.6854 0.00000000000000000000000000000000000000000000000000000000000000000000012056390363701958 Scatter Plot
Source IL7 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.3650 0.00000000000000003351472312669069 Scatter Plot
Source IL7 Source SELL SELL Cell-Cell Contact -0.3252 0.00000000000008859595558898291 Scatter Plot
Source IL7 Source TGFb TGFb Secreted Signaling -0.3234 0.00000000000012167285978592952 Scatter Plot
Source IL7 Source VISTA VISTA Cell-Cell Contact -0.2345 0.0000001126549965590531 Scatter Plot
Source IL7 Source MIF MIF Secreted Signaling -0.2273 0.0000002786309095601232 Scatter Plot
Source IL7 Source ANGPTL ANGPTL Secreted Signaling -0.2123 0.0000016626673082949942 Scatter Plot
Source IL7 Source SEMA4 SEMA4 Cell-Cell Contact -0.1762 0.00007481890053324434 Scatter Plot
Source IL7 Source NCAM NCAM Cell-Cell Contact -0.1494 0.000803173801061 Scatter Plot
Source IL7 Source SPP1 SPP1 Secreted Signaling -0.1084 0.0153313800189933 Scatter Plot
Source IL7 Source ICOS ICOS Cell-Cell Contact 0.1170 0.0088128130475074 Scatter Plot
Source IL7 Target SEMA3 SEMA3 Secreted Signaling 0.1198 0.0073014590400429 Scatter Plot
Source IL7 Target NOTCH NOTCH Cell-Cell Contact 0.1370 0.0021409923959621 Scatter Plot
Source IL7 Target GAS GAS Secreted Signaling 0.1477 0.0009246178232853 Scatter Plot
Source IL7 Target ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact 0.1526 0.0006191008653094 Scatter Plot
Source IL7 Source GP1BA GP1BA Cell-Cell Contact 0.1686 0.0001524929763305 Scatter Plot
Source IL7 Target OSM OSM Secreted Signaling 0.1750 0.00008328163548017146 Scatter Plot
Source IL7 Target THY1 THY1 Cell-Cell Contact 0.1924 0.00001480351172690289 Scatter Plot
Source IL7 Source CD1D2 CD1D2 Cell-Cell Contact 0.1928 0.000014225766924672355 Scatter Plot
Source IL7 Target GALECTIN GALECTIN Secreted Signaling 0.1940 0.000012446796725714598 Scatter Plot
Source IL7 Target VEGF VEGF Secreted Signaling 0.1993 0.0000070831317874995015 Scatter Plot
Source IL7 Target RANKL RANKL Secreted Signaling 0.2037 0.000004405163849767194 Scatter Plot
Source IL7 Target SPP1 SPP1 Secreted Signaling 0.2055 0.000003613410073810259 Scatter Plot
Source IL7 Source VCAM VCAM Cell-Cell Contact 0.2113 0.00000186390495895622 Scatter Plot
Source IL7 Target CD23 CD23 Cell-Cell Contact 0.2141 0.000001361196374843378 Scatter Plot
Source IL7 Target NCAM NCAM Cell-Cell Contact 0.2228 0.0000004829100646320975 Scatter Plot
Source IL7 Target MK MK Secreted Signaling 0.2298 0.00000020298573462871762 Scatter Plot
Source IL7 Target AGT AGT Secreted Signaling 0.2498 0.000000014957630264077876 Scatter Plot
Source IL7 Target NODAL NODAL Secreted Signaling 0.2591 0.0000000041122337507987355 Scatter Plot
Source IL7 Target CADM CADM Cell-Cell Contact 0.2603 0.000000003443643134857921 Scatter Plot
Source IL7 Target PTN PTN Secreted Signaling 0.2606 0.000000003291316497146477 Scatter Plot
Source IL7 Target IL6 IL6 Secreted Signaling 0.2610 0.000000003119555447271785 Scatter Plot
Source IL7 Source THY1 THY1 Cell-Cell Contact 0.2654 0.000000001646374962662071 Scatter Plot
Source IL7 Target FN1 FN1 ECM-Receptor 0.2665 0.0000000014172852426699151 Scatter Plot
Source IL7 Target EPHA EPHA Cell-Cell Contact 0.2689 0.0000000009841381680644795 Scatter Plot
Source IL7 Target COMPLEMENT COMPLEMENT Secreted Signaling 0.2895 0.000000000041263749521026425 Scatter Plot
Source IL7 Target GDF GDF Secreted Signaling 0.3016 0.000000000005638757775623578 Scatter Plot
Source IL7 Target COLLAGEN COLLAGEN ECM-Receptor 0.3035 0.000000000004120372224437889 Scatter Plot
Source IL7 Target ADIPONECTIN ADIPONECTIN Secreted Signaling 0.3079 0.0000000000019107302351748906 Scatter Plot
Source IL7 Target VISFATIN VISFATIN Secreted Signaling 0.3118 0.0000000000009811107511398737 Scatter Plot
Source IL7 Target SEMA6 SEMA6 Cell-Cell Contact 0.3135 0.000000000000729504986601208 Scatter Plot
Source IL7 Target SEMA5 SEMA5 Cell-Cell Contact 0.3160 0.0000000000004652900692931756 Scatter Plot
Source IL7 Target SEMA7 SEMA7 Cell-Cell Contact 0.3229 0.00000000000013516500285505492 Scatter Plot
Source IL7 Target ANGPTL ANGPTL Secreted Signaling 0.3256 0.00000000000008212385026899997 Scatter Plot
Source IL7 Target KIT KIT Secreted Signaling 0.3418 0.000000000000003739465977387682 Scatter Plot
Source IL7 Target THBS THBS ECM-Receptor 0.3472 0.0000000000000012945698874005158 Scatter Plot
Source IL7 Source IL16 IL16 Secreted Signaling 0.3533 0.00000000000000037888205080558212 Scatter Plot
Source IL7 Source CSF CSF Secreted Signaling 0.3645 0.00000000000000003704888597112568 Scatter Plot
Source IL7 Target PARs PARs Secreted Signaling 0.3687 0.000000000000000014947113386725686 Scatter Plot
Source IL7 Target NPR2 NPR2 Secreted Signaling 0.3731 0.000000000000000005832949671555608 Scatter Plot
Source IL7 Target EPHB EPHB Cell-Cell Contact 0.3764 0.000000000000000002823685777473535 Scatter Plot
Source IL7 Target ANGPT ANGPT Secreted Signaling 0.3815 0.0000000000000000009079642154122511 Scatter Plot
Source IL7 Source IGF IGF Secreted Signaling 0.3867 0.00000000000000000027787526834173613 Scatter Plot
Source IL7 Target BAFF BAFF Secreted Signaling 0.3906 0.0000000000000000001134347260229579 Scatter Plot
Source IL7 Target LAMININ LAMININ ECM-Receptor 0.3949 0.00000000000000000004083153679301532 Scatter Plot
Source IL7 Target CSPG4 CSPG4 Cell-Cell Contact 0.4061 0.00000000000000000000278447926541142 Scatter Plot
Source IL7 Source ICAM ICAM Cell-Cell Contact 0.4081 0.0000000000000000000017164773876132515 Scatter Plot
Source IL7 Target CD22 CD22 Cell-Cell Contact 0.4097 0.0000000000000000000011685774799706233 Scatter Plot
Source IL7 Source CD45 CD45 Cell-Cell Contact 0.4097 0.0000000000000000000011685774799706233 Scatter Plot
Source IL7 Target TGFb TGFb Secreted Signaling 0.4173 0.00000000000000000000017130207517672577 Scatter Plot
Source IL7 Target VTN VTN ECM-Receptor 0.4188 0.00000000000000000000011740685931836022 Scatter Plot
Source IL7 Target BMP BMP Secreted Signaling 0.4190 0.00000000000000000000011221144543719432 Scatter Plot
Source IL7 Source CX3C CX3C Secreted Signaling 0.4214 0.0000000000000000000000605843789843064 Scatter Plot
Source IL7 Target SEMA4 SEMA4 Cell-Cell Contact 0.4264 0.000000000000000000000016371839675818444 Scatter Plot
Source IL7 Target ACTIVIN ACTIVIN Secreted Signaling 0.4278 0.000000000000000000000011469494141883881 Scatter Plot
Source IL7 Target VWF VWF ECM-Receptor 0.4294 0.000000000000000000000007394302588700326 Scatter Plot
Source IL7 Target IGF IGF Secreted Signaling 0.4354 0.0000000000000000000000014982442515903836 Scatter Plot
Source IL7 Source CD86 CD86 Cell-Cell Contact 0.4390 0.0000000000000000000000005644740975118691 Scatter Plot
Source IL7 Target CDH CDH Cell-Cell Contact 0.4575 0.000000000000000000000000003103364436058146 Scatter Plot
Source IL7 Target PERIOSTIN PERIOSTIN Secreted Signaling 0.4610 0.0000000000000000000000000010981941178193346 Scatter Plot
Source IL7 Target BSP BSP ECM-Receptor 0.4733 0.000000000000000000000000000027519671544431367 Scatter Plot
Source IL7 Source SEMA7 SEMA7 Cell-Cell Contact 0.4792 0.000000000000000000000000000004416301282104626 Scatter Plot
Source IL7 Source MK MK Secreted Signaling 0.4810 0.000000000000000000000000000002507646107235143 Scatter Plot
Source IL7 Target DMP1 DMP1 ECM-Receptor 0.4844 0.0000000000000000000000000000008697955076997664 Scatter Plot
Source IL7 Target NRG NRG Secreted Signaling 0.4874 0.0000000000000000000000000000003328493040512341 Scatter Plot
Source IL7 Target CD200 CD200 Cell-Cell Contact 0.5019 0.0000000000000000000000000000000028461442559902778 Scatter Plot
Source IL7 Target TENASCIN TENASCIN ECM-Receptor 0.5161 0.000000000000000000000000000000000021494624724820032 Scatter Plot
Source IL7 Target CD39 CD39 Cell-Cell Contact 0.5219 0.0000000000000000000000000000000000027509179842463736 Scatter Plot
Source IL7 Target FGF FGF Secreted Signaling 0.5232 0.0000000000000000000000000000000000016946027626750086 Scatter Plot
Source IL7 Source BST2 BST2 Cell-Cell Contact 0.5274 0.00000000000000000000000000000000000037246394847465362 Scatter Plot
Source IL7 Target ncWNT ncWNT Secreted Signaling 0.5516 0.000000000000000000000000000000000000000037191758198756916 Scatter Plot
Source IL7 Target JAM JAM Cell-Cell Contact 0.5646 0.0000000000000000000000000000000000000000001894323037607818 Scatter Plot
Source IL7 Target CD34 CD34 Cell-Cell Contact 0.5650 0.00000000000000000000000000000000000000000016164484755115681 Scatter Plot
Source IL7 Target SLURP SLURP Secreted Signaling 0.5674 0.00000000000000000000000000000000000000000005767935962590099 Scatter Plot
Source IL7 Target ESAM ESAM Cell-Cell Contact 0.5690 0.00000000000000000000000000000000000000000002999790823584505 Scatter Plot
Source IL7 Source ESAM ESAM Cell-Cell Contact 0.5690 0.00000000000000000000000000000000000000000002999790823584505 Scatter Plot
Source IL7 Target APP APP Cell-Cell Contact 0.5698 0.000000000000000000000000000000000000000000020939352022414962 Scatter Plot
Source IL7 Target WNT WNT Secreted Signaling 0.5721 0.000000000000000000000000000000000000000000007985736382218034 Scatter Plot
Source IL7 Target MIF MIF Secreted Signaling 0.6233 0.0000000000000000000000000000000000000000000000000000003611148679367901 Scatter Plot
Source IL7 Source MHC-I MHC-I Cell-Cell Contact 0.6393 0.00000000000000000000000000000000000000000000000000000000007967772061016057 Scatter Plot
Source IL7 Source CD52 CD52 Cell-Cell Contact -0.4173 0.00000000000000000000017225162041525773 Scatter Plot
Source IL7 Source ITGAL-ITGB2 ITGAL-ITGB2 Cell-Cell Contact -0.3650 0.00000000000000003351749304069813 Scatter Plot
Source IL7 Target ICAM ICAM Cell-Cell Contact -0.3545 0.0000000000000002983183799142917 Scatter Plot
Source IL7 Source COMPLEMENT COMPLEMENT Secreted Signaling -0.3264 0.00000000000007062752657483566 Scatter Plot
Source IL7 Source PARs PARs Secreted Signaling -0.3061 0.000000000002606519313160885 Scatter Plot
Source IL7 Target CD52 CD52 Cell-Cell Contact -0.2992 0.000000000008412346962307385 Scatter Plot
Source IL7 Target VCAM VCAM Cell-Cell Contact -0.2572 0.000000005374133919794726 Scatter Plot
Source IL7 Target CXCL CXCL Secreted Signaling -0.2434 0.000000035442258983617596 Scatter Plot
Source IL7 Target CSF CSF Secreted Signaling -0.2373 0.00000007890977214979414 Scatter Plot
Source IL7 Source CLEC CLEC Cell-Cell Contact -0.2194 0.0000007274804061185773 Scatter Plot
Source IL7 Target CCL CCL Secreted Signaling -0.2031 0.000004669399403956519 Scatter Plot
Source IL7 Target IL17 IL17 Secreted Signaling -0.1962 0.000009885969814524362 Scatter Plot
Source IL7 Target CLEC CLEC Cell-Cell Contact -0.1743 0.00008957060197815013 Scatter Plot
Source IL7 Target CEACAM CEACAM Cell-Cell Contact -0.1718 0.0001132358085532 Scatter Plot
Source IL7 Target IFN-II IFN-II Secreted Signaling -0.1676 0.0001658286615247 Scatter Plot
Source IL7 Target VEGF VEGF Secreted Signaling -0.1589 0.0003622187141588 Scatter Plot
Source IL7 Source TNF TNF Secreted Signaling -0.1307 0.0034028296657996 Scatter Plot
Source IL7 Source NKG2D NKG2D Cell-Cell Contact -0.1070 0.0166601515928742 Scatter Plot
Source IL7 Source ANNEXIN ANNEXIN Secreted Signaling -0.0962 0.0314214929496404 Scatter Plot
Source IL7 Target GRN GRN Secreted Signaling -0.0961 0.0316764586063504 Scatter Plot

Cells that are targets of IL7 from HSCs*

Cells that are source of IL7 to HSCs*

    No cell populations

Ligands:

Receptors:

*Cell types are filtered such that they interact with at least 5% of HSCs.